Full Text Journal Articles by
Author Lee Goldstein

Advertisement

Find full text journal articles






Association of probable REM sleep behavior disorder with pathology and years of contact sports play in chronic traumatic encephalopathy.

Jason W Adams, Michael L Alosco, Jesse Mez, Victor E Alvarez, Bertrand R Huber, Yorghos Tripodis, Charles H Adler, Carol Kubilius, Kerry A Cormier, Rebecca Mathais, Raymond Nicks, Hunter J Kelley, Nicole Saltiel, Madeline Uretsky, Evan Nair, Nurgul Aytan, Jonathan D Cherry, Christopher J Nowinski, Neil W Kowall, Lee E Goldstein, Brigid Dwyer, Douglas I Katz, Robert C Cantu, Robert A Stern, Ann C McKee, Thor D Stein,

Probable rapid eye movement (REM) sleep behavior disorder (pRBD) is a synucleinopathy-associated parasomnia in which loss of REM sleep muscle atonia results in motor behavior during REM sleep, including dream enactment. Traumatic brain injury is independently associated with increased risk of pRBD and Lewy body disease, and both pRBD and ... Read more >>

Acta Neuropathol. (Acta neuropathologica)
[2020, :]

Cited: 0 times

View full text PDF listing >>



In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans.

Olga Minaeva, Srikant Sarangi, Danielle M Ledoux, Juliet A Moncaster, Douglas S Parsons, Kevin J Washicosky, Caitlin A Black, Frank J Weng, Maria Ericsson, Robert D Moir, Yorghos Tripodis, John I Clark, Rudolph E Tanzi, David G Hunter, Lee E Goldstein,

The absence of clinical tools to evaluate individual variation in the pace of aging represents a major impediment to understanding aging and maximizing health throughout life. The human lens is an ideal tissue for quantitative assessment of molecular aging in vivo. Long-lived proteins in lens fiber cells are expressed during ... Read more >>

J. Gerontol. A Biol. Sci. Med. Sci. (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2020, 75(9):e53-e62]

Cited: 0 times

View full text PDF listing >>



Advertisement

Does infection prolong the QT interval?

Frieda Wolf, Mohammad Homiedi, Mazen Elias, Nahum Freedberg, Lee H Goldstein,

BACKGROUND:The corrected QT (QTc) interval is a strong predictor of ischaemic heart disease and cardiovascular mortality. It may trigger lethal arrhythmias and sudden death. Risk factors include electrolyte disorders, medications, prior cardiovascular disease and genetic predisposition. We previously demonstrated that QTc intervals are prolonged in patients hospitalised with pneumonia, regardless ... Read more >>

Intern Med J (Internal medicine journal)
[2020, 50(9):1078-1084]

Cited: 0 times

View full text PDF listing >>



Increasing adverse drug reaction reporting-How can we do better?

Miri Potlog Shchory, Lee H Goldstein, Lidia Arcavi, Renata Shihmanter, Matitiahu Berkovitch, Amalia Levy,

Adverse drug reactions (ADRs) are associated with morbidity and mortality worldwide. Although national systems for reporting ADRs exist there is a low reporting rate. The aim of the current study was to evaluate an intervention plan for improving ADRs reporting among medical professionals (physicians and nurses). A multicentre intervention study ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0235591]

Cited: 0 times

View full text PDF listing >>



Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme.

Michael L Alosco, Jonathan D Cherry, Bertrand Russell Huber, Yorghos Tripodis, Zachary Baucom, Neil W Kowall, Nicole Saltiel, Lee E Goldstein, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Joseph N Palmisano, Brett Martin, Robert C Cantu, Robert A Stern, Victor E Alvarez, Jesse Mez, Thor D Stein, Ann C McKee,

Chronic traumatic encephalopathy (CTE) is a tauopathy associated with repetitive head impacts (RHI) that has been neuropathologically diagnosed in American football players and other contact sport athletes. In 2013, McKee and colleagues proposed a staging scheme for characterizing the severity of the hyperphosphorylated tau (p-tau) pathology, the McKee CTE staging ... Read more >>

Acta Neuropathol. (Acta neuropathologica)
[2020, 140(4):495-512]

Cited: 0 times

View full text PDF listing >>



Repetitive Head Trauma Induces Chronic Traumatic Encephalopathy by Multiple Mechanisms.

