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3-Arylcoumarin inhibits vascular calcification by inhibiting the generation of AGEs and anti-oxidative stress.

YuFei Li, Yinbo Pan, Liying Wang, Xiaojing Wang, Haiping Chu, Yan Li, Yanling Mu, Jie Sun,

<h4>Objective</h4>This work aims to screen drugs for preventing and treating vascular calcification. <b>Method:</b> We screened a series of 3-arylcoumarins for the detection of vascular calcification-associated factors using human aortic vascular smooth muscle cells.<h4>Results</h4>We found that compounds <b>14</b> and <b>32</b> significantly inhibited alkaline phosphatase (ALP) activity similar to aminoguanidine hydrochloride (AGH) ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2022, 37(1):2147-2157]

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MiR-140 targets lncRNA FAM230B to suppress cell proliferation in acute myeloid leukemia running title: MiR-140 targets FAM230B in AML.

Yan Wang, Fangfang Wang, Yang Lu, Yan Li, Haonan Ran, Feihu Yan, Yuyang Tian,

<h4>Background</h4>FAM230B serves as an oncogenic lncRNA in both gastric cancer and papillary thyroid cancer, while its role in acute myeloid leukemia (AML) is unclear. We predicted that FAM230B could be a target of miR-140, a well-characterized tumor suppressor, and analyzed their interaction in AML.<h4>Methods</h4>Differential expressions of FAM230B and miR-140 in ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2022, 27(1):700-705]

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