Full Text Journal Articles by
Author Lhassane Ismaili

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Synthesis and biological assessment of new pyrimidopyrimidines as inhibitors of breast cancer resistance protein (ABCG2).

Imen Dakhlaoui, Sahel Vahdati, Emna Maalej, Fakher Chabchoub, Michael Wiese, Jose Marco-Contelles, Lhassane Ismaili,

Multidrug resistance constitutes a serious obstacle of the treatment success of cancer by chemotherapy. Mostly it is driven by expression of ABC transport proteins that actively efflux the anticancer agents out of the cell. This work describes the design and synthesis of 12 new pyrimidopyrimidines, as well as their inhibition ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2021, 116:105326]

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Synthesis of new Hantzsch adducts showing Ca2+ channel blockade capacity, cholinesterase inhibition and antioxidant power.

Irene Pachón-Angona, Maciej Maj, Artur Wnorowski, Helene Martin, Krzysztof Jóźwiak, Lhassane Ismaili,

<b>Background:</b> Alzheimer's disease is a chronic neurodegenerative chronic disease with a heavy social and economic impact in our developed societies, which still lacks an efficient therapy. <b>Method:</b> This paper describes the Hantzsch multicomponent synthesis of twelve alkyl hexahydro-quinoline-3-carboxylates, <b>4a-l</b>, along with the evaluation of their Ca<sup>2+</sup> channel blockade capacity, cholinesterase inhibition and ... Read more >>

Future Med Chem (Future medicinal chemistry)
[2021, 13(20):1717-1729]

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(±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease.

Lhassane Ismaili, Julie Monnin, Adeline Etievant, Raquel L Arribas, Lucía Viejo, Bernard Refouvelet, Ondrej Soukup, Jana Janockova, Vendula Hepnarova, Jan Korabecny, Tomas Kucera, Daniel Jun, Rudolf Andrys, Kamil Musilek, Aurelie Baguet, Eva M García-Frutos, Angela De Simone, Vincenza Andrisano, Manuela Bartolini, Cristóbal de Los Ríos, José Marco-Contelles, Emmanuel Haffen,

Multitarget-directed ligands (MTDLs) are considered a promising therapeutic strategy to address the multifactorial nature of Alzheimer's disease (AD). Novel MTDLs have been designed as inhibitors of human acetylcholinesterases/butyrylcholinesterases, monoamine oxidase A/B, and glycogen synthase kinase 3β and as calcium channel antagonists via the Biginelli multicomponent reaction. Among these MTDLs, (±)<b>-BIGI-3h</b> ... Read more >>

ACS Chem Neurosci (ACS chemical neuroscience)
[2021, 12(8):1328-1342]

Cited: 1 time

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Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments.

Óscar M Bautista-Aguilera, Lhassane Ismaili, Isabel Iriepa, Daniel Diez-Iriepa, Fakher Chabchoub, José Marco-Contelles, Marta Pérez,

Herein we have reviewed our recent developments for the identification of new tacrine analogues for Alzheimer's disease (AD) therapy. Tacrine, the first cholinesterase inhibitor approved for AD treatment, did not stop the progression of AD, producing only some cognitive improvements, but exhibited secondary effects mainly due to its hepatotoxicity. Thus, ... Read more >>

Chem Rec (Chemical record (New York, N.Y.))
[2021, 21(1):162-174]

Cited: 2 times

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Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives.

Irene Pachón Angona, Helene Martin, Solene Daniel, Ignacio Moraleda, Alexandre Bonet, Artur Wnorowski, Maciej Maj, Krzysztof Jozwiak, Isabel Iriepa, Bernard Refouvelet, José Marco-Contelles, Lhassane Ismaili,

We report herein the design, synthesis, biological evaluation, and molecular modelling of new inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), able to block Ca<sup>+2</sup> channels also showing antioxidant and neuroprotective activities. The new MTDL, dialkyl 2,6-dimethyl-4-(4-((5-aminoalkyl)oxy)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate <b>3a-p</b>, have been obtained via Hantzsch reaction from appropriate and commercially available precursors. Pertinent ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(20):]

Cited: 1 time

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Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy.