Jonathan D Cherry, Katharine J Babcock, Lee E Goldstein,

Exposure to repetitive neurotrauma increases lifetime risk for developing progressive cognitive deficits, neurobehavioral abnormalities, and chronic traumatic encephalopathy (CTE). CTE is a tau protein neurodegenerative disease first identified in boxers and recently described in athletes participating in other contact sports (notably American football, ice hockey, rugby, and wrestling) and in ... Read more >>

Semin Neurol (Seminars in neurology)
[2020, 40(4):430-438]

Cited: 0 times

View full text PDF listing >>



Low venous thromboembolism incidence in high risk medical patients in an Israeli hospital. Can risk assessment be extrapolated to different populations?

Ofir Koren, Arin Nasser, Mazen Elias, Gilat Avraham, Nahum Freidberg, Walid Saliba, Lee H Goldstein,

BACKGROUND:Guidelines recommend venous thromboembolism (VTE) prophylaxis in hospitalized medical patients with Padua prediction score (PPS) ≥4 points. This recommendation is based on the high risk of symptomatic VTE observed among these patients in the Italian PPS derivation study, and the fivefold risk reduction with VTE-prophylaxis. This study aims to assess ... Read more >>

PLoS ONE (PloS one)
[2020, 15(7):e0235683]

Cited: 0 times

View full text PDF listing >>



Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players.

Ronel Veksler, Udi Vazana, Yonatan Serlin, Ofer Prager, Jonathan Ofer, Nofar Shemen, Andrew M Fisher, Olga Minaeva, Ning Hua, Rotem Saar-Ashkenazy, Itay Benou, Tammy Riklin-Raviv, Ellen Parker, Griffin Mumby, Lyna Kamintsky, Steven Beyea, Chris V Bowen, Ilan Shelef, Eoin O'Keeffe, Matthew Campbell, Daniela Kaufer, Lee E Goldstein, Alon Friedman,

Repetitive mild traumatic brain injury in American football players has garnered increasing public attention following reports of chronic traumatic encephalopathy, a progressive tauopathy. While the mechanisms underlying repetitive mild traumatic brain injury-induced neurodegeneration are unknown and antemortem diagnostic tests are not available, neuropathology studies suggest a pathogenic role for microvascular ... Read more >>

Brain (Brain : a journal of neurology)
[2020, 143(6):1826-1842]

Cited: 0 times

View full text PDF listing >>



A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer's disease.

Michael A Sugarman, Henrik Zetterberg, Kaj Blennow, Yorghos Tripodis, Ann C McKee, Thor D Stein, Brett Martin, Joseph N Palmisano, Eric G Steinberg, Irene Simkin, Andrew E Budson, Ronald Killiany, Maureen K O'Connor, Rhoda Au, Wendy Wei Qiao Qiu, Lee E Goldstein, Neil W Kowall, Jesse Mez, Robert A Stern, Michael L Alosco,

We examined baseline and longitudinal associations between plasma neurofilament light (NfL) and total tau (t-tau), and the clinical presentation of Alzheimer's disease (AD). A total of 579 participants (238, normal cognition [NC]; 185, mild cognitive impairment [MCI]; 156, AD dementia) had baseline blood draws; 82% had follow-up evaluations. Plasma samples ... Read more >>

Neurobiol. Aging (Neurobiology of aging)
[2020, 94:60-70]

Cited: 0 times

View full text PDF listing >>



The effect of an intervention program on the knowledge and attitudes among medical staff regarding adverse drug reaction reporting.

Miri Potlog Shchory, Lee Hilery Goldstein, Lidia Arcavi, Renata Shihmanter, Matitiahu Berkovitch, Amalia Levy,

PURPOSE:Adverse drug reactions (ADRs) are a growing important public health problem; however, underreporting of ADRs is very common. The aim of the current study was to explore the effect of an intervention program on the knowledge and attitudes among physicians and nurses regarding ADRs reporting. METHODS:A multicentre study consisted of ... Read more >>

Pharmacoepidemiol Drug Saf (Pharmacoepidemiology and drug safety)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Beneficial association of angiotensin-converting enzyme inhibitors and statins on the occurrence of possible Alzheimer's disease after traumatic brain injury.

