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Author Lea Maitre

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Applying the exposome concept in birth cohort research: a review of statistical approaches.

Susana Santos, Léa Maitre, Charline Warembourg, Lydiane Agier, Lorenzo Richiardi, Xavier Basagaña, Martine Vrijheid,

The exposome represents the totality of life course environmental exposures (including lifestyle and other non-genetic factors), from the prenatal period onwards. This holistic concept of exposure provides a new framework to advance the understanding of complex and multifactorial diseases. Prospective pregnancy and birth cohort studies provide a unique opportunity for ... Read more >>

Eur. J. Epidemiol. (European journal of epidemiology)
[2020, 35(3):193-204]

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Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children.

Nikos Stratakis, David V Conti, Eva Borras, Eduardo Sabido, Theano Roumeliotaki, Eleni Papadopoulou, Lydiane Agier, Xavier Basagana, Mariona Bustamante, Maribel Casas, Shohreh F Farzan, Serena Fossati, Juan R Gonzalez, Regina Grazuleviciene, Barbara Heude, Lea Maitre, Rosemary R C McEachan, Ioannis Theologidis, Jose Urquiza, Marina Vafeiadi, Jane West, John Wright, Rob McConnell, Anne-Lise Brantsaeter, Helle-Margrete Meltzer, Martine Vrijheid, Leda Chatzi,

Importance:The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to date is unknown. Objective:To assess the associations of fish intake and mercury exposure during pregnancy with metabolic syndrome in children and alterations in biomarkers of inflammation in children. Design, Setting, ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(3):e201007]

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Using methylome data to inform exposome-health association studies: An application to the identification of environmental drivers of child body mass index.

Solène Cadiou, Mariona Bustamante, Lydiane Agier, Sandra Andrusaityte, Xavier Basagaña, Angel Carracedo, Leda Chatzi, Regina Grazuleviciene, Juan R Gonzalez, Kristine B Gutzkow, Léa Maitre, Dan Mason, Frédéric Millot, Mark Nieuwenhuijsen, Eleni Papadopoulou, Gillian Santorelli, Pierre-Jean Saulnier, Marta Vives, John Wright, Martine Vrijheid, Rémy Slama,

BACKGROUND:The exposome is defined as encompassing all environmental exposures one undergoes from conception onwards. Challenges of the application of this concept to environmental-health association studies include a possibly high false-positive rate. OBJECTIVES:We aimed to reduce the dimension of the exposome using information from DNA methylation as a way to more ... Read more >>

Environ Int (Environment international)
[2020, 138:105622]

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Obesity is associated with shorter telomeres in 8 year-old children.

Diana B P Clemente, Lea Maitre, Mariona Bustamante, Leda Chatzi, Theano Roumeliotaki, Serena Fossati, Regina Grazuleviciene, Kristine B Gützkow, Johanna Lepeule, Dries S Martens, Rosie R C McEachan, Helle M Meltzer, Inga Petraviciene, Rémy Slama, Ibon Tamayo-Uria, Jose Urquiza, Marina Vafeiadi, John Wright, Tim S Nawrot, Martine Vrijheid,

Telomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte telomere length (LTL) in childhood, data from 1,396 mother-child pairs of the multi-centre European birth cohort study HELIX were ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):18739]

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Association between DNA methylation and ADHD symptoms from birth to school age: A prospective meta-analysis

Alexander Neumann, Esther Walton, Silvia Alemany, Charlotte Cecil, Juan Ramon González, Dereje Jima, Jari Lahti, Samuli Tuominen, Edward Barker, Elisabeth Binder, Doretta Caramaschi, Ángel Carracedo, Darina Czamara, Jorunn Evandt, Janine Felix, Bernard Fuemmeler, Kristine Gutzkow, Cathrine Hoyo, Jordi Julvez, Eero Kajantie, Hannele Laivuori, Rachel Maguire, Léa Maitre, Susan Murphy, Mario Murcia, Pia Villa, Gemma Sharp, Jordi Sunyer, Katri Raikkönen, Marian Bakermans-Kranenburg, Marinus van IJzendoorn, Mònica Guxens, Caroline Relton, Henning Tiemeier,

ABSTRACT Attention-deficit and hyperactivity disorder (ADHD) is a common childhood disorder with a substantial genetic component. However, the extent to which epigenetic mechanisms play a role in the etiology of the disorder is not known. We performed epigenome-wide association studies (EWAS) within the Pregnancy And Childhood Epigenetics (PACE) Consortium to ... Read more >>

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Early life tobacco exposure and children's telomere length: The HELIX project.

