Full Text Journal Articles by
Author Les Irwig

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Katy Bell, Jenny Doust, Kevin McGeechan, Andrea R Horvath, Alexandra Barratt, Andrew Hayen, Christopher Semsarian, Les Irwig,

J Hypertens (Journal of hypertension)
[2021, 39(5):1045-1046]

Cited: 0 times

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Can Patient-Led Surveillance Detect Subsequent New Primary or Recurrent Melanomas and Reduce the Need for Routinely Scheduled Follow Up? A Protocol for the MEL-SELF Randomised Controlled Trial.

Deonna Ackermann, Amelia Smit, Monika Janda, Cathelijne van Kemenade, Mbathio Dieng, Rachael Morton, Robin Turner, Anne Cust, Les Irwig, Jolyn Hersch, Pascale Guitera, Peter Soyer, Victoria Mar, Robyn P.M. Saw, Donald Low, Cynthia Low, Dorothy Drabarek, David Espinoza, Jon Emery, Peter Murchie, John Thompson, Richard Scolyer, Anthony Azzi, Alister Lilleyman, Katy Bell,

<h4>Background: </h4> Most subsequent new primary or recurrent melanomas might be self-detected if patients are trained to systematically self-examine their skin and have access to timely medical review (patient-led surveillance). Routinely scheduled clinic visits (clinician-led surveillance) is resource-intensive and has not been shown to improve health outcomes; fewer visits may ... Read more >>

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Equity and evidence during vaccine rollout: stepped wedge cluster randomised trials could help.

Katy J L Bell, Paul Glasziou, Fiona Stanaway, Patrick Bossuyt, Les Irwig,

BMJ (BMJ (Clinical research ed.))
[2021, 372:n435]

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The potential for overdiagnosis and underdiagnosis because of blood pressure variability: a comparison of the 2017 ACC/AHA, 2018 ESC/ESH and 2019 NICE hypertension guidelines.

Katy Bell, Jenny Doust, Kevin McGeechan, Andrea Rita Horvath, Alexandra Barratt, Andrew Hayen, Christopher Semsarian, Les Irwig,

<h4>Objective</h4>To estimate the extent that BP measurement variability may drive over- and underdiagnosis of 'hypertension' when measurements are made according to current guidelines.<h4>Methods</h4>Using data from the National Health and Nutrition Examination Survey and empirical estimates of within-person variability, we simulated annual SBP measurement sets for 1 000 000 patients over 5 years. ... Read more >>

J Hypertens (Journal of hypertension)
[2021, 39(2):236-242]

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COVID-19: estimated number of deaths if Australia had experienced a similar outbreak to England and Wales.

Fiona Stanaway, Les M Irwig, Armando Teixeira-Pinto, Katy Jl Bell,

Med J Aust (The Medical journal of Australia)
[2021, 214(2):95-95.e1]

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How to use imperfect tests for COVID-19 (SARS-CoV-2) to make clinical decisions.

Katy Jl Bell, Fiona F Stanaway, Les M Irwig, Andrea R Horvath, Armando Teixeira-Pinto, Clement Loy,

Med J Aust (The Medical journal of Australia)
[2021, 214(2):69-73.e1]

Cited: 1 time

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Mammography screening for breast cancer-the UK Age trial.

Katy J L Bell, Les Irwig, Brooke Nickel, Jolyn Hersch, Andrew Hayen, Alexandra Barratt,

Lancet Oncol (The Lancet. Oncology)
[2020, 21(11):e504]

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Correction to: Estimation of treatment preference effects in clinical trials when some participants are indifferent to treatment choice.

Stephen D Walter, Robin M Turner, Petra Macaskill, Kirsten J McCaffery, Les Irwig,

In the original publication of this article [1], the number "- 0.49" in the below sentence in the Results section should be changed to "-3.23", and this typo does not affect the wider conclusions. ... Read more >>

BMC Med Res Methodol (BMC medical research methodology)
[2020, 20(1):82]

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Correction: Prognostic impact of systolic blood pressure variability in people with diabetes.

Katy J L Bell, Lamiae Azizi, Peter M Nilsson, Andrew Hayen, Les Irwig, Carl J Östgren, Johan Sundström,

[This corrects the article DOI: 10.1371/journal.pone.0194084.]. ... Read more >>

PLoS One (PloS one)
[2019, 14(10):e0224538]

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Is the NHS 'Heart Age Test' too much medicine?

Carissa Bonner, Shannon McKinn, Kirsten McCaffrey, Paul Glasziou, Les Irwig, Jenny Doust, Jesse Jansen, Katy Bell,

Br J Gen Pract (The British journal of general practice : the journal of the Royal College of General Practitioners)
[2019, 69(688):560-561]

Cited: 0 times

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Patients' Views About Skin Self-examination After Treatment for Localized Melanoma.

