Full Text Journal Articles by
Author Laure F Pittet

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Management of Bacille Calmette-Guérin Lymphadenitis and Abscess in Immunocompetent Children: A Systematic Review.

Paola Villanueva, Laure F Pittet, Nigel Curtis,

<h4>Background</h4>There is no consensus on managing common adverse reactions to Bacille Calmette-Guérin (BCG) vaccination. We systematically reviewed the management of BCG-associated regional lymphadenitis and injection site abscess in immunocompetent individuals.<h4>Methods</h4>Searches of Medline, Embase and PubMed were done until November 2020. Randomized controlled trials (RCTs) and cohort studies that compared management ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(11):1037-1045]

Cited: 0 times

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Neonatal Bacille Calmette-Guérin Vaccination and Infections in the First Year of Life: The MIS BAIR Randomized Controlled Trial.

Nicole L Messina, Laure F Pittet, Kaya Gardiner, Bridget Freyne, Kate L Francis, Christel Zufferey, Veronica Abruzzo, Clare Morrison, Katrina J Allen, Katie L Flanagan, Anne-Louise Ponsonby, Roy Robins-Browne, Frank Shann, Mike South, Peter Vuillermin, Susan Donath, Dan Casalaz, Nigel Curtis,

<h4>Background</h4>Bacille Calmette-Guérin (BCG) vaccination has beneficial off-target effects that may include protecting against non-mycobacterial infectious diseases. We aimed to determine whether neonatal BCG vaccination reduces lower respiratory tract infections (LRTI) in infants in the Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR) trial.<h4>Methods</h4>In this investigator-blinded trial, neonates ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2021, 224(7):1115-1127]

Cited: 1 time

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Prevention of infant eczema by neonatal bacille Calmette-Guérin vaccination: The MIS BAIR randomized controlled trial.

Laure F Pittet, Nicole L Messina, Kaya Gardiner, Bridget Freyne, Veronica Abruzzo, Kate L Francis, Clare Morrison, Christel Zufferey, Peter Vuillermin, Katrina J Allen, Anne-Louise Ponsonby, Roy Robins-Browne, Frank Shann, Katie L Flanagan, Rod Phillips, Susan Donath, Dan Casalaz, Nigel Curtis,

<h4>Background</h4>Bacille Calmette-Guérin (BCG) vaccine could play a role in counteracting the rising prevalence of atopic diseases, through its beneficial off-target effects. We aimed to determine whether neonatal BCG vaccination reduces the incidence of eczema in infants.<h4>Methods</h4>Randomized controlled trial with 1272 infants allocated to receive BCG-Denmark or no BCG at birth. ... Read more >>

Allergy (Allergy)
[2021, :]

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Impact of antibiotic allergy labels on patient outcomes in a tertiary paediatric hospital.

Anthony C Catalano, Laure F Pittet, Sharon Choo, Ahuva Segal, David Stephens, Noel E Cranswick, Amanda Gwee,

<h4>Aims</h4>Antibiotic allergies are reported in 5-15% of children. This study aimed to evaluate the impact of common β-lactam antibiotic allergy labels (AALs) on hospital treatment, focusing on length of stay and appropriateness of antibiotic prescribing.<h4>Methods</h4>This was a retrospective cohort study over 21 months at the Royal Children's Hospital Melbourne, Australia. A ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2021, :]

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Candidemia in Children: A 16-year Longitudinal Epidemiologic Study.

Eloise J Silvester, Melissa M Y Watanabe, Laure F Pittet, Alison Boast, Penelope A Bryant, Gabrielle M Haeusler, Andrew J Daley, Nigel Curtis, Amanda Gwee,

<h4>Background</h4>Candida species are the most common cause of systemic fungal infections in children. Risk factors for candidemia vary in different patient populations, posing challenges for clinical prediction of infection. We describe the epidemiology and clinical disease of candidemia in children admitted to a tertiary pediatric hospital.<h4>Methods</h4>Retrospective audit of children ≤18 ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(6):537-543]

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Risk of Vaccine-Preventable Infections in Swiss Adults with Inflammatory Bowel Disease.

