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Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis.

Mengge Chen, Yanpeng Ding, Yuan Ke, Yifei Zeng, Nuomin Liu, Yahua Zhong, Xinying Hua, Zheng Li, Yudi Xiong, Chaoyan Wu, Haijun Yu,

Zinc pyrithione (ZPT) is widely used as an antimicrobial. Zinc is a necessary trace element of the human whose homeostasis associated with several cancers. However, the anticancer effect of increased Zinc in ovarian cancer is still unclear. This study focussed on the anti-tumour effects of ZPT combined with Zinc in ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):824-833]

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Effects of Moist Exposed Burn Therapy and Ointment (MEBT/MEBO) on the autophagy mTOR signalling pathway in diabetic ulcer wounds.

Aitian Zheng, Huadan Ma, Xianbin Liu, Qing Huang, Zheng Li, Lin Wang, Na Zeng, Biaoliang Wu,

Context: Burn therapy (MEBT)/moist exposed burn ointment (MEBO) is an effective traditional Chinese medicine method to treat diabetic wound, but the mechanism is unclear. Autophagy has been proved to be closely related with wound healing, so MEBO/MEBT is hypothesized to promote diabetic wound healing by regulating autophagy.Objective: To explore the ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):124-130]

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Magnetically hard ferrite nanoparticles synthesized through aerogel nanoreactor.

Rui Ji, Zefan Shao, Zheng Li, Jieyu Wang, Lu An, Zipeng Guo, Chi Zhou, Shenqiang Ren,

Magnetic ferrite materials have been extensively studied for a range of technological applications, such as magnetic motors, recording media, and millimetre-wave devices. In this context, the nanosized epsilon phase of Fe2O3 (ϵ-Fe2O3) attracts significant attention due to its high coercive field at room temperature. Here, we report the in-situ aerogel ... Read more >>

Nanotechnology (Nanotechnology)
[2020, 31(46):465606]

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Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression

Guangli Sun, Zheng Li, Zhongyuan He, Weizhi Wang, Sen Wang, Xing Zhang, Jiacheng Cao, Penghui Xu, Haixiao Wang, Xiaoxu Huang, Yiwen Xia, Jialun Lv, Zhe Xuan, Tianlu Jiang, Lang Fang, Jing Yang, Diancai Zhang, Hao Xu, Ze-Kuan Xu,

Abstract Background: Cisplatin (CDDP) is the first-line chemotherapy for gastric cancer (GC). The poor prognosis of GC patients is partially due to the development of CDDP resistance. Circular RNAs (circRNAs) are a subclass of noncoding RNAs that function as microRNA (miRNA) sponges. The role of circRNAs in CDDP resistance in ... Read more >>

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High-precision digital terahertz phase manipulation within a multichannel field perturbation coding 2DEG meta-chip

Hongxin Zeng, Huajie Liang, Yaxin Zhang, Ziqiang Yang, Feng Lan, Shixiong Liang, Zheng Li, Lan Wang, Xilin Zhang, Sen Gong, Yubin Gong, Ziqiang Yang,

Abstract Terahertz phase manipulation has always been based on direct coupling of the resonance of quasi-optical terahertz waves with metamaterials, which is accompanied by unnecessary amplitude modulation, thus limiting the accuracy of phase manipulation and its application in monolithic integrated systems. Here, we propose a coding meta-chip composed of transmission ... Read more >>

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Sodium Lignosulfonate Modified Polystyrene for the Removal of Phenol from Wastewater.

Keyan Yang, Jingchen Xing, Jianmin Chang, Fei Gu, Zheng Li, Zhenhua Huang, Liping Cai,

An eco-friendly and novel water treatment material was synthesized using sodium lignosulfonate modified polystyrene (SLPS), which can be used to eliminate phenols in aqueous solution. SLPS was characterized by BET, FTIR, SEM, and EDS. The effect of the initial pH value, phenol content, adsorption time, and temperature on the absorbability ... Read more >>

Polymers (Basel) (Polymers)
[2020, 12(11):]

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Area-Selective Atomic Layer Deposition of TiN Using Trimethoxy(octadecyl)silane as a Passivation Layer.

