Full Text Journal Articles by
Author Leslie Cho

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Summary of Updated Recommendations for Primary Prevention of Cardiovascular Disease in Women: JACC State-of-the-Art Review.

Leslie Cho, Melinda Davis, Islam Elgendy, Kelly Epps, Kathryn J Lindley, Puja K Mehta, Erin D Michos, Margo Minissian, Carl Pepine, Viola Vaccarino, Annabelle Santos Volgman, ,

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality for women in the United States and worldwide. There has been no American College of Cardiology (ACC)/American Heart Association guideline update specifically for the prevention of CVD in women since 2011. Since then, the body of sex-specific data has ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2020, 75(20):2602-2618]

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A practical approach to the cholesterol guidelines and ASCVD prevention.

Leslie Cho,

Lifestyle factors remain the bedrock of atherosclerotic cardiovascular disease (ASCVD) prevention. Statins remain the first-line therapy for primary and secondary prevention of ASCVD. Physicians are encouraged to discuss the risks and benefits of statins with patients before beginning therapy. Nonstatins and proprotein convertase subtilisin-kexin type 9 inhibitors are recommended for ... Read more >>

Cleve Clin J Med (Cleveland Clinic journal of medicine)
[2020, 87(5 suppl 1):15-20]

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Association of adoption of transradial access for percutaneous coronary intervention in ST elevation myocardial infarction with door-to-balloon time.

Chetan P Huded, Samir R Kapadia, Jad A Ballout, Amar Krishnaswamy, Stephen G Ellis, Russell Raymond, Leslie Cho, Conrad Simpfendorfer, Chris Bajzer, Joseph Martin, Ravi Nair, A Michael Lincoff, Kathleen Kravitz, Venu Menon, Scott Hantz, Umesh N Khot,

OBJECTIVES:We aimed to study adoption of transradial primary percutaneous coronary intervention (TR-PPCI) for ST elevation myocardial infarction (STEMI) ("radial first" approach) and its association with door-to-balloon time (D2BT). BACKGROUND:TR-PPCI for STEMI is underutilized in the United States due to concerns about prolonging D2BT. Whether operators and hospitals adopting a radial ... Read more >>

Catheter Cardiovasc Interv (Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions)
[2020, :]

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Fifth generation troponin T assay is subject to antibody interference.

Jeffrey Hedley, Venu Menon, Leslie Cho, Adam J McShane,

BACKGROUND:The fifth generation (high-sensitivity) troponin T assay offers increased precision and analytical sensitivity to the predecessor method. The assay has proven utility in risk stratification and patient management. Upon clinical suspicion and discordant 4th generation troponin T and troponin I results, we investigated a sample for suspected interfering substances to ... Read more >>

Clin. Chim. Acta (Clinica chimica acta; international journal of clinical chemistry)
[2020, 505:98-99]

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High Submaximal Exercise Heart Rate Impacts Exercise Intolerance in the Postural Orthostatic Tachycardia Syndrome.

Erik H Van Iterson, Luke J Laffin, Kenneth A Mayuga, Erika Hutt Centeno, Taha Ahmed, Leslie Cho, Haitham M Ahmed,

PURPOSE:Exercise intolerance is a hallmark of the postural orthostatic tachycardia syndrome (POTS). However, no data are available on the implications of an exaggerated submaximal heart rate (HR) on exercise intolerance in patients. We investigated whether exaggerated HR responses occurring early on during incremental stress testing relate with increased odds of ... Read more >>

J Cardiopulm Rehabil Prev (Journal of cardiopulmonary rehabilitation and prevention)
[2020, 40(3):195-201]

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The Role of Lipoprotein (a) as a Marker of Residual Risk in Patients With Diabetes and Established Cardiovascular Disease on Optimal Medical Therapy: Post Hoc Analysis of ACCELERATE.

Nishant P Shah, Qiuqing Wang, Katherine E Wolski, Leslie Cho, Ellen McErlean, Giacomo Ruotolo, Govinda Weerakkody, Jeffrey S Riesmeyer, Stephen J Nicholls, A Michael Lincoff, Steven E Nissen, Venu Menon,

Diabetes Care (Diabetes care)
[2020, 43(2):e22-e24]

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Migraine Headache: An Under-Appreciated Risk Factor for Cardiovascular Disease in Women.