Laure F Pittet, Charlotte M Verolet, Pierre Michetti, Elsa Gaillard, Marc Girardin, Pascal Juillerat, Christian Mottet, Michel H Maillard, Claire-Anne Siegrist, Klara M Posfay-Barbe, ,

<h4>Background</h4>Patients with inflammatory bowel disease (IBD) have a higher risk of infection and are frequently not up to date with their immunizations.<h4>Objectives</h4>This study aims to review vaccination status and evaluate whether age, disease type, or treatment regimen could predict the absence of seroprotection against selected vaccine-preventable infection in adults with ... Read more >>

Digestion (Digestion)
[2021, :1-9]

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Postnatal Exposure to Herpes Simplex Virus: To Treat or Not to Treat?

Laure F Pittet, Nigel Curtis,

Neonatal herpes simplex virus (HSV) infection carries significant morbidity and mortality. In contrast to perinatal exposure, there are no clear guidelines for the management of postnatal HSV exposure. This review focuses on the risk of HSV infection following postnatal exposure and suggests an approach to management. While many infants are ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(5S):S16-S21]

Cited: 1 time

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Chlamydia pneumoniae and Mycoplasma pneumoniae in children with cystic fibrosis: impact on bacterial respiratory microbiota diversity.

Laure F Pittet, Claire Bertelli, Valentin Scherz, Isabelle Rochat, Chiara Mardegan, René Brouillet, Katia Jaton, Anne Mornand, Laurent Kaiser, Klara Posfay-Barbe, Sandra A Asner, Gilbert Greub,

<h4>Objectives</h4>The contribution of intracellular and fastidious bacteria in Cystic fibrosis (CF) pulmonary exacerbations, and progressive lung function decline remains unknown. This project aimed to explore their impact on bacterial microbiota diversity over time in CF children.<h4>Methods</h4>Sixty-one children enrolled in the MUCOVIB multicentre prospective cohort provided 746 samples, mostly nasopharyngeal swabs, ... Read more >>

Pathog Dis (Pathogens and disease)
[2021, 79(1):]

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Mycobacterium ulcerans-specific immune response after immunisation with bacillus Calmette-Guérin (BCG) vaccine.

Laure F Pittet, Marc Tebruegge, Binita Dutta, Susan Donath, Nicole Messina, Dan Casalaz, Willem A Hanekom, Warwick J Britton, Roy Robins-Browne, Nigel Curtis, Nicole Ritz, ,

<h4>Background</h4>Bacillus Calmette-Guérin (BCG) vaccine provides partial protection against Buruli ulcer caused by Mycobacterium ulcerans in epidemiological studies. This study aimed to quantify M. ulcerans-specific immune responses induced by BCG immunisation.<h4>Methods</h4>Intracellular cytokine analysis of in-vitro experiments done 10 weeks after BCG immunisation in 130 Australian infants randomised to one of three BCG ... Read more >>

Vaccine (Vaccine)
[2021, 39(4):652-657]

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Does bacillus Calmette-Guérin vaccine prevent herpes simplex virus recurrences? A systematic review.

Laure F Pittet, Nigel Curtis,

Recurrent infections with herpes simplex virus (HSV) in the orofacial (cold sores), ocular or genital region are common and sometimes disabling, calling for an effective preventive intervention. The bacillus Calmette-Guérin (BCG) vaccine has beneficial off-target effects that might impact recurrence of HSV infections. In this systematic review, Medline, EMBASE, and ... Read more >>

Rev Med Virol (Reviews in medical virology)
[2021, 31(1):1-9]

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Amoxicillin Course Length or Use in Childhood Pneumonia in Underserved Areas.

Laure F Pittet, Seilesh Kadambari, Yara-Natalie Abo,

N Engl J Med (The New England journal of medicine)
[2020, 383(14):1391-1392]

Cited: 0 times

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Management and prevention of varicella and measles infections in pediatric solid organ transplant candidates and recipients: An IPTA survey of current practice.