Mingfei Li, Joel Reisman, Benjamin Morris-Eppolito, Shirley X Qian, Lewis E Kazis, Benjamin Wolozin, Lee E Goldstein, Weiming Xia,

BACKGROUND:Pathological analysis of brain tissue from animals and humans with a history of traumatic brain injury (TBI) suggests that TBI could be one of the risk factors facilitating onset of dementia with possible Alzheimer's disease (AD), but medications to prevent or delay AD onset are not yet available. METHODS:This study ... Read more >>

Alzheimers Res Ther (Alzheimer's research & therapy)
[2020, 12(1):33]

Cited: 0 times

View full text PDF listing >>



Nonhomogeneous Gadolinium Retention in the Cerebral Cortex after Intravenous Administration of Gadolinium-based Contrast Agent in Rats and Humans.

Olga Minaeva, Ning Hua, Erich S Franz, Nicola Lupoli, Asim Z Mian, Chad W Farris, Audrey M Hildebrandt, Patrick T Kiernan, Laney E Evers, Allison D Griffin, Xiuping Liu, Sarah E Chancellor, Katharine J Babcock, Juliet A Moncaster, Hernan Jara, Victor E Alvarez, Bertrand R Huber, Ali Guermazi, Lawrence L Latour, Ann C McKee, Jorge A Soto, Stephan W Anderson, Lee E Goldstein,

Background Gadolinium retention after repeated gadolinium-based contrast agent (GBCA) exposure has been reported in subcortical gray matter. However, gadolinium retention in the cerebral cortex has not been systematically investigated. Purpose To determine whether and where gadolinium is retained in rat and human cerebral cortex. Materials and Methods The cerebral cortex ... Read more >>

Radiology (Radiology)
[2020, 294(2):377-385]

Cited: 0 times

View full text PDF listing >>



Association of White Matter Rarefaction, Arteriolosclerosis, and Tau With Dementia in Chronic Traumatic Encephalopathy.

Michael L Alosco, Thor D Stein, Yorghos Tripodis, Alicia S Chua, Neil W Kowall, Bertrand Russell Huber, Lee E Goldstein, Robert C Cantu, Douglas I Katz, Joseph N Palmisano, Brett Martin, Jonathan D Cherry, Ian Mahar, Ronald J Killiany, Michael D McClean, Rhoda Au, Victor Alvarez, Robert A Stern, Jesse Mez, Ann C McKee,

Importance:Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head impacts, including those from US football, that presents with cognitive and neuropsychiatric disturbances that can progress to dementia. Pathways to dementia in CTE are unclear and likely involve tau and nontau pathologic conditions. Objective:To investigate the association of ... Read more >>

JAMA Neurol (JAMA neurology)
[2019, :]

Cited: 1 time

View full text PDF listing >>



Pathophysiology of Concussion.

Sarah E Chancellor, Erich S Franz, Olga V Minaeva, Lee E Goldstein,

Although concussion has been a subject of interest for centuries, this condition remains poorly understood. The mechanistic underpinnings and accepted definition of concussion remain elusive. To make sense of these issues, this article presents a brief history of concussion studies, detailing the evolution of motivations and experimental conclusions over time. ... Read more >>

Semin Pediatr Neurol (Seminars in pediatric neurology)
[2019, 30:14-25]

Cited: 1 time

View full text PDF listing >>



Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports.

Jason W Adams, Victor E Alvarez, Jesse Mez, Bertrand R Huber, Yorghos Tripodis, Weiming Xia, Gaoyuan Meng, Caroline A Kubilus, Kerry Cormier, Patrick T Kiernan, Daniel H Daneshvar, Alicia S Chua, Sarah Svirsky, Raymond Nicks, Bobak Abdolmohammadi, Laney Evers, Todd M Solomon, Jonathan D Cherry, Nurgul Aytan, Ian Mahar, Sherral Devine, Sanford Auerbach, Michael L Alosco, Christopher J Nowinski, Neil W Kowall, Lee E Goldstein, Brigid Dwyer, Douglas I Katz, Robert C Cantu, Robert A Stern, Rhoda Au, Ann C McKee, Thor D Stein,

Traumatic brain injury has been associated with increased risk of Parkinson disease and parkinsonism, and parkinsonism and Lewy body disease (LBD) can occur with chronic traumatic encephalopathy (CTE). To test whether contact sports and CTE are associated with LBD, we compared deceased contact sports athletes (n = 269) to cohorts from the ... Read more >>

J. Neuropathol. Exp. Neurol. (Journal of neuropathology and experimental neurology)
[2018, 77(9):757-768]

Cited: 8 times

View full text PDF listing >>



Predicting Factors Associated with Postoperative Hypotension following Carotid Artery Stenting.