Citlalli Osorio-Yáñez, Diana B P Clemente, Lea Maitre, Martha Vives-Usano, Mariona Bustamante, David Martinez, Maribel Casas, Jan Alexander, Cathrine Thomsen, Leda Chatzi, Kristine B Gützkow, Regina Grazuleviciene, Dries S Martens, Michelle Plusquin, Remy Slama, Rosemary C McEachan, John Wright, Tiffany C Yang, Jose Urquiza, Ibon Tamayo, Jordi Sunyer, Marina Vafeiadi, Tim S Nawrot, Martine Vrijheid,

Telomere length and mitochondrial DNA content are considered biomarkers of cellular aging, oxidative stress, and inflammation, but there is almost no information on their association with tobacco smoke exposure in fetal and early life. The aim of this study was to assess whether prenatal and childhood tobacco exposure were associated ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 711:135028]

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Diet as a Source of Exposure to Environmental Contaminants for Pregnant Women and Children from Six European Countries.

Eleni Papadopoulou, Line Småstuen Haug, Amrit Kaur Sakhi, Sandra Andrusaityte, Xavier Basagaña, Anne Lise Brantsaeter, Maribel Casas, Sílvia Fernández-Barrés, Regina Grazuleviciene, Helle Katrine Knutsen, Lea Maitre, Helle Margrete Meltzer, Rosemary R C McEachan, Theano Roumeliotaki, Remy Slama, Marina Vafeiadi, John Wright, Martine Vrijheid, Cathrine Thomsen, Leda Chatzi,

BACKGROUND:Pregnant women and children are especially vulnerable to exposures to food contaminants, and a balanced diet during these periods is critical for optimal nutritional status. OBJECTIVES:Our objective was to study the association between diet and measured blood and urinary levels of environmental contaminants in mother-child pairs from six European birth ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2019, 127(10):107005]

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Early-Life Environmental Exposures and Blood Pressure in Children.

Charline Warembourg, Léa Maitre, Ibon Tamayo-Uria, Serena Fossati, Theano Roumeliotaki, Gunn Marit Aasvang, Sandra Andrusaityte, Maribel Casas, Enrique Cequier, Lida Chatzi, Audrius Dedele, Juan-Ramon Gonzalez, Regina Gražulevičienė, Line Smastuen Haug, Carles Hernandez-Ferrer, Barbara Heude, Marianna Karachaliou, Norun Hjertager Krog, Rosemary McEachan, Mark Nieuwenhuijsen, Inga Petraviciene, Joane Quentin, Oliver Robinson, Amrit Kaur Sakhi, Rémy Slama, Cathrine Thomsen, Jose Urquiza, Marina Vafeiadi, Jane West, John Wright, Martine Vrijheid, Xavier Basagaña,

BACKGROUND:Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously. OBJECTIVES:This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2019, 74(10):1317-1328]

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Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort.

Lydiane Agier, Xavier Basagaña, Lea Maitre, Berit Granum, Philippa K Bird, Maribel Casas, Bente Oftedal, John Wright, Sandra Andrusaityte, Montserrat de Castro, Enrique Cequier, Leda Chatzi, David Donaire-Gonzalez, Regina Grazuleviciene, Line S Haug, Amrit K Sakhi, Vasiliki Leventakou, Rosemary McEachan, Mark Nieuwenhuijsen, Inga Petraviciene, Oliver Robinson, Theano Roumeliotaki, Jordi Sunyer, Ibon Tamayo-Uria, Cathrine Thomsen, Jose Urquiza, Antonia Valentin, Rémy Slama, Martine Vrijheid, Valérie Siroux,

BACKGROUND:Several single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range of prenatal and postnatal lifestyle and environmental exposures and lung function in children. METHODS:In this analysis, we used data ... Read more >>

Lancet Planet Health (The Lancet. Planetary health)
[2019, 3(2):e81-e92]

Cited: 1 time

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Socioeconomic position and exposure to multiple environmental chemical contaminants in six European mother-child cohorts.

