Full Text Journal Articles by
Author Leslie Cho

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Unique cardiovascular risk in women.

Laura Young, Leslie Cho,

Despite an overall reduction in cardiovascular disease (CVD) mortality in the USA, the rate of coronary heart disease and CVD mortality is on the rise in younger women aged 35 to 54 years. This has been attributed to an increasing prevalence of CVD risk factors, which can portend disparate outcomes ... Read more >>

Heart (Heart (British Cardiac Society))
[2019, :]

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Reclassification of coronary heart disease risk in a primary prevention setting: traditional risk factor assessment vs. coronary artery calcium scoring.

Alaa Alashi, Richard Lang, Raul Seballos, Steven Feinleib, Roxanne Sukol, Leslie Cho, Paul Schoenhagen, Brian P Griffin, Scott D Flamm, Milind Y Desai,

Background:In a primary prevention screening program of asymptomatic middle-aged subjects, we sought to assess the degree of risk-reclassification provided by traditional risk assessment vs. coronary artery calcification scoring (CACS). Methods:A total of 1,806 consecutive asymptomatic subjects (age 55 years, 76% men), who underwent comprehensive screening in a primary prevention clinic ... Read more >>

Cardiovasc Diagn Ther (Cardiovascular diagnosis and therapy)
[2019, 9(3):214-220]

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Incremental Prognostic Value of Exercise Stress Testing in Primary Prevention.

Alaa Alashi, Haris Riaz, Richard Lang, Raul Seballos, Steven Feinleib, Roxanne Sukol, Leslie Cho, Paul Cremer, Wael Jaber, Brian P Griffin, Milind Y Desai,

In primary prevention, addition of C-reactive protein and family history to standard risk factor assessment (Reynolds Risk Score or RRS) provides superior risk stratification for future cardiovascular (CV) events. We sought to assess whether addition of functional capacity to RRS provided incremental prognostic value. This was a prospective observational cohort ... Read more >>

Am. J. Cardiol. (The American journal of cardiology)
[2019, 124(2):216-223]

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Prevalence of Coronary Vasospasm Using Coronary Reactivity Testing in Patients With Spontaneous Coronary Artery Dissection.

Khendi White Solaru, Frederick Heupler, Leslie Cho, Esther S H Kim,

Spontaneous coronary artery dissection (SCAD) is an important cause of myocardial infarction and sudden cardiac death, particularly in young to middle-aged women. Coronary vasospasm is another condition believed to be associated with SCAD; however, this has only been shown in isolated case reports to date. We sought to examine the ... Read more >>

Am. J. Cardiol. (The American journal of cardiology)
[2019, 123(11):1812-1815]

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Estimated age based on exercise stress testing performance outperforms chronological age in predicting mortality.

Serge C Harb, Paul C Cremer, Yuping Wu, Bo Xu, Leslie Cho, Venu Menon, Wael A Jaber,

AIMS:We sought to estimate patients' age based on their stress testing exercise performance (A-BEST), and evaluate whether A-BEST would be a better predictor of mortality when compared to chronological age. METHODS:We included 126,356 consecutive patients referred for exercise (electrocardiography, echocardiography or myocardial perfusion imaging) stress testing at our institution from ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2019, :2047487319826400]

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Predictors of cardiorespiratory fitness improvement in phase II cardiac rehabilitation.

Ahmed Abu-Haniyeh, Nishant P Shah, Yuping Wu, Leslie Cho, Haitham M Ahmed,

BACKGROUND:Cardiac rehabilitation (CR) improves cardiorespiratory fitness (CRF) and has been shown to reduce cardiovascular events and death. However, data about predictors of fitness improvement during CR are limited and conflicting. The objective of this study was to determine predictors of improvement in metabolic equivalents of task (METs) based on formal ... Read more >>

Clin Cardiol (Clinical cardiology)
[2018, 41(12):1563-1569]

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Sex Differences in the Etiology of Surgical Mitral Valve Disease.

Sneha Vakamudi, Christine Jellis, Stephanie Mick, Yuping Wu, A Marc Gillinov, Tomislav Mihaljevic, Delos M Cosgrove, Lars Svensson, Leslie Cho,

Circulation (Circulation)
[2018, 138(16):1749-1751]

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Effect of Evolocumab on Coronary Plaque Composition.

