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Real-World Effectiveness of Initial Disease-Modifying Therapies in Pediatric Multiple Sclerosis.

Kristen M Krysko, Jennifer S Graves, Mary Rensel, Bianca Weinstock-Guttman, Alice Rutatangwa, Gregory Aaen, Anita Belman, Leslie Benson, Tanuja Chitnis, Mark Gorman, Manu S Goyal, Yolanda Harris, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Moses Rodriguez, John Rose, Teri Schreiner, Jan-Mendelt Tillema, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

OBJECTIVE:To assess real-world effectiveness of initial treatment with newer compared to injectable disease-modifying therapies (DMTs) on disease activity in pediatric multiple sclerosis (MS) and clinically isolated syndrome (CIS). METHODS:This is a cohort study of children with MS/CIS followed at 12 clinics in the US Network of Pediatric MS Centers, who ... Read more >>

Ann. Neurol. (Annals of neurology)
[2020, :]

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Cognitive processing speed in pediatric-onset multiple sclerosis: Baseline characteristics of impairment and prediction of decline.

Asya I Wallach, Michael Waltz, T Charles Casper, Gregory Aaen, Anita Belman, Leslie Benson, Tanuja Chitnis, Mark Gorman, Jennifer Graves, Yolanda Harris, Timothy E Lotze, Soe Mar, Manikum Moodley, Jayne M Ness, Mary Rensel, Moses Rodriguez, John W Rose, Teri Schreiner, Jan-Mendelt Tillema, Emmanuelle Waubant, Bianca Weinstock-Guttman, Leigh E Charvet, Lauren B Krupp,

BACKGROUND:Cognitive impairment occurs in approximately one-third of pediatric-onset multiple sclerosis (POMS) patients. The Symbol Digit Modalities Test (SDMT), a widely used cognitive screen in adults, has yet to be incorporated early into the standard care of POMS. OBJECTIVE:To screen for cognitive impairment early in the course of POMS and analyze ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2019, :1352458519891984]

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Pan-viral serology implicates enteroviruses in acute flaccid myelitis.

Ryan D Schubert, Isobel A Hawes, Prashanth S Ramachandran, Akshaya Ramesh, Emily D Crawford, John E Pak, Wesley Wu, Carly K Cheung, Brian D O'Donovan, Cristina M Tato, Amy Lyden, Michelle Tan, Rene Sit, Gavin A Sowa, Hannah A Sample, Kelsey C Zorn, Debarko Banerji, Lillian M Khan, Riley Bove, Stephen L Hauser, Amy A Gelfand, Bethany L Johnson-Kerner, Kendall Nash, Kalpathy S Krishnamoorthy, Tanuja Chitnis, Joy Z Ding, Hugh J McMillan, Charles Y Chiu, Benjamin Briggs, Carol A Glaser, Cynthia Yen, Victoria Chu, Debra A Wadford, Samuel R Dominguez, Terry Fei Fan Ng, Rachel L Marine, Adriana S Lopez, W Allan Nix, Ariane Soldatos, Mark P Gorman, Leslie Benson, Kevin Messacar, Jennifer L Konopka-Anstadt, M Steven Oberste, Joseph L DeRisi, Michael R Wilson,

Since 2012, the United States of America has experienced a biennial spike in pediatric acute flaccid myelitis (AFM)1-6. Epidemiologic evidence suggests non-polio enteroviruses (EVs) are a potential etiology, yet EV RNA is rarely detected in cerebrospinal fluid (CSF)2. CSF from children with AFM (n = 42) and other pediatric neurologic disease controls ... Read more >>

Nat. Med. (Nature medicine)
[2019, 25(11):1748-1752]

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Unmet Needs in the Evaluation, Treatment, and Recovery for 167 Children Affected by Acute Flaccid Myelitis Reported by Parents Through Social Media.

