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NL-CALIC Soft Decoding Using Strict Constrained Wide-Activated Recurrent Residual Network.

Yi Niu, Chang Liu, Mingming Ma, Fu Li, Zhiwen Chen, Guangming Shi,

In this work, we propose a normalized Tanh activate strategy and a lightweight wide-activate recurrent structure to solve three key challenges of the soft-decoding of near-lossless codes: 1. How to add an effective strict constrained peak absolute error (PAE) boundary to the network; 2. An end-to-end solution that is suitable ... Read more >>

IEEE Trans Image Process (IEEE transactions on image processing : a publication of the IEEE Signal Processing Society)
[2022, 31:1243-1257]

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Identification of Novel Multi-Omics Expression Landscapes and Meta-Analysis of Landscape-Based Competitive Endogenous RNA Networks in ALDH+ Lung Adenocarcinoma Stem Cells

Wei Yang, Yong Liang, Yuan Yuan Zheng, Hai Tao Luo, Xiao Fei Yang, Fu Rong Li,

ALHD+ H1975 lung adenocarcinoma stem cells(LSCs), confirmed to be found in LUAD, is one rare subset within lung adenocarcinoma(LUAD) cancer cells. They could self-renew, drive tumor initiation, growth, metastasis, and recurrence, and are also considered to be the main cause of poor prognosis because of their intrinsic resistance to drug ... Read more >>

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Severe versus common COVID-19: an early warning nomogram model.

Yanxin Chang, Xuying Wan, Xiaohui Fu, Ziyu Yang, Zhijie Lu, Zhenmeng Wang, Li Fu, Lei Yin, Yongjie Zhang, Qian Zhang,

The wide spread of coronavirus disease 2019 is currently the most rigorous health threat, and the clinical outcomes of severe patients are extremely poor. In this study, we establish an early warning nomogram model related to severe versus common COVID-19. A total of 1059 COVID-19 patients were analyzed in the ... Read more >>

Aging (Albany NY) (Aging)
[2022, 14(undefined):]

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Characteristics of two terbutylazine-degrading bacteria and the construction of a live bacterial agent for effective degradation of terbutylazine in soil.

Jiangwei Zhu, Yan Zhao, Xiaolou Li, L I Fu,

Two kinds of bacteria, named TDJ-7 and TDJ-9, were isolated from the soil, which could degrade terbutylazine effectively. TDJ-7 and TDJ-9 were identified as Bacillus pumilus and Bacillus subtilis. The degradation efficiency of 10mg/L of terbutylazine by TDJ-7 could reach 95% within 6 days, and the strain TDJ-9 could reach ... Read more >>

An Acad Bras Cienc (Anais da Academia Brasileira de Ciencias)
[2022, 94(1):e20200658]

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Genetic risk of hyperuricemia in hypertensive patients associated with antihypertensive drug therapy: A longitudinal study.

Yu Chen, Yunyun Yang, Yixuan Zhong, Jian Li, Tao Kong, Shuyuan Zhang, Shujun Yang, Cunjin Wu, Bing Cui, Li Fu, Rutai Hui, Weili Zhang,

Elevated serum uric acid (UA) level has been shown to be influenced by multiple genetic variants, but it remains uncertain how UA-associated variants differ in their influence on hyperuricemia risk in people taking antihypertensive drugs. We examined a total of 43 UA-related variants at 29 genes in 1840 patients with ... Read more >>

Clin Genet (Clinical genetics)
[2022, :]

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Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast.

Qianqian Shi, Kang Shao, Hongqin Jia, Boyang Cao, Weidong Li, Shichen Dong, Jian Liu, Kailiang Wu, Meng Liu, Fangfang Liu, Hanlin Zhou, Jianke Lv, Feng Gu, Luyuan Li, Shida Zhu, Shuai Li, Guibo Li, Li Fu,

Invasive micropapillary carcinoma (IMPC) has very high rates of lymphovascular invasion and lymph node metastasis and has been reported in several organs. However, the genomic mechanisms underlying its metastasis are unclear. Here, we perform whole-genome sequencing of tumor cell clusters from primary IMPC and paired axillary lymph node metastases. Cell ... Read more >>

Nat Commun (Nature communications)
[2022, 13(1):111]

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Monophosphoryl lipid A tolerance against chronic stress-induced depression-like behaviors in mice.

