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Author Laura Maria Krabbe

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Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer.

David D'Andrea, Peter C Black, Homayoun Zargar, Kamran Zargar-Shoshtari, Francesco Soria, Adrian S Fairey, Laura S Mertens, Colin P Dinney, Maria C Mir, Laura-Maria Krabbe, Michael S Cookson, Niels-Erik Jacobsen, Jeffrey S Montgomery, Nikhil Vasdev, Evan Y Yu, Evanguelos Xylinas, Nicholas J Campain, Wassim Kassouf, Marc A Dall'Era, Jo-An Seah, Cesar E Ercole, Simon Horenblas, Srikala S Sridhar, John S McGrath, Jonathan Aning, Jonathan L Wright, Andrew C Thorpe, Todd M Morgan, Jeff M Holzbeierlein, Trinity J Bivalacqua, Scott North, Daniel A Barocas, Yair Lotan, Petros Grivas, Andrew J Stephenson, Jay B Shah, Bas W van Rhijn, Siamak Daneshmand, Philippe E Spiess, Shahrokh F Shariat,

<h4>Purpose</h4>To assess the association of patient age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer (MIBC).<h4>Materials and methods</h4>We analyzed data from 1105 patients with MIBC. Patients age was evaluated as continuous variable and stratified in quartiles. Pathologic objective response (pOR; ypT0-Ta-Tis-T1N0) and pathologic complete response (pCR; ypT0N0), ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Discrepancy between German S3 Guideline Recommendations and Daily Urologic Practice in the Management of Nonmuscle Invasive Bladder Cancer: Results of a Binational Survey.

Julian P Struck, Martin J P Hennig, Marie C Hupe, Nadim Moharam, Pia Paffenholz, Tim Nestler, Tanja Frank, Thomas S Worst, Markus Grabbert, Philippe-Fabian Pohlmann, Serkan Dogan, Sebastian L Hofbauer, Charis Kalogirou, Angelika Mattigk, Maximilian P Brandt, Laura-Maria Krabbe, Henning Reis, Franz F Dressler, Mario W Kramer, Johannes Salem,

<h4>Introduction</h4>Guideline recommendations are meant to help minimize morbidity and to improve the care of nonmuscle invasive bladder cancer (NMIBC) patients but studies have suggested an underuse of guideline-recommended care. The aim of this study was to evaluate the level of adherence of German and Austrian urologists to German guideline recommendations.<h4>Methods</h4>A ... Read more >>

Urol Int (Urologia internationalis)
[2021, :1-11]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, 80(4):507-515]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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[Treatment of metastatic renal cell carcinoma using targeted therapy].

Laura-Maria Krabbe,

Urologe A (Der Urologe. Ausg. A)
[2021, 60(1):89-93]

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Intravesical Bacillus Calmette-Guérin versus mitomycin C for Ta and T1 bladder cancer: Abridged summary of the Cochrane Review.

Stefanie Schmidt, Frank Kunath, Bernadette Coles, Desiree Louise Draeger, Laura-Maria Krabbe, Rick Dersch, Samuel Kilian, Katrin Jensen, Philipp Dahm, Joerg J Meerpohl,

Investig Clin Urol (Investigative and clinical urology)
[2020, 61(4):349-354]

Cited: 1 time

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Impact of sex on response to neoadjuvant chemotherapy in patients with bladder cancer.

David D'Andrea, Peter C Black, Homayoun Zargar, Kamran Zargar-Shoshtari, Sonja Zehetmayer, Adrian S Fairey, Laura S Mertens, Colin P Dinney, Maria C Mir, Laura-Maria Krabbe, Michael S Cookson, Niels-Erik Jacobsen, Jeffrey S Montgomery, Nikhil Vasdev, Evan Y Yu, Evanguelos Xylinas, Nicholas J Campain, Wassim Kassouf, Marc A Dall'Era, Jo-An Seah, Cesar E Ercole, Simon Horenblas, Srikala S Sridhar, John S McGrath, Jonathan Aning, Jonathan L Wright, Andrew C Thorpe, Todd M Morgan, Jeffrey M Holzbeierlein, Trinity J Bivalacqua, Scott North, Daniel A Barocas, Yair Lotan, Petros Grivas, Andrew J Stephenson, Jay B Shah, Bas W van Rhijn, Siamak Daneshmand, Philippe E Spiess, Shahrokh F Shariat,

<h4>Objective</h4>To assess the effect of patient's sex on response to neoadjuvant chemotherapy (NAC) in patients with clinically nonmetastatic muscle-invasive bladder cancer (MIBC).<h4>Methods</h4>Complete pathologic response, defined as ypT0N0 at radical cystectomy, and downstaging were evaluated using sex-adjusted univariable and multivariable logistic regression modeling. We used interaction terms to account for age ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(7):639.e1-639.e9]

Cited: 1 time

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Efficacy of Preoperative Chemotherapy for High Risk Upper Tract Urothelial Carcinoma.

