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Author Lauren R Sorce

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SCCM/ACCM Guideline and Toolkit Development Pathways.

Sandra L Kane-Gill, Julie Winkle, Lewis J Kaplan, Vinay Nadkarni, Lauren R Sorce, Lori Harmon, Greg S Martin,

Crit Care Med (Critical care medicine)
[2021, 49(11):1851-1854]

Cited: 0 times

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Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.

Kusum Menon, Luregn J Schlapbach, Samuel Akech, Andrew Argent, Paolo Biban, Enitan D Carrol, Kathleen Chiotos, Mohammod Jobayer Chisti, Idris V R Evans, David P Inwald, Paul Ishimine, Niranjan Kissoon, Rakesh Lodha, Simon Nadel, Cláudio Flauzino Oliveira, Mark Peters, Benham Sadeghirad, Halden F Scott, Daniela C de Souza, Pierre Tissieres, R Scott Watson, Matthew O Wiens, James L Wynn, Jerry J Zimmerman, Lauren R Sorce, ,

<h4>Objective</h4>To determine the associations of demographic, clinical, laboratory, organ dysfunction, and illness severity variable values with: 1) sepsis, severe sepsis, or septic shock in children with infection and 2) multiple organ dysfunction or death in children with sepsis, severe sepsis, or septic shock.<h4>Data sources</h4>MEDLINE, Embase, and the Cochrane Central Register ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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The Evolution of Toolkits and Bundles to Improve the Care of Sepsis Patients.

Greg S Martin, Sandra L Kane-Gill, Vinay Nadkarni, Lauren R Sorce, Lewis J Kaplan, Maurizio Cecconi, Elie Azoulay, Jean-Louis Teboul, Lui Forni, Jozef Kesecioglu,

Crit Care Med (Critical care medicine)
[2021, 49(11):1849-1850]

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Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial.

Ana Carolina Costa Monteiro, Heidi Flori, Mary K Dahmer, Myung Shin Sim, Michael W Quasney, Martha A Q Curley, Michael A Matthay, Anil Sapru, ,

<h4>Background</h4>Acute respiratory failure (ARF) can progress to acute respiratory distress syndrome and death. Biomarkers may allow for risk stratification and prognostic enrichment in ARF. Thrombomodulin (TM) is a transmembrane antithrombotic mediator expressed in endothelial cells. It is cleaved into its soluble form (sTM) during inflammation and vascular injury. Levels of ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):271]

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The Impact of Preintubation Noninvasive Ventilation on Outcomes in Pediatric Acute Respiratory Distress Syndrome.

Whitney Kopp, Rainer G Gedeit, Lisa A Asaro, Gwenn E McLaughlin, David Wypij, Martha A Q Curley, ,

<h4>Objectives</h4>There is evidence that noninvasive ventilation decreases the need for invasive mechanical ventilation. However, children with pediatric acute respiratory distress syndrome who fail noninvasive ventilation may have worse outcomes than those who are intubated without exposure to noninvasive ventilation. Our objective was to evaluate the impact of preintubation noninvasive ventilation ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(5):816-827]

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Association of Race and Ethnicity with Sedation Management in Pediatric Intensive Care.

JoAnne E Natale, Lisa A Asaro, Jill G Joseph, Christine Ulysse, Judith Ascenzi, Cindy Bowens, David Wypij, Martha A Q Curley, ,

<b>Rationale:</b> Racial disparities in pain management have been previously reported for children receiving emergency care.<b>Objectives:</b> To determine whether patient race or ethnicity is associated with the broader goal of pain management and sedation among pediatric patients mechanically ventilated for acute respiratory failure.<b>Methods:</b> Planned secondary analysis of RESTORE (Randomized Evaluation of ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(1):93-102]

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Are Mothers Certain About Their Perceptions of Recalled Infant Feeding History?

Lauren R Sorce, Michael E Schoeny, Martha A Q Curley, Paula P Meier,

<h4>Introduction</h4>Maternal recall of infant feeding, a potential measurement bias, is used to identify the relationship between mothers' own milk (MOM) feeding and subsequent health outcomes. This study describes maternal recall certainty of MOM feedings at four time periods.<h4>Method</h4>In this secondary analysis, mothers of children ages 4-36 months describe infants' MOM ... Read more >>

J Pediatr Health Care (Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners)
[2021, 35(2):156-162]

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A Randomized Comparative Trial to Evaluate a PICU Navigator-Based Parent Support Intervention.

