Full Text Journal Articles by
Author Laurie Smith

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Highlighting strengths and resources that increase ownership of cervical cancer screening for Indigenous communities in Northern British Columbia: Community-driven approaches.

Alexanne Dick, Travis Holyk, Darlene Taylor, Charlotte Wenninger, Judith Sandford, Laurie Smith, Gina Ogilvie, Alexandra Thomlinson, Sheona Mitchell-Foster,

<h4>Objective</h4>To examine the unique and diverse strengths held by rural and remote Indigenous communities in northern British Columbia, including multi-generational support systems in health and wellness, profound connections to the land, and strong cultural foundations, and harness these strengths, allowing communities to engage in innovative and empowering health and wellness ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

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High-risk HPV prevalence among women undergoing cervical cancer screening: Findings a decade after HPV vaccine implementation in British Columbia, Canada.

Charles Litwin, Laurie Smith, Robine Donken, Mel Krajden, Dirk van Niekerk, Monika Naus, Darrel Cook, Arianne Albert, Gina Ogilvie,

<h4>Background</h4>British Columbia (BC) introduced a publicly funded, school-based human papillomavirus (HPV) immunization program in 2008 with the quadrivalent vaccine. In 2010/2011, a baseline evaluation of HPV prevalence was conducted among women undergoing cervical cancer screening. After 10 years of publicly funded HPV vaccination, HPV-type prevalence was re-evaluated.<h4>Methods</h4>From August 2017 to March ... Read more >>

Vaccine (Vaccine)
[2021, 39(36):5198-5204]

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Intention to receive a COVID-19 vaccine by HIV status among a population-based sample of women and gender diverse individuals in British Columbia, Canada

Angela Kaida, Lori Brotto, Melanie C.M. Murray, Hélène Côté, Arianne Albert, Valerie Nicholson, Rebecca Gormley, Shanlea Gordon, Amy Booth, Laurie Smith, Ally Baaske, Liisa Galea, Manish Sadarangani, Gina Ogilvie,

<h4>ABSTRACT</h4> <h4>Introduction</h4> COVID-19 vaccination is recommended for people living with HIV (PLWH), among whom social inequities and co-morbidities may drive risks of COVID-19 infection and outcome severity. Among a provincial (British Columbia) sample, we determined the prevalence of COVID-19 vaccine intention by HIV status and assessed socio-demographic, vaccine hesitancy, and ... Read more >>

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ATTITUDES AND PREFERENCES REGARDING NON-CLINIC BASED SELF-COLLECTION FOR STI TESTING AMONG CLINIC ATTENDEES IN BRITISH COLUMBIA, CANADA.

Anna Gottschlich, Laurie W Smith, Hannah Caird, Mark Gilbert, Troy Grennan, Gina Ogilvie,

<h4>Background</h4>Sexually transmitted infections (STI) are a global epidemic; while screening programs reduce transmission, barriers, including access and stigma, hinder success. The WHO highlights the ability to maintain health without the direct support of a health care provider as one form of self-care, which can be applied to STI testing. Self-care ... Read more >>

Sex Transm Dis (Sexually transmitted diseases)
[2021, :]

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Systematic Review of Mind-Body Interventions to Treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Samaneh Khanpour Ardestani, Mohammad Karkhaneh, Eleanor Stein, Salima Punja, Daniela R Junqueira, Tatiana Kuzmyn, Michelle Pearson, Laurie Smith, Karin Olson, Sunita Vohra,

<i>Background and Objectives</i>: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic condition distinguished by disabling fatigue associated with post-exertional malaise, as well as changes to sleep, autonomic functioning, and cognition. Mind-body interventions (MBIs) utilize the ongoing interaction between the mind and body to improve health and wellbeing. Purpose: To systematically ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2021, 57(7):]

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Lung MRI with hyperpolarised gases: current & future clinical perspectives.

