Full Text Journal Articles by
Author Laurel Glaser

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Development and Evaluation of a Molecular Hepatitis A Virus Assay for Serum and Stool Specimens.

Robert A Kozak, Candace Rutherford, Melissa Richard-Greenblatt, N Y Elizabeth Chau, Ana Cabrera, Mia Biondi, Jamie Borlang, Jaqueline Day, Carla Osiowy, Sumathi Ramachandran, Nancy Mayer, Laurel Glaser, Marek Smieja,

Hepatitis A virus (HAV) is an emerging public health concern and there is an urgent need for ways to rapidly identify cases so that outbreaks can be managed effectively. Conventional testing for HAV relies on anti-HAV IgM seropositivity. However, studies estimate that 10-30% of patients may not be diagnosed by ... Read more >>

Viruses (Viruses)
[2022, 14(1):]

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Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Tracking.

Hui Chen, Zhao Li, Sheng Feng, Melissa Richard-Greenblatt, Emily Hutson, Stefen Andrianus, Laurel J Glaser, Kyle G Rodino, Jianing Qian, Dinesh Jayaraman, Ronald G Collman, Abigail Glascock, Frederic D Bushman, Jae Seung Lee, Sara Cherry, Alejandra Fausto, Susan R Weiss, Hyun Koo, Patricia M Corby, Alfonso Oceguera, Una O'Doherty, Alfred L Garfall, Dan T Vogl, Edward A Stadtmauer, Ping Wang,

<h4>Background</h4>High-sensitivity severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen assays are desirable to mitigate false negative results. Limited data are available to quantify and track SARS-CoV-2 antigen burden in respiratory samples from different populations.<h4>Methods</h4>We developed the Microbubbling SARS-CoV-2 Antigen Assay (MSAA) with smartphone readout, with a limit of detection of ... Read more >>

Clin Chem (Clinical chemistry)
[2021, 68(1):230-239]

Cited: 2 times

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733. Carbapenem-Resistant Enterobacterales (CRE) Colonization Prevalence in Botswana: an Antibiotic Resistance in Communities and Hospitals (ARCH) Study

Naledi Mannathoko, Mosepele Mosepele, Rachel Smith, Robert Gross, Laurel Glaser, Kevin Alby, Melissa Richard-Greenblatt, Aditya Sharma, Anne Jaskowiak, Kgotlaetsile Sewawa, Emily Reesey, Laura Cowden, Leigh Cressman, Dimpho Otukile, Giacomo Paganotti, Margaret Mokomane, Ebbing Lautenbach,

Abstract <h4>Background</h4> Although CRE are a global threat, data in low- and middle-income countries are scarce. Colonization data are vital for informing antibiotic resistance strategies. We characterized the colonization prevalence of CRE in various settings in Botswana. <h4>Methods</h4> This study was conducted in 3 districts in Botswana (1 hospital and ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(Suppl 1):S464-S465]

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751. Impact of Changing from a Three-step to Two-step Testing Algorithm for the Diagnosis of Clostridioides difficile

Jonathan Lapin, Vasilios Athans, Shawn Binkley, Tiffany Lee, Sonal Patel, Melissa Richard-Greenblatt, Laurel Glaser, Keith W Hamilton, Stephen Saw,

Abstract <h4>Background</h4> The optimal method for laboratory diagnosis of Clostridioides difficile infection (CDI) remains undefined and national guidelines do not make a recommendation for a preferred diagnostic algorithm. Aiming to improve infection control measures, the Hospital of the University of Pennsylvania changed its testing process for the diagnosis of CDI ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(Suppl 1):S473-S473]

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82. Assessment of Clinical Outcomes and Antibiotic Prescribing Patterns Following Implementation of the GenMark ePlex® Blood Culture Identification Panel for Gram-positive Bloodstream Infections

Megan Wein, Shawn Binkley, Vasilios Athans, Stephen Saw, Tiffany Lee, Sonal Patel, Keith W Hamilton, Amanda Binkley, Kathleen Degnan, Laurel Glaser, Lauren Dutcher, Naasha J Talati, Melissa Richard-Greenblatt,