Parisa Montazeri, Cathrine Thomsen, Maribel Casas, Jeroen de Bont, Line S Haug, Léa Maitre, Eleni Papadopoulou, Amrit K Sakhi, Rémy Slama, Pierre Jean Saulnier, Jose Urquiza, Regina Grazuleviciene, Sandra Andrusaityte, Rosie McEachan, John Wright, Leda Chatzi, Xavier Basagaña, Martine Vrijheid,

BACKGROUND:Human exposure to environmental chemical contaminants at critical periods of development can lead to lifelong health consequences. Traditionally, socioeconomically disadvantaged groups are thought to experience higher contaminant exposures; however, this relationship may not hold for all contaminants. METHODS:Using data from six European birth cohorts (1301 mother-child pairs), we determined biomarkers ... Read more >>

Int J Hyg Environ Health (International journal of hygiene and environmental health)
[2019, 222(5):864-872]

Cited: 1 time

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Urine Metabolic Signatures of Multiple Environmental Pollutants in Pregnant Women: An Exposome Approach.

Léa Maitre, Oliver Robinson, David Martinez, Mireille B Toledano, Jesús Ibarluzea, Loreto Santa Marina, Jordi Sunyer, Cristina M Villanueva, Hector C Keun, Martine Vrijheid, Muireann Coen,

Exposure to environmental pollutants, particularly during pregnancy, can have adverse consequences on child development but little is known about the effects of pollutant mixtures on endogenous metabolism in pregnant women. We aimed to identify urinary metabolic signatures associated with low level exposure to multiple environmental pollutants in pregnant women from ... Read more >>

Environ. Sci. Technol. (Environmental science & technology)
[2018, 52(22):13469-13480]

Cited: 1 time

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Determinants of the urinary and serum metabolome in children from six European populations.

Chung-Ho E Lau, Alexandros P Siskos, Léa Maitre, Oliver Robinson, Toby J Athersuch, Elizabeth J Want, Jose Urquiza, Maribel Casas, Marina Vafeiadi, Theano Roumeliotaki, Rosemary R C McEachan, Rafaq Azad, Line S Haug, Helle M Meltzer, Sandra Andrusaityte, Inga Petraviciene, Regina Grazuleviciene, Cathrine Thomsen, John Wright, Remy Slama, Leda Chatzi, Martine Vrijheid, Hector C Keun, Muireann Coen,

BACKGROUND:Environment and diet in early life can affect development and health throughout the life course. Metabolic phenotyping of urine and serum represents a complementary systems-wide approach to elucidate environment-health interactions. However, large-scale metabolome studies in children combining analyses of these biological fluids are lacking. Here, we sought to characterise the ... Read more >>

BMC Med (BMC medicine)
[2018, 16(1):202]

Cited: 6 times

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The early-life exposome: Description and patterns in six European countries.

Ibon Tamayo-Uria, Léa Maitre, Cathrine Thomsen, Mark J Nieuwenhuijsen, Leda Chatzi, Valérie Siroux, Gunn Marit Aasvang, Lydiane Agier, Sandra Andrusaityte, Maribel Casas, Montserrat de Castro, Audrius Dedele, Line S Haug, Barbara Heude, Regina Grazuleviciene, Kristine B Gutzkow, Norun H Krog, Dan Mason, Rosemary R C McEachan, Helle M Meltzer, Inga Petraviciene, Oliver Robinson, Theano Roumeliotaki, Amrit K Sakhi, Jose Urquiza, Marina Vafeiadi, Dagmar Waiblinger, Charline Warembourg, John Wright, Rémy Slama, Martine Vrijheid, Xavier Basagaña,

Characterization of the "exposome", the set of all environmental factors that one is exposed to from conception onwards, has been advocated to better understand the role of environmental factors on chronic diseases. Here, we aimed to describe the early-life exposome. Specifically, we focused on the correlations between multiple environmental exposures, ... Read more >>

Environ Int (Environment international)
[2019, 123:189-200]

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In-utero and childhood chemical exposome in six European mother-child cohorts.