Neil J Stewart, Laurie J Smith, Ho-Fung Chan, James A Eaden, Smitha Rajaram, Andrew J Swift, Nicholas D Weatherley, Alberto Biancardi, Guilhem J Collier, David Hughes, Gill Klafkowski, Christopher S Johns, Noreen West, Kelechi Ugonna, Stephen M Bianchi, Rod Lawson, Ian Sabroe, Helen Marshall, Jim M Wild,

The use of pulmonary MRI in a clinical setting has historically been limited. Whilst CT remains the gold-standard for <i>structural</i> lung imaging in many clinical indications, technical developments in ultrashort and zero echo time MRI techniques are beginning to help realise non-ionising <i>structural</i> imaging in certain lung disorders. In this ... Read more >>

Br J Radiol (The British journal of radiology)
[2021, :20210207]

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The influence of sex, gender, age, and ethnicity on psychosocial factors and substance use throughout phases of the COVID-19 pandemic

Lori Brotto, Kyle Chankasingh, Alexandra Baaske, Arianne Albert, Amy Booth, Angela Kaida, Laurie Smith, Sarai Racey, Anna Gottschlich, Melanie C.M. Murray, Manish Sadarangani, Gina Ogilvie, Liisa Galea,

The SARS-CoV-2 (COVID-19) pandemic has had profound physical and mental health effects on populations around the world. Limited empirical research has used a gender-based lens to evaluate the mental health impacts of the pandemic, overlooking the impact of public health measures on marginalized groups, such as women, and the gender ... Read more >>

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Long-term cervical precancer outcomes after a negative DNA- or RNA-based human papillomavirus test result.

Talia H R Strang, Anna Gottschlich, Darrel A Cook, Laurie W Smith, Lovedeep Gondara, Eduardo L Franco, Dirk J van Niekerk, Gina S Ogilvie, Mel Krajden,

<h4>Background</h4>Cervical cancer, a preventable disease associated with the human papillomavirus, is responsible for significant morbidity and mortality globally. Primary human papillomavirus testing is more sensitive in detecting precancerous cervical lesions than cytologic screening and can be conducted using either DNA- or RNA-based assays. Screening programs must select the most appropriate ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, :]

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Sociodemographic characteristics of women with invasive cervical cancer in British Columbia, 2004-2013: a descriptive study.

Jonathan Simkin, Laurie Smith, Dirk van Niekerk, Hannah Caird, Tania Dearden, Kimberly van der Hoek, Nadine R Caron, Ryan R Woods, Stuart Peacock, Gina Ogilvie,

<h4>Background</h4>Although cancer screening has led to reductions in the incidence of invasive cervical cancer (ICC) across Canada, benefits of prevention efforts are not equitably distributed. This study investigated the sociodemographic characteristics of women with ICC in British Columbia compared with the general female population in the province.<h4>Methods</h4>In this descriptive study, ... Read more >>

CMAJ Open (CMAJ open)
[2021, 9(2):E424-E432]

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Intention to receive a COVID-19 vaccine: results from a population-based survey in Canada.

Gina S Ogilvie, Shanlea Gordon, Laurie W Smith, Arianne Albert, C Sarai Racey, Amy Booth, Anna Gottschlich, David Goldfarb, Melanie C M Murray, Liisa A M Galea, Angela Kaida, Lori A Brotto, Manish Sadarangani,

<h4>Background</h4>The success of any COVID-19 vaccine program ultimately depends on high vaccine uptake. This study determined overall intention to receive a COVID-19 vaccine and identified factors that predict intentions to be vaccinated against COVID-19 in Canada, specifically in key priority groups identified by the American Committee on Immunization Practice (ACIP) ... Read more >>

BMC Public Health (BMC public health)
[2021, 21(1):1017]

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Cost-effectiveness analysis of primary human papillomavirus testing in cervical cancer screening: Results from the HPV FOCAL Trial.