Lazhar Zribi, Irene Pachòn-Angona, Òscar M Bautista-Aguilera, Daniel Diez-Iriepa, José Marco-Contelles, Lhassane Ismaili, Isabel Iriepa, Fakher Chabchoub,

Alzheimer's disease (AD) is multifactorial disease characterized by the accumulation of abnormal extracellular deposits of amyloid-beta (Aβ) peptide, and intracellular neurofibrillary tangles (NFTs), along with dramatic neuronal death and decreased levels of choline acetyltransferase. Given the limited therapeutic success of available drugs, it is urgent to explore all the opportunities ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(14):]

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Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.

Óscar M Bautista-Aguilera, Lhassane Ismaili, Mourad Chioua, Rudolf Andrys, Monika Schmidt, Petr Bzonek, María Ángeles Martínez-Grau, Christopher D Beadle, Tatiana Vetman, Francisco López-Muñoz, Isabel Iriepa, Bernard Refouvelet, Kamil Musilek, José Marco-Contelles,

In this communication, we report the synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of 19 quinolinones (<b>QN1</b>-<b>19</b>) and 13 dihydroquinolinones (<b>DQN1</b>-<b>13</b>) designed as potential multitarget small molecules (MSM) for Alzheimer's disease therapy. Contrary to our expectations, none of them showed significant <i>human recombinant</i> MAO inhibition, but compounds <b>QN8</b>, <b>QN9</b>, and ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(11):]

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Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels.

Irene Pachòn Angona, Solene Daniel, Helene Martin, Alexandre Bonet, Artur Wnorowski, Maciej Maj, Krzysztof Jóźwiak, Tiago Barros Silva, Bernard Refouvelet, Fernanda Borges, José Marco-Contelles, Lhassane Ismaili,

We report herein the design, synthesis and biological evaluation of new antioxidant and neuroprotective multitarget directed ligands (MTDLs) able to block Ca<sup>2+</sup> channels. New dialkyl 2,6-dimethyl-4-(4-(prop-2-yn-1-yloxy)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate MTDLs <b>3a</b>-<b>t</b>, resulting from the juxtaposition of nimodipine, a Ca<sup>2+</sup> channel antagonist, and rasagiline, a known MAO inhibitor, have been obtained from appropriate and ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(6):]

Cited: 1 time

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Chromenones as Multineurotargeting Inhibitors of Human Enzymes.

Carina Lemke, Joscha Christmann, Jiafei Yin, José M Alonso, Estefanía Serrano, Mourad Chioua, Lhassane Ismaili, María Angeles Martínez-Grau, Christopher D Beadle, Tatiana Vetman, Florian M Dato, Ulrike Bartz, Paul W Elsinghorst, Markus Pietsch, Christa E Müller, Isabel Iriepa, Timo Wille, José Marco-Contelles, Michael Gütschow,

The complex nature of multifactorial diseases, such as Morbus Alzheimer, has produced a strong need to design multitarget-directed ligands to address the involved complementary pathways. We performed a purposive structural modification of a tetratarget small-molecule, that is contilisant, and generated a combinatorial library of 28 substituted chromen-4-ones. The compounds comprise ... Read more >>

ACS Omega (ACS omega)
[2019, 4(26):22161-22168]

Cited: 2 times

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Synthesis of new ferulic/lipoic/comenic acid-melatonin hybrids as antioxidants and Nrf2 activators via Ugi reaction.

Irene Pachón-Angona, Helène Martin, Stecy Chhor, María-Jesús Oset-Gasque, Bernard Refouvelet, José Marco-Contelles, Lhassane Ismaili,

Aim: Oxidative stress has been implicated in the pathogenesis of many neurodegenerative diseases, and particularly in Alzheimer's disease. Results: This work describes the Ugi multicomponent synthesis, antioxidant power and Nrf2 pathway induction in antioxidant response element cells of (E)-N-(2-((2-(1H-indol-3-yl)ethyl)amino)-2-oxoethyl)-N-(2-(5-(benzyloxy)-1H-indol-3-yl)ethyl)-3-(4-hydroxy-3-methoxyphenyl)acryl amides 8a-d, N-(2-((2-(1H-indol-3-yl)ethyl)amino)-2-oxoethyl)-N-(2-(5-(benzyloxy)-1H-indol-3-yl)ethyl)-5-(1,2-dithiolan-3-yl)pentanamides 8e-h and N-(2-((2-(1H-indol-3-yl)ethyl)amino)-2-oxoethyl)-N-(2-(5-(benzyloxy)-1H-indol-3-yl)ethyl)-5-hydroxy-4-oxo-4H-pyran-2-carboxamides 8i,j. Conclusion: We have identified compounds ... Read more >>

Future Med Chem (Future medicinal chemistry)
[2019, 11(24):3097-3108]

Cited: 2 times

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New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition.

