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Author Laurent J Brochard

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Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis.

Shannon M Fernando, Alexandre Tran, Behnam Sadeghirad, Karen E A Burns, Eddy Fan, Daniel Brodie, Laveena Munshi, Ewan C Goligher, Deborah J Cook, Robert A Fowler, Margaret S Herridge, Pierre Cardinal, Samir Jaber, Morten Hylander Møller, Arnaud W Thille, Niall D Ferguson, Arthur S Slutsky, Laurent J Brochard, Andrew J E Seely, Bram Rochwerg,

<h4>Purpose</h4>Systematic review and network meta-analysis to investigate the efficacy of noninvasive respiratory strategies, including noninvasive positive pressure ventilation (NIPPV) and high-flow nasal cannula (HFNC), in reducing extubation failure among critically ill adults.<h4>Methods</h4>We searched databases from inception through October 2021 for randomized controlled trials (RCTs) evaluating noninvasive respiratory support therapies (NIPPV, ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, :]

Cited: 0 times

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Separation from mechanical ventilation and survival after spinal cord injury: a systematic review and meta-analysis.

Annia F Schreiber, Jacopo Garlasco, Fernando Vieira, Yie Hui Lau, Dekel Stavi, David Lightfoot, Andrea Rigamonti, Karen Burns, Jan O Friedrich, Jeffrey M Singh, Laurent J Brochard,

<h4>Background</h4>Prolonged need for mechanical ventilation greatly impacts life expectancy of patients after spinal cord injury (SCI). Weaning outcomes have never been systematically assessed. In this systematic review and meta-analysis, we aimed to investigate the probability of weaning success, duration of mechanical ventilation, mortality, and their predictors in mechanically ventilated patients ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):149]

Cited: 0 times

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Prognostic factors for development of acute respiratory distress syndrome following traumatic injury - a systematic review and meta-analysis.

Alexandre Tran, Shannon M Fernando, Laurent J Brochard, Eddy Fan, Kenji Inaba, Niall D Ferguson, Carolyn S Calfee, Karen E A Burns, Daniel Brodie, Victoria A McCredie, Dennis Y Kim, Kwadwo Kyeremanteng, Jacinthe Lampron, Arthur S Slutsky, Alain Combes, Bram Rochwerg,

<h4>Purpose</h4>To summarise the prognostic associations between various clinical risk factors and the development of the acute respiratory distress syndrome (ARDS) following traumatic injury.<h4>Methods</h4>We conducted this review in accordance with the PRISMA and CHARMS guidelines. We searched six databases from inception through December 2020. We included English language studies describing the ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, :]

Cited: 0 times

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Ventilatory Variables and Mechanical Power in Patients with Acute Respiratory Distress Syndrome.

Eduardo L V Costa, Arthur S Slutsky, Laurent J Brochard, Roy Brower, Ary Serpa-Neto, Alexandre B Cavalcanti, Alain Mercat, Maureen Meade, Caio C A Morais, Ewan Goligher, Carlos R R Carvalho, Marcelo B P Amato,

<b>Rationale:</b> Mortality in acute respiratory distress syndrome (ARDS) has decreased after the adoption of lung-protective strategies. Lower Vt, lower driving pressure (ΔP), lower respiratory rates (RR), and higher end-expiratory pressure have all been suggested as key components of lung protection strategies. A unifying theoretical explanation has been proposed that attributes ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(3):303-311]

Cited: 10 times

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Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study.

Tài Pham, Antonio Pesenti, Giacomo Bellani, Gordon Rubenfeld, Eddy Fan, Guillermo Bugedo, José Angel Lorente, Antero do Vale Fernandes, Frank Van Haren, Alejandro Bruhn, Fernando Rios, Andres Esteban, Luciano Gattinoni, Anders Larsson, Daniel F McAuley, Marco Ranieri, B Taylor Thompson, Hermann Wrigge, Laurent J Brochard, John G Laffey, ,

<h4>Background</h4>Current incidence and outcome of patients with acute hypoxaemic respiratory failure requiring mechanical ventilation in the intensive care unit (ICU) are unknown, especially for patients not meeting criteria for acute respiratory distress syndrome (ARDS).<h4>Methods</h4>An international, multicentre, prospective cohort study of patients presenting with hypoxaemia early in the course of mechanical ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 57(6):]

Cited: 6 times

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Abdominal Muscle Use During Spontaneous Breathing and Cough in Patients Who Are Mechanically Ventilated: A Bi-center Ultrasound Study.

