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Biodistribution of etoposide via intratumoral chemotherapy with etoposide-loaded implants.

Chunsheng Wu, Xiangting Yi, Renzhi Xu, Maokuan Zhang, Yan Xu, Yan Ma, Li Gao, Zhengbao Zha,

Etoposide (VP16) is the traditional antitumor agent which has been widely used in a variety of cancers. However, intravenous administration of VP16 was limited in clinical application because of its low aqueous solubility, poor bioavailability and dose-limiting adverse effects. Local chemotherapy with VP16-loaded drug delivery systems could provide a continuous ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):974-982]

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Ginsenoside Rg3 Attenuates Aluminum-Induced Osteoporosis Through Regulation of Oxidative Stress and Bone Metabolism in Rats.

Miao Song, Fubo Jia, Zheng Cao, Haiyang Zhang, Menglin Liu, Li Gao,

Aluminum (Al)-induced bone metabolism disorder is a primary cause of osteoporosis. Ginsenoside Rg3 (Rg3) has demonstrated therapeutic properties in the treatment of osteoporosis. The present study aimed to identify potential bone protection mechanisms of Rg3 against Al-induced osteoporosis in rats. In this study, forty healthy male Sprague-Dawley rats were randomly ... Read more >>

Biol Trace Elem Res (Biological trace element research)
[2020, 198(2):557-566]

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An Effective Cooling Device for Minimal-Incision Kidney Transplantation.

Yansheng Li, Xiuwu Han, Bayan-Undur Dagvadorj, Yongwei Zhao, Xin Zhang, Xuhui Zhu, Tao Li, Peng Zhang, Yuanhao Chen, Gao Li, Lkhamsuren Jambaljav,

BACKGROUND This study investigated the safety and efficacy of a new cooling device for use in minimal-incision kidney transplantation (MIKT). MATERIAL AND METHODS From June 2016 to December 2021, 9 patients underwent MIKT surgery in our hospitals using the new cooling device to maintain hypothermia. We recorded and analyzed information ... Read more >>

Ann Transplant (Annals of transplantation)
[2020, 25:e928773]

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Efficient enantiorecognition of amino acids under a stimuli-responsive system: synthesis, characterization and application of electroactive rotaxane.

Datong Wu, Fei Pan, Gao-Chao Fan, Ziming Zhu, Li Gao, Yongxin Tao, Yong Kong,

In this study, an electroactive rotaxane, (S,S)-crown-3, consisting of a polymeric chiral ionic liquid as a flexible axle and 18-crown-6 as the wheel, was designed and synthesized. It is worth noting that a stimuli-responsive system was developed, in which the wheel could switch its location between the chiral carbamido group ... Read more >>

Analyst (The Analyst)
[2019, 144(21):6415-6421]

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Danggui Sini Decoction (herbal medicine) for the treatment of primary dysmenorrhoea: a systematic review and meta-analysis.

Cuilan Ma, Ning Liang, Li Gao, Chunhua Jia,

Danggui Sini Decoction (DSD), a traditional herbal prescription, has been commonly used in the treatment of primary dysmenorrhoea (PD). We investigated the current evidence of randomised controlled trials (RCTs) and performed a systematic review to evaluate the efficacy of DSD in the treatment of PD. We registered the protocol for ... Read more >>

J Obstet Gynaecol (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology)
[2020, :1-9]

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Recombinant Lactococcus Expressing a Novel Variant of Infectious Bursal Disease Virus VP2 Protein Can Induce Unique Specific Neutralizing Antibodies in Chickens and Provide Complete Protection.

Zhihao Wang, Jielan Mi, Yulong Wang, Tingting Wang, Xiaole Qi, Kai Li, Qing Pan, Yulong Gao, Li Gao, Changjun Liu, Yanping Zhang, Xiaomei Wang, Hongyu Cui,

Recent reports of infectious bursal disease virus (IBDV) infections in China, Japan, and North America have indicated the presence of variant, and the current conventional IBDV vaccine cannot completely protect against variant IBDV. In this study, we constructed recombinant Lactococcus lactis (r-L. lactis) expressing a novel variant of IBDV VP2 ... Read more >>

Viruses (Viruses)
[2020, 12(12):]

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Atomically precise nanoclusters with reversible isomeric transformation for rotary nanomotors.

