Full Text Journal Articles by
Author Li Da Su

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PQBP1: A New Player in Metabotropic Glutamate Receptor Signaling and Synaptic Plasticity.

Li-Da Su, Ying Shen,

Neurosci Bull (Neuroscience bulletin)
[2021, :]

Cited: 0 times

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Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective.

Li-Da Su, Na Wang, Junhai Han, Ying Shen,

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are activated by glutamate in the central nervous system (CNS). Basically, mGluRs contribute to fine-tuning of synaptic efficacy and control the accuracy and sharpness of neurotransmission. Among eight subtypes, mGluR1 and mGluR5 belong to group 1 (Gp1) family, and are implicated ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211021018]

Cited: 0 times

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Cerebellar Dysfunction, Cerebro-cerebellar Connectivity and Autism Spectrum Disorders.

Li-Da Su, Fang-Xiao Xu, Xin-Tai Wang, Xin-Yu Cai, Ying Shen,

The cerebellum has long been conceptualized to control motor learning and motor coordination. However, increasing evidence suggests its roles in cognition and emotion behaviors. In particular, the cerebellum has been recognized as one of key brain regions affected in autism spectrum disorder (ASD). To better understand the contribution of the ... Read more >>

Neuroscience (Neuroscience)
[2021, 462:320-327]

Cited: 1 time

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Single Ethanol Withdrawal Regulates Extrasynaptic δ-GABAA Receptors Via PKCδ Activation.

Juan Chen, Yang He, Yan Wu, Hang Zhou, Li-Da Su, Wei-Nan Li, Richard W Olsen, Jing Liang, Yu-Dong Zhou, Yi Shen,

Alcohol (ethanol, EtOH) is one of the most widely abused drugs with profound effects on brain function and behavior. GABAA receptors (GABAARs) are one of the major targets for EtOH in the brain. Temporary plastic changes in GABAARs after withdrawal from a single EtOH exposure occur both in vivo and ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2018, 11:141]

Cited: 0 times

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Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy.

Lin Zhou, Liang Zhou, Li-da Su, Sheng-Long Cao, Ya-Jun Xie, Na Wang, Chong-Yu Shao, Ya-Nan Wang, Jia-Huan Zhou, John K Cowell, Ying Shen,

Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited syndrome caused by mutations in the leucine-rich glioma inactivated 1 (LGI1) gene. It is known that glutamatergic transmission is altered in LGI1 mutant mice, and seizures can be reduced by restoring LGI1 function. Yet, the mechanism underlying ADLTE is unclear. Here, ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2018, 38(13):3346-3357]

Cited: 4 times

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Potassium channels-mediated electrophysiologic responses are inhibited by cytosolic phospholipase A2α ablation.

Na Wang, Ying-Hong Hu, Li-Da Su,

Cytosolic phospholipase A2α (cPLA2α) is implicated in the progression of excitotoxic neuronal injury and cerebral ischemia. Previous work suggests that cPLA2α increases aberrant electrophysiologic events through attenuating K channel functions. Nevertheless, which K channels are affected by cPLA2α needs to be determined. Here we examined K channels-mediated electrophysiologic responses in ... Read more >>

Neuroreport (Neuroreport)
[2018, 29(1):59-64]

Cited: 0 times

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Chronic Ethanol Consumption Impairs the Tactile-Evoked Long-Term Depression at Cerebellar Molecular Layer Interneuron-Purkinje Cell Synapses in vivo in Mice.

Da-Yong Li, Yan-Hua Bing, Chun-Ping Chu, Xun Cui, Song-Biao Cui, De-Lai Qiu, Li-Da Su,

The cerebellum is sensitive to ethanol (EtOH) consumption. Chronic EtOH consumption impairs motor learning by modulating the cerebellar circuitry synaptic transmission and long-term plasticity. Under in vitro conditions, acute EtOH inhibits both parallel fiber (PF) and climbing fiber (CF) long-term depression (LTD). However, thus far it has not been investigated ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2018, 12:521]

Cited: 2 times

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Ablation of TFR1 in Purkinje Cells Inhibits mGlu1 Trafficking and Impairs Motor Coordination, But Not Autistic-Like Behaviors.