Mbathio Dieng, Amelia K Smit, Jolyn Hersch, Rachael L Morton, Anne E Cust, Les Irwig, Donald Low, Cynthia Low, Katy J L Bell,

<h4>Importance</h4>Skin self-examination (SSE) is a key factor in the early detection of melanoma, and many new and recurrent melanomas are first detected by patients themselves or their family members.<h4>Objective</h4>To explore the views of patients with melanoma regarding SSE in general, as well as their attitudes toward using novel digital technologies ... Read more >>

JAMA Dermatol (JAMA dermatology)
[2019, :]

Cited: 1 time

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Legacy effects of statins on cardiovascular and all-cause mortality: a meta-analysis.

Agnish Nayak, Andrew Hayen, Lin Zhu, Kevin McGeechan, Paul Glasziou, Les Irwig, Jenny Doust, Gabriel Gregory, Katy Bell,

<h4>Objectives</h4>To assess evidence for 'legacy' (post-trial) effects on cardiovascular disease (CVD) mortality and all-cause mortality among adult participants of placebo-controlled randomised controlled trials (RCTs) of statins.<h4>Design</h4>Meta-analysis of aggregate data.<h4>Setting/participants</h4>Placebo-controlled statin RCTS for primary and secondary CVD prevention.<h4>Methods</h4>Data sources: PubMed, Embase from inception and forward citations of Cholesterol Treatment Trialists' Collaborators ... Read more >>

BMJ Open (BMJ open)
[2018, 8(9):e020584]

Cited: 8 times

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Use of shared care and routine tests in follow-up after treatment for localised cutaneous melanoma.

Wei-Yin Lim, Robin M Turner, Rachael L Morton, Marisa C Jenkins, Les Irwig, Angela C Webster, Mbathio Dieng, Robyn P M Saw, Pascale Guitera, Donald Low, Cynthia Low, Katy J L Bell,

<h4>Background</h4>Patients may decide to undertake shared care with a general practitioner (GP) during follow-up after treatment for localised melanoma. Routine imaging tests for surveillance may be commonly used despite no evidence of clinical utility. This study describes the frequency of shared care and routine tests during follow-up after treatment for ... Read more >>

BMC Health Serv Res (BMC health services research)
[2018, 18(1):477]

Cited: 2 times

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Prognostic impact of systolic blood pressure variability in people with diabetes.

Katy J L Bell, Lamiae Azizi, Peter M Nilsson, Andrew Hayen, Les Irwig, Carl J Östgren, Johan Sundröm,

OBJECTIVE:Blood pressure variability (BPV) has been associated with risk of cardiovascular events in observational studies, independently of mean BP levels. In states with higher autonomic imbalance, such as in diabetes, the importance of BP variability may theoretically be even greater. We aimed to investigate the incremental value of BPV for ... Read more >>

PLoS One (PloS one)
[2018, 13(4):e0194084]

Cited: 2 times

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Should heart age calculators be used alongside absolute cardiovascular disease risk assessment?

Carissa Bonner, Katy Bell, Jesse Jansen, Paul Glasziou, Les Irwig, Jenny Doust, Kirsten McCaffery,

National estimates of 'heart age' by government health organisations in the US, UK and China show most people have an older heart age than current age. While most heart age calculators are promoted as a communication tool for lifestyle change, they may also be used to justify medication when clinical ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2018, 18(1):19]

Cited: 7 times

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Patient Preferences for Follow-up After Recent Excision of a Localized Melanoma.

Wei-Yin Lim, Rachael L Morton, Robin M Turner, Marisa C Jenkins, Pascale Guitera, Les Irwig, Angela C Webster, Mbathio Dieng, Robyn P M Saw, Donald Low, Cynthia Low, Katy J L Bell,

Importance:The standard model of follow-up posttreatment of localized melanoma relies on clinician detection of recurrent or new melanoma, through routinely scheduled clinics (clinician-led surveillance). An alternative model is to increase reliance on patient detection of melanoma, with fewer scheduled visits and increased support for patients' skin self-examination (SSE) (eg, using ... Read more >>

JAMA Dermatol (JAMA dermatology)
[2018, 154(4):420-427]

Cited: 8 times

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How information about overdetection changes breast cancer screening decisions: a mediation analysis within a randomised controlled trial.

Jolyn Hersch, Kevin McGeechan, Alexandra Barratt, Jesse Jansen, Les Irwig, Gemma Jacklyn, Nehmat Houssami, Haryana Dhillon, Kirsten McCaffery,

<h4>Objectives</h4>In a randomised controlled trial, we found that informing women about overdetection changed their breast screening decisions. We now present a mediation analysis exploring the psychological pathways through which study participants who received the intervention processed information about overdetection and how this influenced their decision-making. We examined a series of ... Read more >>

BMJ Open (BMJ open)
[2017, 7(10):e016246]

Cited: 2 times

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Carcinoma in situ of the breast in New South Wales, Australia: Current status and trends over the last 40 year.