Kelly N Michelson, Joel Frader, Elizabeth Charleston, Karen Rychlik, Danica Y Aniciete, Jody D Ciolino, Lauren R Sorce, Marla L Clayman, Melanie Brown, Patricia Fragen, Marcelo Malakooti, Sabrina Derrington, Douglas White, ,

<h4>Objectives</h4>Communication breakdowns in PICUs contribute to inadequate parent support and poor post-PICU parent outcomes. No interventions supporting communication have demonstrated improvements in parental satisfaction or psychologic morbidity. We compared parent-reported outcomes from parents receiving a navigator-based parent support intervention (PICU Supports) with those from parents receiving an informational brochure.<h4>Design</h4>Patient-level, randomized ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(9):e617-e627]

Cited: 1 time

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Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce.

Kusum Menon, Luregn J Schlapbach, Samuel Akech, Andrew Argent, Kathleen Chiotos, Mohammod Jobayer Chisti, Jemila Hamid, Paul Ishimine, Niranjan Kissoon, Rakesh Lodha, Cláudio Flauzino Oliveira, Mark Peters, Pierre Tissieres, R Scott Watson, Matthew O Wiens, James L Wynn, Lauren R Sorce,

<h4>Objectives</h4>Sepsis is responsible for a substantial proportion of global childhood morbidity and mortality. However, evidence demonstrates major inaccuracies in the use of the term "sepsis" in clinical practice, coding, and research. Current and previous definitions of sepsis have been developed using expert consensus but the specific criteria used to identify ... Read more >>

Crit Care Explor (Critical care explorations)
[2020, 2(6):e0123]

Cited: 2 times

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Navigator-Based Intervention to Support Communication in the Pediatric Intensive Care Unit: A Pilot Study.

Kelly N Michelson, Elizabeth Charleston, Danica Y Aniciete, Lauren R Sorce, Patricia Fragen, Stephen D Persell, Jody D Ciolino, Marla L Clayman, Karen Rychlik, Virginia A Jones, Pamela Spadino, Marcelo Malakooti, Melanie Brown, Douglas White,

<h4>Background</h4>Communication in the pediatric intensive care unit (PICU) between families and the health care team affects the family experience, caregiver psychological morbidity, and patient outcomes.<h4>Objective</h4>To test the feasibility of studying and implementing a PICU communication intervention called PICU Supports, and to assess families' and health care teams' perceptions of the ... Read more >>

Am J Crit Care (American journal of critical care : an official publication, American Association of Critical-Care Nurses)
[2020, 29(4):271-282]

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Joint Society of Critical Care Medicine-Extracorporeal Life Support Organization Task Force Position Paper on the Role of the Intensivist in the Initiation and Management of Extracorporeal Membrane Oxygenation.

Jeffrey DellaVolpe, Ryan P Barbaro, Jeremy W Cannon, Eddy Fan, Wendy R Greene, Kyle J Gunnerson, Lena M Napolitano, Ace Ovil, Jeremy C Pamplin, Matthieu Schmidt, Lauren R Sorce, Daniel Brodie,

<h4>Objectives</h4>To define the role of the intensivist in the initiation and management of patients on extracorporeal membrane oxygenation.<h4>Design</h4>Retrospective review of the literature and expert consensus.<h4>Setting</h4>Series of in-person meetings, conference calls, and emails from January 2018 to March 2019.<h4>Subjects</h4>A multidisciplinary, expert Task Force was appointed and assembled by the Society of ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(6):838-846]

Cited: 0 times

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Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure.

Mary K Dahmer, Heidi Flori, Anil Sapru, Joseph Kohne, Heidi M Weeks, Martha A Q Curley, Michael A Matthay, Michael W Quasney, ,

<h4>Background</h4>Elevated surfactant protein D (SP-D) is a relatively specific indicator of lung injury and is associated with both acute and chronic lung disease in adults and respiratory distress syndrome in premature infants. The relationship between plasma SP-D and lung injury in children with acute respiratory failure is unclear.<h4>Research question</h4>Is plasma ... Read more >>

Chest (Chest)
[2020, 158(3):1027-1035]

Cited: 5 times

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Evolution of Advanced Practice Provider Education.

