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Author Lei Zhao

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Anti-hyperuricemic potential of stevia (Stevia rebaudiana Bertoni) residue extract in hyperuricemic mice.

Arshad Mehmood, Liang Zhao, Muhammad Ishaq, Wang Xin, Lei Zhao, Chengtao Wang, Imam Hossen, Huimin Zhang, Yunhe Lian, Meili Xu,

Hyperuricemia (HUA) is considered a potent risk factor for the development of gout, renal failure, and cardiovascular disease. The current project was designed to use stevia (Stevia rebaudiana Bertoni) byproduct, named stevia residue extract (STVRE), for the treatment of HUA. Male Kunming mice were divided into six groups: normal control, ... Read more >>

Food Funct (Food & function)
[2020, 11(7):6387-6406]

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Nanostructures based on vanadium disulfide growing on UCNPs: simple synthesis, dual-mode imaging, and photothermal therapy.

Shuhan Wang, Wensong Xi, Zhuo Wang, Huijun Zhao, Lei Zhao, Jianhui Fang, Haifang Wang, Lining Sun,

It remains a great challenge to integrate effective photothermal therapeutic materials with upconversion nanoparticles (UCNPs) into one structure with small size. Herein, a new and simple method was developed to combine the luminescent UCNPs with vanadium disulfide (VS2) heterogeneously growing on the UCNPs. VS2 was grown directly on the surface ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2020, 8(27):5883-5891]

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Three-dimensional hydrogen distribution and quantitative determination of titanium alloys via neutron tomography.

Lixia Yang, Linfeng He, Danqi Huang, Yaoqi Wang, Quanwei Song, Lei Zhao, Xuejing Shen, Zhiling Tian, Haizhou Wang,

Thermohydrogen processing (THP) is an attractive technique that uses hydrogen as a temporary alloying element to modify the microstructure and properties of titanium alloys. However, the hydrogen diffusion behavior during THP is not fully understood owing to limited scope of methods to detect hydrogen distributions. Herein, we introduce neutron tomography ... Read more >>

Analyst (The Analyst)
[2020, 145(12):4156-4163]

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An electronic enzyme-linked immunosorbent assay platform for protein analysis based on magnetic beads and AlGaN/GaN high electron mobility transistors.

Jin Wang, Zhiqi Gu, Xinsheng Liu, Lei Zhao, Huoxiang Peng, Jiadong Li,

AlGaN/GaN high electron mobility transistor (HEMT) biosensors have attracted attention due to their high sensitivity, stability, and fast response characteristics. Some related studies have been explored but a Debye screening problem exists in physiological solutions hindering the detection of bio-macromolecules. Herein, a novel fast analytical platform for electronic enzyme-linked immunosorbent ... Read more >>

Analyst (The Analyst)
[2020, 145(7):2725-2730]

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A sponge-templated sandwich-like cobalt-embedded nitrogen-doped carbon polyhedron/graphene composite as a highly efficient catalyst for Zn-air batteries.

Jia-Jun Cai, Qing-Yan Zhou, Bing Liu, Xiao-Fei Gong, Yun-Long Zhang, Kokswee Goh, Da-Ming Gu, Lei Zhao, Xu-Lei Sui, Zhen-Bo Wang,

Non-noble metal materials are regarded as the most promising catalysts for the oxygen reduction reaction (ORR) to overcome the inherent defects of Pt-based catalysts, like high cost, limited availability and insufficient stability. Here, we fabricate sandwich-like Co encapsulated nitrogen doped carbon polyhedron/graphene ([email protected]/rGO) via a facile and scalable strategy by ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(2):973-982]

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Stevia residue extract increases intestinal uric acid excretion via interactions with intestinal urate transporters in hyperuricemic mice.