Li Zheng, Wei He, Valentina Spampinato, Alexis Franquet, Stefanie Sergeant, Stefan De Gendt, Silvia Armini,

Area-selective deposition (ASD) offers tremendous advantages when compared with conventional patterning processes, such as the possibility of achieving three-dimensional features in a bottom-up additive fashion. Recently, ASD is gaining more and more attention from IC manufacturers and equipment and material suppliers. Through combination of self-assembled monolayer (SAM) surface passivation of ... Read more >>

Langmuir (Langmuir : the ACS journal of surfaces and colloids)
[2020, :]

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An update on the roles of circular RNAs in osteosarcoma.

Zheng Li, Xingye Li, Derong Xu, Xin Chen, Shugang Li, Lin Zhang, Matthew T V Chan, William K K Wu,

Osteosarcoma is the most common primary bone malignancy and is a neoplasm thought to be derived from the bone-forming mesenchymal stem cells. Aberrant activation of oncogenes and inactivation of tumour suppressor genes by somatic mutations and epigenetic mechanisms play a pivotal pathogenic role in osteosarcoma. Aside from alterations in these ... Read more >>

Cell Prolif (Cell proliferation)
[2020, :e12936]

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Attenuated Self-serving Bias in People with Internet Gaming Disorder is Related to Altered Neural Activity in Subcortical-Cortical Midline Structures

Yifan Wang, Li Zheng, Chenggong Wang, Xiuyan Guo,

Abstract Background: To protect and maintain the positivity of self-concept, normal people usually show a self-serving bias (internal attribution of positive events and external attribution of negative events) by the motives of self-enhancement and self-protection. Additionally, self-serving assessments predominantly activate the subcortical-cortical midline structures (CMS) in healthy individuals. However, little ... Read more >>

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Attenuated self-serving bias in people with internet gaming disorder is related to altered neural activity in subcortical-cortical midline structures.

Yifan Wang, Li Zheng, Chenggong Wang, Xiuyan Guo,

BACKGROUND:To protect and maintain the positivity of self-concept, normal people usually show a self-serving bias (internal attribution of positive events and external attribution of negative events) by the motives of self-enhancement and self-protection. Additionally, self-serving assessments predominantly activate the subcortical-cortical midline structures (CMS) in healthy individuals. However, little is known ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2020, 20(1):512]

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Upper airway lengthening caused by weight increase in obstructive sleep apnea patients.

Hongyi Lin, Huahui Xiong, Changjin Ji, Cunting Wang, Yong Li, Yunqiang An, Geng Li, Jianggui Guo, Xiaoqing Huang, Han Zhang, Hong Liu, Ting Li, Zheng Li, Junfang Xian, Yaqi Huang,

BACKGROUND:The longer upper airway is more collapsible during sleep. This study aims to reveal relationships among upper airway length, weight, and obstructive sleep apnea (OSA), particularly to answer why the upper airway of OSA patients is longer than that of healthy people and why some obese people suffer from OSA ... Read more >>

Respir Res (Respiratory research)
[2020, 21(1):272]

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Coronary CTA to Investigate Predictive Value of Left Atrial Appendage for Cardiogenic Stroke in Patients with Nonvalvular Atrial Fibrillation.

Runrong Wang, Chunhong Hu, Zheng Li, Shuai Zhang, Wei Li, Hongling Hou,

Purpose:To investigate the predictive value of changes in LAA size and function for cardiogenic stroke (CS) in patients with NVAF by coronary CTA examination. Materials and Method. 179 patients with NVAF were selected and grouped according to the outbreak of acute ischemic stroke and TIA within 2 years after coronary ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:7351876]

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Calmodulin Directly Interacts with the Cx43 Carboxyl-Terminus and Cytoplasmic Loop Containing Three ODDD-Linked Mutants (M147T, R148Q, and T154A) that Retain α-Helical Structure, but Exhibit Loss-of-Function and Cellular Trafficking Defects.

