Full Text Journal Articles by
Author Lea C Steffes

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Coronavirus disease 2019 respiratory disease in children: clinical presentation and pathophysiology.

Lea C Steffes, David N Cornfield,

<h4>Purpose of review</h4>Pediatric coronavirus disease 2019 (COVID-19) respiratory disease is a distinct entity from adult illness, most notable in its milder phenotype. This review summarizes the current knowledge of the clinical patterns, cellular pathophysiology, and epidemiology of COVID-19 respiratory disease in children with specific attention toward factors that account for ... Read more >>

Curr Opin Pediatr (Current opinion in pediatrics)
[2021, 33(3):302-310]

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Three Infants with Pathogenic Variants in the ABCA3 Gene: Presentation, Treatment, and Clinical Course.

Xin Si, Lea C Steffes, Jennifer C Schymick, Florette K Hazard, Michael C Tracy, David N Cornfield,

ABCA3 deficiency is a rare cause of neonatal respiratory failure. Biallelic complete loss of function variants lead to neonatal demise without lung transplantation, but children with partial function variants have variable outcomes. The favorable clinical course of 3 such infants presenting with respiratory distress at birth is described. ... Read more >>

J Pediatr (The Journal of pediatrics)
[2021, 231:278-283.e2]

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A Notch3-Marked Subpopulation of Vascular Smooth Muscle Cells Is the Cell of Origin for Occlusive Pulmonary Vascular Lesions.

Lea C Steffes, Alexis A Froistad, Adam Andruska, Mario Boehm, Madeleine McGlynn, Fan Zhang, Wenming Zhang, David Hou, Xuefei Tian, Lucile Miquerol, Kari Nadeau, Ross J Metzger, Edda Spiekerkoetter, Maya E Kumar,

BACKGROUND:Pulmonary arterial hypertension (PAH) is a fatal disease characterized by profound vascular remodeling in which pulmonary arteries narrow because of medial thickening and occlusion by neointimal lesions, resulting in elevated pulmonary vascular resistance and right heart failure. Therapies targeting the neointima would represent a significant advance in PAH treatment; however, ... Read more >>

Circulation (Circulation)
[2020, 142(16):1545-1561]

Cited: 1 time

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