Riley Bove, William Rowles, Mia Carleton, Erin Olivera, Mikell Sheehan, Heather P Werdal, Rachel Scott, LaMay Axton, Leslie Benson,

BACKGROUND:We aimed to characterize the outcomes of 167 children affected by acute flaccid myelitis by leveraging the power of social media. METHODS:Members of a closed social media (Facebook) group were invited to participate in an anonymous online survey. Descriptive statistics were applied to quantitative responses, and free-text responses were grouped ... Read more >>

Pediatr. Neurol. (Pediatric neurology)
[2020, 102:20-27]

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Serological and metagenomic interrogation of cerebrospinal fluid implicates enteroviruses in pediatric acute flaccid myelitis

Ryan Schubert, Isobel Hawes, Prashanth Ramachandran, Akshaya Ramesh, Emily Crawford, John Pak, Wesley Wu, Carly Cheung, Brian O’Donovan, Cristina Tato, Amy Lyden, Michelle Tan, Rene Sit, Gavin Sowa, Hannah Sample, Kelsey Zorn, Debarko Banerji, Lillian Khan, Riley Bove, Stephen Hauser, Amy Gelfand, Bethany Johnson-Kerner, Kendall Nash, Kalpathy Krishnamoorthy, Tanuja Chitnis, Joy Ding, Hugh McMillan, Charles Chiu, Benjamin Briggs, Carol Glaser, Cynthia Yen, Victoria Chu, Debra Wadford, Samuel Dominguez, Terry Fei Fan Ng, Rachel Marine, Adriana Lopez, Allan Nix, Ariane Soldatos, Mark Gorman, Leslie Benson, Kevin Messacar, Jennifer Konopka-Anstadt, Steven Oberste, Joseph DeRisi, Michael Wilson,

Abstract Background Since 2014, the United States has experienced a biennial spike in pediatric acute flaccid myelitis (AFM). Epidemiologic evidence suggests non-polio enteroviruses (EVs) are a potential etiology, yet EV RNA is rarely detected in cerebrospinal fluid (CSF) and only inconsistently identified from the respiratory tract, serum, or stool. Methods ... Read more >>

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Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG.

Emmanuelle Waubant, Brenda Banwell, Evangeline Wassmer, Maria-Pia Sormani, Maria-Pia Amato, Rogier Hintzen, Lauren Krupp, Kevin Rostásy, Silvia Tenembaum, Tanuja Chitnis, ,

OBJECTIVE:The impetus for this consensus discussion was to recommend clinical trial designs that can deliver high-quality data for effective therapies for pediatric patients, in a reasonable timeframe, with a key focus on short- and long-term safety. METHODS:The International Pediatric Multiple Sclerosis Study Group convened a meeting of experts to review ... Read more >>

Neurology (Neurology)
[2019, 92(22):e2538-e2549]

Cited: 1 time

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Vitamin D genes influence MS relapses in children.

Jennifer S Graves, Lisa F Barcellos, Lauren Krupp, Anita Belman, Xiaorong Shao, Hong Quach, Janace Hart, Tanuja Chitnis, Bianca Weinstock-Guttman, Gregory Aaen, Leslie Benson, Mark Gorman, Benjamin Greenberg, Timothy Lotze, Mar Soe, Jayne Ness, Moses Rodriguez, John Rose, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, T Charles Casper, Emmanuelle Waubant,

OBJECTIVE:The aim of this study was to determine whether a vitamin D genetic risk score (vitDGRS) is associated with 25-hydroxyvitamin D (25(OH)D) level and multiple sclerosis (MS) relapses in children. METHODS:DNA samples were typed for single nucleotide polymorphisms (SNPs) from four genes previously identified to be associated with 25(OH)D levels. ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2019, :1352458519845842]

Cited: 1 time

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miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS.

Brooke Rhead, Xiaorong Shao, Jennifer S Graves, Tanuja Chitnis, Amy T Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Lauren Krupp, Benjamin M Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Moses Rodriguez, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan S Candee, Mark Gorman, Leslie Benson, Soe Mar, Ilana Kahn, John Rose, T Charles Casper, Hong Quach, Diana Quach, Catherine Schaefer, Emmanuelle Waubant, Lisa F Barcellos, ,

Objective:Onset of multiple sclerosis (MS) occurs in childhood for approximately 5% of cases (pediatric MS, or ped-MS). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from microRNAs (miRNAs), small noncoding RNAs that affect gene expression by binding target gene mRNAs. Few studies have specifically examined ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2019, 6(6):1053-1061]

Cited: 1 time

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Pediatric CNS-isolated hemophagocytic lymphohistiocytosis.