Arshad Mehmood, Lei Zhao, Chengtao Wang, Imam Hossen, Rifat Nowshin Raka, Huimin Zhang,

Hyperuricemia (HUA) is a metabolic disorder that occurs due to the overproduction or under-excretion of uric acid (UA) and is directly linked to the development of many life-threatening diseases. There is a growing interest among many researchers regarding how to overcome the encumbrance of HUA because conventional drugs are associated ... Read more >>

Food Funct (Food & function)
[2019, 10(12):7900-7912]

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Expression of a highly active β-glucosidase from Aspergillus niger AS3.4523 in Escherichia coli and its application in gardenia blue preparation

Shuai Hao, Yuanpu Liu, Yu Qin, Lei Zhao, Jiawen Zhang, Tingting Wu, Baoguo Sun, Chengtao Wang,

PURPOSE: Gardenia blue is one of the natural food additives used in East Asia for many years. Its biosynthesis relies on a key rate-limiting cellulase: β-glucosidase (BGL), which mainly exists in Aspergillus niger (A. niger) cells. The purpose of this study was to obtain active β-glucosidase by cell engineering method ... Read more >>

(Annals of microbiology)
[2020, 70(1):32]

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The effect of the pungent sensation elicited by Sichuan pepper oleoresin on the sensory perception of saltiness throughout younger and older age groups

Lu-Lu Zhang, Lei Zhao, Qing-Bin Zhang, Bo-Lin Shi, Kui Zhong, Hou-Yin Wang, Ran Xie, Long-Yun Liu,

Excessive salt in the diet can pose significant health risks and, therefore, the reduction of salt derived from food is an important issue relating to human nutrition and health. Furthermore, the perception of saltiness will be different among people when considering their innate sensitivity, gender, age, psychological traits and dietary ... Read more >>

(Food quality and preference.)
[2020, 86:Not Available]

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DNA methylation of AHCY may increase the risk of ischemic stroke.

Lei Zhao, Xiaosheng Chen, Shengjun Zhou, Zhiqing Lin, Xi Yu, Yi Huang,

Genetic factors play an important role in the pathogenesis of ischemic stroke. Of these, epigenetic modifications provide a new direction for the study of ischemic stroke pathogenesis. This study aimed to determine the correlation between DNA methylation of the gene encoding S-adenosylhomocysteine hydrolase (AHCY) and the risk of ischemic stroke ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):471-476]

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Live poultry feeding and trading network and the transmission of avian influenza A(H5N6) virus in a large city in China, 2014-2015

Rusheng Zhang, Zhao Lei, Chan Liu, Yuanzhao Zhu, Jingfang Chen, Dong Yao, Xinhua Ou, Wen Ye, Zheng Huang, Li Luo, Biancheng Sun, Tianmu Chen,

Abstract To understand clearly the mechanism of H5N6 transmission, the role of a live poultry feeding and trading network should be explored deeply. However, there is little data to show the network in an area. In this study, we performed a field epidemiological investigation to collect the numbers of farms, ... Read more >>

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HIGH-TILLERING AND DWARF 12 regulates photosynthesis and plant architecture by affecting carotenoid biosynthesis in rice.

Hui Zhou, Mai Yang, Lei Zhao, Zuofeng Zhu, Fengxia Liu, Hongying Sun, Chuanqing Sun, Lubin Tan,

Photosynthesis and plant architecture are important factors influencing grain yield in rice (Oryza sativa L.). Here, we identified the high-tillering and dwarf 12 (htd12) mutant and analyzed the effects of the HTD12 mutation on these important factors. HTD12 encodes a 15-cis-ζ-carotene isomerase (Z-ISO) belonging to the NnrU protein family, as ... Read more >>

J Exp Bot (Journal of experimental botany)
[2020, :]

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Hematite nanorod arrays top-decorated with an MIL-101 layer for photoelectrochemical water oxidation.

Huali Wang, Xuan He, Weixin Li, Hui Chen, Wei Fang, Pan Tian, Feng Xiao, Lei Zhao,

The construction of a nano-heterojunction photoanode is an attractive strategy for accelerated charge separation. Here, α-Fe2O3 nanorod arrays (Fe2O3 NAs) top-decorated with an MIL-101 layer are achieved via the CVD method for constructing one intimate contact between two layers. The systematical analysis in time-dependent deposition shows that the photoelectric response ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(76):11382-11385]

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High-Stable X-ray Imaging from All-Inorganic Perovskite Nanocrystals under a High Dose Radiation.

