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Differential development and electrophysiological activity in cultured cortical neurons from the mouse and cynomolgus monkey.

Xue-Yan Zhang, Jun Li, Cai-Juan Li, Ying-Qi Lin, Chun-Hui Huang, Xiao Zheng, Xi-Chen Song, Zhu-Chi Tu, Xiao-Jiang Li, Sen Yan,

In vitro cultures of primary cortical neurons are widely used to investigate neuronal function. However, it has yet to be fully investigated whether there are significant differences in development and function between cultured rodent and primate cortical neurons, and whether these differences influence the utilization of cultured cortical neurons to ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2446-2452]

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MicroRNA-25-3p promotes cisplatin resistance in Non-small-cell lung carcinoma (NSCLC) through adjusting PTEN/PI3K/AKT route.

Butong Sun, Nanjun Hu, Dan Cong, Kang Chen, Jun Li,

MicroRNAs exert crucial effects in the drug resistance. The purpose of this research was to investigate the miR-25-3p effects on DDP resistance in NSCLC. We used RT-qPCR to evaluate the expression of miR-25-3p. Cell growth was determined using MTS assay. Cellular bio-activity was analyzed via Colony formation, Annexin V/PI, and ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3219-3228]

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Nitrapyrin coupled with organic amendment mitigates N2O emissions by inhibiting different ammonia oxidizers in alkaline and acidic soils

Rui Tao, Xiran Zhao, Xiaoliang Wu, Baowei Hu, Kollie B Vanyanbah, Jun Li, Guixin Chu,

The aim of this study was to investigate the combined effects of organic manure and nitrification inhibitor on nitrogen (N) transformation, nitrous oxide (N₂O) emissions and the gene abundance of ammonia oxidizers in acidic and alkaline soils. Therefore, an incubation experiment was conducted with red (pH 5.51) and calcareous soils (pH 8.12) ... Read more >>

Appl Soil Ecol (Applied soil ecology.)
[2021, 166:Not Available]

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Identification and management of severe multiple radiation-induced heart disease: case reports from locally advanced esophageal cancer patient.

Yi-Xun Gu, Xi-Zhi Zhang, Jun Li, Yong Chen,

J Geriatr Cardiol (Journal of geriatric cardiology : JGC)
[2021, 18(2):141-145]

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Role of circular RNA expression in the pathological progression after spinal cord injury.

Wen-Zhao Wang, Jun Li, Lei Liu, Zheng-Dong Zhang, Ming-Xin Li, Qin Li, Hui-Xu Ma, Hai Yang, Xiao-Ling Hou,

Differential expression of non-coding RNA after traumatic spinal cord injury (TSCI) is closely related to the pathophysiological process. The purposes of this study were to systematically profile and characterize expression of circular RNA (circRNA) in the lesion epicenter of spinal tissues after TSCI, and predict the structure and potential function ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(10):2048-2055]

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Correction to: lipase-catalyzed transesterification of soybean oil and phytosterol in supercritical CO2.

Lizhi Hu, Libin Sun, Jun Li, Liangjun Qi, Xu Zhang, Dianyu Yu, Elfalleh Walid, Lianzhou Jiang,

Bioprocess Biosyst Eng (Bioprocess and biosystems engineering)
[2021, 44(9):2001]

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Molecular cloning and characterization of FADD from the grass carp (Ctenopharyngodon idellus) in response to bacterial infection

Zhijie Lu, Meizhen Tang, Yanan Li, Fei Shi, Fanbin Zhan, Menglan Zhang, Lijuan Zhao, Jun Li, Li Lin, Zhendong Qin,

Fas-associated protein with Death Domain (FADD) is closely associated with cell death and plays a key role in hematopoiesis, cell cycle regulation, embryogenesis, and particularly, innate immune signaling. However, the mechanisms underlying the apoptotic and immune responses against bacterial infection associated with FADD in teleost fish have yet to be ... Read more >>

Aquaculture (Aquaculture (Amsterdam, Netherlands))
[2021, 542:Not Available]

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Comparative study on the growth, survival, gonad development and trait segregation of F2 hybrids and their grandparent species (Crassostrea ariakensis and C. hongkongensis)

Yanping Qin, Xingyou Li, Qingliang Liao, Jun Li, Haitao Ma, Riguan Mo, Yuehuan Zhang, Ziniu Yu,

In previous studies, we showed that F₁ hybrids of Crassostrea ariakensis and C. hongkongensis had faster growth and higher survival rates than the parent species. Further intraspecific crossing of F₁ hybrids allowed us to further understand the law of trait segregation and indicated a potential direction for breeding of a ... Read more >>

Aquaculture (Aquaculture (Amsterdam, Netherlands))
[2021, 541:Not Available]

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DDAH2 (-449 G/C) G allele is positively associated with leukoaraiosis in northeastern China: a double-blind, intergroup comparison, case-control study.