Leslie A Benson, Hojun Li, Lauren A Henderson, Isaac H Solomon, Ariane Soldatos, Jennifer Murphy, Bibiana Bielekova, Alyssa L Kennedy, Michael J Rivkin, Kimberly J Davies, Amy P Hsu, Steven M Holland, William A Gahl, Robert P Sundel, Leslie E Lehmann, Michelle A Lee, Sanda Alexandrescu, Barbara A Degar, Christine N Duncan, Mark P Gorman,

Objective:To highlight a novel, treatable syndrome, we report 4 patients with CNS-isolated inflammation associated with familial hemophagocytic lymphohistiocytosis (FHL) gene mutations (CNS-FHL). Methods:Retrospective chart review. Results:Patients with CNS-FHL are characterized by chronic inflammation restricted to the CNS that is not attributable to any previously described neuroinflammatory etiology and have germline ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2019, 6(3):e560]

Cited: 1 time

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Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome.

Olha Halyabar, Margaret H Chang, Michelle L Schoettler, Marc A Schwartz, Ezgi H Baris, Leslie A Benson, Catherine M Biggs, Mark Gorman, Leslie Lehmann, Mindy S Lo, Peter A Nigrovic, Craig D Platt, Gregory P Priebe, Jared Rowe, Robert P Sundel, Neeraj K Surana, Katja G Weinacht, Alison Mann, Jenny Chan Yuen, Patricia Meleedy-Rey, Amy Starmer, Taruna Banerjee, Fatma Dedeoglu, Barbara A Degar, Melissa M Hazen, Lauren A Henderson,

BACKGROUND:Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) were historically thought to be distinct entities, often managed in isolation. In fact, these conditions are closely related. A collaborative approach, which incorporates expertise from subspecialties that previously treated HLH/MAS independently, is needed. We leveraged quality improvement (QI) techniques in the form ... Read more >>

Pediatr Rheumatol Online J (Pediatric rheumatology online journal)
[2019, 17(1):7]

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Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry.

Calvin Chi, Xiaorong Shao, Brooke Rhead, Edlin Gonzales, Jessica B Smith, Anny H Xiang, Jennifer Graves, Amy Waldman, Timothy Lotze, Teri Schreiner, Bianca Weinstock-Guttman, Gregory Aaen, Jan-Mendelt Tillema, Jayne Ness, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Tanuja Chitnis, Soe Mar, Anita Belman, Theron Charles Casper, John Rose, Manikum Moodley, Mary Rensel, Moses Rodriguez, Benjamin Greenberg, Llana Kahn, Jennifer Rubin, Catherine Schaefer, Emmanuelle Waubant, Annette Langer-Gould, Lisa F Barcellos,

Multiple sclerosis (MS) is an autoimmune disease with high prevalence among populations of northern European ancestry. Past studies have shown that exposure to ultraviolet radiation could explain the difference in MS prevalence across the globe. In this study, we investigate whether the difference in MS prevalence could be explained by ... Read more >>

PLoS Genet. (PLoS genetics)
[2019, 15(1):e1007808]

Cited: 2 times

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Central nervous system-restricted familial hemophagocytic lymphohistiocytosis responds to hematopoietic cell transplantation.

Hojun Li, Leslie A Benson, Lauren A Henderson, Isaac H Solomon, Alyssa L Kennedy, Ariane Soldatos, Bibiana Bielekova, Jennifer Murphy, Kimberly J Davies, Leslie E Lehmann, Michelle A Lee, Sanda Alexandrescu, Barbara A Degar, Mark P Gorman, Christine N Duncan,

Blood Adv (Blood advances)
[2019, 3(4):503-507]

Cited: 1 time

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Clinical Subpopulations in a Sample of North American Children Diagnosed With Acute Flaccid Myelitis, 2012-2016.

