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Author Laurent Chatre

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The Reactive Species Interactome in the brain.

Elise Malard, Samuel Valable, Myriam Bernaudin, Elodie Pérès, Laurent Chatre,

<h4>Significance</h4>Redox pioneer Helmut Sies attempted to explain reactive species' challenges faced by organelles, cells, tissues, and organs via three complementary definitions: (1) oxidative stress, i.e. the disturbance in the prooxidant-antioxidant defense balance in favor of the prooxidants, (2) oxidative eustress, the low physiological exposure to prooxidants, and (3) oxidative distress, ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2021, :]

Cited: 0 times

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Multimodal evaluation of hypoxia in brain metastases of lung cancer and interest of hypoxia image-guided radiotherapy.

Aurélien Corroyer-Dulmont, Samuel Valable, Jade Fantin, Laurent Chatre, Jérôme Toutain, Sylvain Teulier, Céline Bazille, Elise Letissier, Jérôme Levallet, Didier Divoux, Méziane Ibazizène, Stéphane Guillouet, Cécile Perrio, Louisa Barré, Sébastien Serres, Nicola R Sibson, Françoise Chapon, Guénaëlle Levallet, Myriam Bernaudin,

Lung cancer patients frequently develop brain metastases (BM). Despite aggressive treatment including neurosurgery and external-radiotherapy, overall survival remains poor. There is a pressing need to further characterize factors in the microenvironment of BM that may confer resistance to radiotherapy (RT), such as hypoxia. Here, hypoxia was first evaluated in 28 ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):11239]

Cited: 2 times

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mTRIP, an Imaging Tool to Investigate Mitochondrial DNA Dynamics in Physiology and Disease at the Single-Cell Resolution.

Laurent Chatre, Miria Ricchetti,

Mitochondrial physiology and metabolism are closely linked to replication and transcription of mitochondrial DNA (mtDNA). However, the characterization of mtDNA processing is poorly defined at the single-cell level. We developed mTRIP (mitochondrial Transcription and Replication Imaging Protocol), an imaging approach based on modified fluorescence in situ hybridization (FISH), which simultaneously ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2275:247-263]

Cited: 0 times

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Correction: Endonuclease G promotes mitochondrial genome cleavage and replication.

Rahel Stefanie Wiehe, Boris Gole, Laurent Chatre, Paul Walther, Enrico Calzia, Anja Palmer, J Christof M Gebhardt, Miria Ricchetti, Lisa Wiesmüller,

[This corrects the article DOI: 10.18632/oncotarget.24822.]. ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(45):27908]

Cited: 0 times

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Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis.

Francesca Pala, Daniela Di Girolamo, Sébastien Mella, Siham Yennek, Laurent Chatre, Miria Ricchetti, Shahragim Tajbakhsh,

During growth, homeostasis and regeneration, stem cells are exposed to different energy demands. Here, we characterise the metabolic pathways that mediate the commitment and differentiation of mouse skeletal muscle stem cells, and how their modulation can influence the cell state. We show that quiescent satellite stem cells have low energetic ... Read more >>

J Cell Sci (Journal of cell science)
[2018, 131(14):]

Cited: 31 times

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Endonuclease G promotes mitochondrial genome cleavage and replication.

Rahel Stefanie Wiehe, Boris Gole, Laurent Chatre, Paul Walther, Enrico Calzia, Miria Ricchetti, Lisa Wiesmüller,

Endonuclease G (EndoG) is a nuclear-encoded endonuclease, mostly localised in mitochondria. In the nucleus EndoG participates in site-specific cleavage during replication stress and genome-wide DNA degradation during apoptosis. However, the impact of EndoG on mitochondrial DNA (mtDNA) metabolism is poorly understood. Here, we investigated whether EndoG is involved in the ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(26):18309-18326]

Cited: 7 times

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Helicobacter pylori targets mitochondrial import and components of mitochondrial DNA replication machinery through an alternative VacA-dependent and a VacA-independent mechanisms.