Beat Foerster, Mohammad Abufaraj, Firas Petros, Mounsif Azizi, Mohit Gupta, Donald Schweitzer, Vitaly Margulis, Takehiro Iwata, Shoji Kimura, Ahmad Shabsigh, Alberto Briganti, Ja H Ku, Tim Muilwijk, Wassim Kassouf, Surena F Matin, Philippe E Spiess, Phillip M Pierorazio, Kees Hendricksen, Shahrokh F Shariat, ,

PURPOSE:The impact of preoperative chemotherapy in patients with upper urinary tract urothelial carcinoma remains poorly investigated. We assessed the rates of pathological complete response (pT0N0/X) and downstaging (pT1N0/X or less) at radical nephroureterectomy after preoperative chemotherapy and evaluated their impact on survival. MATERIALS AND METHODS:This was an international observational study ... Read more >>

J Urol (The Journal of urology)
[2020, 203(6):1101-1108]

Cited: 3 times

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Prognostic Implications of Immunohistochemical Biomarkers in Non-muscle-invasive Blad Cancer and Muscle-invasive Bladder Cancer.

Martin Boegemann, Laura-Maria Krabbe,

Urothelial carcinoma of the bladder (UCB) is a very heterogeneous disease and divided into invasive and non-invasive disease. In non-muscle-invasive bladder cancer (NMIBC), recurrence after transurethral resection or instillation-therapy, and progression to invasive disease are issues of concern. In muscle-invasive bladder cancer (MIBC), systemic recurrence after radical treatment is a ... Read more >>

Mini Rev Med Chem (Mini reviews in medicinal chemistry)
[2020, 20(12):1133-1152]

Cited: 2 times

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Intravesical Bacillus Calmette-Guérin versus mitomycin C for Ta and T1 bladder cancer.

Stefanie Schmidt, Frank Kunath, Bernadette Coles, Desiree Louise Draeger, Laura-Maria Krabbe, Rick Dersch, Samuel Kilian, Katrin Jensen, Philipp Dahm, Joerg J Meerpohl,

<h4>Background</h4>People with urothelial carcinoma of the bladder are at risk for recurrence and progression following transurethral resection of a bladder tumour (TURBT). Mitomycin C (MMC) and Bacillus Calmette-Guérin (BCG) are commonly used, competing forms of intravesical therapy for intermediate- or high-risk non-muscle invasive (Ta and T1) urothelial bladder cancer but ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2020, 1:CD011935]

Cited: 3 times

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Considerations for AR-V7 testing in clinical routine practice.

Christof Bernemann, Laura-Maria Krabbe, Andres Jan Schrader,

Ann Transl Med (Annals of translational medicine)
[2019, 7(Suppl 8):S378]

Cited: 0 times

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The prognostic value of the neutrophil-to-lymphocyte ratio in patients with muscle-invasive bladder cancer treated with neoadjuvant chemotherapy and radical cystectomy.

Anna J Black, Homayoun Zargar, Kamran Zargar-Shoshtari, Adrian S Fairey, Laura S Mertens, Colin P Dinney, Maria C Mir, Laura-Maria Krabbe, Michael S Cookson, Niels-Erik Jacobsen, Joshua Griffin, Jeffrey S Montgomery, Nikhil Vasdev, Evan Y Yu, Evanguelos Xylinas, Nicholas J Campain, Wassim Kassouf, Marc A Dall'Era, Jo-An Seah, Cesar E Ercole, Simon Horenblas, John S McGrath, Jonathan Aning, Shahrokh F Shariat, Jonathan L Wright, Andrew C Thorpe, Todd M Morgan, Jeff M Holzbeierlein, Trinity J Bivalacqua, Scott North, Daniel A Barocas, Yair Lotan, Petros Grivas, Andrew J Stephenson, Jay B Shah, Bas W van Rhijn, Philippe E Spiess, Siamak Daneshmand, Srikala S Sridhar, Peter C Black,

<h4>Introduction</h4>The neutrophil-to-lymphocyte ratio (NLR) is an attractive marker because it is derived from routine bloodwork. NLR has shown promise as a prognostic factor in muscle invasive bladder cancer (MIBC) but its value in patients receiving neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) is not yet established. Since NLR is related ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(1):3.e17-3.e27]

Cited: 5 times

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A prognostic score for overall survival in patients treated with abiraterone in the pre- and post-chemotherapy setting.