Laure F Pittet, Lara Danziger-Isakov, Upton D Allen, Monica I Ardura, Abanti Chaudhuri, Elizabeth Goddard, Britta Höcker, Marian G Michaels, Dimitri Van der Linden, Michael Green, Klara M Posfay-Barbe,

<h4>Background</h4>Varicella and measles infections can be life-threatening after solid organ transplantation (SOT) but may be preventable with live-attenuated vaccines (LAV).<h4>Methods</h4>This survey conducted in January 2019 among subscribers of the International Pediatric Transplantation Association listserv aimed to explore the current strategies to prevent and manage both infections in the pediatric SOT ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, 24(8):e13830]

Cited: 0 times

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Are decontamination measures effective in preventing recurrent staphylococcal skin infection in children?

Laure F Pittet, Nigel Curtis,

Arch Dis Child (Archives of disease in childhood)
[2020, 105(6):603-607]

Cited: 0 times

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Missed vaccinations and critical care admission: all you may wish to know or rediscover-a narrative review.

Laure F Pittet, Mohamed Abbas, Claire-Anne Siegrist, Didier Pittet,

Most vaccines are so effective that they could lead to the control/elimination of the diseases they target and directly impact on intensive care admissions or complications. This is best illustrated by the use of vaccines against Haemophilus influenzae type b, Streptococcus pneumoniae, zoster, yellow fever, Ebola virus, influenza or measles-but ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(2):202-214]

Cited: 1 time

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Long-term Seroprotection of Varicella-zoster Immunization in Pediatric Liver Transplant Recipients.

Charlotte M Verolet, Laure F Pittet, Barbara E Wildhaber, Valérie A McLin, Maria Rodriguez, Stéphane Grillet, Claire-Anne Siegrist, Klara M Posfay-Barbe,

<h4>Background</h4>Chickenpox is a highly contagious vaccine-preventable disease that can lead to severe complications, especially in immunocompromised patients. Varicella-zoster virus (VZV) vaccine appears to be safe and immunogenic in pediatric solid organ transplant recipients, but there are few data on the long-term vaccine-induced seroprotection.<h4>Methods</h4>In this prospective interventional study, we offered 2 ... Read more >>

Transplantation (Transplantation)
[2019, 103(11):e355-e364]

Cited: 2 times

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Atypical pulmonary lesion in a young patient: One train may hide another, do not forget tuberculosis.

Laure F Pittet, Isabelle Rochat, Chiara Simoni, Mengu Ma Tooh, Carole Gengler, Pierre-Alex Crisinel,

Pediatr Pulmonol (Pediatric pulmonology)
[2020, 55(2):278-279]

Cited: 0 times

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Does oral antiviral suppressive therapy prevent recurrent herpes labialis in children?

Laure F Pittet, Nigel Curtis,

Arch Dis Child (Archives of disease in childhood)
[2019, 104(9):916-919]

Cited: 1 time

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High Immunogenicity of the Pneumococcal Conjugated Vaccine in Immunocompromised Adults With Inflammatory Bowel Disease.

Laure F Pittet, Charlotte M Verolet, Pierre Michetti, Marc Girardin, Pascal Juillerat, Christian Mottet, Michel H Maillard, Claire-Anne Siegrist, Klara M Posfay-Barbe, ,

<h4>Introduction</h4>Patients with inflammatory bowel disease (IBD) are predisposed to pneumococcal infections due to their underlying disease and iatrogenic immunosuppression. Vaccination with the 13-valent pneumococcal conjugated vaccine (PCV13) is recommended, but with poor take-up and few data available. We performed an open-label, phase IV, multicenter study to evaluate the safety and ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2019, 114(7):1130-1141]

Cited: 2 times

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Multimodal safety assessment of measles-mumps-rubella vaccination after pediatric liver transplantation.