Islam Y Elgendy, Stephen E Nadeau, C Noel Bairey Merz, Carl J Pepine, , ,

J Am Heart Assoc (Journal of the American Heart Association)
[2019, 8(22):e014546]

Cited: 1 time

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Risk for Anaphylactic Reaction From Cardiac Catheterization in Patients Receiving β-Adrenergic Blockers or Angiotensin-Converting Enzyme-Inhibitors.

Martin A Smith, Lisanne P Newton, Maria A Barcena Blanch, Lyda Cuervo-Pardo, Leslie Cho, David Newton, Xiaofeng Wang, Manshi Li, David M Lang,

BACKGROUND:β-Adrenergic blockers (BBs) have been associated with increased risk for severe anaphylactic reaction (AR) from contrast media; however, this was shown with intravenous contrast media, before widespread use of low osmolar contrast media, angiotensin-converting enzyme-inhibitors (ACE-Is), and cardioselective BBs. OBJECTIVE:To assess the risk for AR during cardiac catheterization (CC) associated ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2019, :]

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Comparison of Long-Term Clinical Outcomes After Drug-Eluting Stenting in Blacks-vs-Whites.

Stephen G Ellis, Leslie Cho, Russell Raymond, Ravi Nair, Conrad Simpfendorfer, Murat Tuzcu, Christopher Bajzer, Abraham Michael Lincoff, Samir Kapadia,

Patients of different racial backgrounds may have socioeconomic, cultural, or genetic differences that impact outcomes after percutaneous coronary intervention (PCI). There are limited data beyond 2 to 3 years for Blacks to inform discussions and perhaps improve outcomes. We studied consecutive limus-stent treated patients, having their first PCI at our ... Read more >>

Am. J. Cardiol. (The American journal of cardiology)
[2019, 124(8):1179-1185]

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Unique cardiovascular risk factors in women.

Laura Young, Leslie Cho,

Despite an overall reduction in cardiovascular disease (CVD) mortality in the USA, the rate of coronary heart disease and CVD mortality is on the rise in younger women aged 35 to 54 years. This has been attributed to an increasing prevalence of CVD risk factors, which can portend disparate outcomes ... Read more >>

Heart (Heart (British Cardiac Society))
[2019, 105(21):1656-1660]

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Reclassification of coronary heart disease risk in a primary prevention setting: traditional risk factor assessment vs. coronary artery calcium scoring.

Alaa Alashi, Richard Lang, Raul Seballos, Steven Feinleib, Roxanne Sukol, Leslie Cho, Paul Schoenhagen, Brian P Griffin, Scott D Flamm, Milind Y Desai,

Background:In a primary prevention screening program of asymptomatic middle-aged subjects, we sought to assess the degree of risk-reclassification provided by traditional risk assessment vs. coronary artery calcification scoring (CACS). Methods:A total of 1,806 consecutive asymptomatic subjects (age 55 years, 76% men), who underwent comprehensive screening in a primary prevention clinic ... Read more >>

Cardiovasc Diagn Ther (Cardiovascular diagnosis and therapy)
[2019, 9(3):214-220]

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Incremental Prognostic Value of Exercise Stress Testing in Primary Prevention.

Alaa Alashi, Haris Riaz, Richard Lang, Raul Seballos, Steven Feinleib, Roxanne Sukol, Leslie Cho, Paul Cremer, Wael Jaber, Brian P Griffin, Milind Y Desai,

In primary prevention, addition of C-reactive protein and family history to standard risk factor assessment (Reynolds Risk Score or RRS) provides superior risk stratification for future cardiovascular (CV) events. We sought to assess whether addition of functional capacity to RRS provided incremental prognostic value. This was a prospective observational cohort ... Read more >>

Am. J. Cardiol. (The American journal of cardiology)
[2019, 124(2):216-223]

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Prevalence of Coronary Vasospasm Using Coronary Reactivity Testing in Patients With Spontaneous Coronary Artery Dissection.