Ian Cromwell, Laurie W Smith, Kim van der Hoek, Lindsay Hedden, Andrew J Coldman, Darrel Cook, Eduardo L Franco, Mel Krajden, Ruth Martin, Marette H Lee, Gavin Stuart, Dirk van Niekerk, Gina Ogilvie, Stuart Peacock,

The Human Papillomavirus FOr CervicAL cancer (HPV FOCAL) trial is a large randomized controlled trial comparing the efficacy of primary HPV testing to cytology among women in the population-based Cervix Screening Program in British Columbia, Canada. We conducted a cost-effectiveness analysis based on the HPV FOCAL trial to estimate the ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(9):2996-3003]

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Omega-3 Use for the Treatment of Hypertriglyceridemia, Low High-Density Lipoprotein Cholesterol Levels, and Nonalcoholic Fatty Liver Disease in Children with Obesity.

Kristin M W Stackpole, Nicholas J Ollberding, Laurie A Smith, Paula Casson, Shelley Kirk, Robert Siegel,

<b><i>Background:</i></b> Omega-3 fatty acid supplementation has been investigated in treating elevated triglycerides (TGs), nonalcoholic fatty liver disease (NAFLD), and low high-density lipoprotein cholesterol (HDL) in adults, but has not been well studied in youth with obesity. This retrospective study examined the effectiveness of omega-3 as an adjunct therapy for these ... Read more >>

Child Obes (Childhood obesity (Print))
[2021, 17(5):357-364]

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Novel bi-allelic variants expand the SPTBN4-related genetic and phenotypic spectrum.

Markus Buelow, David Süßmuth, Laurie D Smith, Omid Aryani, Claudia Castiglioni, Werner Stenzel, Enrico Bertini, Markus Schuelke, Ellen Knierim,

Neurodevelopmental disorder with hypotonia, neuropathy, and deafness (NEDHND, OMIM #617519) is an autosomal recessive disease caused by homozygous or compound heterozygous variants in SPTBN4 coding for type 4 βIV-spectrin, a non-erythrocytic member of the β-spectrin family. Variants in SPTBN4 disrupt the cytoskeletal machinery that controls proper localization of ion channels ... Read more >>

Eur J Hum Genet (European journal of human genetics : EJHG)
[2021, 29(7):1121-1128]

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Declining rates of cervical intraepithelial neoplasia in British Columbia, Canada: An ecological analysis on the effects of the school-based human papillomavirus vaccination program.

Robine Donken, Dirk van Niekerk, Jeremy Hamm, John J Spinelli, Laurie Smith, Manish Sadarangani, Arianne Albert, Deborah Money, Simon Dobson, Dianne Miller, Marette Lee, Sheona Mitchell-Foster, Mel Krajden, Monika Naus, Gina Ogilvie,

Since 2008, girls in British Columbia (BC), Canada, have been offered HPV vaccination through a school-based, publicly funded immunization program. The oldest birth cohort eligible for the vaccination program was born in 1994 and uptake is on average 63%. To evaluate the impact of the HPV vaccine in BC, ecological ... Read more >>

Int J Cancer (International journal of cancer)
[2021, 149(1):191-199]

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COVID-19 in pediatric kidney transplantation: The Improving Renal Outcomes Collaborative.

Charles Varnell, Lyndsay A Harshman, Laurie Smith, Chunyan Liu, Shiran Chen, Samhar Al-Akash, Gina-Marie Barletta, Craig Belsha, Paul Brakeman, Abanti Chaudhuri, Paul Fadakar, Rouba Garro, Caroline Gluck, Jens Goebel, David Kershaw, Debora Matossian, Corina Nailescu, Hiren P Patel, Cozumel Pruette, Saritha Ranabothu, Nancy Rodig, Jodi Smith, Judith Sebestyen VanSickle, Patricia Weng, Lara Danziger-Isakov, David K Hooper, Michael Seifert,

There are limited data on the impact of COVID-19 in children with a kidney transplant (KT). We conducted a prospective cohort study through the Improving Renal Outcomes Collaborative (IROC) to collect clinical outcome data about COVID-19 in pediatric KT patients. Twenty-two IROC centers that care for 2732 patients submitted testing ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2021, 21(8):2740-2748]