Zhaoxian Qin, Jiangwei Zhang, Chongqing Wan, Shuang Liu, Hadi Abroshan, Rongchao Jin, Gao Li,

Thermal-stimuli responsive nanomaterials hold great promise in designing multifunctional intelligent devices for a wide range of applications. In this work, a reversible isomeric transformation in an atomically precise nanocluster is reported. We show that biicosahedral [Au13Ag12(PPh3)10Cl8]SbF6 nanoclusters composed of two icosahedral Au7Ag6 units by sharing one common Au vertex can ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):6019]

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The clinical phenotype of bronchiectasis and its clinical guiding implications.

Li Gao, Ke-Ru Qin, Ting Li, Hai-Long Wang, Min Pang,

Bronchiectasis is a chronic airway disease with abnormal and persistent bronchial dilatation caused by a variety of reasons. In recent years, numerous reports have shown that bronchiectasis is heterogeneous, the clinical characteristics of patients with different phenotypes are different, and the efficacy of a treatment regimen may vary greatly in ... Read more >>

Exp Biol Med (Maywood) (Experimental biology and medicine (Maywood, N.J.))
[2020, :1535370220972324]

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Clinical characteristics of primary fallopian tube carcinoma: a single-institution retrospective study of 57 cases.

Zhihua Ma, Li Gao, Han Li, Jie Li, Guanjun Zhang, Yan Xue,

OBJECTIVE:To analyze the clinical profile and prognosis of primary fallopian tube cancer (PFTC) in order to improve earlier diagnosis. METHODS:In this retrospective study, 57 patients with PFTC were assessed from 2006 to 2016. Pathological, clinical index, recurrence, and survival condition were analyzed. RESULTS:The mean age was 57.35±9.01 years, and 73% ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2020, :]

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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.