Khendi White Solaru, Frederick Heupler, Leslie Cho, Esther S H Kim,

Spontaneous coronary artery dissection (SCAD) is an important cause of myocardial infarction and sudden cardiac death, particularly in young to middle-aged women. Coronary vasospasm is another condition believed to be associated with SCAD; however, this has only been shown in isolated case reports to date. We sought to examine the ... Read more >>

Am. J. Cardiol. (The American journal of cardiology)
[2019, 123(11):1812-1815]

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Estimated age based on exercise stress testing performance outperforms chronological age in predicting mortality.

Serge C Harb, Paul C Cremer, Yuping Wu, Bo Xu, Leslie Cho, Venu Menon, Wael A Jaber,

AIMS:We sought to estimate patients' age based on their stress testing exercise performance (A-BEST), and evaluate whether A-BEST would be a better predictor of mortality when compared to chronological age. METHODS:We included 126,356 consecutive patients referred for exercise (electrocardiography, echocardiography or myocardial perfusion imaging) stress testing at our institution from ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2019, :2047487319826400]

Cited: 1 time

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Predictors of cardiorespiratory fitness improvement in phase II cardiac rehabilitation.

Ahmed Abu-Haniyeh, Nishant P Shah, Yuping Wu, Leslie Cho, Haitham M Ahmed,

BACKGROUND:Cardiac rehabilitation (CR) improves cardiorespiratory fitness (CRF) and has been shown to reduce cardiovascular events and death. However, data about predictors of fitness improvement during CR are limited and conflicting. The objective of this study was to determine predictors of improvement in metabolic equivalents of task (METs) based on formal ... Read more >>

Clin Cardiol (Clinical cardiology)
[2018, 41(12):1563-1569]

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Effect of Evolocumab on Coronary Plaque Composition.

Stephen J Nicholls, Rishi Puri, Todd Anderson, Christie M Ballantyne, Leslie Cho, John J P Kastelein, Wolfgang Koenig, Ransi Somaratne, Helina Kassahun, Jingyuan Yang, Scott M Wasserman, Satoshi Honda, Daisuke Shishikura, Daniel J Scherer, Marilyn Borgman, Danielle M Brennan, Kathy Wolski, Steven E Nissen,

BACKGROUND:Incremental low-density lipoprotein (LDL) cholesterol lowering with the proprotein convertase subtilisin kexin type 9 inhibitor evolocumab regresses coronary atherosclerosis in statin-treated patients. OBJECTIVES:The purpose of this study was to evaluate the effect of adding evolocumab to statin therapy on coronary plaque composition. METHODS:A total of 968 statin-treated coronary artery disease ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2018, 72(17):2012-2021]

Cited: 1 time

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The Metabolic Syndrome, Cardiovascular Fitness and Survival in Patients With Advanced Systolic Heart Failure.

Amanda Ruth Vest, James Bernard Young, Leslie Cho,

The metabolic syndrome (MetS), which incorporates insulin resistance, visceral adiposity, and dyslipidemia, is an independent risk factor for incident heart failure (HF), but the impact on survival is uncertain. We sought to determine the relation between the metabolic syndrome and survival in ambulatory systolic HF patients and the impact of ... Read more >>

Am. J. Cardiol. (The American journal of cardiology)
[2018, 122(9):1513-1519]

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Sex Differences in the Etiology of Surgical Mitral Valve Disease.

Sneha Vakamudi, Christine Jellis, Stephanie Mick, Yuping Wu, A Marc Gillinov, Tomislav Mihaljevic, Delos M Cosgrove, Lars Svensson, Leslie Cho,

Circulation (Circulation)
[2018, 138(16):1749-1751]

Cited: 1 time

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Familial Chylomicronemia Syndrome: Clinical Characteristics and Long-Term Cardiovascular Outcomes.