Rim Malek, Raquel L Arribas, Alejandra Palomino-Antolin, Perle Totoson, Celine Demougeot, Tereza Kobrlova, Ondrej Soukup, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, Justyna Godyń, Dawid Panek, Barbara Malawska, Monika Głuch-Lutwin, Barbara Mordyl, Agata Siwek, Fakher Chabchoub, José Marco-Contelles, Katarzyna Kiec-Kononowicz, Javier Egea, Cristóbal de Los Ríos, Lhassane Ismaili,

New tritarget small molecules combining Ca2+ channels blockade, cholinesterase, and H3 receptor inhibition were obtained by multicomponent synthesis. Compound 3p has been identified as a very promising lead, showing good Ca2+ channels blockade activity (IC50 = 21 ± 1 μM), potent affinity against hH3R (Ki = 565 ± 62 nM), ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2019, 62(24):11416-11422]

Cited: 6 times

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Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.

Maria do Carmo Carreiras, Lhassane Ismaili, José Marco-Contelles,

Current options for the treatment of Alzheimeŕs disease have been restricted to prescription of acetylcholinesterase inhibitors or N-methyl-d-aspartate receptor antagonist, memantine. Propargylamine-derived multi-target directed ligands, such as ladostigil, M30, ASS234 and contilisant, involve different pathways. Apart from acting as inhibitors of both cholinesterases and monoamine oxidases, they show improvement of ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2020, 30(3):126880]

Cited: 3 times

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Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.

Irene Pachón-Angona, Bernard Refouvelet, Rudolf Andrýs, Helène Martin, Vincent Luzet, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, María-Jesús Oset-Gasque, José Marco-Contelles, Kamil Musilek, Lhassane Ismaili,

We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer's disease (AD) therapy. We have identified compound 14n as promising multitarget small molecule showing strong BuChE inhibition (IC<sub>50</sub> = 11.90 ± 0.05 nM), moderate hAChE (IC<sub>50</sub> = 1.73 ± 0.34 μM), hMAO A (IC<sub>50</sub> = 2.78 ± 0.12 μM), and MAO B (IC<sub>50</sub> = 21.29 ± 3.85 μM) inhibition, while keeping ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2019, 34(1):479-489]

Cited: 10 times

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Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy.

Youssef Dgachi, Hélène Martin, Rim Malek, Daniel Jun, Jana Janockova, Vendula Sepsova, Ondrej Soukup, Isabel Iriepa, Ignacio Moraleda, Emna Maalej, M Carmo Carreiras, Bernard Refouvelet, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili,

In view of the multifactorial nature of Alzheimer's disease (AD), multitarget small molecules (MTSM) represent the most potent and attractive therapeutic strategy to design new drugs for Alzheimer's disease therapy. The new MTSM KojoTacrines (KTs) were designed and synthesized by juxtaposition of selected pharmacophoric motifs from kojic acid and tacrine. ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2019, 34(1):163-170]

Cited: 2 times

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Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer's disease therapy.

Rim Malek, Maciej Maj, Artur Wnorowski, Krzysztof Jóźwiak, Helene Martin, Isabel Iriepa, Ignacio Moraleda, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili,

In this work we describe the synthesis, Ca<sup>+2</sup> channel blockade capacity and antioxidant power of N<sup>3</sup>,N<sup>5</sup>-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)-2,6-dimethyl-4-aryl-1,4-dihydropyridine-3,5-dicarboxamides 1-9, a number of multi-target small 1,4-dihydropyridines (DHP), designed by juxtaposition of melatonin and nimodipine. As a result, we have identified antioxidant DHP 7 (Ca<sup>2+</sup> channel blockade: 55%, and 8.78 Trolox/Equivalents), the most balanced ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2019, 91:103205]

Cited: 6 times

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Synthesis and Biological Evaluation of Novel Chromone+Donepezil Hybrids for Alzheimer's Disease Therapy.