Gemma Jacklyn, Stephen Morrell, Kevin McGeechan, Nehmat Houssami, Les Irwig, Nirmala Pathmanathan, Alexandra Barratt,

<h4>Background</h4>The incidence of non-invasive breast cancer has increased substantially over time. We aim to describe temporal trends in the incidence of carcinoma in situ of the breast in New South Wales (NSW), Australia.<h4>Methods</h4>Descriptive study of trends in the incidence of ductal carcinoma in situ (DCIS) and lobular carcinoma in situ ... Read more >>

Breast (Breast (Edinburgh, Scotland))
[2018, 37:170-178]

Cited: 5 times

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Impact of extending screening mammography to older women: Information to support informed choices.

Gemma Jacklyn, Kirsten Howard, Les Irwig, Nehmat Houssami, Jolyn Hersch, Alexandra Barratt,

From 2013 through 2017, the Australian national breast cancer screening programme is gradually inviting women aged 70-74 years to attend screening, following a policy decision to extend invitations to older women. We estimate the benefits and harms of the new package of biennial screening from age 50-74 compared with the ... Read more >>

Int J Cancer (International journal of cancer)
[2017, 141(8):1540-1550]

Cited: 4 times

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STARD for Abstracts: essential items for reporting diagnostic accuracy studies in journal or conference abstracts.

Jérémie F Cohen, Daniël A Korevaar, Constantine A Gatsonis, Paul P Glasziou, Lotty Hooft, David Moher, Johannes B Reitsma, Henrica Cw de Vet, Patrick M Bossuyt, ,

BMJ (BMJ (Clinical research ed.))
[2017, 358:j3751]

Cited: 14 times

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Trends in stage-specific breast cancer incidence in New South Wales, Australia: insights into the effects of 25 years of screening mammography.

Gemma Jacklyn, Kevin McGeechan, Les Irwig, Nehmat Houssami, Stephen Morrell, Katy Bell, Alexandra Barratt,

<h4>Purpose</h4>Screening mammography aims to improve breast cancer (BC) prognosis by increasing the incidence of early-stage tumours in order to decrease the incidence of late-stage cancer, but no reports have investigated these potential effects in an Australian population. Therefore we aimed to identify temporal trends in stage-specific BC in New South ... Read more >>

Breast Cancer Res Treat (Breast cancer research and treatment)
[2017, 166(3):843-854]

Cited: 4 times

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Fear of new or recurrent melanoma after treatment for localised melanoma.

Katy J L Bell, Yachna Mehta, Robin M Turner, Rachael L Morton, Mbathio Dieng, Robyn Saw, Pascale Guitera, Kirsten McCaffery, Donald Low, Cynthia Low, Marisa Jenkins, Les Irwig, Angela C Webster,

<h4>Objective</h4>To estimate the amount of fear of new or recurrent melanoma among people treated for localised melanoma in an Australian specialist centre.<h4>Methods</h4>We randomly selected 400 potential participants from all those treated for localised melanoma at the Melanoma Institute Australia during 2014 (n = 902). They were asked to complete an adapted version ... Read more >>

Psychooncology (Psycho-oncology)
[2017, 26(11):1784-1791]

Cited: 5 times

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EARLY CRT MONITORING USING TIME-DOMAIN OPTICAL COHERENCE TOMOGRAPHY DOES NOT ADD TO VISUAL ACUITY FOR PREDICTING VISUAL LOSS IN PATIENTS WITH CENTRAL RETINAL VEIN OCCLUSION TREATED WITH INTRAVITREAL RANIBIZUMAB: A Secondary Analysis of Trial Data.

Katy J L Bell, Andrew Hayen, Paul Glasziou, Andrew S Mitchell, Maria Farris, Jonathan Wright, Hans-Peter Duerr, Paul Mitchell, Les Irwig,

<h4>Purpose</h4>Our primary purpose was to assess the clinical (predictive) validity of central retinal thickness (CRT) and best corrected visual acuity (BCVA) at 1 week and 1 month after starting treatment with ranibizumab for central retinal vein occlusion. The authors also assessed detectability of response to treatment.<h4>Methods</h4>The authors used data from ... Read more >>

Retina (Retina (Philadelphia, Pa.))
[2017, 37(3):509-514]

Cited: 1 time

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Change in Bone Mineral Density Is an Indicator of Treatment-Related Antifracture Effect.

Katy J L Bell, Andrew Hayen, Paul Glasziou, Les Irwig, Douglas C Bauer,

Ann Intern Med (Annals of internal medicine)
[2017, 166(2):152]

Cited: 0 times

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Estimation of treatment preference effects in clinical trials when some participants are indifferent to treatment choice.

Stephen D Walter, Robin M Turner, Petra Macaskill, Kirsten J McCaffery, Les Irwig,

<h4>Background</h4>In the two-stage randomised trial design, a randomly sampled subset of study participants are permitted to choose their own treatment, while the remaining participants are randomised to treatment in the usual way. Appropriate analysis of the data from both arms of the study allows investigators to estimate the impact on ... Read more >>

BMC Med Res Methodol (BMC medical research methodology)
[2017, 17(1):29]

Cited: 4 times

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