Fu Li, Xu Lu, Yaoying Ma, Yue Gu, Ting Ye, Chao Huang,

<h4>Backgrounds</h4>Our recent studies reported that a single injection with lipopolysaccharide (LPS) before stress exposure prevents depression-like behaviors in stressed mice. Monophosphoryl lipid A (MPL) is a derivative of LPS that lacks the undesirable properties of LPS. We hypothesize that MPL can exert a prophylactic effect on depression.<h4>Methods</h4>The experimental mice were ... Read more >>

Int J Neuropsychopharmacol (The international journal of neuropsychopharmacology)
[2022, :]

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Sestrin2 ablation attenuates the exercise-induced browning of white adipose tissue in C57BL/6J mice.

Lu Wang, Xinmeng Liu, Sujuan Liu, Yanmei Niu, Li Fu,

<h4>Aim</h4>With exercise, white adipose tissues (WAT) are readily convertible to a "brown-like" state, altering from lipid-storing to energy-catabolizing function, which counteracts obesity and increases insulin sensitivity. Sestrin2 (SESN2) is a stress-inducible protein that can regulate the cold-induced increase of uncoupling protein 1 (UCP1), which is paramount for the thermogenic capacity ... Read more >>

Acta Physiol (Oxf) (Acta physiologica (Oxford, England))
[2022, :e13785]

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One-Pot Enzymatic Synthesis of Heparin from N-Sulfoheparosan.

Li Fu, Robert J Linhardt,

Heparin, a glycosaminoglycan-based anticoagulant drug, is prepared as an extract of animal tissues. Heparosan, an Escherichia coli (E. coli) K5 capsular polysaccharide with the structure →4)-β-D-glucuronic acid (1 → 4)-β-D-N-acetylglucosamine (1→, corresponds to the precursor backbone in the Golgi-based biosynthesis of heparin. Anticoagulant heparin is prepared in a one-pot synthesis using a ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2303:3-11]

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Innate immune stimulation by monophosphoryl lipid A prevents chronic social defeat stress-induced anxiety-like behaviors in mice.

Fu Li, Haitao Xiang, Yue Gu, Ting Ye, Xu Lu, Chao Huang,

<h4>Background</h4>Innate immune pre-stimulation can prevent the development of depression-like behaviors in chronically stressed mice; however, whether the same stimulation prevents the development of anxiety-like behaviors in animals remains unclear. We addressed this issue using monophosphoryl lipid A (MPL), a derivative of lipopolysaccharide (LPS) that lacks undesirable properties of LPS but ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2022, 19(1):12]

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FecB mutation and litter size are associated with a 90-base pair deletion in BMPR1B in East Friesian and Hu crossbred sheep.

Danni Li, Lei Zhang, Yuchen Wang, Xingzhuo Chen, Fu Li, Lichun Yang, Jiuzeng Cui, Ran Li, Binyun Cao, Xiaopeng An, Yuxuan Song,

Litter size is a critical economic trait in livestock, but only a few studies have focused on associated indel mutations in <i>BMPR1B</i>, a key regulator of ovulation and litter size in sheep. We evaluated the effects of <i>BMPR1B</i> mutations on the reproductive performance of sheep. We used Hu, East Friesian, ... Read more >>

Anim Biotechnol (Animal biotechnology)
[2022, :1-10]

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3-D Stochastic Numerical Breast Phantoms for Enabling Virtual Imaging Trials of Ultrasound Computed Tomography.

Fu Li, Umberto Villa, Seonyeong Park, Mark A Anastasio,

Ultrasound computed tomography (USCT) is an emerging imaging modality for breast imaging that can produce quantitative images that depict the acoustic properties of tissues. Computer-simulation studies, also known as virtual imaging trials, provide researchers with an economical and convenient route to systematically explore imaging system designs and image reconstruction methods. ... Read more >>

IEEE Trans Ultrason Ferroelectr Freq Control (IEEE transactions on ultrasonics, ferroelectrics, and frequency control)
[2022, 69(1):135-146]

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[Research Progress in Immunosuppressive Tumor Microenvironment of Gastrointestinal Cancer].

Yu-Ting Li, Xiang-Yu Tan, Liu-Na Huang, Li-Xiang Ma, Li Fu,

Gastrointestinal (GI) cancer, a common malignant tumor with a high incidence in China, is showing a trend of rising incidence and is afflicting increasingly younger patients. Meanwhile, there have been constant development and innovations in new therapeutic technologies, among which, immunotherapy is now leading in a new era in the ... Read more >>

Sichuan Da Xue Xue Bao Yi Xue Ban (Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition)
[2022, 53(1):7-14]

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Coreactant-Free and Direct Electrochemiluminescence from Dual-Stabilizer-Capped InP/ZnS Nanocrystals: A New Route Involving n-Type Luminophore.