Jia-Huan Zhou, Xin-Tai Wang, Liang Zhou, Lin Zhou, Fang-Xiao Xu, Li-Da Su, Hao Wang, Fan Jia, Fu-Qiang Xu, Gui-Quan Chen, Chris I De Zeeuw, Ying Shen,

Group 1 metabotropic glutamate receptors (mGlu1/5s) are critical to synapse formation and participate in synaptic LTP and LTD in the brain. mGlu1/5 signaling alterations have been documented in cognitive impairment, neurodegenerative disorders, and psychiatric diseases, but underlying mechanisms for its modulation are not clear. Here, we report that transferrin receptor ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2017, 37(47):11335-11352]

Cited: 9 times

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Downregulation of Glutamate Transporter EAAT4 by Conditional Knockout of Rheb1 in Cerebellar Purkinje Cells.

Nan-Wei Jiang, De-Juan Wang, Ya-Jun Xie, Liang Zhou, Li-Da Su, Huashun Li, Qin-Wen Wang, Ying Shen,

Excitatory amino acid transporter 4 (EAAT4) is believed to be critical to the synaptic activity of cerebellar Purkinje cells by limiting extracellular glutamate concentrations and facilitating the induction of long-term depression. However, the modulation of EAAT4 expression has not been elucidated. It has been shown that Ras homolog enriched in ... Read more >>

Cerebellum (Cerebellum (London, England))
[2016, 15(3):314-321]

Cited: 2 times

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LGI1 is involved in the development of mouse brain.

Li-Da Su, Ya-Jun Xie, Liang Zhou, Ying Shen, Ying-Hong Hu,

Mutations in leucine-rich glioma inactivated 1 (LGI1) are linked to human autosomal dominant lateral temporal lobe epilepsy. It has been shown that LGI1 prevents the inactivation of voltage-gated potassium channels, mediates postnatal maturation of glutamatergic synapses, and regulates excitatory neurotransmission. However, other functions of LGI1 in the central nervous system ... Read more >>

Cerebellum (Cerebellum (London, England))
[2015, 14(1):12-14]

Cited: 1 time

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Long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses requires presynaptic and postsynaptic signaling cascades.

De-Juan Wang, Li-Da Su, Ya-Nan Wang, Dong Yang, Cheng-Long Sun, Lin Zhou, Xin-Xin Wang, Ying Shen,

Long-term depression (LTD) and long-term potentiation (LTP) at cerebellar parallel fiber-Purkinje cell (PF-PC) synapses play critical roles in motor learning. The 1 Hz stimulation at PF-PC synapses induces a postsynaptically expressed LTP that requires a postsynaptic Ca(2+) transient, phosphatases, and nitric oxide (NO). However, the mechanism underlying 1 Hz PF-LTP ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2014, 34(6):2355-2364]

Cited: 33 times

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Retrograde cPLA2α/arachidonic acid/2-AG signaling is essential for cerebellar depolarization-induced suppression of excitation and long-term potentiation.

Li-Da Su, De-Juan Wang, Dong Yang, Ying Shen, Ying-Hong Hu,

Cytosolic phospholipase A2 alpha (cPLA2α) responds to micromolar intracellular Ca(2+) and produces arachidonic acid, which regulates cellular homeostasis, neurotoxicity, and inflammation. Endocannabinoids are the derivates of arachidonic acid and widely distributed in the cerebellum. However, the role of cPLA2α/arachidonic acid pathway in cerebellar synaptic transmission and plasticity is unknown. We ... Read more >>

Cerebellum (Cerebellum (London, England))
[2013, 12(3):297-299]

Cited: 7 times

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Distinct functions of nuclear distribution proteins LIS1, Ndel1 and NudCL in regulating axonal mitochondrial transport.

Chong-Yu Shao, Jia Zhu, Ya-Jun Xie, Zheng Wang, Ya-Nan Wang, Yin Wang, Li-Da Su, Liang Zhou, Tian-Hua Zhou, Ying Shen,

Neurons critically depend on the long-distance transport of mitochondria. Motor proteins kinesin and dynein control anterograde and retrograde mitochondrial transport, respectively in axons. The regulatory molecules that link them to mitochondria need to be better characterized. Nuclear distribution (Nud) family proteins LIS1, Ndel1 and NudCL are critical components of cytoplasmic ... Read more >>

Traffic (Traffic (Copenhagen, Denmark))
[2013, 14(7):785-797]

Cited: 24 times

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ATP regulates sodium channel kinetics in pancreatic islet beta cells.