Annia F Schreiber, Michele Bertoni, Benjamin Coiffard, Samira Fard, Jenna Wong, W Darlene Reid, Laurent J Brochard, Simone Piva, Ewan C Goligher,

<h4>Background</h4>Ultrasound may be useful to assess the structure, activity, and function of the abdominal muscles in patients who are mechanically ventilated.<h4>Research question</h4>Does measurement of abdominal muscle thickening on ultrasound in patients who are mechanically ventilated provide clinically relevant information about abdominal muscle function and weaning outcomes?<h4>Study design and methods</h4>This study ... Read more >>

Chest (Chest)
[2021, 160(4):1316-1325]

Cited: 0 times

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Effect of Lowering Vt on Mortality in Acute Respiratory Distress Syndrome Varies with Respiratory System Elastance.

Ewan C Goligher, Eduardo L V Costa, Christopher J Yarnell, Laurent J Brochard, Thomas E Stewart, George Tomlinson, Roy G Brower, Arthur S Slutsky, Marcelo P B Amato,

<b>Rationale:</b> If the risk of ventilator-induced lung injury in acute respiratory distress syndrome (ARDS) is causally determined by driving pressure rather than by Vt, then the effect of ventilation with lower Vt on mortality would be predicted to vary according to respiratory system elastance (Ers). <b>Objectives:</b> To determine whether the ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(11):1378-1385]

Cited: 11 times

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CPAP to Counterbalance Elevated Pleural Pressure in Obese Patients: Restoring Functional Residual Capacity or Simply Keeping All Airways Open?

Michael R Pinsky, Laurent J Brochard,

Chest (Chest)
[2021, 159(6):2145-2146]

Cited: 0 times

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Positive End-Expiratory Pressure, Pleural Pressure, and Regional Compliance during Pronation: An Experimental Study.

Bhushan H Katira, Kohei Osada, Doreen Engelberts, Luca Bastia, L Felipe Damiani, Xuehan Li, Han Chen, Takeshi Yoshida, Marcelo B P Amato, Niall D Ferguson, Martin Post, Brian P Kavanagh, Laurent J Brochard,

<b>Rationale:</b> The physiological basis of lung protection and the impact of positive end-expiratory pressure (PEEP) during pronation in acute respiratory distress syndrome are not fully elucidated. <b>Objectives:</b> To compare pleural pressure (Ppl) gradient, ventilation distribution, and regional compliance between dependent and nondependent lungs, and investigate the effect of PEEP during ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(10):1266-1274]

Cited: 5 times

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Response to Ventilator Adjustments for Predicting Acute Respiratory Distress Syndrome Mortality. Driving Pressure versus Oxygenation.

Nadir Yehya, Carol L Hodgson, Marcelo B P Amato, Jean-Christophe Richard, Laurent J Brochard, Alain Mercat, Ewan C Goligher,

<b>Rationale:</b> Clinicians commonly use short-term physiologic markers to assess the benefit of ventilator adjustments. Improved arterial oxygen tension/pressure (Pa<sub>O<sub>2</sub></sub>)/fraction of inspired oxygen (Fi<sub>O<sub>2</sub></sub>) after ventilator adjustment in acute respiratory distress syndrome is associated with lower mortality. However, as driving pressure (ΔP) reflects lung stress and strain, changes in ΔP may ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(5):857-864]

Cited: 1 time

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High-Flow Oxygen Therapy in Tracheostomized Subjects With Prolonged Mechanical Ventilation: A Randomized Crossover Physiologic Study.

Patharapan Lersritwimanmaen, Nuttapol Rittayamai, Jamsak Tscheikuna, Laurent J Brochard,

<h4>Background</h4>High-flow oxygen therapy via tracheostomy (HFT) can be used in tracheostomized patients during ventilator disconnection. The physiologic effects of this technique are unknown. We hypothesized that HFT would reduce inspiratory effort and improve breathing pattern compared to conventional oxygen therapy via T-tube. This study aimed to evaluate the physiologic effects ... Read more >>

Respir Care (Respiratory care)
[2021, 66(5):806-813]

Cited: 0 times

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Diaphragm echodensity in mechanically ventilated patients: a description of technique and outcomes.

Benjamin Coiffard, Stephen Riegler, Michael C Sklar, Martin Dres, Stefannie Vorona, W Darlene Reid, Laurent J Brochard, Niall D Ferguson, Ewan C Goligher,

<h4>Background</h4>Acute increases in muscle sonographic echodensity reflect muscle injury. Diaphragm echodensity has not been measured in mechanically ventilated patients. We undertook to develop a technique to characterize changes in diaphragm echodensity during mechanical ventilation and to assess whether these changes are correlated with prolonged mechanical ventilation.<h4>Methods</h4>Diaphragm ultrasound images were prospectively ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):64]

Cited: 2 times

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Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method.