Li Zheng, Sylvie Chenavas, Fabien Kieken, Andrew Trease, Sarah Brownell, Asokan Anbanandam, Paul L Sorgen, Gaelle Spagnol,

The autosomal-dominant pleiotropic disorder called oculodentodigital dysplasia (ODDD) is caused by mutations in the gap junction protein Cx43. Of the 73 mutations identified to date, over one-third are localized in the cytoplasmic loop (Cx43CL) domain. Here, we determined the mechanism by which three ODDD mutations (M147T, R148Q, and T154A), all ... Read more >>

Biomolecules (Biomolecules)
[2020, 10(10):]

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Effects of plant density on tillering in the weed grass Aegilops tauschii Coss. and its phytohormonal regulation.

Haiyan Yu, Juan Yang, Hailan Cui, Zheng Li, Fang Jia, Jingchao Chen, Xiangju Li,

Aegilops tauschii Coss, a notorious wheat field weed, poses a serious threat to wheat in China. Tillers are an important agronomic tool for yield. In this study, a total of 12 Ae. tauschii populations were collected from China to investigate the effect of plant density on tiller occurrence and its ... Read more >>

Plant Physiol Biochem (Plant physiology and biochemistry : PPB)
[2020, 157:70-78]

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Hierarchical Structural Engineering of Ultrahigh-Molecular-Weight Polyethylene.

Lu An, Zefan Shao, Jason N Armstrong, Yulong Huang, Yong Hu, Zheng Li, Danial Faghihi, Shenqiang Ren,

Nature has inspired the design of next-generation lightweight architectured structural materials, for example, nacre-bearing extreme impact and paw-pad absorbing energy. Here, a bioinspired functional gradient structure, consisting of an impact-resistant hard layer and an energy-absorbing ductile layer, is applied to additively manufacture ultrahigh-molecular-weight polyethylene (UHMWPE). Its crystalline graded and directionally ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, :]

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Network-level functional connectivity alterations in chemotherapy treated breast cancer patients: a longitudinal resting state functional MRI study.

Yun Feng, Yun Fei Wang, Li Juan Zheng, Zhao Shi, Wei Huang, Long Jiang Zhang,

BACKGROUND:Previous studies have found abnormal structural and functional brain alterations in breast cancer survivors undergoing chemotherapy. However, the network-level brain changes following chemotherapy remain unknown. The purpose of this study was to investigate the dynamic changes of large-scale within- and between-network functional connectivity in chemotherapy-treated breast cancer patients. METHODS:Seventeen breast ... Read more >>

Cancer Imaging (Cancer imaging : the official publication of the International Cancer Imaging Society)
[2020, 20(1):73]

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Effect of Food on the Pharmacokinetic and Pharmacodynamic Profiles of Hetrombopag in Healthy Volunteers.

Zhenlei Wang, Xiaogang Chen, Aiwei Li, Li Chen, Yongsheng Wang, Li Zheng,

PURPOSE:Hetrombopag, a novel, oral small molecule thrombopoietin receptor agonist, exhibits an obvious thrombocytopoietic effect with good safety. Hetrombopag is currently under clinical development for the treatment of chronic idiopathic thrombocytopenic purpura (ITP). The objectives of this study were to assess the effect of high-fat and high-calorie food on the pharmacokinetic ... Read more >>

Clin Ther (Clinical therapeutics)
[2020, :]

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Cobalt Phosphide Nanoflake-Induced Flower-like Sulfur for High Redox Kinetics and Fast Ion Transfer in Lithium-Sulfur Batteries.

Congyu Qi, Zheng Li, Changzhi Sun, Chunhua Chen, Jun Jin, Zhaoyin Wen,

Sulfur reactivity in lithium-sulfur batteries highly depends on its distribution and morphology during cycling, which is of great significance to suppress the shuttle effect and promote conversion reaction. Herein, cobalt phosphide nanoflakes are prepared and used as a sulfur host. An improved redox kinetics from sulfur to lithium sulfide and ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, :]

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Methanol-derived high-performance Na3V2(PO4)3/C: from kilogram-scale synthesis to pouch cell safety detection.