Abstract <h4>Background</h4> Rapid diagnostic testing (RDT) of bloodstream pathogens provides key information sooner than conventional identification and susceptibility testing. The GenMark ePlex® blood culture identification gram-positive (BCID-GP) panel is a molecular-based multiplex platform, with 20 Gram-positive target pathogens and 4 bacterial resistance genes that can be detected within 1.5 hours ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(Suppl 1):S157-S157]

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Imaging Sensitive and Drug-Resistant Bacterial Infection with [11C]-TMP: In Vitro and First-in-Human Evaluation

Iris Lee, Daniel Jacome, Joshua Cho, Vincent Tu, Anthony Young, Tiffany Dominguez, Justin Northrup, Jean Etersque, Hsiaoju Lee, Andrew Ruff, Ouniol Aklilu, Kyle Bittinger, Laurel Glaser, Daniel Dorgan, Denis Hadjiliadis, Rahul Kohli, Robert Mach, David Mankoff, Robert Doot, Mark Sellmyer,

Recently, several molecular imaging strategies have developed to image bacterial infections in humans. Nuclear approaches, specifically positron emission tomography (PET), affords sensitive detection and the ability to non-invasively locate infections deep within the body. Two key radiotracer classes have arisen: metabolic approaches targeting bacterial specific biochemical transformations, and antibiotic-based approaches ... Read more >>

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The Brief Case: A Variant on a Classic-Abiotrophia defectiva Endocarditis with Discitis.

Rebekah E Dumm, Anna Wing, Aaron Richterman, Jerry Jacob, Laurel J Glaser, Kyle G Rodino,

J Clin Microbiol (Journal of clinical microbiology)
[2021, 59(10):e0309320]

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Closing The Brief Case: A Variant on a Classic-Abiotrophia defectiva Endocarditis with Discitis.

Rebekah E Dumm, Anna Wing, Aaron Richterman, Jerry Jacob, Laurel J Glaser, Kyle G Rodino,

J Clin Microbiol (Journal of clinical microbiology)
[2021, 59(10):e0309420]

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Anemia in a young Guinean male.

Nicholas S Wilcox, Chantal Tapé, Anthony J Cordisco, Minh T Than, Leah Zuroff, Jane Dobkin, Ryan C Massa, Andrew G Lytle, Adam Bagg, Htun Min, Laurel J Glaser, Laura M Kosseim,

The etiology of anemia in adults is often multifactorial. This case highlights an uncommon combination of causes of anemia and the importance of a diagnostic workup guided by a patient's unique history, risk factors, and laboratory findings. ... Read more >>

Clin Case Rep (Clinical case reports)
[2021, 9(8):e04593]

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Quantifying the Impact of Nasopharyngeal Specimen Quality on Severe Acute Respiratory Syndrome Coronavirus 2 Test Performance.

Melissa Richard-Greenblatt, Matthew J Ziegler, Valerie Bromberg, Elizabeth Huang, Hatem Abdallah, Pam Tolomeo, Ebbing Lautenbach, Laurel Glaser, Brendan J Kelly,

<h4>Background</h4>The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse-transcription polymerase chain reaction (RT-PCR) cycle threshold (Ct) has been used to estimate quantitative viral load, with the goal of targeting isolation precautions for individuals with coronavirus disease 2019 (COVID-19) and guiding public health interventions. However, variability in specimen quality can alter ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(6):ofab235]

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Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Dynamics Tracking

Hui Chen, Zhao Li, Sheng Feng, Anni Wang, Melissa Richard-Greenblatt, Emily Hutson, Stefen Andrianus, Laurel Glaser, Kyle Rodino, Jianing Qian, Dinesh Jayaraman, Ronald Collman, Abigail Glascock, Frederic Bushman, Jae Seung Lee, Sara Cherry, Alejandra Fausto, Susan Weiss, Hyun Koo, Patricia Corby, Una O’Doherty, Alfred Garfall, Dan Vogl, Edward Stadtmauer, Ping Wang,

<h4>Background</h4> Little is known about the dynamics of SARS-CoV-2 antigen burden in respiratory samples in different patient populations at different stages of infection. Current rapid antigen tests cannot quantitate and track antigen dynamics with high sensitivity and specificity in respiratory samples. <h4>Methods</h4> We developed and validated an ultra-sensitive SARS-CoV-2 antigen ... Read more >>

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Investigating hospital Mycobacterium chelonae infection using whole genome sequencing and hybrid assembly.