Stephen J Nicholls, Rishi Puri, Todd Anderson, Christie M Ballantyne, Leslie Cho, John J P Kastelein, Wolfgang Koenig, Ransi Somaratne, Helina Kassahun, Jingyuan Yang, Scott M Wasserman, Satoshi Honda, Daisuke Shishikura, Daniel J Scherer, Marilyn Borgman, Danielle M Brennan, Kathy Wolski, Steven E Nissen,

BACKGROUND:Incremental low-density lipoprotein (LDL) cholesterol lowering with the proprotein convertase subtilisin kexin type 9 inhibitor evolocumab regresses coronary atherosclerosis in statin-treated patients. OBJECTIVES:The purpose of this study was to evaluate the effect of adding evolocumab to statin therapy on coronary plaque composition. METHODS:A total of 968 statin-treated coronary artery disease ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2018, 72(17):2012-2021]

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The Metabolic Syndrome, Cardiovascular Fitness and Survival in Patients With Advanced Systolic Heart Failure.

Amanda Ruth Vest, James Bernard Young, Leslie Cho,

The metabolic syndrome (MetS), which incorporates insulin resistance, visceral adiposity, and dyslipidemia, is an independent risk factor for incident heart failure (HF), but the impact on survival is uncertain. We sought to determine the relation between the metabolic syndrome and survival in ambulatory systolic HF patients and the impact of ... Read more >>

Am. J. Cardiol. (The American journal of cardiology)
[2018, 122(9):1513-1519]

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Familial Chylomicronemia Syndrome: Clinical Characteristics and Long-Term Cardiovascular Outcomes.

Nishant P Shah, Leslie Cho, Haitham M Ahmed,

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2018, 72(10):1177-1179]

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Persistent Safety and Efficacy of Evolocumab in Patients with Statin Intolerance: a Subset Analysis of the OSLER Open-Label Extension Studies.

Leslie Cho, Ricardo Dent, Erik S G Stroes, Evan A Stein, David Sullivan, Andrea Ruzza, Andrea Flower, Ransi Somaratne, Robert S Rosenson,

PURPOSE:Evolocumab reduced low-density lipoprotein cholesterol (LDL-C) in 12-week trials in statin-intolerant patients (GAUSS-1 and GAUSS-2); however, the persistence of efficacy during longer-term treatment is unknown. This subset analysis of the open-label extension studies (OSLER-1 and OSLER-2) aimed to evaluate the safety and efficacy of evolocumab up to 2 years in statin-intolerant ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2018, 32(4):365-372]

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Cardioprotective anti-hyperglycaemic medications: a review of clinical trials.

Haitham M Ahmed, Haitham Khraishah, Leslie Cho,

Despite extensive clinical efforts to achieve stricter glycaemic control over the past few decades, cardiovascular (CV) disease remains the leading cause of death among diabetic patients. Recently, sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 receptor (GLP-1-R) agonists have gained attention due to their apparent effects in reducing CV mortality. Four ... Read more >>

Eur. Heart J. (European heart journal)
[2018, 39(25):2368-2375]

Cited: 5 times

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Cardiac rehabilitation: A class 1 recommendation.

Margo Simon, Kaitlyn Korn, Leslie Cho, Gordon G Blackburn, Chad Raymond,

Cardiac rehabilitation, consisting of prescribed exercise and counseling for risk modification, has proven benefits for patients with cardiovascular disease. Nevertheless, rates of referral and use remain low. Efforts to increase program referral and participation are ongoing. ... Read more >>

Cleve Clin J Med (Cleveland Clinic journal of medicine)
[2018, 85(7):551-558]

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Clevidipine as a therapeutic and cost-effective alternative to sodium nitroprusside in patients with acute aortic syndromes.

Carlos L Alviar, Alejandra Gutierrez, Leslie Cho, Amar Krishnaswamy, Amr Saleh, Michael A Lincoff, Eric Roselli, Michael Militello, Venu Menon,

Sodium nitroprusside is the preferred agent for the treatment of high blood pressure during acute aortic syndrome if blood pressure remains elevated after heart rate control with beta-blockers. The increasing cost of sodium nitroprusside in the USA led us to assess the efficacy and safety of intravenous clevidipine, a calcium ... Read more >>

Eur Heart J Acute Cardiovasc Care (European heart journal. Acute cardiovascular care)
[2018, :2048872618777919]

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Impact of Atrial Fibrillation on Exercise Capacity and Mortality in Heart Failure With Preserved Ejection Fraction: Insights From Cardiopulmonary Stress Testing.

