Full Text Journal Articles by
Author Leanne M Redman

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Effect of Aerobic Exercise-induced Weight Loss on the Components of Daily Energy Expenditure.

Nicholas T Broskey, Corby K Martin, Jeffrey H Burton, Timothy S Church, Eric Ravussin, Leanne M Redman,

<h4>Introduction</h4>Exercise usually results in less weight loss than expected. This suggests increased energy intake and/or deceased expenditure counteract the energy deficit induced by exercise. The aim of this study was to evaluate changes in components of daily energy expenditure (doubly labeled water and room calorimetry) after 24 wk of exercise ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2021, 53(10):2164-2172]

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Impact of COVID-19 Stay-at-Home Orders on Health Behaviors and Anxiety in Black and White Americans.

Joshua R Sparks, Maryam Kebbe, Emily W Flanagan, Robbie A Beyl, Abby D Altazan, Shengping Yang, Leanne M Redman,

<h4>Background</h4>In the United States (US), the incidence and severity of COVID-19 infections, hospitalizations, and deaths are higher in Black compared to White residents. Systemic inequities and differences in health behaviors may contribute to disparities in COVID-19 health outcomes. The aim of this study was to examine the impact of COVID-19 ... Read more >>

J Racial Ethn Health Disparities (Journal of racial and ethnic health disparities)
[2021, :]

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Maternal metabolic health drives mesenchymal stem cell metabolism and infant fat mass at birth.

Melissa L Erickson, Zachary W Patinkin, Allison M Duensing, Dana Dabelea, Leanne M Redman, Kristen E Boyle,

Exposure to maternal obesity may promote metabolic dysfunction in offspring. We used infant mesenchymal stem cells (MSCs) to experimentally examine cellular mechanisms of intergenerational health transmission. Our earlier reports show MSCs collected from infants of mothers with obesity had a dichotomous distribution in metabolic efficiency; they were either efficient (Ef-Ob) ... Read more >>

JCI Insight (JCI insight)
[2021, 6(13):]

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Effect of 2-year caloric restriction on organ and tissue size in nonobese 21- to 50-year-old adults in a randomized clinical trial: the CALERIE study.

Wei Shen, Jun Chen, Jane Zhou, Corby K Martin, Eric Ravussin, Leanne M Redman,

<h4>Background</h4>Sustained calorie restriction (CR) promises to extend the lifespan. The effect of CR on changes in body mass across tissues and organs is unclear.<h4>Objectives</h4>We used whole-body MRI to evaluate the effect of 2 y of CR on changes in body composition.<h4>Methods</h4>In an ancillary study of the Comprehensive Assessment of Long-term ... Read more >>

Am J Clin Nutr (The American journal of clinical nutrition)
[2021, :]

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Factors Protecting against a Decline in Physical Activity during the COVID-19 Pandemic.

S Nicole Fearnbach, Emily W Flanagan, Christoph Höchsmann, Robbie A Beyl, Abby D Altazan, Corby K Martin, Leanne M Redman,

<h4>Purpose</h4>The spread of COVID-19 and the associated stay-at-home orders and shutdowns of gyms and fitness centers have drastically influenced health behaviors leading to widespread reductions in physical activity (PA). The recent Call to Action from the American College of Sports Medicine has promoted "innovative strategies to promote PA during the ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2021, 53(7):1391-1399]

Cited: 6 times

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Beyond weight loss: current perspectives on the impact of calorie restriction on healthspan and lifespan.

Maryam Kebbe, Joshua R Sparks, Emily W Flanagan, Leanne M Redman,

<b>Introduction</b>: Changes to mental, physical, and physiological functions drive the complex processes underlying the variable progression of human aging. Nutritional interventions are one of the most promising non-pharmacological therapeutics to attenuate aging in humans. This narrative review aims to describe the implications of moderate and prolonged calorie restriction (CR) in ... Read more >>

Expert Rev Endocrinol Metab (Expert review of endocrinology & metabolism)
[2021, 16(3):95-108]

Cited: 1 time

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The moderating role of the built environment in prenatal lifestyle interventions.