Mary E McBride, Carrie Alden, Lauren R Sorce,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2019, 20(12):1192-1193]

Cited: 0 times

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Outcomes Associated With Multiple Organ Dysfunction Syndrome in Critically Ill Children With Hyperglycemia.

Lauren E Marsillio, Lisa A Asaro, Vijay Srinivasan, David Wypij, Lauren R Sorce, Michael S D Agus, Vinay M Nadkarni, ,

OBJECTIVES:Patterns and outcomes of multiple organ dysfunction syndrome are unknown in critically ill children with hyperglycemia. We aimed to determine whether tight glycemic control to a lower vs. higher range influenced timing, duration, or resolution of multiple organ dysfunction syndrome as well as characterize the clinical outcomes of subgroups of ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2019, 20(12):1147-1156]

Cited: 0 times

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Mother's Own Milk Feeding and Severity of Respiratory Illness in Acutely Ill Children: An Integrative Review.

Lauren R Sorce, Martha A Q Curley, Ruth Kleinpell, Barbara Swanson, Paula P Meier,

<h4>Problem</h4>Breastfed infants experience less severe infections while actively breastfeeding. However, little is known about whether a history of prior breastfeeding affects severity of illness. Therefore, the purpose of this integrative review was to examine the relationship between previous exposure to mother's own milk (MOM) feeding and severity of respiratory infectious ... Read more >>

J Pediatr Nurs (Journal of pediatric nursing)
[2020, 50:5-13]

Cited: 0 times

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A prospective investigation of interleukin-8 levels in pediatric acute respiratory failure and acute respiratory distress syndrome.

Heidi Flori, Anil Sapru, Michael W Quasney, Ginny Gildengorin, Martha A Q Curley, Michael A Matthay, Mary K Dahmer, ,

<h4>Background</h4>The association of plasma interleukin-8 (IL-8), or IL-8 genetic variants, with pediatric acute respiratory distress syndrome (PARDS) in children with acute respiratory failure at risk for PARDS has not been examined. The purpose of this study was to examine the association of early and sequential measurement of plasma IL-8 and/or ... Read more >>

Crit Care (Critical care (London, England))
[2019, 23(1):128]

Cited: 9 times

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Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment.

Kaitlin M Best, Lisa A Asaro, Martha A Q Curley, ,

<h4>Objective</h4>To compare current analgesia and sedation management practices between critically ill children with pre-existing cognitive impairment and critically ill neurotypical children, including possible indicators of therapeutic efficacy.<h4>Study design</h4>This study used secondary analysis of prospective data from the RESTORE clinical trial, with 2449 children admitted to the pediatric intensive care unit ... Read more >>

J Pediatr (The Journal of pediatrics)
[2019, 206:204-211.e1]

Cited: 2 times

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Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure.

Mary K Dahmer, Michael W Quasney, Anil Sapru, Ginny Gildengorin, Martha A Q Curley, Michael A Matthay, Heidi Flori, ,

<h4>Objectives</h4>To test whether plasma interleukin-1 receptor antagonist or variants within the gene encoding for interleukin-1ra (IL1RN), or proteins involved in regulating interleukin-1β levels or interleukin-1β response, are associated with pediatric acute respiratory distress syndrome or outcomes in mechanically ventilated children with parenchymal lung disease.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>Twenty-two PICUs participating in the ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2018, 19(10):930-938]

Cited: 12 times

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Does Extracorporeal Membrane Oxygenation Improve Survival in Pediatric Acute Respiratory Failure?

Ryan P Barbaro, Yuejia Xu, Santiago Borasino, Edward J Truemper, R Scott Watson, Ravi R Thiagarajan, David Wypij, Martha A Q Curley, ,

<h4>Rationale</h4>Extracorporeal membrane oxygenation (ECMO) has supported gas exchange in children with severe respiratory failure for more than 40 years, without ECMO efficacy studies.<h4>Objectives</h4>To compare the mortality and functional status of children with severe acute respiratory failure supported with and without ECMO.<h4>Methods</h4>This cohort study compared ECMO-supported children to pair-matched non-ECMO-supported control ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2018, 197(9):1177-1186]

Cited: 18 times

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Long-Term Outcomes after Protocolized Sedation versus Usual Care in Ventilated Pediatric Patients.