Cited: 2 times

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Intention to receive a COVID-19 vaccine: Results from a population-based survey in Canada

Gina Ogilvie, Shanlea Gordon, Laurie Smith, Arianne Albert, Sarai Racey, Amy Booth, Anna Gottschlich, David Goldfarb, Melanie C.M. Murray, Liisa A.M. Galea, Angela Kaida, Lori Brotto, Manish Sadarangani,

<h4>Background</h4> The success of any COVID-19 vaccine program ultimately depends on high vaccine uptake. This study determined overall intention to receive a COVID-19 vaccine and identified factors that predict intentions to be vaccinated against COVID-19 in Canada, specifically in key priority groups identified by the American Committee on Immunization Practice ... Read more >>

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Quantification of pulmonary perfusion in idiopathic pulmonary fibrosis with first pass dynamic contrast-enhanced perfusion MRI.

Nicholas D Weatherley, James A Eaden, Paul J C Hughes, Matthew Austin, Laurie Smith, Jody Bray, Helen Marshall, Stephen Renshaw, Stephen M Bianchi, Jim M Wild,

<h4>Introduction</h4>Idiopathic pulmonary fibrosis (IPF) is a fatal disease of lung scarring. Many patients later develop raised pulmonary vascular pressures, sometimes disproportionate to the interstitial disease. Previous therapeutic approaches that have targeted pulmonary vascular changes have not demonstrated clinical efficacy, and quantitative assessment of regional pulmonary vascular involvement using perfusion imaging ... Read more >>

Thorax (Thorax)
[2021, 76(2):144-151]

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Structure-function analysis of the maize bulliform cell cuticle and its potential role in dehydration and leaf rolling.

Susanne Matschi, Miguel F Vasquez, Richard Bourgault, Paul Steinbach, James Chamness, Nicholas Kaczmar, Michael A Gore, Isabel Molina, Laurie G Smith,

The hydrophobic cuticle of plant shoots serves as an important interaction interface with the environment. It consists of the lipid polymer cutin, embedded with and covered by waxes, and provides protection against stresses including desiccation, UV radiation, and pathogen attack. Bulliform cells form in longitudinal strips on the adaxial leaf ... Read more >>

Plant Direct (Plant direct)
[2020, 4(10):e00282]

Cited: 1 time

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Assessing 10-Year Safety of a Single Negative HPV Test for Cervical Cancer Screening: Evidence from FOCAL-DECADE Cohort.

Anna Gottschlich, Dirk van Niekerk, Laurie W Smith, Lovedeep Gondara, Joy Melnikow, Darrel A Cook, Marette Lee, Gavin Stuart, Ruth E Martin, Stuart Peacock, Eduardo L Franco, Andrew Coldman, Mel Krajden, Gina Ogilvie,

<h4>Background</h4>Long-term safety of a single negative human papillomavirus (HPV) test for cervical cancer screening is unclear. The HPV FOr cerviCAL Cancer Trial (FOCAL) was a randomized trial comparing HPV testing with cytology. The FOCAL-DECADE cohort tracked women who received one HPV test during FOCAL, and were HPV negative, for up ... Read more >>

Cancer Epidemiol Biomarkers Prev (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2021, 30(1):22-29]

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Impacts of Human Papillomavirus Immunization Programs on Rates of Anogenital Warts in British Columbia, Canada, 2000 to 2017.

Christine D Lukac, Robine Donken, Michael Otterstatter, Olga Mazo, Stanley Wong, Fawziah Marra, Laurie Smith, Monika Naus, Deborah Money, Mel Krajden, Troy Grennan, Mark Gilbert, Jason Wong, Gina S Ogilvie,

<h4>Background</h4>In 2008, British Columbia (BC) implemented a school-based quadrivalent human papillomavirus (HPV-4) immunization program for girls born in 1994 or later. In 2015, an expanded clinic-based program included men who report sex with men (MSM) born in 1989 or later. To evaluate the impacts of HPV-4 programs on anogenital warts ... Read more >>

Sex Transm Dis (Sexually transmitted diseases)
[2020, 47(10):691-697]

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The effect of acute maximal exercise on the regional distribution of ventilation using ventilation MRI in CF.