Suzanne Phelan, Fred Marquez, Leanne M Redman, Sonia Arteaga, Rebecca Clifton, Brian A Grice, Debra Haire-Joshu, Corby K Martin, Candice A Myers, Jeremy Pomeroy, Eileen Vincent, Linda Van Horn, Alan Peaceman, Maxine Ashby-Thompson, Dympna Gallagher, Xavier Pi-Sunyer, Trisha Boekhoudt, Kimberly Drews, Greg Brown, ,

This study examined whether the neighborhood built environment moderated gestational weight gain (GWG) in LIFE-Moms clinical trials. Participants were 790 pregnant women (13.9 weeks' gestation) with overweight or obesity randomized within four clinical centers to standard care or lifestyle intervention to reduce GWG. Geographic information system (GIS) was used to ... Read more >>

Int J Obes (Lond) (International journal of obesity (2005))
[2021, 45(6):1357-1361]

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Association between Home Environment in Infancy and Child Movement Behaviors.

Chelsea L Kracht, Leanne M Redman, Patrick H Casey, Rebecca A Krukowski, Aline Andres,

<b><i>Introduction:</i></b> An adequate balance of movement behaviors, including physical activity (PA), sleep, and screen time, is important for preventing excess weight gain in children. This study examined the relationship between the infant home environment and movement behaviors later in life. <b><i>Methods:</i></b> Pregnant women were recruited for a cohort study related ... Read more >>

Child Obes (Childhood obesity (Print))
[2021, 17(2):100-109]

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A Role for Exercise to Counter Skeletal Muscle Clock Disruption.

Melissa L Erickson, Karyn A Esser, William E Kraus, Thomas W Buford, Leanne M Redman,

Disruption of the skeletal muscle circadian clock leads to a preferential shift toward lipid oxidation while reducing carbohydrate oxidation. These effects are apparent at the whole-body level, including glucose intolerance, increased energy expenditure, and fasting hyperglycemia. We hypothesize that exercise counters these metabolic disturbances by modifying the skeletal muscle clock ... Read more >>

Exerc Sport Sci Rev (Exercise and sport sciences reviews)
[2021, 49(1):35-41]

Cited: 2 times

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Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.

James L Dorling, Stephan van Vliet, Kim M Huffman, William E Kraus, Manjushri Bhapkar, Carl F Pieper, Tiffany Stewart, Sai Krupa Das, Susan B Racette, Susan B Roberts, Eric Ravussin, Leanne M Redman, Corby K Martin, ,

Caloric restriction (CR) is a strategy that attenuates aging in multiple nonhuman species. The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trials are part of a research program aiming to test the effects of CR on aging and longevity biomarkers in humans. Building on CALERIE phase ... Read more >>

Nutr Rev (Nutrition reviews)
[2021, 79(1):98-113]

Cited: 2 times

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Effect of Overeating Dietary Protein at Different Levels on Circulating Lipids and Liver Lipid: The PROOF Study.

George A Bray, Leanne M Redman, Jennifer Rood, Lilian de Jonge, Steven R Smith,

<h4>Background</h4>During overeating, a low protein diet slowed the rate of weight gain and increased the energy cost of the added weight, suggesting that low protein diets reduced energy efficiency. The Protein Overfeeding (PROOF) study explored the metabolic changes to low and high protein diets, and this sub-study examined the changes ... Read more >>

Nutrients (Nutrients)
[2020, 12(12):]

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Identification of changes in sleep across pregnancy and the impact on cardiometabolic health and energy intake in women with obesity.

Emily W Flanagan, Jasper Most, Nicholas T Broskey, Abby D Altazan, Robbie A Beyl, Sarah K Keadle, Kimberly L Drews, Prachi Singh, Leanne M Redman,

This prospective, observational study investigated changes in sleep and the effect on energy intake, gestational weight gain, and cardiometabolic health across pregnancy in 52 healthy pregnant women with obesity. Habitual sleep was assessed by wrist-worn actigraphy (time spent in bed; TIB, total sleep time; TST, and sleep efficiency) in early ... Read more >>

Sleep Med (Sleep medicine)
[2021, 77:120-127]

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Metabolic adaptation: is it really an illusion?

Eric Ravussin, Leanne M Redman,

Am J Clin Nutr (The American journal of clinical nutrition)
[2020, 112(6):1653-1654]

Cited: 0 times

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The Impact of COVID-19 Stay-At-Home Orders on Health Behaviors in Adults.

Emily W Flanagan, Robbie A Beyl, S Nicole Fearnbach, Abby D Altazan, Corby K Martin, Leanne M Redman,

<h4>Objective</h4>Stay-at-home orders in response to the coronavirus disease 2019 (COVID-19) pandemic have forced abrupt changes to daily routines. This study assessed lifestyle changes across different BMI classifications in response to the global pandemic.<h4>Methods</h4>The online survey targeting adults was distributed in April 2020 and collected information on dietary behaviors, physical activity, ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2021, 29(2):438-445]

Cited: 36 times

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Attenuated early pregnancy weight gain by prenatal lifestyle interventions does not prevent gestational diabetes in the LIFE-Moms consortium.