Na Zou, Xiao Wu, Yan-Yan Jin, Meng-Zao He, Xin-Xin Wang, Li-Da Su, Marjan Rupnik, Zhen-Yong Wu, Li Liang, Ying Shen,

Pancreatic beta cells act as glucose sensors, in which intracellular ATP ([ATP](i)) are altered with glucose concentration change. The characterization of voltage-gated sodium channels under different [ATP](i) remains unclear. Here, we demonstrated that increasing [ATP](i) within a certain range of concentrations (2-8 mM) significantly enhanced the voltage-gated sodium channel currents, compared ... Read more >>

J Membr Biol (The Journal of membrane biology)
[2013, 246(2):101-107]

Cited: 11 times

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Cytosolic phospholipase A2 alpha/arachidonic acid signaling mediates depolarization-induced suppression of excitation in the cerebellum.

De-Juan Wang, Dong Yang, Li-Da Su, Ya-jun Xie, Lin Zhou, Cheng-Long Sun, Yin Wang, Xin-Xin Wang, Liang Zhou, Ying Shen,

<h4>Background</h4>Depolarization-induced suppression of excitation (DSE) at parallel fiber-Purkinje cell synapse is an endocannabinoid-mediated short-term retrograde plasticity. Intracellular Ca(2+) elevation is critical for the endocannabinoid production and DSE. Nevertheless, how elevated Ca(2+) leads to DSE is unclear.<h4>Methodology/principal findings</h4>We utilized cytosolic phospholipase A(2) alpha (cPLA(2)α) knock-out mice and whole-cell patch clamp in ... Read more >>

PLoS One (PloS one)
[2012, 7(8):e41499]

Cited: 9 times

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Correction: Cytosolic Phospholipase A2 alpha/Arachidonic Acid Signaling Mediates Depolarization-Induced Suppression of Excitation in the Cerebellum

De-Juan Wang, Dong Yang, Li-Da Su, Ya-jun Xie, Lin Zhou, Cheng-Long Sun, Yin Wang, Xin-Xin Wang, Liang Zhou, Ying Shen,

PLoS One (PloS one)
[2012, 7(11):]

Cited: 0 times

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Cerebellar long-term depression is deficient in Niemann-Pick type C disease mice.

Cheng-Long Sun, Li-Da Su, Qiong Li, Xin-Xin Wang, Ying Shen,

Niemann-Pick type C disease (NPC) is an autosomal recessive lipidosis characterized by progressive neurodegeneration. Although several studies have revealed unusual accumulation of unesterfied cholesterol in astrocytic lysosome of NPC, pathophysiological basis of cerebellar neuronal dysfunction remains unclear. We compared parallel fiber-Purkinje cell synaptic transmission and long-term depression (LTD) in +/+npc ... Read more >>

Cerebellum (Cerebellum (London, England))
[2011, 10(1):88-95]

Cited: 13 times

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Ethanol acutely modulates mGluR1-dependent long-term depression in cerebellum.

Li-Da Su, Cheng-Long Sun, Ying Shen,

<h4>Background</h4>Acute and chronic ethanol exposure produces profound impairments in motor functioning. Individuals with lower sensitivity to the acute motor impairing effects of ethanol have an increased risk of developing alcohol dependence and abuse, and infants with subtle delays in motor coordination development may have an increased risk for subsequently developing ... Read more >>

Alcohol Clin Exp Res (Alcoholism, clinical and experimental research)
[2010, 34(7):1140-1145]

Cited: 21 times

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Blockade of glutamate transporters facilitates cerebellar synaptic long-term depression.

Li-Da Su, Ying Shen,

Excitatory amino acid transporters (EAATs) are believed to limit extracellular glutamate concentrations with specific roles poorly understood. At cerebellar climbing fiber-Purkinje cell synapse, EAAT4 and metabotropic glutamate receptor 1 (mGluR1) are closely expressed in surrounding postsynaptic locations, suggesting that EAAT4 may regulate mGluR1 activation. We examined the actions of EAAT4 ... Read more >>

Neuroreport (Neuroreport)
[2009, 20(5):502-507]

Cited: 7 times

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[Relationship between drug resistance and the expression of NF-kappaB induced in leukemic cells].

Xiao-hong Zhang, Li-da Su, Qing-hua Lu, Yun Liang, Xiao-ying Zhao,

<h4>Objective</h4>To explore the relationship between drug resistance of leukemic cells and the expression of both IkappaB-alpha and NF-kappaB associated with apoptosis induced by arsenic trioxide (As2O3) in K562 and K562/ADR cells.<h4>Methods</h4>Apoptosis was induced in K562 and K562/ADR cells cultured with As2O3 in different concentrations. Western blot was used to analyze ... Read more >>

Zhejiang Da Xue Xue Bao Yi Xue Ban (Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences)
[2004, 33(5):421-426]

Cited: 1 time

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