Laurie J Smith, Helen Marshall, Jody Bray, Martin Wildman, Noreen West, Alex Horsley, Jim M Wild,

<h4>Background</h4>The importance of exercise in the management of people with CF is well recognised, yet the effect of exercise on lung function is not well understood. FEV<sub>1</sub> is insensitive to the detection of small changes in lung function. Ventilation MRI and LCI are both more sensitive to mild lung disease ... Read more >>

J Cyst Fibros (Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society)
[2021, 20(4):625-631]

Cited: 1 time

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The assessment of short and long term changes in lung function in CF using 129Xe MRI.

Laurie J Smith, Alex Horsley, Jody Bray, Paul J C Hughes, Alberto Biancardi, Graham Norquay, Martin Wildman, Noreen West, Helen Marshall, Jim M Wild,

<h4>Introduction</h4><sup>129</sup>Xe ventilation MRI is sensitive to detect early CF lung disease and response to treatment. <sup>129</sup>Xe-MRI could play a significant role in clinical trials and patient management. Here we present data on the repeatability of imaging measurements and their sensitivity to longitudinal change.<h4>Methods</h4>29 children and adults with CF and a ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, :]

Cited: 3 times

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Correction of cilia structure and function alleviates multi-organ pathology in Bardet-Biedl syndrome mice.

Hervé Husson, Nikolay O Bukanov, Sarah Moreno, Mandy M Smith, Brenda Richards, Cheng Zhu, Tyler Picariello, Hyejung Park, Bing Wang, Thomas A Natoli, Laurie A Smith, Stefano Zanotti, Ryan J Russo, Stephen L Madden, Katherine W Klinger, Vijay Modur, Oxana Ibraghimov-Beskrovnaya,

Bardet-Biedl syndrome (BBS) is a pleiotropic autosomal recessive ciliopathy affecting multiple organs. The development of potential disease-modifying therapy for BBS will require concurrent targeting of multi-systemic manifestations. Here, we show for the first time that monosialodihexosylganglioside accumulates in Bbs2-/- cilia, indicating impairment of glycosphingolipid (GSL) metabolism in BBS. Consequently, we ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2020, 29(15):2508-2522]

Cited: 1 time

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The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study.

H Javanmard-Emamghissi, H Boyd-Carson, M Hollyman, B Doleman, A Adiamah, J N Lund, R Clifford, L Dickerson, S Richards, L Pearce, J Cornish, S Hare, S Lockwood, S J Moug, G M Tierney, ,

<h4>Background</h4>Acute appendicitis (AA) is the most common general surgical emergency. Early laparoscopic appendicectomy is the gold-standard management. SARS-CoV-2 (COVID-19) brought concerns of increased perioperative mortality and spread of infection during aerosol generating procedures: as a consequence, conservative management was advised, and open appendicectomy recommended when surgery was unavoidable. This study ... Read more >>

Tech Coloproctol (Techniques in coloproctology)
[2021, 25(4):401-411]

Cited: 16 times

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Strangulated right-sided diaphragmatic hernia presenting and treated as lung empyema: beware of the differential diagnosis.

Sapna Gupta, Daniel Warrell, Laurie Smith, Gethin Llewellyn Williams,

A 78-year-old man with no surgical history or recent trauma presented to the emergency department with sudden onset right-sided chest pain and dyspnoea. He was admitted under the physicians for investigations and was subsequently diagnosed with empyema of the right thorax. After no improvement with intravenous antibiotics, a chest drain ... Read more >>

BMJ Case Rep (BMJ case reports)
[2020, 13(7):]

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