Leanne M Redman, Kimberly L Drews, Samuel Klein, Linda Van Horn, Rena R Wing, Xavier Pi-Sunyer, Mary Evans, Kaumudi Joshipura, S Sonia Arteaga, Alison G Cahill, Rebecca G Clifton, Kimberly A Couch, Paul W Franks, Dympna Gallagher, Debra Haire-Joshu, Corby K Martin, Alan M Peaceman, Suzanne Phelan, Elizabeth A Thom, Susan Z Yanovski, William C Knowler, ,

<h4>Aims</h4>To examine the effect of lifestyle (diet and physical activity) interventions on the prevalence of GDM, considering the method of GDM ascertainment and its association with early pregnancy characteristics and maternal and neonatal outcomes in the LIFE-Moms consortium.<h4>Methods</h4>LIFE-Moms evaluated the effects of lifestyle interventions to optimize gestational weight gain in ... Read more >>

Diabetes Res Clin Pract (Diabetes research and clinical practice)
[2021, 171:108549]

Cited: 0 times

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Discrimination of wear and non-wear in infants using data from hip- and ankle-worn devices.

Samuel R LaMunion, Scott E Crouter, Nicholas T Broskey, Abby D Altazan, Leanne M Redman,

<h4>Introduction</h4>A key component to analyzing wearable sensor data is identifying periods of non-wear. Traditionally, strings of consecutive zero counts (e.g. >60-minutes) are identified indicating periods of non-movement. The non-movement window length is then evaluated as wear or non-wear. Given that non-movement is not equivalent to non-wear, additional criteria should be ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0240604]

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A Novel Approach to Assess Metabolic Flexibility Overnight in a Whole-Body Room Calorimeter.

David H McDougal, Kara L Marlatt, Robbie A Beyl, Leanne M Redman, Eric Ravussin,

<h4>Objective</h4>This study aimed to investigate a novel approach for determining the effects of energy-standardized dinner meals (high-fat and low-fat) on respiratory exchange ratio (RER) dynamics and metabolic flexibility.<h4>Methods</h4>Using a randomized crossover study design, energy expenditure, RER, and macronutrient oxidation rates were assessed in response to a single dinner meal during ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2020, 28(11):2073-2077]

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Complement in Reproductive White Adipose Tissue Characterizes the Obese Preeclamptic-Like BPH/5 Mouse Prior to and During Pregnancy.

Kelsey N Olson, Dorien Reijnders, Viviane C L Gomes, R Caitlin Hebert, Chin-Chi Liu, Jacqueline M Stephens, Leanne M Redman, Nataki C Douglas, Jennifer L Sones,

Preeclampsia (PE) is a serious hypertensive disorder of pregnancy characterized by abnormal placental development with an unknown etiology. To better understand which women will develop PE, a number of maternal risk factors have been identified, including obesity. Visceral white adipose tissue (WAT) contains inflammatory mediators that may contribute to PE. ... Read more >>

Biology (Basel) (Biology)
[2020, 9(9):]

Cited: 1 time

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The Design of a Randomized Clinical Trial to Evaluate a Pragmatic and Scalable eHealth Intervention for the Management of Gestational Weight Gain in Low-Income Women: Protocol for the SmartMoms in WIC Trial.

Emily W Flanagan, Abby D Altazan, Natalie R Comardelle, L Anne Gilmore, John W Apolzan, Jessica St Romain, Julie C Hardee, Renee S Puyau, Christy L Mayet, Robbie A Beyl, S Ariel Barlow, Sarah Surber Bounds, Kelsey N Olson, Betty M Kennedy, Daniel S Hsia, Leanne M Redman,

<h4>Background</h4>Less than one-third of women gain an appropriate amount of weight during pregnancy, which can influence the long-term health of both the mother and the child. Economically disadvantaged women are the most vulnerable to maternal obesity, excessive weight gain during pregnancy, and poor birth outcomes. Effective and scalable health care ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(9):e18211]

Cited: 0 times

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Effect of 2 years of calorie restriction on liver biomarkers: results from the CALERIE phase 2 randomized controlled trial.