Ying Fan, Qiang Gao, Jia-Xin Guan, Lei Liu, Ming Hong, Li Jun, Li Wang, Hai-Feng Ding, Li-Hong Jiang, Bo-Yu Hou, Mei Li, Zhi-Qiang Song, De-Qin Sun, Chao-Qi Yan, Lan Ma,

Cerebrovascular endothelial dysfunction is involved in the progression of leukoaraiosis. Asymmetric dimethylarginine is a competitive inhibitor of nitric oxide, which is highly expressed in patients with leukoaraiosis. Dimethylarginine dimethylaminohydrolase (DDAH) is a hydrolytic enzyme that is primarily responsible for eliminating asymmetric dimethylarginine, and it plays a role in the pathogenesis ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(8):1592-1597]

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Long-term Survival after Combined Epidural-General Anesthesia or General Anesthesia Alone: Follow-up of a Randomized Trial.

Ya-Ting Du, Ya-Wei Li, Bin-Jiang Zhao, Xiang-Yang Guo, Yi Feng, Ming-Zhang Zuo, Cong Fu, Wei-Jie Zhou, Huai-Jin Li, Ya-Fei Liu, Tong Cheng, Dong-Liang Mu, Yuan Zeng, Peng-Fei Liu, Yan Li, Hai-Yan An, Sai-Nan Zhu, Xue-Ying Li, Hui-Juan Li, Yang-Feng Wu, Dong-Xin Wang, Daniel I Sessler, ,

<h4>Background</h4>Experimental and observational research suggests that combined epidural-general anesthesia may improve long-term survival after cancer surgery by reducing anesthetic and opioid consumption and by blunting surgery-related inflammation. This study therefore tested the primary hypothesis that combined epidural-general anesthesia improves long-term survival in elderly patients.<h4>Methods</h4>This article presents a long-term follow-up of ... Read more >>

Anesthesiology (Anesthesiology)
[2021, 135(2):233-245]

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Retraction Note: Extracellular vesicle-associated microRNA-221-3p secreted by drug-resistant lung cancer cells targets HMBOX1 to promote the progression of lung cancer.

Jun Li, Yongjuan Zhao, Jing Wang,

Cancer Gene Ther (Cancer gene therapy)
[2021, :]

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Molecular cloning and biochemical characterization of a new coumarin glycosyltransferase CtUGT1 from Cistanche tubulosa.

Xiping Xu, Yaru Yan, Wenqian Huang, Ting Mo, Xiaohui Wang, Juan Wang, Jun Li, Shepo Shi, Xiao Liu, Pengfei Tu,

UDP-glycosyltransferases (UGTs) are an important and functionally diverse family of enzymes involved in secondary metabolite biosynthesis. Coumarin is one of the most common skeletons of natural products with candidate pharmacological activities. However, to date, many reported GTs from plants mainly recognized flavonoids as sugar acceptors. Only limited GTs could catalyze ... Read more >>

Fitoterapia (Fitoterapia)
[2021, :104995]

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Application of Ultrasonography in Conservative Treatment of Humeral Shaft Fracture in Children

Jun Li, Xin Tan, Xiang Li, Pan Gou, Xiaowei Yuan, Tao Liu, Mingyan Shi, Xing Liu,

<h4>Background: </h4> Most of humeral shaft fractures in children could be treated satisfactorily by conservative treatment. This study aimed to evaluate the application value of ultrasonography in conservative treatment of humeral shaft fracture in children.Methods : We retrospectively reviewed children admitted to our hospital, for humeral shaft fracture from January ... Read more >>

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Molecular Dynamics and Light Absorption Properties of Atmospheric Dissolved Organic Matter.