Mohamed B Elshazly, Todd Senn, Yuping Wu, Bruce Lindsay, Walid Saliba, Oussama Wazni, Leslie Cho,

Atrial fibrillation (AF) has been objectively associated with exercise intolerance in patients with heart failure with reduced ejection fraction; however, its impact in patients with heart failure with preserved ejection fraction has not been fully scrutinized.We identified 1744 patients with heart failure and ejection fraction ≥50% referred for cardiopulmonary stress ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2017, 6(11):]

Cited: 4 times

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Comparing SF-36® scores versus biomarkers to predict mortality in primary cardiac prevention patients.

Rony Lahoud, Vasutakarn Chongthammakun, Yuping Wu, Nael Hawwa, Danielle M Brennan, Leslie Cho,

Risk stratification plays an important role in evaluating patients with no known cardiovascular disease (CVD). Few studies have investigated health-related quality of life questionnaires such as the Medical Outcomes Study Short Form-36 (SF-36®) as predictive tools for mortality, particularly in direct comparison with biomarkers. Our objective is to measure the ... Read more >>

Eur. J. Intern. Med. (European journal of internal medicine)
[2017, 46:47-55]

Cited: 2 times

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Statin therapy in the frail elderly: A nuanced decision.

Donald Clark, Leslie S Cho,

Cleve Clin J Med (Cleveland Clinic journal of medicine)
[2017, 84(2):143-145]

Cited: 0 times

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Use of Sex-Specific Clinical and Exercise Risk Scores to Identify Patients at Increased Risk for All-Cause Mortality.

Paul C Cremer, Yuping Wu, Haitham M Ahmed, Lee M Pierson, Danielle M Brennan, Mouaz H Al-Mallah, Clinton A Brawner, Jonathan K Ehrman, Steven J Keteyian, Roger S Blumenthal, Michael J Blaha, Leslie Cho,

Importance:Risk assessment tools for exercise treadmill testing may have limited external validity. Cardiovascular mortality has decreased in recent decades, and women have been underrepresented in prior cohorts. Objectives:To determine whether exercise and clinical variables are associated with differential mortality outcomes in men and women and to assess whether sex-specific risk ... Read more >>

JAMA Cardiol (JAMA cardiology)
[2017, 2(1):15-22]

Cited: 2 times

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Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial.

Stephen J Nicholls, Rishi Puri, Todd Anderson, Christie M Ballantyne, Leslie Cho, John J P Kastelein, Wolfgang Koenig, Ransi Somaratne, Helina Kassahun, Jingyuan Yang, Scott M Wasserman, Robert Scott, Imre Ungi, Jakub Podolec, Antonius Oude Ophuis, Jan H Cornel, Marilyn Borgman, Danielle M Brennan, Steven E Nissen,

Reducing levels of low-density lipoprotein cholesterol (LDL-C) with intensive statin therapy reduces progression of coronary atherosclerosis in proportion to achieved LDL-C levels. Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors produce incremental LDL-C lowering in statin-treated patients; however, the effects of these drugs on coronary atherosclerosis have not been evaluated.To ... Read more >>

JAMA (JAMA)
[2016, 316(22):2373-2384]

Cited: 176 times

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Comparison Between the Kansas City Cardiomyopathy Questionnaire and New York Heart Association in Assessing Functional Capacity and Clinical Outcomes.

Nael Hawwa, Amanda R Vest, Rahul Kumar, Rony Lahoud, James B Young, Yuping Wu, Eiran Z Gorodeski, Leslie Cho,

The Kansas City Cardiomyopathy Questionnaire (KCCQ) has emerged as a patient-centered heart failure-specific health status measure. It currently lacks routine and widespread use in clinical practice and trials. The purpose of this study was to examine the correlation between KCCQ and cardiopulmonary exercise testing (CPET) parameters and clinical outcomes, compared ... Read more >>

J. Card. Fail. (Journal of cardiac failure)
[2017, 23(4):280-285]

Cited: 2 times

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Coronary atheroma progression rates in men and women following high-intensity statin therapy: A pooled analysis of REVERSAL, ASTEROID and SATURN.