James L Dorling, Eric Ravussin, Leanne M Redman, Manju Bhapkar, Kim M Huffman, Susan B Racette, Sai K Das, John W Apolzan, William E Kraus, Christoph Höchsmann, Corby K Martin, ,

<h4>Purpose</h4>Calorie restriction (CR) is an effective treatment for obesity-related liver and metabolic disease. However, CR studies in individuals without obesity are needed to see if CR could delay disease onset. Liver biomarkers indicate hepatic health and are linked to cardiometabolic disease. Our aim was to examine the effects of a ... Read more >>

Eur J Nutr (European journal of nutrition)
[2021, 60(3):1633-1643]

Cited: 1 time

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Global Health in Preconception, Pregnancy and Postpartum Alliance: development of an international consumer and community involvement framework.

Heidi J Bergmeier, Virginia Vandall-Walker, Magdalena Skrybant, Helena J Teede, Cate Bailey, Jo-Anna B Baxter, Ana Luiza Vilela Borges, Jacqueline A Boyle, Ayesha Everitt, Cheryce L Harrison, Margely Herrera, Briony Hill, Brian Jack, Samuel Jones, Laura Jorgensen, Siew Lim, Cynthia Montanaro, Leanne M Redman, Judith Stephenson, Hildrun Sundseth, Shakila Thangaratinam, Paula Thynne, Ruth Walker, Helen Skouteris,

Background:The goal of the Global Health in Preconception, Pregnancy and Postpartum (HiPPP) Alliance, comprising consumers and leading international multidisciplinary academics and clinicians, is to generate research and translation priorities and build international collaboration around healthy lifestyle and obesity prevention among women across the reproductive years. In doing so, we actively ... Read more >>

Res Involv Engagem (Research involvement and engagement)
[2020, 6:47]

Cited: 1 time

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Calorie Restriction and Aging in Humans.

Emily W Flanagan, Jasper Most, Jacob T Mey, Leanne M Redman,

Calorie restriction (CR), the reduction of dietary intake below energy requirements while maintaining optimal nutrition, is the only known nutritional intervention with the potential to attenuate aging. Evidence from observational, preclinical, and clinical trials suggests the ability to increase life span by 1-5 years with an improvement in health span ... Read more >>

Annu Rev Nutr (Annual review of nutrition)
[2020, 40:105-133]

Cited: 7 times

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Modifications to Infant Formula Instructions Improve the Accuracy of Formula Dispensing.

Linda A Gilmore, Abby D Altazan, Emily W Flanagan, Alexandra G Beyer, Kelsey N Olson, Alexis A O'Connell, Timothy H Nguyen, Robbie A Beyl, Leanne M Redman,

Readability of infant formula preparation instructions is universally poor, which may result in inaccurate infant feeding. Given that inaccurate formula dispensing can lead to altered infant growth and increased adiposity, there is an increased need for easy to follow instructions for formula preparation. We hypothesize that altering infant formula instruction ... Read more >>

Nutrients (Nutrients)
[2020, 12(4):]

Cited: 1 time

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Increased Energy Intake After Pregnancy Determines Postpartum Weight Retention in Women With Obesity.

Jasper Most, Abby D Altazan, Marshall St Amant, Robbie A Beyl, Eric Ravussin, Leanne M Redman,

<h4>Context</h4>This study was designed to understand causes and critical periods for postpartum weight retention by characterizing changes in body composition, energy intake, energy expenditure and physical activity in women with obesity during pregnancy and postpartum.<h4>Design</h4>In this prospective, observational cohort study, body composition (plethysmography), energy expenditure (doubly labeled water, whole-body room ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2020, 105(4):]

Cited: 1 time

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Health in Preconception, Pregnancy and Postpartum Global Alliance: International Network Pregnancy Priorities for the Prevention of Maternal Obesity and Related Pregnancy and Long-Term Complications.

Briony Hill, Helen Skouteris, Jacqueline A Boyle, Cate Bailey, Ruth Walker, Shakila Thangaratinam, Hildrun Sundseth, Judith Stephenson, Eric Steegers, Leanne M Redman, Cynthia Montanaro, Siew Lim, Laura Jorgensen, Brian Jack, Ana Luiza Vilela Borges, Heidi J Bergmeier, Jo-Anna B Baxter, Cheryce L Harrison, Helena J Teede,

In this article, we describe the process of establishing agreed international pregnancy research priorities to address the global issues of unhealthy lifestyles and rising maternal obesity. We focus specifically on the prevention of maternal obesity to improve related clinical pregnancy and long-term complications. A team of multidisciplinary, international experts in ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(3):]

Cited: 3 times

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