Full Text Journal Articles by
Author Lekha Rani

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Distinct HLA and non-HLA associations in different subtypes of ANCA-associated vasculitides in North India.

Jagdeep Singh, Aman Sharma, Lekha Rani, Navchetan Kaur, Shashi Anand, Biman Saikia, Saket Jha, Ritambhra Nada, Ranjana Walker Minz,

AIM:Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is an autoimmune disease characterized by necrotizing small vessel vasculitis that can affect various organs and present multiple symptoms. Susceptibility to AAV is multifactorial and most likely caused by an amalgamation of genetic and environmental factors. The aim of the present study was to explore the ... Read more >>

Int J Rheum Dis (International journal of rheumatic diseases)
[2020, 23(7):958-965]

Cited: 0 times

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IL-3 Receptor Expression on Activated Human Th Cells Is Regulated by IL-4, and IL-3 Synergizes with IL-4 to Enhance Th2 Cell Differentiation.

Anil Kumar, Lekha Rani, Suhas T Mhaske, Satish T Pote, Shubhanath Behera, Gyan C Mishra, Mohan R Wani,

IL-3, a cytokine secreted by activated T lymphocytes, is known to regulate the proliferation, survival, and differentiation of hematopoietic cells. However, the role of IL-3 in regulation of T cell functions is not fully delineated. Previously, we have reported that IL-3 plays an important role in development of regulatory T ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2020, 204(4):819-831]

Cited: 0 times

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Utility of fine needle aspiration cytology to comprehend the pathogenesis of extrapulmonary tuberculosis.

Shveta Narang, Anjali Solanki, Surender Kashyap, Lekha Rani,

Fine needle aspiration cytology (FNAC) is a precise, cost-effective, and minimal invasive technique for diagnosis of extrapulmonary tuberculosis (EPTB). This study was aimed to analyze clinical and cytological characteristics of EPTB with particular emphasis on pathogenesis.This was a retrospective study analyzing 237 cases of EPTB diagnosed on FNAC. Depending on ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2016, 44(2):98-102]

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Adipose-Derived Mesenchymal Stem Cells Prevent Systemic Bone Loss in Collagen-Induced Arthritis.

Manasa G Garimella, Supinder Kour, Vikrant Piprode, Monika Mittal, Anil Kumar, Lekha Rani, Satish T Pote, Gyan C Mishra, Naibedya Chattopadhyay, Mohan R Wani,

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammatory synovitis leading to joint destruction and systemic bone loss. The inflammation-induced bone loss is mediated by increased osteoclast formation and function. Current antirheumatic therapies primarily target suppression of inflammatory cascade with limited or no success in controlling progression of ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2015, 195(11):5136-5148]

Cited: 20 times

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Predominance of PR3 specific immune response and skewed TH17 vs. T-regulatory milieu in active granulomatosis with polyangiitis.

Lekha Rani, Ranjana W Minz, Aman Sharma, Shashi Anand, Dheeraj Gupta, N K Panda, V K Sakhuja,

OBJECTIVE: We compared levels of Th1/Th2/Th17 cytokines and T-regulatory cells in active and remitting granulomatosis with polyangiitis (GPA). METHODOLOGY: Twenty-one cases of GPA in active state as well as in remitting state and 20 healthy controls (HC) were enrolled in the study. Cytokines were detected in culture supernatants of PBMCs ... Read more >>

Cytokine (Cytokine)
[2015, 71(2):261-267]

Cited: 7 times

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Serum proteomic profiling in granumomatosis with polyangiitis using two-dimensional gel electrophoresis along with matrix assisted laser desorption ionization time of flight mass spectrometry.

Lekha Rani, Ranjana W Minz, Amit Arora, Monica Kannan, Aman Sharma, Shashi Anand, Dheeraj Gupta, Naresh K Panda, Vinay K Sakhuja,

AIM: The present study is a proteomic approach to find differentially expressed proteins in sera of limited and systemic subsets of active disease versus their remitting state in patients with granulomatosis with polyangiitis (GPA) and their correlation with disease activity. METHODS: Eighteen patients with GPA in active as well as ... Read more >>

Int J Rheum Dis (International journal of rheumatic diseases)
[2014, 17(8):910-919]

Cited: 4 times

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Immune deposits in cutaneous lesions of Wegener's granulomatosis: predictor of an active disease.

Seema Chhabra, Ranjana W Minz, Lekha Rani, Nidhi Sharma, Vinay Sakhuja, Aman Sharma,

A retrospective analysis was conducted of eight cases of Wegener's granulomatosis (WG), who presented with cutaneous lesions. The clinical, immunopathologic and histopathologic features of the cutaneous lesions were reviewed. Antineutrophil cytoplasmic antibody (ANCA) status of the patients was established. When possible, a comparison of immunofluorescence findings of skin biopsies was ... Read more >>

Indian J Dermatol (Indian journal of dermatology)
[2011, 56(6):758-762]

Cited: 3 times

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Renal histology in pauci-immune rapidly progressive glomerulonephritis: 8-year retrospective study.

Ranjana W Minz, Seema Chhabra, Kusum Joshi, Lekha Rani, Nidhi Sharma, Vinay Sakhuja, Rajan Duggal, Neelam Pasricha,

CONTEXT: The need to perform reporting of renal biopsies of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides in a more uniform manner required relook at our eight-year data. AIMS: To document detailed renal histopathology of pauci-immune rapidly progressive glomerulonephritis (RPGN) and also to seek any significant differences in renal histology of C-ANCA-positive, ... Read more >>

Indian J Pathol Microbiol (Indian journal of pathology & microbiology)
[2012, 55(1):28-32]

Cited: 6 times

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A decade long experience of anti-neutrophil cytoplasmic antibody testing in a tertiary care referral center in North India: perspective from a developing country.

Ranjana W Minz, Seema Chhabra, Lekha Rani, Surjit Singh, Surinder K Jindal, Vinay Sakhuja,

BACKGROUND: In a developing, tropical country like India, discontinuous power supply, high temperatures during summer, and lack of consistent cold chain and funds provide a challenging atmosphere for anti-neutrophil cytoplasmic antibody (ANCA) testing and reporting. However, a simple in-house test and testing algorithm are described here, which have been developed ... Read more >>

Indian J Pathol Microbiol (Indian journal of pathology & microbiology)
[2011, 54(2):258-263]

Cited: 1 time

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