Brian Stegman, Mingyuan Shao, Stephen J Nicholls, Mohamed Elshazly, Leslie Cho, Peta King, Samir Kapadia, Murat Tuzcu, Steven E Nissen, Rishi Puri,

High-intensity statin therapy (HIST) reduces cardiovascular events, however, sex-related differences in treatment effects are not well characterized.A patient-level post hoc pooled analysis of 3 randomized trials utilizing serial coronary intravascular ultrasound was undertaken, testing the anti-atherosclerotic effects of HIST in coronary disease patients. Sex-related differences in changes (Δ) in coronary ... Read more >>

Atherosclerosis (Atherosclerosis)
[2016, 254:78-84]

Cited: 2 times

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2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts): Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR).

, Massimo F Piepoli, Arno W Hoes, Stefan Agewall, Christian Albus, Carlos Brotons, Alberico L Catapano, Marie-Therese Cooney, Ugo Corrà, Bernard Cosyns, Christi Deaton, Ian Graham, Michael Stephen Hall, F D Richard Hobbs, Maja-Lisa Løchen, Herbert Löllgen, Pedro Marques-Vidal, Joep Perk, Eva Prescott, Josep Redon, Dimitrios J Richter, Naveed Sattar, Yvo Smulders, Monica Tiberi, H Bart van der Worp, Ineke van Dis, W M Monique Verschuren, , , Guy De Backer, Marco Roffi, Victor Aboyans, Norbert Bachl, Héctor Bueno, Scipione Carerj, Leslie Cho, John Cox, Johan De Sutter, Günther Egidi, Miles Fisher, Donna Fitzsimons, Oscar H Franco, Maxime Guenoun, Catriona Jennings, Borut Jug, Paulus Kirchhof, Kornelia Kotseva, Gregory Y H Lip, François Mach, Giuseppe Mancia, Franz Martin Bermudo, Alessandro Mezzani, Alexander Niessner, Piotr Ponikowski, Bernhard Rauch, Lars Rydén, Adrienne Stauder, Guillaume Turc, Olov Wiklund, Stephan Windecker, Jose Luis Zamorano,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2016, 23(11):NP1-NP96]

Cited: 219 times

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Clinical Profile of Statin Intolerance in the Phase 3 GAUSS-2 Study.

Leslie Cho, Michael Rocco, David Colquhoun, David Sullivan, Robert S Rosenson, Ricardo Dent, Allen Xue, Rob Scott, Scott M Wasserman, Erik Stroes,

Recent evidence suggests that statin intolerance may be more common than reported in randomized trials. However, the statin-intolerant population is not well characterized. The goal of this report is to characterize the population enrolled in the phase 3 Goal Achievement after Utilizing an anti-PCSK9 antibody in Statin Intolerant Subjects Study ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2016, 30(3):297-304]

Cited: 7 times

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Reply: Concerning the Role of Gender Difference in Obesity Paradox in Patients With Heart Failure.

Amanda R Vest, Yuping Wu, Rory Hachamovitch, James B Young, Leslie S Cho,

JACC Heart Fail (JACC. Heart failure)
[2016, 4(3):236]

Cited: 1 time

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Impact of PCSK9 inhibition on coronary atheroma progression: Rationale and design of Global Assessment of Plaque Regression with a PCSK9 Antibody as Measured by Intravascular Ultrasound (GLAGOV).

Rishi Puri, Steven E Nissen, Ransi Somaratne, Leslie Cho, John J P Kastelein, Christie M Ballantyne, Wolfgang Koenig, Todd J Anderson, Jingyuan Yang, Helina Kassahun, Scott M Wasserman, Robert Scott, Marilyn Borgman, Stephen J Nicholls,

Statin-mediated low-density lipoprotein cholesterol (LDL-C) lowering fails to prevent more than half of cardiovascular events in clinical trials. Serial plaque imaging studies have highlighted the benefits of aggressive LDL-C lowering, with plaque regression evident in up to two-thirds of patients with achieved LDL-C levels <70 mg/dL. Proprotein convertase subtilisin/kexin type ... Read more >>

Am. Heart J. (American heart journal)
[2016, 176:83-92]

Cited: 16 times

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