Prashant Nasa, Elie Azoulay, Ashish K Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M Arabi, Jan Bakker, Laurent J Brochard, Adam M Deane, Bin Du, Sharon Einav, Andrés Esteban, Ognjen Gajic, Samuel M Galvagno, Claude Guérin, Samir Jaber, Gopi C Khilnani, Younsuck Koh, Jean-Baptiste Lascarrou, Flavia R Machado, Manu L N G Malbrain, Jordi Mancebo, Michael T McCurdy, Brendan A McGrath, Sangeeta Mehta, Armand Mekontso-Dessap, Mervyn Mer, Michael Nurok, Pauline K Park, Paolo Pelosi, John V Peter, Jason Phua, David V Pilcher, Lise Piquilloud, Peter Schellongowski, Marcus J Schultz, Manu Shankar-Hari, Suveer Singh, Massimiliano Sorbello, Ravindranath Tiruvoipati, Andrew A Udy, Tobias Welte, Sheila N Myatra,

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory failure (C-ARF) has resulted in wide variation in clinical practice.<h4>Methods</h4>Using a Delphi process, an international panel of 39 experts developed clinical practice statements on the ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):106]

Cited: 13 times

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Identifying Subjects at Risk for Diaphragm Atrophy During Mechanical Ventilation Using Routinely Available Clinical Data.

Martin Urner, Nicholas Mitsakakis, Stefannie Vorona, Lu Chen, Michael C Sklar, Martin Dres, Gordon D Rubenfeld, Laurent J Brochard, Niall D Ferguson, Eddy Fan, Ewan C Goligher,

<h4>Background</h4>Diaphragmatic respiratory effort during mechanical ventilation is an important determinant of patient outcome, but direct measurement of diaphragmatic contractility requires specialized instrumentation and technical expertise. We sought to determine whether routinely collected clinical variables can predict diaphragmatic contractility and stratify the risk of diaphragm atrophy.<h4>Methods</h4>We conducted a secondary analysis of ... Read more >>

Respir Care (Respiratory care)
[2021, 66(4):551-558]

Cited: 0 times

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A Gas-Powered, Patient-Responsive Automatic Resuscitator for Use in Acute Respiratory Failure: A Bench and Experimental Study.

Annemijn H Jonkman, Bhushan H Katira, Annia Schreiber, Cong Lu, Doreen Engelberts, Fernando Vieira, Alexandra Marquez, Arthur S Slutsky, Paul Dorian, Laurent J Brochard,

<h4>Background</h4>During the COVID-19 pandemic, a need for innovative, inexpensive, and simple ventilator devices for mass use has emerged. The Oxylator (CPR Medical Devices, Markham, Ontario, Canada) is an FDA-approved, fist-size, portable ventilation device developed for out-of-hospital emergency ventilation. It has not been tested in conditions of severe lung injury or ... Read more >>

Respir Care (Respiratory care)
[2021, 66(3):366-377]

Cited: 1 time

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Lung-Protective Ventilation and Associated Outcomes and Costs Among Patients Receiving Invasive Mechanical Ventilation in the ED.

Shannon M Fernando, Eddy Fan, Bram Rochwerg, Karen E A Burns, Laurent J Brochard, Deborah J Cook, Allan J Walkey, Niall D Ferguson, Catherine L Hough, Daniel Brodie, Andrew J E Seely, Venkatesh Thiruganasambandamoorthy, Jeffrey J Perry, Alexandre Tran, Peter Tanuseputro, Kwadwo Kyeremanteng,

<h4>Background</h4>Invasive mechanical ventilation is often initiated in the ED, and mechanically ventilated patients may be kept in the ED for hours before ICU transfer. Although lung-protective ventilation is beneficial, particularly in ARDS, it remains uncertain how often lung-protective tidal volumes are used in the ED, and whether lung-protective ventilation in ... Read more >>

Chest (Chest)
[2021, 159(2):606-618]

Cited: 1 time

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Helmet interface increases lung volumes at equivalent ventilator pressures compared to the face mask interface during non-invasive ventilation.

Kate C Tatham, Matthew Ko, Lisa Palozzi, Stephen E Lapinsky, Laurent J Brochard, Ewan C Goligher,

Crit Care (Critical care (London, England))
[2020, 24(1):504]

Cited: 1 time

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Proportional modes of ventilation: technology to assist physiology.

Annemijn H Jonkman, Michela Rauseo, Guillaume Carteaux, Irene Telias, Michael C Sklar, Leo Heunks, Laurent J Brochard,

Proportional modes of ventilation assist the patient by adapting to his/her effort, which contrasts with all other modes. The two proportional modes are referred to as neurally adjusted ventilatory assist (NAVA) and proportional assist ventilation with load-adjustable gain factors (PAV+): they deliver inspiratory assist in proportion to the patient's effort, ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(12):2301-2313]

Cited: 7 times

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A physiology-based mathematical model for the selection of appropriate ventilator controls for lung and diaphragm protection.