Rim Malek, Bernard Refouvelet, Mohamed Benchekroun, Isabel Iriepa, Ignacio Moraleda, Rudolf Andrys, Kamil Musilek, José Marco-Contelles, Lhassane Ismaili,

<h4>Background</h4>Many factors are involved in Alzheimer's Disease (AD) such as amyloid plaques, neurofibrillary tangles, cholinergic deficit and oxidative stress. To counter the complexity of the disease the new approach for drug development is to create a single molecule able to act simultaneously on different targets.<h4>Objective</h4>We conceived eight drug likeliness compounds ... Read more >>

Curr Alzheimer Res (Current Alzheimer research)
[2019, 16(9):815-820]

Cited: 1 time

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Synthesis, antioxidant and Aβ anti-aggregation properties of new ferulic, caffeic and lipoic acid derivatives obtained by the Ugi four-component reaction.

Mohamed Benchekroun, Irene Pachón-Angona, Vincent Luzet, Helene Martin, María-Jesús Oset-Gasque, José Marco-Contelles, Lhassane Ismaili,

We report herein the synthesis antioxidant and Aβ anti-aggregation capacity of (E)-N-benzyl-N-[2-(benzylamino)-2-oxoethyl]-3-(aryl)acrylamides and related (R)-N-benzyl-N-(2-(benzylamino)-2-oxoethyl)-5-(1,2-dithiolan-3-yl)pentanamides 1-12. These compounds have been obtained, via Ugi four-component reaction, from modest to good yields. Their antioxidant analysis, using the DPPH and ORAC assays, allowed us to identify compounds 8 and 9, as potent antioxidant ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2019, 85:221-228]

Cited: 1 time

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Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.

Mourad Chioua, Eleonora Buzzi, Ignacio Moraleda, Isabel Iriepa, Maciej Maj, Artur Wnorowski, Catia Giovannini, Anna Tramarin, Federica Portali, Lhassane Ismaili, Pilar López-Alvarado, Maria Laura Bolognesi, Krzysztof Jóźwiak, J Carlos Menéndez, José Marco-Contelles, Manuela Bartolini,

Notwithstanding the combination of cholinesterase (ChE) inhibition and calcium channel blockade within a multitarget therapeutic approach is envisaged as potentially beneficial to confront Alzheimer's disease (AD), this strategy has been scarcely investigated. To explore this promising line, a series of 5-amino-4-aryl-3,4,6,7,8,9-hexahydropyrimido [4,5-b]quinoline-2(1H)-thiones (tacripyrimidines) (4a-l) were designed by juxtaposition of tacrine, ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2018, 155:839-846]

Cited: 9 times

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Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.

Óscar M Bautista-Aguilera, Stefanie Hagenow, Alejandra Palomino-Antolin, Víctor Farré-Alins, Lhassane Ismaili, Pierre-Louis Joffrin, María L Jimeno, Ondřej Soukup, Jana Janočková, Lena Kalinowsky, Ewgenij Proschak, Isabel Iriepa, Ignacio Moraleda, Johannes S Schwed, Alejandro Romero Martínez, Francisco López-Muñoz, Mourad Chioua, Javier Egea, Rona R Ramsay, José Marco-Contelles, Holger Stark,

The therapy of complex neurodegenerative diseases requires the development of multitarget-directed drugs (MTDs). Novel indole derivatives with inhibitory activity towards acetyl/butyrylcholinesterases and monoamine oxidases A/B as well as the histamine H<sub>3</sub> receptor (H3R) were obtained by optimization of the neuroprotectant ASS234 by incorporating generally accepted H3R pharmacophore motifs. These small-molecule ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2017, 56(41):12765-12769]

Cited: 18 times

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Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy.

Youssef Dgachi, Helène Martin, Alexandre Bonet, Mourad Chioua, Isabel Iriepa, Ignacio Moraleda, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili,

<h4>Aim</h4>Due to the complex nature of Alzheimer's disease, there is a renewed search for multitarget directed drugs.<h4>Results</h4>This paper describes the synthesis and in vitro biological evaluation of six racemic 13-aryl-2,3,4,13-tetrahydro-1H,12H-benzo[6,7]chromeno[2,3-d]pyrido[1,2-a]pyrimidine-7,12,14-triones (1a-6a), and six racemic 15-aryl-8,9,10,11,12,15-hexahydro-14H-benzo[6',7']chromeno[2',3:4,5] pyr-imido [1,2-a]azepine-5,14,16-triones (1b-6b), showing antioxidant and cholinesterase inhibitory capacity. Among these compounds, 13-phenyl-2,3,4,13-tetrahydro-1H,12H-benzo[6,7]chromeno[2,3-d]pyrido[1,2-a]pyrimidine-7,12,14-trione (1a) is ... Read more >>

Future Med Chem (Future medicinal chemistry)
[2017, 9(8):715-721]

Cited: 1 time

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New (benz)imidazolopyridino tacrines as nonhepatotoxic, cholinesterase inhibitors for Alzheimer disease.

