Full Text Journal Articles by
Author Lesley A Houghton

Advertisement

Find full text journal articles






Editorial: understanding IBS pathophysiology through "converging channels" of research-authors' reply.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1215-1216]

Cited: 0 times

View full text PDF listing >>



Characteristics of, and natural history among, individuals with Rome IV functional bowel disorders.

Vivek C Goodoory, Lesley A Houghton, Christopher J Black, Alexander C Ford,

<h4>Background</h4>Little is known about the natural history of functional bowel disorders using Rome IV criteria. We examined these issues in a longitudinal follow-up study.<h4>Methods</h4>We collected complete demographic, gastrointestinal symptom, and psychological comorbidity data at baseline from 1372 adults who met Rome IV criteria for one of the five functional bowel ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, :e14268]

Cited: 0 times

View full text PDF listing >>



Advertisement

Intestinal chemosensitivity in irritable bowel syndrome associates with small intestinal TRPV channel expression.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

<h4>Background</h4>Irritable bowel syndrome (IBS) patients often experience meal-associated symptoms. However, the underlying mechanisms are unclear.<h4>Aim</h4>To determine small intestinal mechanisms of lipid-induced symptoms and rectal hypersensitivity in IBS METHODS: We recruited 26 IBS patients (12 IBS-C, 14 IBS-D) and 15 healthy volunteers (HV). In vivo permeability was assessed using saccharide excretion ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1179-1192]

Cited: 0 times

View full text PDF listing >>



Impact of Psychological Comorbidity on the Prognosis of Irritable Bowel Syndrome.

Vivek C Goodoory, Antonina Mikocka-Walus, Yan Yiannakou, Lesley A Houghton, Christopher J Black, Alexander C Ford,

<h4>Introduction</h4>Psychological comorbidities are associated with irritable bowel syndrome (IBS), but little is known about their cumulative effect on its prognosis. We examined this issue in a longitudinal 12-month follow-up study.<h4>Methods</h4>We collected complete demographic, symptom, and psychological comorbidity data (anxiety, depression, somatic symptom disorder, perceived stress, and gastrointestinal symptom-specific anxiety) at ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2021, 116(7):1485-1494]

Cited: 1 time

View full text PDF listing >>



Editorial: recognising the efficacy of licensed drug therapies for irritable bowel syndrome on bloating-a step in the right direction for targeted treatment? Authors' reply.

Alfred D Nelson, Christopher J Black, Lesley A Houghton, Nahyr Sofía Lugo-Fagundo, Brian E Lacy, Alexander C Ford,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(2):198-199]

Cited: 0 times

View full text PDF listing >>



Systematic review and network meta-analysis: efficacy of licensed drugs for abdominal bloating in irritable bowel syndrome with constipation.

Alfred D Nelson, Christopher J Black, Lesley A Houghton, Nahyr Sofía Lugo-Fagundo, Brian E Lacy, Alexander C Ford,

<h4>Background</h4>Although bloating is a highly prevalent and troublesome symptom in irritable bowel syndrome with constipation (IBS-C), treatment is empirical with no specific guidelines for its management.<h4>Aim</h4>To conduct a pairwise and network meta-analysis, using a frequentist approach, of Food and Drug Administration-licensed drugs for IBS-C comparing their efficacy for abdominal bloating ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(2):98-108]

Cited: 0 times

View full text PDF listing >>



The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome.

Sandra Mohr, Nikola Fritz, Christian Hammer, Cristina Martínez, Cristina Martínez, Sabrina Berens, Stefanie Schmitteckert, Verena Wahl, Malin Schmidt, Lesley A Houghton, Miriam Goebel-Stengel, Maria Kabisch, Dorothea Götze, Irina Milovač, Mauro D'Amato, Tenghao Zheng, Ralph Röth, Hubert Mönnikes, Felicitas Engel, Annika Gauss, Jonas Tesarz, Martin Raithel, Viola Andresen, Thomas Frieling, Jutta Keller, Christian Pehl, Christoph Stein-Thöringer, Gerard Clarke, Paul J Kennedy, John F Cryan, Timothy G Dinan, Eamonn M M Quigley, Robin Spiller, Caroll Beltrán, Ana María Madrid, Verónica Torres, Edith Pérez de Arce, Wolfgang Herzog, Emeran A Mayer, Gregory Sayuk, Maria Gazouli, George Karamanolis, Lejla Kapur-Pojskič, Mariona Bustamante, Raquel Rabionet, Xavier Estivil, André Franke, Wolfgang Lieb, Guy Boeckxstaens, Mira M Wouters, Magnus Simrén, Gudrun A Rappold, Maria Vicario, Javier Santos, Rainer Schaefert, Justo Lorenzo-Bermejo, Beate Niesler,