Gustavo Rubio, John K Karwowski, Hilene DeAmorim, Lee J Goldstein, Arash Bornak,

BACKGROUND:Prolonged hemodynamic instability after carotid artery stenting (CAS) has been associated with increased incidence of stroke and other major adverse events. The objective of this study is to determine the factors associated with hypotension following CAS. In particular, this study evaluates whether involvement of the carotid bifurcation/bulb and degree of ... Read more >>

Ann Vasc Surg (Annals of vascular surgery)
[2019, 54:193-199]

Cited: 0 times

View full text PDF listing >>



Neurofilament relates to white matter microstructure in older adults.

Elizabeth E Moore, Timothy J Hohman, Faizan S Badami, Kimberly R Pechman, Katie E Osborn, Lealani Mae Y Acosta, Susan P Bell, Michelle A Babicz, Katherine A Gifford, Adam W Anderson, Lee E Goldstein, Kaj Blennow, Henrik Zetterberg, Angela L Jefferson,

Cerebrospinal fluid (CSF) neurofilament light (NFL) is a protein biomarker of axonal injury. To study whether NFL is associated with diffusion tensor imaging (DTI) measurements of white matter (WM) microstructure, Vanderbilt Memory & Aging Project participants with normal cognition (n = 77), early mild cognitive impairment (n = 15), and MCI (n = ... Read more >>

Neurobiol. Aging (Neurobiology of aging)
[2018, 70:233-241]

Cited: 6 times

View full text PDF listing >>



Traumatic Brain Injury and Risk of Suicide.

Lee Goldstein, Ramon Diaz-Arrastia,

JAMA (JAMA)
[2018, 320(6):554-556]

Cited: 0 times

View full text PDF listing >>



Age of first exposure to tackle football and chronic traumatic encephalopathy.

Michael L Alosco, Jesse Mez, Yorghos Tripodis, Patrick T Kiernan, Bobak Abdolmohammadi, Lauren Murphy, Neil W Kowall, Thor D Stein, Bertrand Russell Huber, Lee E Goldstein, Robert C Cantu, Douglas I Katz, Christine E Chaisson, Brett Martin, Todd M Solomon, Michael D McClean, Daniel H Daneshvar, Christopher J Nowinski, Robert A Stern, Ann C McKee,

OBJECTIVE:To examine the effect of age of first exposure to tackle football on chronic traumatic encephalopathy (CTE) pathological severity and age of neurobehavioral symptom onset in tackle football players with neuropathologically confirmed CTE. METHODS:The sample included 246 tackle football players who donated their brains for neuropathological examination. Two hundred eleven ... Read more >>

Ann. Neurol. (Annals of neurology)
[2018, 83(5):886-901]

Cited: 10 times

View full text PDF listing >>



Hybrid Revascularization Combining Iliofemoral Endarterectomy and Iliac Stent Grafting for TransAtlantic Inter-Society Consensus C and D Aortoiliac Occlusive Disease.

Juliet J Ray, Sarah A Eidelson, Charles A Karcutskie, Jonathan P Meizoso, Hilene DeAmorim, Lee J Goldstein, John Karwowski, Arash Bornak,

BACKGROUND:This study examines the outcome of hybrid revascularization combining iliofemoral endarterectomy and iliac artery stenting using covered stents in TransAtlantic Inter-Society Consensus (TASC) C and D aortoiliac occlusive disease (AIOD) involving the common femoral artery (CFA). METHODS:A retrospective review was conducted in patients with TASC C and D AIOD involving ... Read more >>

Ann Vasc Surg (Annals of vascular surgery)
[2018, 50:73-79]

Cited: 0 times

View full text PDF listing >>



Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.