Li Fu, Xuwen Gao, Shuangtian Dong, Jingna Jia, Yuqi Xu, Dongyang Wang, Guizheng Zou,

Electrochemiluminescence (ECL) is conventionally generated in either an annihilation or a coreactant route, and the overwhelming majority of ECL research is conducted in the coreactant route via oxidizing or reducing the coexisting coreactant and luminophore. The coreacant-free ECL generated via merely oxidizing the luminophore would break through the ceiling of ... Read more >>

Anal Chem (Analytical chemistry)
[2022, 94(2):1350-1356]

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Novel Thermal Diffusion Temperature Engineering Leading to High Thermoelectric Performance in Bi2 Te3 -Based Flexible Thin-Films.

Dong-Wei Ao, Wei-Di Liu, Yue-Xing Chen, Meng Wei, Bushra Jabar, Fu Li, Xiao-Lei Shi, Zhuang-Hao Zheng, Guang-Xing Liang, Xiang-Hua Zhang, Ping Fan, Zhi-Gang Chen,

Flexible Bi<sub>2</sub> Te<sub>3</sub> -based thermoelectric devices can function as power generators for powering wearable electronics or chip-sensors for internet-of-things. However, the unsatisfied performance of n-type Bi<sub>2</sub> Te<sub>3</sub> flexible thin films significantly limits their wide application. In this study, a novel thermal diffusion method is employed to fabricate n-type Te-embedded Bi<sub>2</sub> ... Read more >>

Adv Sci (Weinh) (Advanced science (Weinheim, Baden-Wurttemberg, Germany))
[2021, :e2103547]

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Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.

Yuwen Sheng, Yuwen Chen, Zhongqiu Zeng, Wenbi Wu, Jing Wang, Yuling Ma, Yuan Lin, Jichao Zhang, Yulan Huang, Wenhua Li, Qiyu Zhu, Xiao Wei, Suiyan Li, Wisanee Wisanwattana, Fu Li, Wanli Liu, Apichart Suksamrarn, Guolin Zhang, Wei Jiao, Fei Wang,

Cancer cell proliferation in some organs often depends on conversion of pyruvate to oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to support biomass production. In this study, PC was identified as the cellular target of erianin using the photoaffinity labeling-click chemistry-based probe strategy. Erianin potently inhibited ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2022, 65(1):460-484]

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CH02 Peptide Promotes CD34+ Umbilical Cord Blood Hematopoietic Stem Cells Ex Vivo Expansion

Yiqi Yang, Bihui Zhang, Junye Xie, Yuling Cai, Jia Liu, Yibo Zhang, Jieqiong Cao, Zijian Su, Jinting Zhang, Qilin Meng, Jingsheng Li, Fu Li, Zhaodong Zhai, Bin Liu, An Hong, Xiaojia Chen,

<h4>Background: </h4> Umbilical cord blood (UCB) has been clinically used for human hematopoietic stem cells (HSCs) transplantation. However, limited numbers of the functional UCB-HSCs from single cord blood restricts its application in adults, while most of the strategies for stem cells expansion in vitro are either inefficient or costly. To ... Read more >>

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Homo-composition and hetero-structure nanocomposite Pnma Bi2SeS2 - Pnnm Bi2SeS2 with high thermoelectric performance.

Bushra Jabar, Fu Li, Zhuanghao Zheng, Adil Mansoor, Yongbin Zhu, Chongbin Liang, Dongwei Ao, Yuexing Chen, Guangxing Liang, Ping Fan, Weishu Liu,

Nanocomposite engineering decouples the transport of phonons and electrons. This usually involves the in-situ formation or ex-situ addition of nanoparticles to a material matrix with hetero-composition and hetero-structure (heC-heS) interfaces or hetero-composition and homo-structure (heC-hoS) interfaces. Herein, a quasi homo-composition and hetero-structure (hoC-heS) nanocomposite consisting of Pnma Bi<sub>2</sub>SeS<sub>2</sub> - Pnnm ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):7192]

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Near-Infrared Responsive Membrane Nanovesicles Amplify Homologous Targeting Delivery of Anti-PD Immunotherapy against Metastatic Tumors.