Hongxing Jiang, Jun Li, Rong Sun, Chongguo Tian, Jiao Tang, Bin Jiang, Yuhong Liao, Chang-Er Chen, Gan Zhang,

The light-absorbing organic aerosol referred to as brown carbon (BrC) affects the global radiative balance. The linkages between its molecular composition and light absorption properties and how environmental factors influence BrC composition are not well understood. In this study, atmospheric dissolved organic matter (ADOM) in 55 aerosol samples from Guangzhou ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2021, :]

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Metabolomics of the tryptophan-kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Mediterranean diet.

Cristina Razquin, Miguel Ruiz-Canela, Estefania Toledo, Pablo Hernández-Alonso, Clary B Clish, Marta Guasch-Ferré, Jun Li, Clemens Wittenbecher, Courtney Dennis, Angel Alonso-Gómez, Montse Fitó, Liming Liang, Dolores Corella, Enrique Gómez-Gracia, Ramon Estruch, Miquel Fiol, Jose Lapetra, Lluis Serra-Majem, Emilio Ros, Fernando Aros, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González,

<h4>Background</h4>The tryptophan-kynurenine pathway is linked to inflammation. We hypothesize that metabolites implicated in this pathway may be associated with the risk of heart failure (HF) or atrial fibrillation (AF) in a population at high risk of cardiovascular disease.<h4>Objectives</h4>We aimed to prospectively analyze the associations of kynurenine-related metabolites with the risk ... Read more >>

Am J Clin Nutr (The American journal of clinical nutrition)
[2021, :]

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Association of Parenteral Anticoagulation Therapy with Outcomes in Non-ST-Segment Elevation Acute Coronary Syndrome Patients Without Invasive Therapy.

Yuan-Hui Liu, Hua-Lin Fan, Li-Huan Zeng, Chong-Yang Duan, Guo Chen, Peng-Yuan Chen, Dong Zhao, Jing Liu, Yong-Chen Hao, Wen-Fei He, Sha Tao, Xue-Biao Wei, Lei Jiang, Wei Guo, Yan-Song Guo, Wei Chen, Jun Li, Yun-Zhao Hu, Wen-Sheng Li, Yi-Yue Chen, Jian-Fang Luo, Ying-Ling Zhou, Dan-Qing Yu, Ya-Ling Han, Ning Tan, Ji-Yan Chen, Peng-Cheng He,

Our previous study showed that parenteral anticoagulation therapy (PACT) in the context of aggressive antiplatelet therapy failed to improve clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) for non-ST-segment elevation acute coronary syndrome (NSTE-ACS). However, the roles of PACT in patients managed medically remains unknown. This observational cohort study ... Read more >>

Clin Pharmacol Ther (Clinical pharmacology and therapeutics)
[2021, :]

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Multi-component synthesis of dihydro-1,3-azaborinine derived oxindole isosteres.

Jun Li, Constantin G Daniliuc, Jonas Matern, Gustavo Fernández, Gerald Kehr, Gerhard Erker,

We report on the synthesis of the first examples of 1,3-azaborinine derived oxindole systems, the BN-isosteres of the important compound class of the oxindoles. Hydroboration of terminal aryl acetylenes with FmesBH2, followed by treatment with 2 equiv. of a glycine ester derived isonitrile gave a small series of 1,3-azaborinine derived ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, :]

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Polymorphism Rs34562254 In TNFRSF13B is Associated with HCV Infection Outcomes Among Chinese Han Population

Haozhi Fan, Zuqiang Fu, Zhijun Ge, Chen Dong, Chunhui Wang, Chao Shen, Jun Li, Rongbin Yu, Yun Zhang, Ming Yue,

Genetic variations in tumor necrosis factor receptor superfamily ( TNFRSF ) 13B have already proved to be associated with immune- related diseases. This study aimed to explore the relationship of tumor necrosis factor superfamily ( TNFSF ) 13, TNFRSF13B , and TNFRSF14 missense mutations with the susceptibility of HCV infection. ... Read more >>

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Photoactivatable Red Chemiluminescent AIEgen Probe for In Vitro/Vivo Imaging Assay of Hydrazine.