Laurent Chatre, Julien Fernandes, Valérie Michel, Laurence Fiette, Patrick Avé, Giuseppe Arena, Utkarsh Jain, Rainer Haas, Timothy C Wang, Miria Ricchetti, Eliette Touati,

Targeting mitochondria is a powerful strategy for pathogens to subvert cell physiology and establish infection. Helicobacter pylori is a bacterial pathogen associated with gastric cancer development that is known to target mitochondria directly and exclusively through its pro-apoptotic and vacuolating cytotoxin VacA. By in vitro infection of gastric epithelial cells ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):15901]

Cited: 4 times

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A novel paradigm links mitochondrial dysfunction with muscle stem cell impairment in sepsis.

Laurent Chatre, Franck Verdonk, Pierre Rocheteau, Clément Crochemore, Fabrice Chrétien, Miria Ricchetti,

Sepsis is an acute systemic inflammatory response of the body to microbial infection and a life threatening condition associated with multiple organ failure. Survivors may display long-term disability with muscle weakness that remains poorly understood. Recent data suggest that long-term myopathy in sepsis survivors is due to failure of skeletal ... Read more >>

Biochim Biophys Acta Mol Basis Dis (Biochimica et biophysica acta. Molecular basis of disease)
[2017, 1863(10 Pt B):2546-2553]

Cited: 6 times

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A Single-Cell Resolution Imaging Protocol of Mitochondrial DNA Dynamics in Physiopathology, mTRIP, Which Also Evaluates Sublethal Cytotoxicity.

Laurent Chatre, Benjamin Montagne, Miria Ricchetti,

Mitochondria autonomously replicate and transcribe their own genome, which is present in multiple copies in the organelle. Transcription and replication of the mitochondrial DNA (mtDNA), which are defined here as mtDNA processing, are essential for mitochondrial function. The extent, efficiency, and coordination of mtDNA processing are key parameters of the ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2016, 1351:49-65]

Cited: 1 time

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Neuropathological Correlates of Hyperglycemia During Prolonged Polymicrobial Sepsis in Mice.

Romain Sonneville, Inge Derese, Mirna Bastos Marques, Lies Langouche, Sarah Derde, Laurent Chatre, Fabrice Chrétien, Djillali Annane, Tarek Sharshar, Greet Van den Berghe, Ilse Vanhorebeek,

Glucose toxicity may play a crucial role in evoking neurologic complications of critical illness. We studied whether the neuropathological alterations in fatal human critical illness observed under hyperglycemia are present and can be attenuated by maintaining normoglycemia in a mouse model of prolonged sepsis induced by cecal ligation and puncture. ... Read more >>

Shock (Shock (Augusta, Ga.))
[2015, 44(3):245-251]

Cited: 7 times

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Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome.

Laurent Chatre, Denis S F Biard, Alain Sarasin, Miria Ricchetti,

UV-sensitive syndrome (UV(S)S) and Cockayne syndrome (CS) are human disorders caused by CSA or CSB gene mutations; both conditions cause defective transcription-coupled repair and photosensitivity. Patients with CS also display neurological and developmental abnormalities and dramatic premature aging, and their cells are hypersensitive to oxidative stress. We report CSA/CSB-dependent depletion ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2015, 112(22):E2910-9]

Cited: 21 times

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mTRIP: an imaging tool to investigate mitochondrial DNA dynamics in physiology and disease at the single-cell resolution.

Laurent Chatre, Miria Ricchetti,

Mitochondrial physiology and metabolism are closely linked to replication and transcription of the genome of the organelle, the mitochondrial DNA (mtDNA). However, the characterization of mtDNA processing is poorly defined at the single-cell level. Here, we describe mTRIP (mitochondrial transcription and replication imaging protocol), an imaging approach based on modified ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2015, 1264:133-147]

Cited: 3 times

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Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene.