Ya-Nan Tan, Jian-Dong Huang, Yong-Peng Li, Shan-Shan Li, Min Luo, Jie Luo, Anne Wing-Mui Lee, Li Fu, Fu-Qiang Hu, Xin-Yuan Guan,

The major obstacles of anti-PD therapy in metastatic tumors are limited drug delivery in primary tumors and metastatic foci, and the lack of tumor-infiltrating lymphocytes (TILs). Here, the authors constructed a novel cellular membrane nanovesicles platform (M/IR NPs) based on homologous targeting and near-infrared (NIR) responsive release strategy to potentiate ... Read more >>

Adv Healthc Mater (Advanced healthcare materials)
[2021, :e2101496]

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Two-photon fluorogenic probe for visualizing PGP-1 activity in inflammatory tissues and serum from patients.

Hua Bai, Bin Fang, Xujie Wang, Wenjing Qin, Yuhe Chen, Dongliang Zhang, Yan Li, Bo Peng, Xuekang Yang, Li Fu, Lin Li,

A PGP-1-specific one/two-photon fluorogenic probe (BH1), capable of high sensitivity, super selectivity, and visual imaging of endogenous PGP-1 activity from live mammalian cells and serum/skin tissues from patients by using one/two-photon fluorescence microscopy (O/TPFM). ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(97):13186-13189]

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Editorial: Graphene-Enhanced Electrochemical Sensing Platforms.

Li Fu, Fatemeh Karimi, Aimin Yu,

Front Chem (Frontiers in chemistry)
[2021, 9:815981]

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Carbon dots and gold nanoclusters assisted construction of a ratiometric fluorescent biosensor for detection of Gram-negative bacteria.

Li Fu, Qingmei Chen, Li Jia,

A core-satellite nanocomposite was prepared by encapsulating the photostable blue carbon dots (BCDs) in the core of silica as the reference signal readout, and the target-sensitive gold nanoclusters (AuNCs) covalently linked to the surface of silica as the respond signal readout. The nanocomposite ([email protected]<sub>2</sub>@AuNC) was used as a ratiometric fluorescent ... Read more >>

Food Chem (Food chemistry)
[2022, 374:131750]

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A Double-Deck Structure of Reduced Graphene Oxide Modified Porous Ti3C2Tx Electrode towards Ultrasensitive and Simultaneous Detection of Dopamine and Uric Acid.

Yangguang Zhu, Qichen Tian, Xiufen Li, Lidong Wu, Aimin Yu, Guosong Lai, Li Fu, Qiuping Wei, Dan Dai, Nan Jiang, He Li, Chen Ye, Cheng-Te Lin,

Considering the vital physiological functions of dopamine (DA) and uric acid (UA) and their coexistence in the biological matrix, the development of biosensing techniques for their simultaneous and sensitive detection is highly desirable for diagnostic and analytical applications. Therefore, Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>/rGO heterostructure with a double-deck layer was fabricated through electrochemical reduction. ... Read more >>

Biosensors (Basel) (Biosensors)
[2021, 11(11):]

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LncRNA lncAY is upregulated by sulfatide via Myb/MEF2C acetylation to promote the tumorigenicity of hepatocellular carcinoma cells.

Mei Hua Chen, Bing Qi, Qian Qian Cai, Jia Wen Sun, Li Sheng Fu, Chun Lan Kang, Fei Fan, Ming Zhe Ma, Xing Zhong Wu,

LncRNA (long noncoding RNA) is often dysregulated in tumors especially hepatocellular carcinoma (HCC). However, the dysregulation mechanism of lncRNAs is largely unknown. Here, we showed that lncRNA lncAY expression was stimulated in HCC by either endogenous or exogenous sulfatide. Elevated lncAY promoted HCC cell migration or angiogenesis, whereas lncAY silence ... Read more >>

Biochim Biophys Acta Gene Regul Mech (Biochimica et biophysica acta. Gene regulatory mechanisms)
[2021, 1865(1):194777]

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Phase Preservation Neural Network for Electroencephalography Classification in Rapid Serial Visual Presentation Task.

Fu Li, Chong Wang, Yang Li, Hao Wu, Boxun Fu, Youshuo Ji, Yi Niu, Guangming Shi,

Neuroscience studies have demonstrated the phase-locked characteristics of some early event-related potential (ERP) components evoked by stimuli. In this study, we propose a phase preservation neural network (PPNN) to learn phase information to improve the Electroencephalography (EEG) classification in a rapid serial visual presentation (RSVP) task. The PPNN consists of ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2021, PP:]

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