Jun Li, Yingcai Hu, Zuhao Li, Wei Liu, Ting Deng, Jishan Li,

Here, we have developed a novel photoactivatable red chemiluminescent AIEgen probe (ACL), based on the combination of the red-emission AIEgen fluorophore (TPEDC) that shows excellent singlet oxygen (<sup>1</sup>O<sub>2</sub>)-generation ability and the precursor of Schaap's dioxetane (the linker connected to adamantane is the C═C bond) that can be modified to target ... Read more >>

Anal Chem (Analytical chemistry)
[2021, :]

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Multiple Outbreaks Resulting from Asymptomatic Infection in Spreading of COVID-19

Jun Li, Mingju Ma,

In this paper, we establish a compartmental model for the transmission of COVID-19 with both symptomatic and asymptomatic infections. The difference is that in our model, we consider the infection caused by multiple contacts with asymptomatic infected population. Through the dynamic analysis of the model, we found that when there ... Read more >>

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A way to reduce the occurrence of intraoperative capsule rupture in presumed clinically early-stage ovarian cancer with adhesions to abdominal wall.

Jun Li, Jie Duan, Ruonan Mao, Wei Jiang,

<h4>Objective</h4>To present a procedure to reduce the occurrence of intraoperative capsule rupture in presumed clinically early-stage ovarian cancer with adhesions to abdominal wall.<h4>Design</h4>Stepwise presentation of the procedure with narrated video footage SETTING: : The occurrence of intraoperative capsule rupture exerts a negative effect on the prognosis of early-stage ovarian cancer ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2021, :]

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Critical Role of Sc Substitution in Modulating Ferroelectricity in Multiferroic LuFeO3.

Shiqing Deng, Jun Li, Didrik R Småbråten, Shoudong Shen, Wenbin Wang, Jun Zhao, Jing Tao, Ulrich Aschauer, Jun Chen, Yimei Zhu, Jing Zhu,

Understanding how individual dopants or substitutional atoms interact with host lattices enables us to manipulate, control, and improve the functionality of materials. However, because of the intimate coupling among various degrees of freedom in multiferroics, the atomic-scale influence of individual foreign atoms has remained elusive. Here, we unravel the critical ... Read more >>

Nano Lett (Nano letters)
[2021, :]

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Paraneoplastic myelitis associated with durvalumab treatment for extensive-stage small cell lung cancer.

Lan Wang, Haiyan Lou, Bo Li, Jun Li, Yun-Mei Yang,

Paraneoplastic neurologic syndromes(PNSs) caused by immune checkpoint inhibitors(ICIs) is rare and requires clinicians to differentiate between disease progression and immune-related adverse effects(irAEs). We hereby report the case of immune-related myelitis accompanied by positive paraneoplastic autoantibodies following durvalumab treatment for extensive-stage small cell lung cancer (ES-SCLC). A 70-year-old Chinese woman with ... Read more >>

Invest New Drugs (Investigational new drugs)
[2021, :]

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Rev-erbα exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy.

Qingxue Liu, Lei Xu, Meifei Wu, Yiwen Zhou, Junfa Yang, Cheng Huang, Tao Xu, Jun Li, Lei Zhang,

<h4>Background and aims</h4>Alcoholic fatty liver (AFL) is a liver disease caused by long-term excessive drinking and is characterized by hepatic steatosis. Understanding the regulatory mechanism of steatosis is essential for the treatment of AFL. Rev-erbα is a member of the Rev-erbs family of nuclear receptors, playing an important role in ... Read more >>

Cell Biosci (Cell & bioscience)
[2021, 11(1):129]

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Long-Residence Pneumonia Vaccine Developed Using PEG-Grafted Hybrid Nanovesicles from Cell Membrane Fusion of Mycoplasma and IFN-γ-Primed Macrophages.

Zhenzhen Zhang, Haiyan Wang, Xing Xie, Rong Chen, Jun Li, Bo Ni, Pei Yu, Zunfeng Liu, Guoqing Shao, Qiyan Xiong, Yanna Wei, Beibei Liu, Zhixin Feng, Xiang Zhou, Chao Zhang,

CD8<sup>+</sup> T cell responses play a critical regulatory role in protection against mycoplasma infection-related respiratory diseases. Nanovesicles derived from cell membranes have been shown to induce CD8<sup>+</sup> T cell responses. Moreover, the short residence time of mycoplasma membrane-related vaccines in local lymph nodes limits the efficacy of current mycoplasma vaccines. ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2021, :e2101183]

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