Christopher H Gu, Chunyu Zhao, Casey Hofstaedter, Pablo Tebas, Laurel Glaser, Robert Baldassano, Kyle Bittinger, Lisa M Mattei, Frederic D Bushman,

Mycobacterium chelonae is a rapidly growing nontuberculous mycobacterium that is a common cause of nosocomial infections. Here we describe investigation of a possible nosocomial transmission of M. chelonae at the Hospital of the University of Pennsylvania (HUP). M. chelonae strains with similar high-level antibiotic resistance patterns were isolated from two ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0236533]

Cited: 2 times

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Impact of Nasopharyngeal Specimen Quality on SARS-CoV-2 Test Sensitivity

Melissa Richard-Greenblatt, Matthew Ziegler, Valerie Bromberg, Elizabeth Huang, Hatem Abdallah, Pam Tolomeo, Ebbing Lautenbach, Laurel Glaser, Brendan Kelly,

<h4>Background</h4> The SARS-CoV-2 reverse-transcription polymerase chain reaction (RT-PCR) cycle of threshold (Ct) has been used to estimate quantitative viral load, with the goal of targeting isolation precautions for individuals with COVID-19 and guiding public health interventions. However, variability in specimen quality can alter the Ct values obtained from SARS-CoV-2 clinical ... Read more >>

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157. patient to Environment Transmission of Multidrug-resistant Bacteria Within Intensive Care Units

Matthew J Ziegler, Brendan Kelly, Michael Z David, Lauren Dutcher, Pam C Tolomeo, Selamawit Bekele, Sean Loughrey, Emily Reesey, Laurel Glaser, Ebbing Lautenbach,

Abstract <h4>Background</h4> Identifying risk factors for environmental contamination with multidrug-resistant organisms (MDROs) is essential to prioritize methods for prevention of hospital transmission. <h4>Methods</h4> Patients admitted to an ICU with an MDRO detected on clinical culture in the prior 30 days were enrolled. Patients (4 body sites) and high-touch objects (HTO) ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S207-S208]

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Investigating hospital Mycobacterium chelonae infection using whole genome sequencing and hybrid assembly

Christopher Gu, Chunyu Zhao, Casey Hofstaedter, Pablo Tebas, Laurel Glaser, Robert Baldassano, Kyle Bittinger, Lisa Mattei, Frederic Bushman,

Mycobacterium chelonae is a rapidly growing nontuberculous mycobacterium that is a common cause of nosocomial infections. Here we describe investigation of a possible nosocomial transmission of M. chelonae at the Hospital of the University of Pennsylvania (HUP). M. chelonae strains with similar high-level antibiotic resistance patterns were isolated from two ... Read more >>

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Draining dorsal hand pustules, nodules, and ulcers in a patient with immunosuppression.

Michael R Stephens, Oyinade Aderibigbe, Katherine T Steele, David E Elder, Laurel Glaser, Jerry Jacob, Misha Rosenbach,

JAAD Case Rep (JAAD case reports)
[2019, 5(10):846-848]

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Role of Ancillary Techniques in Fluid Cytology.

Gordon H Yu, Laurel J Glaser, Karen S Gustafson,

The cytologic evaluation of serous effusions may be challenging for a number of reasons. Distinction of benign, reactive conditions from malignancy represents the main focus when examining these specimens. The morphologic diagnosis of malignancy may be difficult due to the relative paucity of abnormal cells. In other situations, cellularity is ... Read more >>

Acta Cytol (Acta cytologica)
[2020, 64(1-2):52-62]

Cited: 1 time

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A Practical Guide to the Role of Ancillary Techniques in the Diagnosis of Infectious Agents in Fine Needle Aspiration Samples.