Line Småstuen Haug, Amrit Kaur Sakhi, Enrique Cequier, Maribel Casas, Léa Maitre, Xavier Basagana, Sandra Andrusaityte, Georgia Chalkiadaki, Leda Chatzi, Muireann Coen, Jeroen de Bont, Audrius Dedele, Joane Ferrand, Regina Grazuleviciene, Juan Ramon Gonzalez, Kristine Bjerve Gutzkow, Hector Keun, Rosie McEachan, Helle Margrete Meltzer, Inga Petraviciene, Oliver Robinson, Pierre-Jean Saulnier, Rémy Slama, Jordi Sunyer, José Urquiza, Marina Vafeiadi, John Wright, Martine Vrijheid, Cathrine Thomsen,

BACKGROUND:Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited. OBJECTIVES:To characterize concentrations of a large number of environmental contaminants in pregnant women from Europe and their children, based on chemical analysis of biological samples from mother-child pairs. METHODS:We relied ... Read more >>

Environ Int (Environment international)
[2018, 121(Pt 1):751-763]

Cited: 2 times

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Assessment of metabolic phenotypic variability in children's urine using 1H NMR spectroscopy.

Léa Maitre, Chung-Ho E Lau, Esther Vizcaino, Oliver Robinson, Maribel Casas, Alexandros P Siskos, Elizabeth J Want, Toby Athersuch, Remy Slama, Martine Vrijheid, Hector C Keun, Muireann Coen,

The application of metabolic phenotyping in clinical and epidemiological studies is limited by a poor understanding of inter-individual, intra-individual and temporal variability in metabolic phenotypes. Using 1H NMR spectroscopy we characterised short-term variability in urinary metabolites measured from 20 children aged 8-9 years old. Daily spot morning, night-time and pooled ... Read more >>

Sci Rep (Scientific reports)
[2017, 7:46082]

Cited: 7 times

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Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study.

Léa Maitre, Cristina M Villanueva, Matthew R Lewis, Jesús Ibarluzea, Loreto Santa-Marina, Martine Vrijheid, Jordi Sunyer, Muireann Coen, Mireille B Toledano,

Maternal metabolism during pregnancy is a major determinant of the intra-uterine environment and fetal outcomes. Herein, we characterize the maternal urinary metabolome throughout pregnancy to identify maternal metabolic signatures of fetal growth in two subcohorts and explain potential sources of variation in metabolic profiles based on lifestyle and clinical data.We ... Read more >>

BMC Med (BMC medicine)
[2016, 14(1):177]

Cited: 12 times

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Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer.

Michael Kyriakides, Lea Maitre, Brendan D Stamper, Isaac Mohar, Terrance J Kavanagh, John Foster, Ian D Wilson, Elaine Holmes, Sidney D Nelson, Muireann Coen,

The leading cause of drug-induced liver injury in the developed world is overdose with N-acetyl-p-aminophenol (APAP). A comparative metabonomic approach was applied to the study of both xenobiotic and endogenous metabolic profiles reflective of in vivo exposure to APAP (300 mg/kg) and its structural isomer N-acetyl-m-aminophenol (AMAP; 300 mg/kg) in C57BL/6J mice, ... Read more >>

Arch. Toxicol. (Archives of toxicology)
[2016, 90(12):3073-3085]

Cited: 6 times

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POSTERS.

Microb. Ecol. Health Dis. (Microbial ecology in health and disease)
[2012, 23:]

Cited: 0 times

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Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother-child cohort study.

Léa Maitre, Eleni Fthenou, Toby Athersuch, Muireann Coen, Mireille B Toledano, Elaine Holmes, Manolis Kogevinas, Leda Chatzi, Hector C Keun,

Preterm birth (PB) and fetal growth restriction (FGR) convey the highest risk of perinatal mortality and morbidity, as well as increasing the chance of developing chronic disease in later life. Identifying early in pregnancy the unfavourable maternal conditions that can predict poor birth outcomes could help their prevention and management. ... Read more >>

BMC Med (BMC medicine)
[2014, 12:110]

Cited: 25 times

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