Matthew J Elrick, Eliza Gordon-Lipkin, Thomas O Crawford, Keith Van Haren, Kevin Messacar, Nicole Thornton, Elizabeth Dee, Annie Voskertchian, Jessica R Nance, Laura S Muñoz, Mark P Gorman, Leslie A Benson, David L Thomas, Carlos A Pardo, Aaron M Milstone, Priya Duggal,

Importance:Acute flaccid myelitis (AFM) is an emerging poliolike illness of children whose clinical spectrum and associated pathogens are only partially described. The case definition is intentionally encompassing for epidemiologic surveillance to capture all potential AFM cases. Defining a restrictive, homogenous subpopulation may aid our understanding of this emerging disease. Objective:To ... Read more >>

JAMA Pediatr (JAMA pediatrics)
[2019, 173(2):134-139]

Cited: 1 time

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Histopathologic Correlates of Familial Hemophagocytic Lymphohistiocytosis Isolated to the Central Nervous System.

Isaac H Solomon, Hojun Li, Leslie A Benson, Lauren A Henderson, Barbara A Degar, Mark P Gorman, Christine N Duncan, Hart G Lidov, Sanda Alexandrescu,

Familial hemophagocytic lymphohistiocytosis (HLH) is an immune hyperactivation syndrome caused by mutations in genes associated with cytotoxic T-cell and NK-cell function. While neurological manifestations frequently accompany systemic inflammation at initial presentation, isolated central nervous system (CNS) involvement is rare, and the histological correlates are not well described. We present 3 ... Read more >>

J. Neuropathol. Exp. Neurol. (Journal of neuropathology and experimental neurology)
[2018, 77(12):1079-1084]

Cited: 2 times

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1901. Safety, Tolerability, and Efficacy of Fluoxetine as an Antiviral for Enterovirus D68 Associated Acute Flaccid Myelitis: A Retrospective Multicenter Cohort Study.

Kevin Messacar, Stefan Sillau, Sarah Hopkins, Catherine Otten, Molly Wilson-Murphy, Brian Wong, Jonathan Santoro, Andrew Treister, Harlori Tokhie, Alcy Torres, Luke Zabrocki, Julia Glanternik, Amanda L Hurst, Jan Martin, Teri Schreiner, Naila Makhani, Roberta DeBiasi, Michael Kruer, Adriana H Tremoulet, Keith Van Haren, Jay Desai, Leslie Benson, Mark Gorman, Mark Abzug, Kenneth Tyler, Samuel Dominguez,

AbstractBackgroundMost patients with enterovirus (EV) D68-associated acute flaccid myelitis (AFM) have long-term disability. No effective therapies have been identified. Fluoxetine is the only FDA-approved medication with antiviral activity against EV-D68. This study retrospectively analyzed the safety, tolerability, and efficacy of fluoxetine for EV-D68-associated AFM.MethodsA multicenter cohort study of US ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S546-S546]

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Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis.

Kevin Messacar, Stefan Sillau, Sarah E Hopkins, Catherine Otten, Molly Wilson-Murphy, Brian Wong, Jonathan D Santoro, Andrew Treister, Harlori K Bains, Alcy Torres, Luke Zabrocki, Julia R Glanternik, Amanda L Hurst, Jan A Martin, Teri Schreiner, Naila Makhani, Roberta L DeBiasi, Michael C Kruer, Adriana H Tremoulet, Keith Van Haren, Jay Desai, Leslie A Benson, Mark P Gorman, Mark J Abzug, Kenneth L Tyler, Samuel R Dominguez,

OBJECTIVE:To determine the safety, tolerability, and efficacy of fluoxetine for proven or presumptive enterovirus (EV) D68-associated acute flaccid myelitis (AFM). METHODS:A multicenter cohort study of US patients with AFM in 2015-2016 compared serious adverse events (SAEs), adverse effects, and outcomes between fluoxetine-treated patients and untreated controls. Fluoxetine was administered at ... Read more >>

Neurology (Neurology)
[2019, 92(18):e2118-e2126]

Cited: 5 times

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Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis.