Laurel J Glaser, Kathleen T Montone,

Fine needle aspiration samples and small biopsies provide a minimally invasive diagnostic modality for mass lesions. When an infectious process is suspected based on initial evaluation, ancillary techniques can assist in making a specific diagnosis. Here we review the cytopathology that should prompt additional testing and review the availability and ... Read more >>

Acta Cytol (Acta cytologica)
[2020, 64(1-2):81-91]

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Identification of Clinically Relevant Mycobacterial Species After Extended Incubation Times in the BACTEC MGIT System.

Bryan Rea, Julia R Maisel, Laurel Glaser, Kevin Alby,

<h4>Objectives</h4>Traditionally, for mycobacterial culture both solid and broth media are used and routinely held for 6 weeks minimum to optimize yield. We retrospectively reviewed all positive mycobacterial cultures over a 12-month period to assess growth kinetics of clinically relevant isolates.<h4>Methods</h4>From January to December 2015, 658 positive mycobacteria cultures by solid ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2019, 151(1):63-67]

Cited: 1 time

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1525. Evaluation of Clinical Outcomes With Fosfomycin for E. coli and Non-E. coli Enterobacteriaceae Urinary Tract Infections

Tiffany Lee, Laurel Glaser, Kevin Alby,

Abstract Background Fosfomycin is a broad-spectrum oral antibiotic increasingly used for the treatment of uncomplicated and complicated urinary tract infections (UTIs). The Clinical and Laboratory Standards Institute (CLSI) does not support fosfomycin susceptibility testing on urinary isolates outside of Enterococcus faecalis and Escherichia coli. This is in light of building ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S473-S473]

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Bugs in inflammatory bowel disease - A questionable therapy.

Nya D Nelson, Laurel Glaser, Rashmi Tondon,

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2019, 51(2):323]

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Spinal epidural abscess caused by Gardnerella vaginalis and Prevotella amnii.

Leslie Stewart, Saurabh Sinha, Peter J Madsen, Laurel Glaser, H Isaac Chen, Matthew J Culyba,

We report a case of spinal epidural abscess (SEA) in a 58-year-old woman who had recently been diagnosed with gonococcal infection, but did not receive guideline-recommended therapy. She presented with back pain and signs and symptoms of pelvic inflammatory disease (PID). MRI of the spine demonstrated epidural abscess extending from ... Read more >>

Infect Dis Clin Pract (Baltim Md) (Infectious diseases in clinical practice (Baltimore, Md.))
[2018, 26(4):237-239]

Cited: 1 time

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Data from the analytical performance of the Abaxis Piccolo Xpress point of care analyzer in whole blood, serum, and plasma.

Kazunori Murata, Laurel Glaser, Mary Nardiello, Lakshmi V Ramanathan, Dean C Carlow,

The objective of this study was to examine the analytical performance of 14 comprehensive metabolic panel analytes on the Abaxis Piccolo Xpress® Point of Care analyzer in serum, plasma, and whole blood. A method comparison was performed on all three specimen types intended for use on the Piccolo Xpress®: serum, ... Read more >>

Data Brief (Data in brief)
[2018, 16:81-89]

Cited: 2 times

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Corynebacterium propinquum endocarditis: a confounding presentation of a rare entity.

Bryan Rea, Jaleah Hawkins, Htun Min, Richard Maniglia, Naasha Talati, Laurel Glaser,

Infective endocarditis is rarely caused by Corynebacterium species. We report a unique case of Corynebacterium propinquum endocarditis in an otherwise healthy individual, and it is the first example of this organism causing culture-negative endocarditis. Conflicting clinical and microbiological data led to the use of sequencing to confirm the causative organism. ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2017, 28:71-73]

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Analytical performance of the Abaxis Piccolo Xpress® point of care analyzer in whole blood, serum, and plasma.

Kazunori Murata, Laurel Glaser, Mary Nardiello, Shaun Richardson, Lakshmi V Ramanathan, Dean C Carlow,

<h4>Objectives</h4>To examine the analytical performance of 14 comprehensive metabolic panel analytes on the Abaxis Piccolo Xpress® Point of Care analyzer in serum, plasma, and whole blood.<h4>Design and methods</h4>Precision was evaluated by running two levels of control material over multiple days. Linearity was evaluated using material provided by the manufacturer and ... Read more >>

Clin Biochem (Clinical biochemistry)
[2015, 48(18):1344-1346]

Cited: 7 times

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