Irritable bowel syndrome (IBS) is a gut-brain disorder in which symptoms are shaped by serotonin acting centrally and peripherally. The serotonin transporter gene SLC6A4 has been implicated in IBS pathophysiology, but the underlying genetic mechanisms remain unclear. We sequenced the alternative P2 promoter driving intestinal SLC6A4 expression and identified single ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2021, 25(16):8047-8061]

Cited: 1 time

View full text PDF listing >>



The Perils and Pitfalls of Esophageal Dysmotility in Idiopathic Pulmonary Fibrosis.

Ramsah Cheah, Supphamat Chirnaksorn, Ahmed H Abdelrahim, Laura Horgan, Toby Capstick, John Casey, Daniel Peckham, Alison Boland, Timothy J T Sutherland, Paul Beirne, Augustine S Lee, Kenneth R DeVault, Lesley A Houghton,

<h4>Introduction</h4>Gastroesophageal reflux plays a significant role in idiopathic pulmonary fibrosis (IPF). Given the morbidity and mortality associated with IPF, understanding the mechanisms responsible for reflux is essential if patients are to receive optimal treatment and management, especially given the lack of clear benefit of antireflux therapies. Our aim was to ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2021, 116(6):1189-1200]

Cited: 0 times

View full text PDF listing >>



Natural History and Disease Impact of Rome IV Vs Rome III Irritable Bowel Syndrome: A Longitudinal Follow-Up Study.

Vivek C Goodoory, Lesley A Houghton, Yan Yiannakou, Christopher J Black, Alexander C Ford,

<h4>Background & aims</h4>Irritable bowel syndrome (IBS) is a chronic functional bowel disorder diagnosed using the Rome criteria, which have evolved since their original description 30 years ago. Little is known about the effects on the natural history of IBS of moving to the latest iteration, Rome IV, from the previous ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

Cited: 0 times

View full text PDF listing >>



British Society of Gastroenterology guidelines on the management of irritable bowel syndrome.

Dipesh H Vasant, Peter A Paine, Christopher J Black, Lesley A Houghton, Hazel A Everitt, Maura Corsetti, Anurag Agrawal, Imran Aziz, Adam D Farmer, Maria P Eugenicos, Rona Moss-Morris, Yan Yiannakou, Alexander C Ford,

Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders seen by clinicians in both primary and secondary care. Since publication of the last British Society of Gastroenterology (BSG) guideline in 2007, substantial advances have been made in understanding its complex pathophysiology, resulting in its re-classification as a ... Read more >>

Gut (Gut)
[2021, 70(7):1214-1240]

Cited: 0 times

View full text PDF listing >>



Overlap of Rome IV Irritable Bowel Syndrome and Functional Dyspepsia and Effect on Natural History: A Longitudinal Follow-Up Study.

Brigida Barberio, Yan Yiannakou, Lesley A Houghton, Christopher J Black, Edoardo V Savarino, Alexander C Ford,

<h4>Objectives</h4>Disorders of gut-brain interaction, such as irritable bowel syndrome (IBS) and functional dyspepsia (FD), frequently overlap, but the impact of this on the natural history is unknown. We examined this issue in a longitudinal follow-up study conducted in a large cohort of individuals.<h4>Methods</h4>We collected complete demographic, symptom, mood, and psychological ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Longitudinal follow-up of a novel classification system for irritable bowel syndrome: natural history and prognostic value.

Christopher J Black, Yan Yiannakou, Elspeth Guthrie, Robert West, Lesley A Houghton, Alexander C Ford,

<h4>Background</h4>Conventionally, irritable bowel syndrome (IBS) is subgrouped using predominant stool form, yet it is a complex disorder, with multiple biopsychosocial contributors. We previously derived and validated a latent class model subgrouping people with IBS into seven clusters based on gastrointestinal and extraintestinal symptoms and psychological profile.<h4>Aims</h4>To conduct longitudinal follow-up examining ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 53(10):1126-1137]

Cited: 0 times

View full text PDF listing >>



A Novel Method to Classify and Subgroup Patients With IBS Based on Gastrointestinal Symptoms and Psychological Profiles.