Nishant P Shah, Leslie Cho, Haitham M Ahmed,

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2018, 72(10):1177-1179]

Cited: 0 times

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Persistent Safety and Efficacy of Evolocumab in Patients with Statin Intolerance: a Subset Analysis of the OSLER Open-Label Extension Studies.

Leslie Cho, Ricardo Dent, Erik S G Stroes, Evan A Stein, David Sullivan, Andrea Ruzza, Andrea Flower, Ransi Somaratne, Robert S Rosenson,

PURPOSE:Evolocumab reduced low-density lipoprotein cholesterol (LDL-C) in 12-week trials in statin-intolerant patients (GAUSS-1 and GAUSS-2); however, the persistence of efficacy during longer-term treatment is unknown. This subset analysis of the open-label extension studies (OSLER-1 and OSLER-2) aimed to evaluate the safety and efficacy of evolocumab up to 2 years in statin-intolerant ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2018, 32(4):365-372]

Cited: 1 time

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Cardioprotective anti-hyperglycaemic medications: a review of clinical trials.

Haitham M Ahmed, Haitham Khraishah, Leslie Cho,

Despite extensive clinical efforts to achieve stricter glycaemic control over the past few decades, cardiovascular (CV) disease remains the leading cause of death among diabetic patients. Recently, sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 receptor (GLP-1-R) agonists have gained attention due to their apparent effects in reducing CV mortality. Four ... Read more >>

Eur. Heart J. (European heart journal)
[2018, 39(25):2368-2375]

Cited: 7 times

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Cardiac rehabilitation: A class 1 recommendation.

Margo Simon, Kaitlyn Korn, Leslie Cho, Gordon G Blackburn, Chad Raymond,

Cardiac rehabilitation, consisting of prescribed exercise and counseling for risk modification, has proven benefits for patients with cardiovascular disease. Nevertheless, rates of referral and use remain low. Efforts to increase program referral and participation are ongoing. ... Read more >>

Cleve Clin J Med (Cleveland Clinic journal of medicine)
[2018, 85(7):551-558]

Cited: 1 time

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Clevidipine as a therapeutic and cost-effective alternative to sodium nitroprusside in patients with acute aortic syndromes.

Carlos L Alviar, Alejandra Gutierrez, Leslie Cho, Amar Krishnaswamy, Amr Saleh, Michael A Lincoff, Eric Roselli, Michael Militello, Venu Menon,

Sodium nitroprusside is the preferred agent for the treatment of high blood pressure during acute aortic syndrome if blood pressure remains elevated after heart rate control with beta-blockers. The increasing cost of sodium nitroprusside in the USA led us to assess the efficacy and safety of intravenous clevidipine, a calcium ... Read more >>

Eur Heart J Acute Cardiovasc Care (European heart journal. Acute cardiovascular care)
[2018, :2048872618777919]

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Impact of Atrial Fibrillation on Exercise Capacity and Mortality in Heart Failure With Preserved Ejection Fraction: Insights From Cardiopulmonary Stress Testing.

Mohamed B Elshazly, Todd Senn, Yuping Wu, Bruce Lindsay, Walid Saliba, Oussama Wazni, Leslie Cho,

Atrial fibrillation (AF) has been objectively associated with exercise intolerance in patients with heart failure with reduced ejection fraction; however, its impact in patients with heart failure with preserved ejection fraction has not been fully scrutinized.We identified 1744 patients with heart failure and ejection fraction ≥50% referred for cardiopulmonary stress ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2017, 6(11):]

Cited: 3 times

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Comparing SF-36® scores versus biomarkers to predict mortality in primary cardiac prevention patients.

Rony Lahoud, Vasutakarn Chongthammakun, Yuping Wu, Nael Hawwa, Danielle M Brennan, Leslie Cho,

Risk stratification plays an important role in evaluating patients with no known cardiovascular disease (CVD). Few studies have investigated health-related quality of life questionnaires such as the Medical Outcomes Study Short Form-36 (SF-36®) as predictive tools for mortality, particularly in direct comparison with biomarkers. Our objective is to measure the ... Read more >>

Eur. J. Intern. Med. (European journal of internal medicine)
[2017, 46:47-55]

Cited: 3 times

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