R Scott Watson, Lisa A Asaro, James H Hertzog, Lauren R Sorce, Alicia G Kachmar, Leslie A Dervan, Derek C Angus, David Wypij, Martha A Q Curley, ,

<h4>Rationale</h4>Whether a nurse-implemented goal-directed sedation protocol resulting in more awake yet calm intubated children affects postdischarge functional status, health-related quality of life, or risk for post-traumatic stress disorder is unknown.<h4>Objectives</h4>To compare postdischarge outcomes in children with acute respiratory failure cluster-randomized to a sedation protocol or usual care.<h4>Methods</h4>A stratified random sample ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2018, 197(11):1457-1467]

Cited: 18 times

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Multiple Organ Dysfunction in Children Mechanically Ventilated for Acute Respiratory Failure.

Scott L Weiss, Lisa A Asaro, Heidi R Flori, Geoffrey L Allen, David Wypij, Martha A Q Curley, ,

<h4>Objectives</h4>The impact of extrapulmonary organ dysfunction, independent from sepsis and lung injury severity, on outcomes in pediatric acute respiratory failure is unclear. We sought to determine the frequency, timing, and risk factors for extrapulmonary organ dysfunction and the independent association of multiple organ dysfunction syndrome with outcomes in pediatric acute ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2017, 18(4):319-329]

Cited: 13 times

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Sedation Management in Children Supported on Extracorporeal Membrane Oxygenation for Acute Respiratory Failure.

James B Schneider, Todd Sweberg, Lisa A Asaro, Aileen Kirby, David Wypij, Ravi R Thiagarajan, Martha A Q Curley, ,

<h4>Objectives</h4>To describe sedation management in children supported on extracorporeal membrane oxygenation for acute respiratory failure.<h4>Design</h4>Secondary analysis of prospectively collected data from a multicenter randomized trial of sedation (Randomized Evaluation of Sedation Titration for Respiratory Failure).<h4>Setting</h4>Twenty-one U.S. PICUs.<h4>Patients</h4>One thousand two hundred fifty-five children, 2 weeks to 17 years old, with moderate/severe ... Read more >>

Crit Care Med (Critical care medicine)
[2017, 45(10):e1001-e1010]

Cited: 6 times

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Racial and Ethnic Disparities in Parental Refusal of Consent in a Large, Multisite Pediatric Critical Care Clinical Trial.

Joanne E Natale, Ruth Lebet, Jill G Joseph, Christine Ulysse, Judith Ascenzi, David Wypij, Martha A Q Curley, ,

<h4>Objective</h4>To evaluate whether race or ethnicity was independently associated with parental refusal of consent for their child's participation in a multisite pediatric critical care clinical trial.<h4>Study design</h4>We performed a secondary analyses of data from Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE), a 31-center cluster randomized trial of sedation ... Read more >>

J Pediatr (The Journal of pediatrics)
[2017, 184:204-208.e1]

Cited: 7 times

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Accuracy of an Extubation Readiness Test in Predicting Successful Extubation in Children With Acute Respiratory Failure From Lower Respiratory Tract Disease.

Edward Vincent S Faustino, Rainer Gedeit, Adam J Schwarz, Lisa A Asaro, David Wypij, Martha A Q Curley, ,

<h4>Objective</h4>Identifying children ready for extubation is desirable to minimize morbidity and mortality associated with prolonged mechanical ventilation and extubation failure. We determined the accuracy of an extubation readiness test (Randomized Evaluation of Sedation Titration for Respiratory Failure extubation readiness test) in predicting successful extubation in children with acute respiratory failure ... Read more >>

Crit Care Med (Critical care medicine)
[2017, 45(1):94-102]

Cited: 8 times

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Dexmedetomidine Use in Critically Ill Children With Acute Respiratory Failure.

Mary Jo C Grant, James B Schneider, Lisa A Asaro, Brenda L Dodson, Brent A Hall, Shari L Simone, Allison S Cowl, Michele M Munkwitz, David Wypij, Martha A Q Curley, ,

<h4>Objective</h4>Care of critically ill children includes sedation but current therapies are suboptimal. To describe dexmedetomidine use in children supported on mechanical ventilation for acute respiratory failure.<h4>Design</h4>Secondary analysis of data from the Randomized Evaluation of Sedation Titration for Respiratory Failure clinical trial.<h4>Setting</h4>Thirty-one PICUs.<h4>Patients</h4>Data from 2,449 children; 2 weeks to 17 years ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2016, 17(12):1131-1141]

Cited: 17 times

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