Binghao Zhang, Damian Ratano, Laurent J Brochard, Dimitrios Georgopoulos, James Duffin, Michael Long, Tom Schepens, Irene Telias, Arthur S Slutsky, Ewan C Goligher, Timothy C Y Chan,

Mechanical ventilation is used to sustain respiratory function in patients with acute respiratory failure. To aid clinicians in consistently selecting lung- and diaphragm-protective ventilation settings, a physiology-based decision support system is needed. To form the foundation of such a system, a comprehensive physiological model which captures the dynamics of ventilation ... Read more >>

J Clin Monit Comput (Journal of clinical monitoring and computing)
[2021, 35(2):363-378]

Cited: 1 time

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A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation.

Michele Bertoni, Irene Telias, Martin Urner, Michael Long, Lorenzo Del Sorbo, Eddy Fan, Christer Sinderby, Jennifer Beck, Ling Liu, Haibo Qiu, Jenna Wong, Arthur S Slutsky, Niall D Ferguson, Laurent J Brochard, Ewan C Goligher,

BACKGROUND:Excessive respiratory muscle effort during mechanical ventilation may cause patient self-inflicted lung injury and load-induced diaphragm myotrauma, but there are no non-invasive methods to reliably detect elevated transpulmonary driving pressure and elevated respiratory muscle effort during assisted ventilation. We hypothesized that the swing in airway pressure generated by respiratory muscle ... Read more >>

Crit Care (Critical care (London, England))
[2019, 23(1):346]

Cited: 21 times

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Intrathoracic Airway Closure Impacts CO2 Signal and Delivered Ventilation during Cardiopulmonary Resuscitation.

Domenico L Grieco, Laurent J Brochard, Adrien Drouet, Irene Telias, Stéphane Delisle, Gilles Bronchti, Cecile Ricard, Marceau Rigollot, Bilal Badat, Paul Ouellet, Emmanuel Charbonney, Jordi Mancebo, Alain Mercat, Dominique Savary, Jean-Christophe M Richard,

<h4>Rationale</h4>End-tidal CO<sub>2</sub> (EtCO<sub>2</sub>) is used to monitor cardiopulmonary resuscitation (CPR), but it can be affected by intrathoracic airway closure. Chest compressions induce oscillations in expired CO<sub>2</sub>, and this could reflect variable degrees of airway patency.<h4>Objectives</h4>To understand the impact of airway closure during CPR, and the relationship between the capnogram shape, ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 199(6):728-737]

Cited: 13 times

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Editorial: Every breath you take…should be monitored.

Tài Pham, Laurent J Brochard,

Curr Opin Crit Care (Current opinion in critical care)
[2019, 25(1):1-2]

Cited: 0 times

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Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure.

Ewan C Goligher, Laurent J Brochard, W Darlene Reid, Eddy Fan, Olli Saarela, Arthur S Slutsky, Brian P Kavanagh, Gordon D Rubenfeld, Niall D Ferguson,

Several mechanisms of diaphragm muscle injury (myotrauma) can result in ventilator-induced diaphragm dysfunction, including ventilator over-assistance, under-assistance, eccentric contractions, and end-expiratory shortening. In this Personal View, we summarise the evidence for the clinical relevance of these mechanisms, and present new data based on mediation analysis supporting the hypothesis that myotrauma ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2019, 7(1):90-98]

Cited: 30 times

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Asynchrony Consequences and Management.

Tài Pham, Irene Telias, Thomas Piraino, Takeshi Yoshida, Laurent J Brochard,

Poor synchrony between the delivery of mechanical breaths, the neural respiratory timing, and needs of patients is relatively frequent under mechanical ventilation in the intensive care unit. This review summarizes the current knowledge on the different types of dyssynchrony described to date, their mechanism, consequences, and potential management. There is ... Read more >>

Crit Care Clin (Critical care clinics)
[2018, 34(3):325-341]

Cited: 13 times

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Inspiratory Muscle Rehabilitation in Critically Ill Adults. A Systematic Review and Meta-Analysis.

Stefannie Vorona, Umberto Sabatini, Sulaiman Al-Maqbali, Michele Bertoni, Martin Dres, Bernie Bissett, Frank Van Haren, A Daniel Martin, Cristian Urrea, Debbie Brace, Matteo Parotto, Margaret S Herridge, Neill K J Adhikari, Eddy Fan, Luana T Melo, W Darlene Reid, Laurent J Brochard, Niall D Ferguson, Ewan C Goligher,

<h4>Rationale</h4>Respiratory muscle weakness is common in critically ill patients; the role of targeted inspiratory muscle training (IMT) in intensive care unit rehabilitation strategies remains poorly defined.<h4>Objectives</h4>The primary objective of the present study was to describe the range and tolerability of published methods for IMT. The secondary objectives were to determine ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2018, 15(6):735-744]

Cited: 17 times

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