Houssem Boulebd, Lhassane Ismaili, Helene Martin, Alexandre Bonet, Mourad Chioua, José Marco Contelles, Ali Belfaitah,

<h4>Aim</h4>Due to the multifactorial nature of Alzheimer's disease, there is an urgent search for new more efficient, multitarget-directed drugs.<h4>Results</h4>This paper describes the synthesis, antioxidant and in vitro biological evaluation of ten (benz)imidazopyridino tacrines (7-16), showing less toxicity than tacrine at high doses, and potent cholinesterase inhibitory capacity, in the low ... Read more >>

Future Med Chem (Future medicinal chemistry)
[2017, 9(8):723-729]

Cited: 5 times

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The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.

Mohamed Benchekroun, Alejandro Romero, Javier Egea, Rafael León, Patrycja Michalska, Izaskun Buendía, María Luisa Jimeno, Daniel Jun, Jana Janockova, Vendula Sepsova, Ondrej Soukup, Oscar M Bautista-Aguilera, Bernard Refouvelet, Olivier Ouari, José Marco-Contelles, Lhassane Ismaili,

Novel multifunctional tacrines for Alzheimer's disease were obtained by Ugi-reaction between ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde, and tacrine derivatives, according to the antioxidant additive approach in order to modulate the oxidative stress as therapeutic strategy. Compound 5c has been identified as a promising permeable agent showing excellent ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2016, 59(21):9967-9973]

Cited: 20 times

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Multicomponent Reactions for Multitargeted Compounds for Alzheimer`s Disease.

Lhassane Ismaili, Maria do Carmo Carreiras,

Alzheimer's Disease (AD) is a multifactorial and fatal neurodegenerative disorder affecting around 35 million people worldwide, which is characterized by decline of cholinergic function, deregulation of amyloid beta (Aβ) oligomers formation and Aβ fibril deposition. Multi-Target- Directed Ligands (MTDLs) have emerged as an original strategy for developing new therapeutic agents ... Read more >>

Curr Top Med Chem (Current topics in medicinal chemistry)
[2017, 17(31):3319-3327]

Cited: 4 times

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Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy.

Youssef Dgachi, Olga Sokolov, Vincent Luzet, Justyna Godyń, Dawid Panek, Alexandre Bonet, Hélène Martin, Isabel Iriepa, Ignacio Moraleda, Cristina García-Iriepa, Jana Janockova, Lysiane Richert, Ondrej Soukup, Barbara Malawska, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili,

Herein we report an efficient two step synthesis and biological assessment of 12 racemic tetrahydropyranodiquinolin-8-amines derivatives as antioxidant, cholinesterase inhibitors and non-hepatotoxic agents. Based on the results of the primary screening, we identified 7-(3-methoxyphenyl)-9,10,11,12-tetrahydro-7H-pyrano[2,3-b:5,6-h']diquinolin-8-amine (2h) as a particularly interesting non-hepatotoxic compound that shows moderate antioxidant activity (1.83 equiv Trolox in ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2017, 126:576-589]

Cited: 7 times

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ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.

José Marco-Contelles, Mercedes Unzeta, Irene Bolea, Gerard Esteban, Rona R Ramsay, Alejandro Romero, Ricard Martínez-Murillo, M Carmo Carreiras, Lhassane Ismaili,

<h4>Highlights</h4>ASS2324 is a hybrid compound resulting from the juxtaposition of donepezil and the propargylamine PF9601N ASS2324 is a multi-target directed propargylamine able to bind to all the AChE/BuChE and MAO A/B enzymesASS2324 shows antioxidant, neuroprotective and suitable permeability propertiesASS2324 restores the scopolamine-induced cognitive impairment to the same extent as donepezil, ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2016, 10:294]

Cited: 19 times

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