Gregory Aaen, Michael Waltz, Wendy Vargas, Naila Makhani, Jayne Ness, Yolanda Harris, T Charles Casper, Leslie Benson, Meghan Candee, Tanuja Chitnis, Mark Gorman, Jennifer Graves, Benjamin Greenberg, Timothy Lotze, Soe Mar, Jan-Mendelt Tillema, Mary Rensel, Moses Rodriguez, John Rose, Jennifer Rubin, Teri Schreiner, Amy Waldman, Bianca Weinstock-Guttman, Anita Belman, Emmanuelle Waubant, Lauren Krupp,

Children with pediatric-onset multiple sclerosis and pediatric controls were enrolled across 16 pediatric multiple sclerosis centers in the United States and completed questionnaires that addressed time of first unaided walking and acquisition of 2-word phrases. A total of 467 (308 female) cases and 428 (209 female) controls were enrolled. Pediatric ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2019, 34(3):148-152]

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Magnetic resonance imaging in enterovirus-71, myelin oligodendrocyte glycoprotein antibody, aquaporin-4 antibody, and multiple sclerosis-associated myelitis in children.

Esther M Tantsis, Kristina Prelog, Gulay Alper, Leslie Benson, Mark Gorman, Ming Lim, Shekeeb S Mohammad, Sudarshini Ramanathan, Fabienne Brilot, Russell C Dale, ,

AIM:We used magnetic resonance imaging (MRI) to compare the neuroimaging of children with their first episode of clinical enterovirus 71-associated transverse myelitis (EV71-TM), myelin oligodendrocyte glycoprotein antibody positive transverse myelitis (MOG-TM), aquaporin-4 antibody positive transverse myelitis (AQP4-TM), transverse myelitis in multiple sclerosis (MS-TM), and unclassified transverse myelitis (UNC-TM). METHOD:We performed ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2019, 61(9):1108-1116]

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Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US.

Kristen M Krysko, Jennifer Graves, Mary Rensel, Bianca Weinstock-Guttman, Gregory Aaen, Leslie Benson, Tanuja Chitnis, Mark Gorman, Manu Goyal, Lauren Krupp, Timothy Lotze, Soe Mar, Moses Rodriguez, John Rose, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

OBJECTIVE:To characterize the use and safety of newer disease-modifying therapies (DMTs) in children with multiple sclerosis (MS) and clinically isolated syndrome (CIS) treated under 18 years of age. METHODS:This is a cohort study including children with MS or CIS followed at 12 outpatient practices participating in the US Network of ... Read more >>

Neurology (Neurology)
[2018, 91(19):e1778-e1787]

Cited: 3 times

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Several household chemical exposures are associated with pediatric-onset multiple sclerosis.

Soe Mar, Shannon Liang, Michael Waltz, T Charles Casper, Manu Goyal, Benjamin Greenberg, Bianca Weinstock-Guttman, Moses Rodriguez, Gregory Aaen, Anita Belman, Lisa F Barcellos, John Rose, Mark Gorman, Leslie Benson, Meghan Candee, Tanjua Chitnis, Yolanda Harris, Ilana Kahn, Shelly Roalsted, Janace Hart, Timothy Lotze, Manikum Moodley, Jayne Ness, Mary Rensel, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Lauren Krupp, Jennifer S Graves, Emmanuelle Waubant, ,

Background:There is limited information about the potential associations of multiple sclerosis (MS) and commonly used household chemicals. Methods:We performed a case-control study of exposures to common household chemicals during childhood in children with MS and healthy pediatric controls. Exposures to household products were collected from a comprehensive questionnaire (http://www.usnpmsc.org/Documents/EnvironmentalAssessment.pdf) completed ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(12):1513-1521]

Cited: 1 time

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Heterogeneity in association of remote herpesvirus infections and pediatric MS.