Christopher J Black, Yan Yiannakou, Elspeth A Guthrie, Robert West, Lesley A Houghton, Alexander C Ford,

<h4>Introduction</h4>Conventionally, patients with irritable bowel syndrome (IBS) are subgrouped based on their predominant bowel habit. Given the relevance of psychological comorbidity to IBS symptoms, our aim was to explore an alternative approach to subgrouping by incorporating factors beyond stool form and frequency.<h4>Methods</h4>We collected demographic, symptom, and psychological health data from ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2021, 116(2):372-381]

Cited: 0 times

View full text PDF listing >>



Symptom Stability in Rome IV vs Rome III Irritable Bowel Syndrome.

Brigida Barberio, Lesley A Houghton, Yan Yiannakou, Edoardo V Savarino, Christopher J Black, Alexander C Ford,

<h4>Introduction</h4>Irritable bowel syndrome (IBS) is a chronic functional bowel disorder, which follows a relapsing and remitting course. Little is known about how evolving definitions of IBS or treatment for the condition affect symptom stability. We conducted a 12-month longitudinal follow-up study of individuals who self-identified as having IBS to examine ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2021, 116(2):362-371]

Cited: 0 times

View full text PDF listing >>



Anxiety-related factors associated with symptom severity in irritable bowel syndrome.

Christopher J Black, Yan Yiannakou, Lesley A Houghton, Farag Shuweihdi, Robert West, Elspeth Guthrie, Alexander C Ford,

<h4>Background</h4>Gastrointestinal symptom-specific anxiety and somatization have both been associated with higher symptom severity in patients with irritable bowel syndrome (IBS); however, this relationship has not been explored fully. Moreover, the performance of the visceral sensitivity index (VSI) for measuring gastrointestinal symptom-specific anxiety has not been examined in a UK population. ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2020, 32(8):e13872]

Cited: 2 times

View full text PDF listing >>



Efficacy of psychological therapies for irritable bowel syndrome: systematic review and network meta-analysis.

Christopher J Black, Elyse R Thakur, Lesley A Houghton, Eamonn M M Quigley, Paul Moayyedi, Alexander C Ford,

<h4>Objectives</h4>National guidelines for the management of irritable bowel syndrome (IBS) recommend that psychological therapies should be considered, but their relative efficacy is unknown, because there have been few head-to-head trials. We performed a systematic review and network meta-analysis to try to resolve this uncertainty.<h4>Design</h4>We searched the medical literature through January ... Read more >>

Gut (Gut)
[2020, 69(8):1441-1451]

Cited: 5 times

View full text PDF listing >>



Efficacy of Eluxadoline in Irritable Bowel Syndrome With Diarrhea.

Christopher J Black, Lesley A Houghton, Alexander C Ford,

Am J Gastroenterol (The American journal of gastroenterology)
[2020, 115(3):483-484]

Cited: 0 times

View full text PDF listing >>



Editorial: understanding differences in patient response to ondansetron in irritable bowel syndrome with diarrhoea-are we any closer?

Christopher J Black, Alexander C Ford, Lesley A Houghton,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2019, 50(7):825-826]

Cited: 0 times

View full text PDF listing >>



Epidemiological, Clinical, and Psychological Characteristics of Individuals with Self-reported Irritable Bowel Syndrome Based on the Rome IV vs Rome III Criteria.

Christopher J Black, Yan Yiannakou, Lesley A Houghton, Alexander C Ford,

<h4>Objectives</h4>Few studies have examined the effects of applying the Rome IV criteria for irritable bowel syndrome (IBS) vs the previous standard, the Rome III criteria. We conducted a cross-sectional survey of individuals who self-identify as having IBS to examine this issue.<h4>Methods</h4>We collected complete demographic, symptom, mood, and psychological health data ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2020, 18(2):392-398.e2]

Cited: 7 times

View full text PDF listing >>



Unilateral Versus Bilateral Lung Transplantation: Do Different Esophageal Risk Factors Predict Chronic Allograft Failure?

Anupong Tangaroonsanti, Augustine S Lee, Marcelo F Vela, Michael D Crowell, David Erasmus, Cesar Keller, Jorge Mallea, Francisco Alvarez, Cristina Almansa, Kenneth R DeVault, Lesley A Houghton,

GOALS:To assess the effect of unilateral versus bilateral lung transplantation (LTx) on esophageal motility and gastroesophageal reflux, and the association with the development of obstructive chronic lung allograft dysfunction (o-CLAD). BACKGROUND:We have shown that esophagogastric junction outflow obstruction, incomplete bolus transit, and proximal reflux are all independent risk factors for ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2019, 53(4):284-289]

Cited: 1 time

View full text PDF listing >>



Efficacy of pharmacological therapies in patients with IBS with diarrhoea or mixed stool pattern: systematic review and network meta-analysis.