Liuli Yang, Hao Zhang, Min Zhou, Lei Zhao, Weiqing Chen, Ting Wang, Xue Yu, Dacheng Zhou, Jianbei Qiu, Xuhui Xu,

All-inorganic perovskites of CsPbBr3 nanocrystals (NCs) exhibit strong X-ray absorption and have been demonstrated to be highly efficient scintillators for X-ray detection and imaging. However, the long-term stability of the perovskite remains a major hurdle in practical applications, especially under a commercial dose of X-ray irradiation (0.5-5.5 mGy·s-1). Herein, with ... Read more >>

J Phys Chem Lett (The journal of physical chemistry letters)
[2020, :9203-9209]

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Transcriptional response of Bacillus megaterium FDU301 to PEG200-mediated arid stress

Lei Zhao, Yanjun Zhou, Jianbei Li, Yucheng Xia, Weiyun Wang, Xiuqi Luo, Juan Yin, Jiang Zhong,

Abstract Background For microorganisms on a paper surface, the lack of water is one of the most important stress factors. A strain of Bacillus megaterium FDU301 was isolated from plaques on a paper surface using culture medium with polyethylene glycol 200 (PEG200) to simulate an arid condition. Global transcriptomic analysis ... Read more >>

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Increased ALFF and functional connectivity of the right striatum in bipolar disorder patients.

Zhifang Zhang, Qijing Bo, Feng Li, Lei Zhao, Yun Wang, Rui Liu, Xiongying Chen, Chuanyue Wang, Yuan Zhou,

BACKGROUND:Bipolar disorder (BD) is a serious neuropsychiatric disorder characterized by alternating periods of mania, depression, and euthymia. Abnormal spontaneous brain activity within the cortical-striatal neural circuits has been observed in patients with BD. However, whether the abnormality appears in patients with BD while not in a manic mood state is ... Read more >>

Prog Neuropsychopharmacol Biol Psychiatry (Progress in neuro-psychopharmacology & biological psychiatry)
[2020, :110140]

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Quercetin inhibits caerulein-induced acute pancreatitis through regulating miR-216b by targeting MAP2K6 and NEAT1.

Bo Sheng, Lei Zhao, Xuefeng Zang, Jie Zhen, Yang Liu, Weishuai Bian, Wei Chen,

Acute pancreatitis (AP) is a common acute abdominal disease with high mortality and mortality rates. Increasing evidences clarified that Traditional Chinese Medicine (TCM) adjuvant therapy for AP can be used and it gives a positive effect. Quercetin (3,3',4',5,7-pentahydroxyflavone, QE) is a type of flavone compound with positive effect on cancer ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2020, :]

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The combined use of salivary biomarkers and clinical parameters to predict the outcome of scaling and root planing: A cohort study.

Yiying Liu, Dingyu Duan, Rui Ma, Yi Ding, Yi Xu, Xuedong Zhou, Lei Zhao, Xin Xu,

AIM:To explore the application of the combined use of baseline salivary biomarkers and clinical parameters in predicting the outcome of scaling and root planing (SRP). MATERIALS AND METHODS:Forty patients with advanced periodontitis were included. Baseline saliva samples were analysed for interleukin-1β (IL-1β), matrix metalloproteinase-8 and the loads of Porphyromonas gingivalis, ... Read more >>

J Clin Periodontol (Journal of clinical periodontology)
[2020, 47(11):1379-1390]

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Short term effects of air pollutants on hospital admissions for respiratory diseases among children: A multi-city time-series study in China.

Huihua Yang, Chunxiang Yan, Meng Li, Lei Zhao, Zhen Long, Yali Fan, Zhonggang Zhang, Renjie Chen, Yihui Huang, Congbin Lu, Jianduan Zhang, Jie Tang, Hua Liu, Miao Liu, Wenting Guo, Liangle Yang, Xiaomin Zhang,

Evidence concerning short-term acute association between air pollutants and hospital admissions for respiratory diseases among children in a multi-city setting was quite limited. We conducted a time-series analysis to evaluate the association of six common air pollutants with hospital admissions for respiratory diseases among children aged 0-14 years in 4 ... Read more >>

Int J Hyg Environ Health (International journal of hygiene and environmental health)
[2020, 231:113638]

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Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples.