Ludivine Doridot, Laurent Châtre, Aurélien Ducat, Jean-Luc Vilotte, Anne Lombès, Céline Méhats, Sandrine Barbaux, Rosamaria Calicchio, Miria Ricchetti, Daniel Vaiman,

<h4>Aims</h4>Storkhead box 1 (STOX1) is a winged-helix transcription factor that is implicated in the genetic forms of a high-prevalence human gestational disease, pre-eclampsia. STOX1 overexpression confers pre-eclampsia-like transcriptomic features to trophoblastic cell lines and pre-eclampsia symptoms to pregnant mice. The aim of this work was to evaluate the impact of ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2014, 21(6):819-834]

Cited: 32 times

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Are mitochondria the Achilles' heel of the Kingdom Fungi?

Laurent Chatre, Miria Ricchetti,

A founding event in the origin of eukaryotes is the acquisition of an extraordinary organelle, the mitochondrion, which contains its own genome. Being linked to energy metabolism, oxidative stress, cell signalling, and cell death, the mitochondrion to a certain extent controls life and death in eukaryotic cells. The large metabolic ... Read more >>

Curr Opin Microbiol (Current opinion in microbiology)
[2014, 20:49-54]

Cited: 16 times

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Prevalent coordination of mitochondrial DNA transcription and initiation of replication with the cell cycle.

Laurent Chatre, Miria Ricchetti,

Nuclear (nDNA) and mitochondrial DNA (mtDNA) communication is essential for cell function, but it remains unclear whether the replication of these genomes is linked. We inspected human cells with a novel fluorescence in situ hybridization protocol (mitochondrial Transcription and Replication Imaging Protocol) that identifies mitochondrial structures engaged in initiation of ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2013, 41(5):3068-3078]

Cited: 20 times

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Large heterogeneity of mitochondrial DNA transcription and initiation of replication exposed by single-cell imaging.

Laurent Chatre, Miria Ricchetti,

Mitochondrial DNA (mtDNA) replication and transcription are crucial for cell function, but these processes are poorly understood at the single-cell level. We describe a novel fluorescence in situ hybridization protocol, called mTRIP (mitochondrial transcription and replication imaging protocol), that reveals simultaneously mtDNA and RNA, and that can also be coupled ... Read more >>

J Cell Sci (Journal of cell science)
[2013, 126(Pt 4):914-926]

Cited: 19 times

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Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity.

Mathilde Latil, Pierre Rocheteau, Laurent Châtre, Serena Sanulli, Sylvie Mémet, Miria Ricchetti, Shahragim Tajbakhsh, Fabrice Chrétien,

The accessibility to stem cells from healthy or diseased individuals, and the maintenance of their potency are challenging issues for stem cell biology. Here we report the isolation of viable and functional skeletal myogenic cells from humans up to 17 days, and mice up to 14 days post mortem, much ... Read more >>

Nat Commun (Nature communications)
[2012, 3:903]

Cited: 67 times

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Nuclear mitochondrial DNA activates replication in Saccharomyces cerevisiae.

Laurent Chatre, Miria Ricchetti,

The nuclear genome of eukaryotes is colonized by DNA fragments of mitochondrial origin, called NUMTs. These insertions have been associated with a variety of germ-line diseases in humans. The significance of this uptake of potentially dangerous sequences into the nuclear genome is unclear. Here we provide functional evidence that sequences ... Read more >>

PLoS One (PloS one)
[2011, 6(3):e17235]

Cited: 7 times

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A novel di-acidic motif facilitates ER export of the syntaxin SYP31.

Laurent Chatre, Valérie Wattelet-Boyer, Su Melser, Lilly Maneta-Peyret, Federica Brandizzi, Patrick Moreau,

It is generally accepted that ER protein export is largely influenced by the transmembrane domain (TMD). The situation is unclear for membrane-anchored proteins such as SNAREs, which are anchored to the membrane by their TMD at the C-terminus. For example, in plants, Sec22 and SYP31 (a yeast Sed5 homologue) have ... Read more >>

J Exp Bot (Journal of experimental botany)
[2009, 60(11):3157-3165]

Cited: 12 times

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Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton.