Chad A Tagge, Andrew M Fisher, Olga V Minaeva, Amanda Gaudreau-Balderrama, Juliet A Moncaster, Xiao-Lei Zhang, Mark W Wojnarowicz, Noel Casey, Haiyan Lu, Olga N Kokiko-Cochran, Sudad Saman, Maria Ericsson, Kristen D Onos, Ronel Veksler, Vladimir V Senatorov, Asami Kondo, Xiao Z Zhou, Omid Miry, Linnea R Vose, Katisha R Gopaul, Chirag Upreti, Christopher J Nowinski, Robert C Cantu, Victor E Alvarez, Audrey M Hildebrandt, Erich S Franz, Janusz Konrad, James A Hamilton, Ning Hua, Yorghos Tripodis, Andrew T Anderson, Gareth R Howell, Daniela Kaufer, Garth F Hall, Kun P Lu, Richard M Ransohoff, Robin O Cleveland, Neil W Kowall, Thor D Stein, Bruce T Lamb, Bertrand R Huber, William C Moss, Alon Friedman, Patric K Stanton, Ann C McKee, Lee E Goldstein,

The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic encephalopathy, and the relationships between these disorders, are poorly understood. We examined post-mortem brains from teenage athletes in the acute-subacute period after mild closed-head impact injury and found astrocytosis, myelinated axonopathy, microvascular injury, perivascular neuroinflammation, and phosphorylated tau protein pathology. ... Read more >>

Brain (Brain : a journal of neurology)
[2018, 141(2):422-458]

Cited: 54 times

View full text PDF listing >>



Shining (Laser) Light on Traumatic Brain Injury Blood Biomarkers.

Lee E Goldstein, Ann C McKee,

JAMA Neurol (JAMA neurology)
[2017, 74(9):1045-1047]

Cited: 1 time

View full text PDF listing >>



Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football.

Jesse Mez, Daniel H Daneshvar, Patrick T Kiernan, Bobak Abdolmohammadi, Victor E Alvarez, Bertrand R Huber, Michael L Alosco, Todd M Solomon, Christopher J Nowinski, Lisa McHale, Kerry A Cormier, Caroline A Kubilus, Brett M Martin, Lauren Murphy, Christine M Baugh, Phillip H Montenigro, Christine E Chaisson, Yorghos Tripodis, Neil W Kowall, Jennifer Weuve, Michael D McClean, Robert C Cantu, Lee E Goldstein, Douglas I Katz, Robert A Stern, Thor D Stein, Ann C McKee,

Importance:Players of American football may be at increased risk of long-term neurological conditions, particularly chronic traumatic encephalopathy (CTE). Objective:To determine the neuropathological and clinical features of deceased football players with CTE. Design, Setting, and Participants:Case series of 202 football players whose brains were donated for research. Neuropathological evaluations and retrospective ... Read more >>

JAMA (JAMA)
[2017, 318(4):360-370]

Cited: 146 times

View full text PDF listing >>



Considerations for Experimental Animal Models of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy-These Matters Matter.

Mark W Wojnarowicz, Andrew M Fisher, Olga Minaeva, Lee E Goldstein,

Animal models of concussion, traumatic brain injury (TBI), and chronic traumatic encephalopathy (CTE) are widely available and routinely deployed in laboratories around the world. Effective animal modeling requires careful consideration of four basic principles. First, animal model use must be guided by clarity of definitions regarding the human disease or ... Read more >>

Front Neurol (Frontiers in neurology)
[2017, 8:240]

Cited: 12 times

View full text PDF listing >>



Perioperative Risks of Dietary and Herbal Supplements.

Ilana Levy, Samuel Attias, Eran Ben-Arye, Lee Goldstein, Ibrahim Matter, Mostafa Somri, Elad Schiff,

BACKGROUND:Patients undergoing surgery often use Dietary and Herbal Supplements (DHS). We explored the risk of DHS-drug interactions in the perioperative setting. METHODS:In this cross-sectional prospective study, participants hospitalized for surgery completed a questionnaire regarding DHS use. We used pharmacological databases to assess DHS-drug interactions. We then applied univariate and multivariate ... Read more >>

World J Surg (World journal of surgery)
[2017, 41(4):927-934]

Cited: 5 times

View full text PDF listing >>



Advertisement

Disclaimer
1.2453 s