Martin Boegemann, Katrin Schlack, Lena Früchtenicht, Julie Steinestel, Andres Jan Schrader, Yvonne Wennmann, Laura-Maria Krabbe, Okyaz Eminaga,

<b>Background:</b> Therapy resistance remains a serious dilemma in metastatic castration-resistant prostate cancer (mCRPC) with primary or secondary resistance frequently occurring against any given therapy. Available prognostic models for Abiraterone Acetate (AA) are specifically designed for either pre- or post-chemotherapy settings and mostly based on trial datasets not necessarily reflecting real-life. ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(49):5082-5091]

Cited: 1 time

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External validation of a postoperative nomogram for the prediction of disease-specific survival in patients with papillary renal cell carcinoma using a large multicenter database.

Stefan Zastrow, Laura-Maria Krabbe, Ingmar Wolff, Umberto Capitanio, Tobias Klatte, Thorsten Ecke, Nina Huck, Hendrik Borgmann, Anna Scavuzzo, Luca Cindolo, Luigi Schips, Cristian Surcel, Cristian Mirvald, Antoni Vilaseca Cabo, Mireia Musquera, Georg Hutterer, Kristyna Prochazkova, Christian Stief, Manfred Wirth, Matthias May, Sabine Brookman-May,

<h4>Purpose</h4>Based on data retrieved from a comprehensive multicenter database, we externally validated a published postoperative nomogram for the prediction of disease-specific survival (DSS) in patients with papillary renal cell carcinoma (papRCC).<h4>Methods</h4>A multicenter database containing data of 2325 patients with surgically treated papRCC was used as validation cohort. After exclusion of ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2020, 25(1):145-150]

Cited: 2 times

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[Radical prostatectomy through the years].

Andres Jan Schrader, Johannes Müller, Martin Janssen, Laura-Maria Krabbe,

The operative aspect of radical prostatectomy has changed dramatically in the past 200 years as significant technological advances have been made, particularly during the past 50 years. The work of Dr. Walsh in the late 1970 s and early 1980 s led to a significant reduction in surgical morbidity and is considered ... Read more >>

Aktuelle Urol (Aktuelle Urologie)
[2019, 50(5):486-490]

Cited: 1 time

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Prognostic significance of BAP1 expression in high-grade upper tract urothelial carcinoma: a multi-institutional study.

Ahmet M Aydin, Nirmish Singla, Vandana Panwar, Solomon L Woldu, Yuval Freifeld, Christopher G Wood, Jose A Karam, Alon Z Weizer, Jay D Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Marco Roscigno, Christian Bolenz, Karim Bensalah, Mary E Westerman, Arthur I Sagalowsky, Shahrokh F Shariat, Yair Lotan, Aditya Bagrodia, Payal Kapur, Vitaly Margulis, Laura-Maria Krabbe,

<h4>Purpose</h4>To evaluate the prognostic value of BRCA1-associated protein-1 (BAP1) expression in upper tract urothelial carcinoma (UTUC), as BAP1 mutations have been associated with prognostic implications in urologic and non-urologic malignancies.<h4>Methods</h4>We reviewed a multi-institutional cohort of patients who underwent radical nephroureterectomy (RNU) for high-grade UTUC from 1990-2008. Immunohistochemistry (IHC) for BAP1 ... Read more >>

World J Urol (World journal of urology)
[2019, 37(11):2419-2427]

Cited: 2 times

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[Patients with prostate cancer bone metastases: can bisphosphonates help?]

Laura-Maria Krabbe,

Urologe A (Der Urologe. Ausg. A)
[2019, 58(3):314-318]

Cited: 0 times

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Development and external validation of a pathological nodal staging score for patients with clear cell renal cell carcinoma.

Malte Rieken, Stephen A Boorjian, Luis A Kluth, Umberto Capitanio, Alberto Briganti, R Houston Thompson, Bradley C Leibovich, Laura-Maria Krabbe, Vitaly Margulis, Jay D Raman, Mikhail Regelman, Pierre I Karakiewicz, Morgan Rouprêt, Mohammad Abufaraj, Beat Foerster, Mithat Gönen, Shahrokh F Shariat,

<h4>Objectives</h4>To develop and externally validate a model that quantifies the likelihood that a pathologically node-negative patient with clear cell renal cell carcinoma (cRCC) has, indeed, no lymph node metastasis (LNM).<h4>Patients and methods</h4>Data from 1389 patients treated with radical nephrectomy (RN) and lymph node dissection (LND) were analyzed. For external validation, ... Read more >>

World J Urol (World journal of urology)
[2019, 37(8):1631-1637]

Cited: 3 times

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Molecular markers in bladder cancer.