Praveen Surendran, Elena V Feofanova, Najim Lahrouchi, Ioanna Ntalla, Savita Karthikeyan, James Cook, Lingyan Chen, Borbala Mifsud, Chen Yao, Aldi T Kraja, James H Cartwright, Jacklyn N Hellwege, Ayush Giri, Vinicius Tragante, Gudmar Thorleifsson, Dajiang J Liu, Bram P Prins, Isobel D Stewart, Claudia P Cabrera, James M Eales, Artur Akbarov, Paul L Auer, Lawrence F Bielak, Joshua C Bis, Vickie S Braithwaite, Jennifer A Brody, E Warwick Daw, Helen R Warren, Fotios Drenos, Sune Fallgaard Nielsen, Jessica D Faul, Eric B Fauman, Cristiano Fava, Teresa Ferreira, Christopher N Foley, Nora Franceschini, He Gao, Olga Giannakopoulou, Franco Giulianini, Daniel F Gudbjartsson, Xiuqing Guo, Sarah E Harris, Aki S Havulinna, Anna Helgadottir, Jennifer E Huffman, Shih-Jen Hwang, Stavroula Kanoni, Jukka Kontto, Martin G Larson, Ruifang Li-Gao, Jaana Lindström, Luca A Lotta, Yingchang Lu, Jian'an Luan, Anubha Mahajan, Giovanni Malerba, Nicholas G D Masca, Hao Mei, Cristina Menni, Dennis O Mook-Kanamori, David Mosen-Ansorena, Martina Müller-Nurasyid, Guillaume Paré, Dirk S Paul, Markus Perola, Alaitz Poveda, Rainer Rauramaa, Melissa Richard, Tom G Richardson, Nuno Sepúlveda, Xueling Sim, Albert V Smith, Jennifer A Smith, James R Staley, Alena Stanáková, Patrick Sulem, Sébastien Thériault, Unnur Thorsteinsdottir, Stella Trompet, Tibor V Varga, Digna R Velez Edwards, Giovanni Veronesi, Stefan Weiss, Sara M Willems, Jie Yao, Robin Young, Bing Yu, Weihua Zhang, Jing-Hua Zhao, Wei Zhao, Wei Zhao, Evangelos Evangelou, Stefanie Aeschbacher, Eralda Asllanaj, Stefan Blankenberg, Lori L Bonnycastle, Jette Bork-Jensen, Ivan Brandslund, Peter S Braund, Stephen Burgess, Kelly Cho, Cramer Christensen, John Connell, Renée de Mutsert, Anna F Dominiczak, Marcus Dörr, Gudny Eiriksdottir, Aliki-Eleni Farmaki, J Michael Gaziano, Niels Grarup, Megan L Grove, Göran Hallmans, Torben Hansen, Christian T Have, Gerardo Heiss, Marit E Jørgensen, Pekka Jousilahti, Eero Kajantie, Mihir Kamat, AnneMari Käräjämäki, Fredrik Karpe, Heikki A Koistinen, Csaba P Kovesdy, Kari Kuulasmaa, Tiina Laatikainen, Lars Lannfelt, I-Te Lee, Wen-Jane Lee, , Allan Linneberg, Lisa W Martin, Marie Moitry, Girish Nadkarni, Matt J Neville, Colin N A Palmer, George J Papanicolaou, Oluf Pedersen, James Peters, Neil Poulter, Asif Rasheed, Katrine L Rasmussen, N William Rayner, Reedik Mägi, Frida Renström, Rainer Rettig, Jacques Rossouw, Pamela J Schreiner, Peter S Sever, Emil L Sigurdsson, Tea Skaaby, Yan V Sun, Johan Sundstrom, Gudmundur Thorgeirsson, Tõnu Esko, Elisabetta Trabetti, Philip S Tsao, Tiinamaija Tuomi, Stephen T Turner, Ioanna Tzoulaki, Ilonca Vaartjes, Anne-Claire Vergnaud, Cristen J Willer, Peter W F Wilson, Daniel R Witte, Ekaterina Yonova-Doing, He Zhang, Naheed Aliya, Peter Almgren, Philippe Amouyel, Folkert W Asselbergs, Michael R Barnes, Alexandra I Blakemore, Michael Boehnke, Michiel L Bots, Erwin P Bottinger, Julie E Buring, John C Chambers, Yii-Der Ida Chen, Rajiv Chowdhury, David Conen, Adolfo Correa, George Davey Smith, Rudolf A de Boer, Ian J Deary, George Dedoussis, Panos Deloukas, Emanuele Di Angelantonio, Paul Elliott, , , Stephan B Felix, Jean Ferrières, Ian Ford, Myriam Fornage, Paul W Franks, Stephen Franks, Philippe Frossard, Giovanni Gambaro, Tom R Gaunt, Leif Groop, Vilmundur Gudnason, Tamara B Harris, Caroline Hayward, Branwen J Hennig, Karl-Heinz Herzig, Erik Ingelsson, Jaakko Tuomilehto, Marjo-Riitta Järvelin, J Wouter Jukema, Sharon L R Kardia, Frank Kee, Jaspal S Kooner, Charles Kooperberg, Lenore J Launer, Lars Lind, Ruth J F Loos, Abdulla Al Shafi Majumder, Markku Laakso, Mark I McCarthy, Olle Melander, Karen L Mohlke, Alison D Murray, Børge Grønne Nordestgaard, Marju Orho-Melander, Chris J Packard, Sandosh Padmanabhan, Walter Palmas, Ozren Polasek, David J Porteous, Andrew M Prentice, Michael A Province, Caroline L Relton, Kenneth Rice, Paul M Ridker, Olov Rolandsson, Frits R Rosendaal, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Nilesh J Samani, Naveed Sattar, Wayne H-H Sheu, Blair H Smith, Nicole Soranzo, Timothy D Spector, John M Starr, Sylvain Sebert, Kent D Taylor, Timo A Lakka, Nicholas J Timpson, Martin D Tobin, , Pim van der Harst, Peter van der Meer, Vasan S Ramachandran, Niek Verweij, Jarmo Virtamo, Uwe Völker, David R Weir, Eleftheria Zeggini, Fadi J Charchar, , Nicholas J Wareham, Claudia Langenberg, Maciej Tomaszewski, Adam S Butterworth, Mark J Caulfield, John Danesh, Todd L Edwards, Hilma Holm, Adriana M Hung, Cecilia M Lindgren, Chunyu Liu, Alisa K Manning, Andrew P Morris, Alanna C Morrison, Christopher J O'Donnell, Bruce M Psaty, Danish Saleheen, Kari Stefansson, Eric Boerwinkle, Daniel I Chasman, Daniel Levy, Christopher Newton-Cheh, Patricia B Munroe, Joanna M M Howson,

Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10-8), of which 32 were in new BP-associated loci ... Read more >>

Nat Genet (Nature genetics)
[2020, :]

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Whole genome sequencing of silver carp (Hypophthalmichthys molitrix) and bighead carp (Hypophthalmichthys nobilis) provide novel insights into their evolution and speciation.

Jianbo Jian, Liandong Yang, Xiaoni Gan, Bin Wu, Li Gao, Honghui Zeng, Xuzhen Wang, Zhiqiang Liang, Ying Wang, Lihua Fang, Jie Li, Sanjie Jiang, Kang Du, Beide Fu, Mingzhou Bai, Ming Chen, Xiaodong Fang, Huanzhang Liu, Shunping He,

The edible silver carp (Hypophthalmichthys molitrix) and bighead carp (H. nobilis), which are two of the "Four Domesticated Fish" of China, are cultivated intensively worldwide. Here, we constructed 837 Mb and 845 Mb draft genome assemblies for the silver carp and the bighead carp, respectively, including 24,571 and 24,229 annotated ... Read more >>

Mol Ecol Resour (Molecular ecology resources)
[2020, :]

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Development and Validation of the Peptic Ulcer Scale under the System of Quality of Life Instruments for Chronic Diseases based on Classical Test Theory and Generalizability Theory

chonghua wan, Ying Chen, Li Gao, Qingqing Zhang, Peng Quan, Xiaoyuan Sun,

Abstract Background: Quality of life (QOL) for patients with Peptic ulcer disease (PUD) is of interest worldwide and disease-specific instruments are needed for clinical research and practice. This paper focus on the development and validation of the PUD scale under the system of Quality of Life Instruments for Chronic Diseases ... Read more >>

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Traditional Chinese Medicine Network Pharmacology in Cardiovascular Precision Medicine.

Li Gao, Min Cao, Jia-Qi Li, Xue-Mei Qin, Jian-Song Fang,

Cardiovascular disease is a major disease affecting human health, and its pathogenesis is caused by many factors. Through the use of 'omics' technology, precision medicine is playing an increasingly important role in the prevention and treatment of cardiovascular diseases. Dialectical treatment with traditional Chinese medicine (TCM)will result in personalized treatment, ... Read more >>

Curr Pharm Des (Current pharmaceutical design)
[2020, :]

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Acute toxicity assessment of indoor dust extracts by luminescent bacteria assays with Photobacterium Phosphoreum T3.

Jiafan Li, Tao Yuan, Yuning Ma, Zhemin Shen, Ying Tian, Li Gao, Xiaoyan Dong,

In the last decades, there has been an increasing concern about the human exposure to indoor dust. Therefore, it is imperative to assess the toxicity of indoor dust and associated dust extracts. In this study, the acute toxicity assessment of indoor dust was performed using a bioluminescence test, with Photobacterium ... Read more >>

Environ Res (Environmental research)
[2020, :110447]

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A reassortment vaccine candidate of the novel variant infectious bursal disease virus.

Linjin Fan, Yulong Wang, Nan Jiang, Li Gao, Kai Li, Yulong Gao, Hongyu Cui, Qing Pan, Changjun Liu, Yanping Zhang, Xiaomei Wang, Xiaole Qi,

Infectious bursal disease (IBD), caused by infectious bursal disease virus (IBDV), is the most important immunosuppressive disease threatening the poultry industry worldwide. Recently, the novel variant IBDV has been emerging in large-scale in Asia including China and is becoming a new threat to the healthy development of the poultry industry, ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2020, 251:108905]

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Methyljasmonate and salicylic acid contribute to the control of Tilletia controversa Kühn, causal agent of wheat dwarf bunt.