Christopher J Black, Nicholas E Burr, Michael Camilleri, David L Earnest, Eamonn Mm Quigley, Paul Moayyedi, Lesley A Houghton, Alexander C Ford,

<h4>Objective</h4>Over half of patients with IBS have either diarrhoea (IBS-D) or a mixed stool pattern (IBS-M). The relative efficacy of licenced pharmacological therapies is unclear in the absence of head-to-head trials. We conducted a network meta-analysis to resolve this uncertainty.<h4>Design</h4>We searched MEDLINE, Embase, Embase Classic, the Cochrane central register of ... Read more >>

Gut (Gut)
[2020, 69(1):74-82]

Cited: 11 times

View full text PDF listing >>



Insights into the evaluation and management of dyspepsia: recent developments and new guidelines.

Christopher J Black, Lesley A Houghton, Alexander C Ford,

Dyspepsia is a very common gastrointestinal (GI) condition worldwide. We critically examine the recommendations of recently published guidelines for the management of dyspepsia, including those produced jointly by the American College of Gastroenterology and the Canadian Association of Gastroenterology, and those published by the UK National Institute for Health and ... Read more >>

Therap Adv Gastroenterol (Therapeutic advances in gastroenterology)
[2018, 11:1756284818805597]

Cited: 3 times

View full text PDF listing >>



Efficacy of Secretagogues in Patients With Irritable Bowel Syndrome With Constipation: Systematic Review and Network Meta-analysis.

Christopher J Black, Nicholas E Burr, Eamonn M M Quigley, Paul Moayyedi, Lesley A Houghton, Alexander C Ford,

<h4>Background & aims</h4>Several secretagogues have been approved for the treatment of irritable bowel syndrome with constipation (IBS-C). However, their relative efficacy is unclear because there have been no head-to-head randomized controlled trials. We conducted a network meta-analysis to compare their efficacies in patients with IBS-C.<h4>Methods</h4>We searched MEDLINE, EMBASE, EMBASE Classic, ... Read more >>

Gastroenterology (Gastroenterology)
[2018, 155(6):1753-1763]

Cited: 13 times

View full text PDF listing >>



miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome.

Carolin Wohlfarth, Stefanie Schmitteckert, Janina D Härtle, Lesley A Houghton, Harsh Dweep, Marina Fortea, Ghazaleh Assadi, Alexander Braun, Tanja Mederer, Sarina Pöhner, Philip P Becker, Christine Fischer, Martin Granzow, Hubert Mönnikes, Emeran A Mayer, Gregory Sayuk, Guy Boeckxstaens, Mira M Wouters, Magnus Simrén, Greger Lindberg, Bodil Ohlsson, Peter Thelin Schmidt, Aldona Dlugosz, Lars Agreus, Anna Andreasson, Mauro D'Amato, Barbara Burwinkel, Justo Lorenzo Bermejo, Ralph Röth, Felix Lasitschka, Maria Vicario, Marco Metzger, Javier Santos, Gudrun A Rappold, Cristina Martinez, Beate Niesler,

Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal sensitivity and motility. Serotonin 5-HT4 receptors are promising candidates in IBS pathophysiology since they regulate gut motor function and stool consistency, and targeted 5-HT4R selective drug intervention has been proven beneficial in subgroups of patients. We identified a ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):14680]

Cited: 18 times

View full text PDF listing >>



Impaired Esophageal Motility and Clearance Post-Lung Transplant: Risk For Chronic Allograft Failure.

Anupong Tangaroonsanti, Augustine S Lee, Michael D Crowell, Marcelo F Vela, Daryl R Jones, David Erasmus, Cesar Keller, Jorge Mallea, Francisco Alvarez, Cristina Almansa, Kenneth R DeVault, Lesley A Houghton,

<h4>Objectives</h4>Gastroesophageal reflux is common in patients post-lung transplantation (LTx) and thus considered a risk factor for aspiration and consequently allograft rejection and the development of chronic allograft failure. However, evidence supporting this remains unclear and often contradictory. Our aim was to examine the role played by esophageal motility on gastroesophageal ... Read more >>

Clin Transl Gastroenterol (Clinical and translational gastroenterology)
[2017, 8(6):e102]

Cited: 6 times

View full text PDF listing >>



Advertisement


Disclaimer

3.4704 s