Bardia Nourbakhsh, Alice Rutatangwa, Michael Waltz, Mary Rensel, Manikum Moodley, Jennifer Graves, Theron Charles Casper, Amy Waldman, Anita Belman, Benjamin Greenberg, Manu Goyal, Yolanda Harris, Ilana Kahn, Timothy Lotze, Soe Mar, Teri Schreiner, Gregory Aaen, Janace Hart, Jayne Ness, Jennifer Rubin, Jan-Mendelt Tillema, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, John Rose, Meghan Candee, Bianca Weinstock-Guttman, Xiaorong Shao, Lisa Barcellos, Judith James, Emmanuelle Waubant, ,

Objective:While prior Epstein-Barr virus (EBV) infection has been consistently associated with subsequent risk of developing multiple sclerosis (MS), the association with other common herpesviruses has been more controversial. Our objectives were to determine whether remote infection with EBV and other common herpesviruses affect the susceptibility to pediatric MS and if ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(10):1222-1228]

Cited: 2 times

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Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis.

Leena Suleiman, Emmanuelle Waubant, Gregory Aaen, Anita Belman, Leslie Benson, Meghan Candee, Tanuja Chitnis, Mark Gorman, Manu Goyal, Benjamin Greenberg, Yolanda Harris, Janace Hart, Ilana Kahn, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Bardia Nourbakhsh, Mary Rensel, Moses Rodriguez, John Rose, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Bianca Weinstock-Guttman, T Charles Casper, Michael Waltz, Jennifer S Graves, ,

OBJECTIVE:We sought to determine if early infectious exposures such as daycare, early use of antibiotics, vaccinations and other germ exposures including pacifier use and playing on grass are associated with multiple sclerosis (MS) risk in children. METHODS:This was a case-control study of children with MS or clinically isolated syndrome (CIS) ... Read more >>

Mult Scler Relat Disord (Multiple Sclerosis and Related Disorders)
[2018, 22:103-107]

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Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis.

Axel Petzold, Laura J Balcer, Peter A Calabresi, Fiona Costello, Teresa C Frohman, Elliot M Frohman, Elena H Martinez-Lapiscina, Ari J Green, Randy Kardon, Olivier Outteryck, Friedemann Paul, Sven Schippling, Patrik Vermersch, Pablo Villoslada, Lisanne J Balk, ,

Structural retinal imaging biomarkers are important for early recognition and monitoring of inflammation and neurodegeneration in multiple sclerosis. With the introduction of spectral domain optical coherence tomography (SD-OCT), supervised automated segmentation of individual retinal layers is possible. We aimed to investigate which retinal layers show atrophy associated with neurodegeneration in ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2017, 16(10):797-812]

Cited: 55 times

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Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis.

Saeedeh Azary, Teri Schreiner, Jennifer Graves, Amy Waldman, Anita Belman, Bianca Weinstock Guttman, Gregory Aaen, Jan-Mendelt Tillema, Soe Mar, Janace Hart, Jayne Ness, Yolanda Harris, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, John Rose, Lisa F Barcellos, Tim Lotze, Suzan L Carmichael, Shelly Roalstad, Charles T Casper, Emmanuelle Waubant,

OBJECTIVE:The role of diet in multiple sclerosis (MS) course remains largely unknown. Children with MS have a higher relapse rate compared with MS in adults. Thus, studying the effect of diet on relapse rate in this age group is likely to provide more robust answers. METHODS:This is a multicentre study ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2018, 89(1):28-33]

Cited: 13 times

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Genetic risk factors for pediatric-onset multiple sclerosis.

Milena A Gianfrancesco, Pernilla Stridh, Xiaorong Shao, Brooke Rhead, Jennifer S Graves, Tanuja Chitnis, Amy Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Benjamin Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Soe Mar, Ilana Kahn, John Rose, Shelly Roalstad, T Charles Casper, Ling Shen, Hong Quach, Diana Quach, Jan Hillert, Anna Hedstrom, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Catherine Schaefer, Lisa F Barcellos, Emmanuelle Waubant, ,

BACKGROUND:Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology. OBJECTIVE:We comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS. METHODS:Cases with onset <18 years (n = 569) and controls (n = 16,251) were included from ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2018, 24(14):1825-1834]

Cited: 4 times

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