Ghulam Muhae-Ud-Din, Delai Chen, Taiguo Liu, Wanquan Chen, Li Gao,

Tilletia controversa Kühn (TCK) is the causal agent of dwarf bunt of wheat, a destructive disease in wheat-growing regions of the world. The role of Meja, SA and Meja + SA were characterized for their control of TCK into roots, coleoptiles and anthers. The response of the defence genes PR-10a, Catalase, COI1-1, ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):19175]

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Effect of rhG-CSF Combined With Decitabine Prophylaxis on Relapse of Patients With High-Risk MRD-Negative AML After HSCT: An Open-Label, Multicenter, Randomized Controlled Trial.

Lei Gao, Yanqi Zhang, Sanbin Wang, Peiyan Kong, Yi Su, Jiong Hu, Ming Jiang, Hai Bai, Tao Lang, Jishi Wang, Li Liu, Tonghua Yang, Xiaobing Huang, Fang Liu, Shifeng Lou, Yao Liu, Cheng Zhang, Hong Liu, Li Gao, Jia Liu, Lidan Zhu, Qin Wen, Ting Chen, Ping Wang, Jun Rao, Min Mao, Cunbang Wang, Xianlin Duan, Le Luo, Xiangui Peng, Kaniel Cassady, Jiang F Zhong, Xi Zhang,

PURPOSE:Relapse is a major cause of treatment failure after allogeneic hematopoietic stem-cell transplantation (allo-HSCT) for high-risk acute myeloid leukemia (HR-AML). The aim of this study was to explore the effect of recombinant human granulocyte colony-stimulating factor (rhG-CSF) combined with minimal-dose decitabine (Dec) on the prevention of HR-AML relapse after allo-HSCT. ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, :JCO1903277]

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Distinct clinicopathological differences between early gastric cardiac and non-cardiac carcinomas: A single-center retrospective study of 329 radical resection cases

Yaohui Wang, Xiu Qing Li, Li Li Gao, Chen Xi Wang, Yi Fen Zhang, Qin Huang,

Abstract Background Early gastric carcinoma is heterogeneous and can be divided into early gastric cardiac carcinoma (EGCC) and early gastric non-cardiac carcinoma (EGNCC) groups. At present, differences in clinicopathology remains obscure between EGCC and EGNCC fundus-corpus and antrum-angularis-pylorus subgroups, especially between EGCC with and without oesophageal invasion. Methods In this ... Read more >>

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The Bipartite Sequence Motif in the N and C Termini of gp85 of Subgroup J Avian Leukosis Virus Plays a Crucial Role in Receptor Binding and Viral Entry.

Yao Zhang, Mengmeng Yu, Lixiao Xing, Peng Liu, Yuntong Chen, Fangfang Chang, Suyan Wang, Yuanling Bao, Muhammad Farooque, Xinyi Li, Xiaolu Guan, Yongzhen Liu, Aijing Liu, Xiaole Qi, Qing Pan, Yanping Zhang, Li Gao, Kai Li, Changjun Liu, Hongyu Cui, Xiaomei Wang, Yulong Gao,

Subgroup J avian leukemia virus (ALV-J), belonging to the genus Alpharetrovirus, enters cells through its envelope surface unit (gp85) via specifically recognizing the cellular receptor chicken Na+/H+ exchanger type I (chNHE1), the 28 to 39 N-terminal residues of which were characterized as the minimal receptor functional domain in our previous ... Read more >>

J Virol (Journal of virology)
[2020, 94(22):]

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Donor-derived CD19 CAR-T cell therapy of relapse of CD19-positive B-ALL post allotransplant.