Sandrine Barbier, Laurent Chatre, Marlène Bras, Patricia Sancho, Gaël Roué, Clémence Virely, Victor J Yuste, Sylvie Baudet, Manuel Rubio, Josep E Esquerda, Marika Sarfati, Hélène Merle-Béral, Santos A Susin,

<h4>Background</h4>Programmed cell death has been traditionally related with caspase activation. However, it is now accepted that caspase-independent forms of programmed cell death also regulate cell death. In chronic lymphocytic leukemia, CD47 ligation induces one of these alternative forms of cell death: type III programmed cell death. This poorly understood process ... Read more >>

Haematologica (Haematologica)
[2009, 94(4):507-517]

Cited: 18 times

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Plant Sar1 isoforms with near-identical protein sequences exhibit different localisations and effects on secretion.

Sally L Hanton, Laurent Chatre, Loren A Matheson, Marika Rossi, Michael A Held, Federica Brandizzi,

In plants, differentiation of subdomains of the endoplasmic reticulum (ER) dedicated to protein export, the ER export sites (ERES), is influenced by the type of export-competent membrane cargo to be delivered to the Golgi. This raises a fundamental biological question: is the formation of transport intermediates at the ER for ... Read more >>

Plant Mol Biol (Plant molecular biology)
[2008, 67(3):283-294]

Cited: 38 times

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Dynamic organization of COPII coat proteins at endoplasmic reticulum export sites in plant cells.

Sally L Hanton, Loren A Matheson, Laurent Chatre, Federica Brandizzi,

Protein export from the endoplasmic reticulum (ER) is mediated by the accumulation of COPII proteins such as Sar1, Sec23/24 and Sec13/31 at specialized ER export sites (ERES). Although the distribution of COPII components in mammalian and yeast systems is established, a unified model of ERES dynamics has yet to be ... Read more >>

Plant J (The Plant journal : for cell and molecular biology)
[2009, 57(6):963-974]

Cited: 36 times

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Post-Golgi protein traffic in the plant secretory pathway.

Sally L Hanton, Loren A Matheson, Laurent Chatre, Marika Rossi, Federica Brandizzi,

The Golgi apparatus in plants is organized as a multitude of individual stacks that are motile in the cytoplasm and in close association with the endoplasmic reticulum (ER) (Boevink et al. in Plant J 15:441-447, 1998). These stacks operate as a sorting centre for cargo molecules, providing modification and redirection ... Read more >>

Plant Cell Rep (Plant cell reports)
[2007, 26(9):1431-1438]

Cited: 19 times

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De novo formation of plant endoplasmic reticulum export sites is membrane cargo induced and signal mediated.

Sally L Hanton, Laurent Chatre, Luciana Renna, Loren A Matheson, Federica Brandizzi,

The plant endoplasmic reticulum (ER) contains functionally distinct subdomains at which cargo molecules are packed into transport carriers. To study these ER export sites (ERES), we used tobacco (Nicotiana tabacum) leaf epidermis as a model system and tested whether increased cargo dosage leads to their de novo formation. We have ... Read more >>

Plant Physiol (Plant physiology)
[2007, 143(4):1640-1650]

Cited: 59 times

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Correct targeting of plant ARF GTPases relies on distinct protein domains.

Loren A Matheson, Sarabjeet S Suri, Sally L Hanton, Laurent Chatre, Federica Brandizzi,

Indispensable membrane trafficking events depend on the activity of conserved small guanosine triphosphatases (GTPases), anchored to individual organelle membranes. In plant cells, it is currently unknown how these proteins reach their correct target membranes and interact with their effectors. To address these important biological questions, we studied two members of ... Read more >>

Traffic (Traffic (Copenhagen, Denmark))
[2008, 9(1):103-120]

Cited: 20 times

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