Ling Leng, Ruiyuan Cao, Jie Ma, Danlei Mou, Yunping Zhu, Wei Li, Luye Lv, Dunqin Gao, Shikun Zhang, Feng Gong, Lei Zhao, Bintao Qiu, Haiping Xiang, Zhongjie Hu, Yingmei Feng, Yan Dai, Jiang Zhao, Zhihong Wu, Hongjun Li, Wu Zhong,

The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown. To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach, fresh ... Read more >>

Signal Transduct Target Ther (Signal transduction and targeted therapy)
[2020, 5(1):240]

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Quetiapine-Associated Rhabdomyolysis: A Case Report and Literature Review.

Tian Li, Yimeng Wang, Weidi Li, Yue Sun, Lei Zhao, Zhen Mao, Chuanyue Wang, Qijing Bo,

J Clin Psychopharmacol (Journal of clinical psychopharmacology)
[2020, :]

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Epidemiology of tsutsugamushi disease and its relationship with meteorological factors in Xiamen city, China.

Li Luo, Zhinan Guo, Zhao Lei, Qingqing Hu, Min Chen, Fanghua Chen, Zeyu Zhao, Jia Rui, Xingchun Liu, Yuanzhao Zhu, Yao Wang, Meng Yang, Tianmu Chen,

Tsutsugamushi disease (TD) is an acute infectious disease caused by Orientia tsutsugamushi. This study aimed to analyze the epidemiological features of TD, investigate chigger mites and their hosts, and investigate the meteorological factors affecting TD incidence and the host of O. tsutsugamushi in Xiamen city, China. Data on reported TD ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2020, 14(10):e0008772]

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[Role of bone morphogenetic protein 1/tolloid proteinase family in the development of teeth and bone].

Xu-Dong Xie, Lei Zhao, Ya-Fei Wu, Jun Wang,

The bone morphogenetic protein (BMP) 1/tolloid (TLD) proteinase family is a group of important metalloproteinases, which play key roles in the growth and development of tissues and organs via regulating the biosynthetic processing of the extracellular matrix. Clinical reports have revealed that mutations in the genes encoding BMP1/TLD proteinases lead ... Read more >>

Hua Xi Kou Qiang Yi Xue Za Zhi (Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology)
[2020, 38(5):589-593]

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Clinical and Proteomic Correlates of Plasma ACE2 (Angiotensin-Converting Enzyme 2) in Human Heart Failure.

Julio A Chirinos, Jordana B Cohen, Lei Zhao, Thomas Hanff, Nancy Sweitzer, James Fang, Vicente Corrales-Medina, Ron Anmar, Michael Morley, Payman Zamani, Priyanka Bhattacharya, Jeff Brandimarto, Yi Jia, Michael D Basso, Zhaoqing Wang, Christina Ebert, Francisco Ramirez-Valle, Peter H Schafer, Dietmar Seiffert, David A Gordon, Thomas Cappola,

ACE2 (angiotensin-converting enzyme 2) is a key component of the renin-angiotensin-aldosterone system. Yet, little is known about the clinical and biologic correlates of circulating ACE2 levels in humans. We assessed the clinical and proteomic correlates of plasma (soluble) ACE2 protein levels in human heart failure. We measured plasma ACE2 using ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2020, 76(5):1526-1536]

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Correction to: IL-17A Induces MIP-1α Expression in Primary Astrocytes Via Src/MAPK/PI3K/NF-kB Pathways: Implications for Multiple Sclerosis.

Hongwei Yi, Ying Bai, Xinjian Zhu, Lin Lin, Lei Zhao, Xiaodong Wu, Shilpa Buch, Longxin Wang, Jie Chao, Honghong Yao,

The original version of this article unfortunately contained a mistake in Fig. 5B. The corrected Fig. 5 is given below. The authors declare that this amendment does not change the result or conclusion of the paper, and apologize for this oversight. ... Read more >>

J Neuroimmune Pharmacol (Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology)
[2020, :]

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PD-L1 Expression Level Displays a Positive Correlation with Immune Response in Pancreatic Cancer.

Lei Zhao, Yaming Cao,

The expression of PD-L1 could be a novel biomarker which predicts that patients are more likely to respond to immunotherapy. Our study investigated the relationship among clinicopathological characteristics, prognosis, PD-L1 expression levels, and FOXP3+ Treg infiltration. In addition, the relationship among clinicopathological characteristics, prognosis, PD-L1 expression levels, and FOXP3+ Treg ... Read more >>

Dis Markers (Disease markers)
[2020, 2020:8843146]

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