Laure F Pittet, Charlotte M Verolet, Valérie A McLin, Barbara E Wildhaber, Maria Rodriguez, Pascal Cherpillod, Laurent Kaiser, Claire-Anne Siegrist, Klara M Posfay-Barbe,

Live-attenuated vaccines are currently contraindicated in solid-organ transplant recipients. However, the risk of vaccine-preventable infections is lifelong, and can be particularly severe after transplantation. In this prospective interventional national cohort study, 44 pediatric liver transplant recipients with measles IgG antibodies <150 IU/L (below seroprotection threshold) received measles-mumps-rubella vaccine (MMR) at ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2019, 19(3):844-854]

Cited: 4 times

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Optimizing seroprotection against pneumococcus in children with nephrotic syndrome using the 13-valent pneumococcal conjugate vaccine.

Laure F Pittet, Klara M Posfay-Barbe, Hassib Chehade, Christoph Rudin, Alexandra Wilhelm-Bals, Maria Rodriguez, Claire-Anne Siegrist, Paloma Parvex,

<h4>Background</h4>Infections are among the main life-threatening complications in patients with nephrotic syndrome (NS), in particular with Streptococcus pneumoniae, the first cause of bacterial peritonitis and sepsis in these patients. This study aims to evaluate the baseline seroprotection of NS patients against S. pneumoniae, and immunize them with the 13-valent pneumococcal ... Read more >>

Vaccine (Vaccine)
[2016, 34(41):4948-4954]

Cited: 4 times

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Bordetella holmesii: Still Emerging and Elusive 20 Years On.

Laure F Pittet, Klara M Posfay-Barbe,

Since the first description of Bordetella holmesii in 1995, almost 100 publications have contributed to the increasing knowledge of this emerging bacterium. Although first reported to induce bacteremia mainly in immunocompromised patients, it has also been isolated in healthy persons and has shown the capacity to induce pertussis-like symptoms and ... Read more >>

Microbiol Spectr (Microbiology spectrum)
[2016, 4(2):]

Cited: 3 times

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Striking but benign: acute haemorrhagic oedema of infancy.

Laure F Pittet, Johan N Siebert, Laurence E Lacroix,

Lancet (Lancet (London, England))
[2015, :]

Cited: 1 time

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Bordetella holmesii infection: current knowledge and a vision for future research.

Laure F Pittet, Klara M Posfay-Barbe,

Bordetella holmesii is a recently recognized Gram-negative bacterium causing both pertussis-like respiratory symptoms and invasive infections, such as bacteremia, pneumonia, meningitis, arthritis, pericarditis and endocarditis. Few data are available on its epidemiological characteristics, mostly related to respiratory infections. However, these are frequently misdiagnosed as a Bordetella pertussis infection as most ... Read more >>

Expert Rev Anti Infect Ther (Expert review of anti-infective therapy)
[2015, 13(8):965-971]

Cited: 3 times

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Effect of glucocorticoids on growth and bone mineral density in children with nephrotic syndrome.

Diana Ribeiro, Sophie Zawadynski, Laure F Pittet, Thierry Chevalley, Eric Girardin, Paloma Parvex,

<h4>Unlabelled</h4>Glucocorticosteroids (GCs) are the first-line treatment for idiopathic nephrotic syndrome (NS), but prolonged administration interferes with growth and bone mineralization. We conducted a retrospective study to analyze the long-term impact of prednisone on growth and bone mineral density (BMD) in children with NS. Data from children with NS followed during ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2015, 174(7):911-917]

Cited: 17 times

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Diagnosis of whooping cough in Switzerland: differentiating Bordetella pertussis from Bordetella holmesii by polymerase chain reaction.

Laure F Pittet, Stéphane Emonet, Patrice François, Eve-Julie Bonetti, Jacques Schrenzel, Melanie Hug, Martin Altwegg, Claire-Anne Siegrist, Klara M Posfay-Barbe,

Bordetella holmesii, an emerging pathogen, can be misidentified as Bordetella pertussis by routine polymerase chain reaction (PCR). In some reports, up to 29% of the patients diagnosed with pertussis have in fact B. holmesii infection and invasive, non-respiratory B. holmesii infections have been reported worldwide. This misdiagnosis undermines the knowledge ... Read more >>

PLoS One (PloS one)
[2014, 9(2):e88936]

Cited: 10 times

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