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Author Leanza Liu


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In vivo misfolding of proinsulin below the threshold of frank diabetes.

Israel Hodish, Afaf Absood, Leanza Liu, Ming Liu, Leena Haataja, Dennis Larkin, Ahmed Al-Khafaji, Anthony Zaki, Peter Arvan,

<h4>Objective</h4>Endoplasmic reticulum (ER) stress has been described in pancreatic β-cells after onset of diabetes-a situation in which failing β-cells have exhausted available compensatory mechanisms. Herein we have compared two mouse models expressing equally small amounts of transgenic proinsulin in pancreatic β-cells.<h4>Research design and methods</h4>In hProCpepGFP mice, human proinsulin (tagged with ... Read more >>

Diabetes (Diabetes)
[2011, 60(8):2092-2101]

Cited: 27 times

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Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.

Israel Hodish, Ming Liu, Gautam Rajpal, Dennis Larkin, Ronald W Holz, Aaron Adams, Leanza Liu, Peter Arvan,

It has previously been shown that misfolded mutant Akita proinsulin in the endoplasmic reticulum engages directly in protein complexes either with nonmutant proinsulin or with "hProCpepGFP" (human proinsulin bearing emerald-GFP within the C-peptide), impairing the trafficking of these "bystander" proinsulin molecules (Liu, M., Hodish, I., Rhodes, C. J., and Arvan, ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2010, 285(1):685-694]

Cited: 42 times

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