Cheng Zhang, Xiao-Qi Wang, Rong-Li Zhang, Fang Liu, Yi Wang, Zhi-Ling Yan, Yong-Ping Song, Ting Yang, Ping Li, Zhen Wang, Ying-Ying Ma, Lei Gao, Yao Liu, Li Gao, Pei-Yan Kong, Jun Liu, Xu Tan, Jiang F Zhong, Yu-Qing Chen, Ai-Bin Liang, Jin-Hua Ren, Zhen-Yu Li, Jiang Cao, Quan-Li Gao, Jian Zhou, Ying Gao, Ding Zhang, Fang-Yi Fan, Ming-Zhe Han, Robert Peter Gale, Xi Zhang,

Safety and efficacy of allogeneic anti-CD19 chimeric antigen receptor T cells (CAR-T cells) in persons with CD19-positive B-cell acute lymphoblastic leukemia (B-ALL) relapsing after an allotransplant remain unclear. Forty-three subjects with B-ALL relapsing post allotransplant received CAR-T cells were analyzed. 34 (79%; 95% confidence interval [CI]: 66, 92%) achieved complete ... Read more >>

Leukemia (Leukemia)
[2020, :]

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Resequencing of 296 cultivated and wild lotus accessions unravels its evolution and breeding history.

Zhengwei Liu, Honglian Zhu, Juhong Zhou, Sanjie Jiang, Yun Wang, Jing Kuang, Qun Ji, Jing Peng, Jie Wang, Li Gao, Mingzhou Bai, Jianbo Jian, Weidong Ke,

Lotus (family: Nelumbonaceae) are perennial aquatic plants that represent one of the most ancient basal dicots. In the present study, we resequenced 296 lotus accessions from various geographical locations and germplasms to explore their genomic diversity and population structure. This germplasm set consisted of four accessions of American wild lotus ... Read more >>

Plant J (The Plant journal : for cell and molecular biology)
[2020, :]

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Identification of novel CEBPA double mutations capable of promoting familial AML via the suppression of myeloid differentiation.

Yunjing Zheng, Hui Zhang, Qin Lu, Xinran Chu, Li Gao, Peifang Xiao, Jian Pan, Shaoyan Hu,

CCAAT-enhancer-binding protein α (CEBPA) gene carrying two mutations (CEBPA double mutations) is known to promote familial acute myeloid leukemia (AML). However, the underlying mechanism by which CEBPA double mutations promote AML remains poorly understood. Here we report that a family with three generations suffering from familial AML carries novel double ... Read more >>

Am J Transl Res (American journal of translational research)
[2020, 12(10):6965-6972]

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Designed variants of ACE2-Fc that decouple anti-SARS-CoV-2 activities from unwanted cardiovascular effects.

Pan Liu, Xinfang Xie, Li Gao, Jing Jin,

Angiotensin-converting enzyme 2 (ACE2) is the entry receptor for SARS-CoV-2, and recombinant ACE2 decoys are being evaluated as new antiviral therapies. We designed and tested an antibody-like ACE2-Fc fusion protein, which has the benefit of long pharmacological half-life and the potential to facilitate immune clearance of the virus. Out of ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2020, 165(Pt B):1626-1633]

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Modified bluing treatment to produce nickel-cobalt-iron spinel oxide with promoted oxygen-evolving performance.

Junfeng Xie, Shanshan Cao, Li Gao, Fengcai Lei, Pin Hao, Bo Tang,

A rapid modified bluing treatment approach was proposed for the facile synthesis of a ternary NiCoFe spinel oxide catalyst. Benefitted from the synergy of multi-elements, the enriched high-valence species and good structural stability, highly efficient and durable oxygen-evolving performance was achieved, offering an economic route for the batch preparation of ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(66):9841-9844]

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The Heritability of Type D Personality by an Extended Twin-Pedigree Analysis in the Netherlands Twin Register.

Ruifang Li-Gao, Dorret I Boomsma, Eco J C de Geus, Johan Denollet, Nina Kupper,

Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiovascular disease. We aimed to (1) validate a new proxy based on the Achenbach System of Empirically Based Assessment (ASEBA) for Type D personality and its NA and SI subcomponents ... Read more >>

Behav Genet (Behavior genetics)
[2020, :]

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