Yuqiang Pi, Zhiwei Gan, Zheng Li, Yushan Ruan, Cunyuan Pei, Hui Yu, Kang Han, Yaowen Ge, Qinyou An, Liqiang Mai,

Na3V2(PO4)3 (NVP) is regarded as a potential cathode material that can be applied in sodium ion batteries (SIBs) owing to its NASICON structure. However, most of the reported works have focused on the synthesis of materials and the improvement of their electrochemical properties, with little research on the design and ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(41):21165-21171]

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Emerging Magnetic Interactions in van der Waals Heterostructures.

Yulong Huang, Christian Wolowiec, Taishan Zhu, Yong Hu, Lu An, Zheng Li, Jeffrey C Grossman, Ivan K Schuller, Shenqiang Ren,

Vertical van der Waals (vdWs) heterostructures based on layered materials are attracting interest as a new class of quantum materials, where interfacial charge-transfer coupling can give rise to fascinating strongly correlated phenomena. Transition metal chalcogenides are a particularly exciting material family, including ferromagnetic semiconductors, multiferroics, and superconductors. Here, we report ... Read more >>

Nano Lett (Nano letters)
[2020, :]

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NRN1 and CAT Gene Polymorphisms, Complex Noise, and Lifestyles Interactively Affect the Risk of Noise-Induced Hearing Loss

Shuang-yan LIU, Jia-Rui XIN, Zheng LI, Song LEI, Ying-Qi CHEN, Tian-Yu ZHAO, Hai-Yan WANG, Liang-Wen XU, Mei-Bian ZHANG, Lei YANG,

Abstract Background: Multiple genetic and environmental factors influence the severity of NIHL. However, few studies have reported interactions among such factors in modulating the risk of NIHL. This study aimed to assess for interactions among gene polymorphisms, noise metrics, and lifestyles on the risk of NIHL. Methods: A case-control study ... Read more >>

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Genome-wide identification, characterization, and expression patterns analysis of the SBP-box gene family in wheat (Triticum aestivum L.).

Ying Li, Qilu Song, Yamin Zhang, Zheng Li, Jialin Guo, Xinhong Chen, Gaisheng Zhang,

SQUAMOSA promoter-binding protein (SBP)-box genes encode a family of plant-specific transcription factors that play roles in plant growth and development. The characteristics of SBP-box genes in rice (Oryza sativa) and Arabidopsis have been reported, but their potential roles in wheat (Triticum aestivum) are not fully understood. In this study, 48 ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):17250]

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Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor.

Jintong Zhou, Zhenghui Huang, Li Zheng, Zhoufei Hei, Zhiyong Wang, Biao Yu, Lubin Jiang, Jing Wang, Pengfei Fang,

Aminoacyl-tRNA synthetases are attractive targets for the development of antibacterial, antifungal, antiparasitic agents and for the treatment of other human diseases. Lysyl-tRNA synthetase (LysRS) from this family has been validated as a promising target for the development of antimalarial drugs. Here, we developed a high-throughput compatible assay and screened 1215 ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2020, :]

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Novel deletion mutations of the PIH1D3 gene in an infertile young man with primary ciliary dyskinesia and his cousin with Kartagener's syndrome.

Chuan Huang, Na-Chuan Liu, Xiao-Bo Wang, Ben-Hong Gu, Jian-Xiong Zhang, Li-Zhang, Zheng Li,

Asian J Androl (Asian journal of andrology)
[2020, :]

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DUS4L Silencing Suppresses Cell Proliferation and Promotes Apoptosis in Human Lung Adenocarcinoma Cell Line A549.

Zheng Li, Ci Yin, Bin Li, Qi-Yao Yu, Wen-Jie Mao, Jie Li, Jun-Ping Lin, Yu-Qi Meng, Hai-Ming Feng, Tao Jing,

Purpose:This study aims to investigate the potential role of DUS4L (dihydrouridine synthase 4 like) in lung adenocarcinoma (LUAD) and explore its associated pathways in human LUAD. Methods:Firstly, we evaluated the relationships between clinicopathological characteristics and DUS4L expression via analysis of TCGA RNA sequencing data and other publicly available databases. Then, ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:9905-9913]

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