Francesco Soria, Laura-Maria Krabbe, Tilman Todenhöfer, Jakub Dobruch, Anirban P Mitra, Brant A Inman, Kilian M Gust, Yair Lotan, Shahrokh F Shariat, Shahrokh F Shariat,

<h4>Purpose</h4>Use of molecular markers in urine, tissue or blood offers potential opportunities to improve understanding of bladder cancer biology which may help identify disease earlier, risk stratify patients, improve prediction of outcomes or help target therapy.<h4>Methods</h4>A review of the published literature was performed, without restriction of time.<h4>Results</h4>Despite the fast-growing literature ... Read more >>

World J Urol (World journal of urology)
[2019, 37(1):31-40]

Cited: 17 times

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Practice Patterns and Impact of Postchemotherapy Retroperitoneal Lymph Node Dissection on Testicular Cancer Outcomes.

Solomon L Woldu, Joseph A Moore, Bo Ci, Yuval Freifeld, Timothy N Clinton, Ahmet M Aydin, Nirmish Singla, Krabbe Laura-Maria, Ryan C Hutchinson, James F Amatruda, Arthur Sagalowsky, Yair Lotan, Yull Arriaga, Vitaly Margulis, Yang Xie, Aditya Bagrodia,

<h4>Background</h4>Owing to surgical complexity and controversy regarding indications, there are wide practice variations in the use of postchemotherapy retroperitoneal lymph node dissection (PC-RPLND).<h4>Objective</h4>To evaluate patterns of PC-RPLND use in the USA and evaluate the association between PC-RPLND and survival in advanced nonseminomatous germ cell tumors (NSGCTs).<h4>Design setting and participants</h4>A retrospective, ... Read more >>

Eur Urol Oncol (European urology oncology)
[2018, 1(3):242-251]

Cited: 1 time

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Incidence and Outcomes of Delayed Targeted Therapy After Cytoreductive Nephrectomy for Metastatic Renal-Cell Carcinoma: A Nationwide Cancer Registry Study.

Solomon L Woldu, Justin T Matulay, Timothy N Clinton, Nirmish Singla, Yuval Freifeld, Oner Sanli, Laura-Maria Krabbe, Ryan C Hutchinson, Yair Lotan, Hans Hammers, Raquibul Hannan, James Brugarolas, Aditya Bagrodia, Vitaly Margulis,

<h4>Background</h4>The optimal timing of targeted therapy (TT) initiation for metastatic renal-cell carcinoma (mRCC) is not clear. We used a nationwide cancer registry to determine clinical and social factors associated with delayed TT and to evaluate the association of a delayed approach with overall survival (OS).<h4>Patients and methods</h4>We performed a retrospective ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2018, 16(6):e1221-e1235]

Cited: 3 times

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Molecularly-driven precision medicine for advanced bladder cancer.

Laura-Maria Krabbe, Vitaly Margulis, Andres Jan Schrader, Shahrokh F Shariat, Kilian M Gust, Martin Boegemann,

Urothelial carcinoma of the bladder is a heterogeneous disease with many challenges for clinicians and patients alike. However, for the most part of the last three decades, treatment and outcomes for patients with this disease have not changed a lot. With recent advances in immunooncology leading to the approval of ... Read more >>

World J Urol (World journal of urology)
[2018, 36(11):1749-1757]

Cited: 2 times

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Therapeutic strategies for upper tract urothelial carcinoma.

Yuval Freifeld, Laura-Maria Krabbe, Timothy N Clinton, Solomon L Woldu, Vitaly Margulis,

INTRODUCTION:Many controversies exist regarding the appropriate management of patients with upper tract urothelial carcinoma (UTUC), including staging, surgical management, use of systemic therapy, and prevention of bladder recurrence. Due to the rarity of this condition, high-level evidence is often lacking and in many cases guidelines are extrapolated from existing evidence ... Read more >>

Expert Rev Anticancer Ther (Expert review of anticancer therapy)
[2018, 18(8):765-774]

Cited: 1 time

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Multi-institutional evaluation of the prognostic significance of EZH2 expression in high-grade upper tract urothelial carcinoma.

Nirmish Singla, Laura-Maria Krabbe, Ahmet M Aydin, Vandana Panwar, Solomon L Woldu, Yuval Freifeld, Christopher G Wood, Jose A Karam, Alon Z Weizer, Jay D Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Marco Roscigno, Christian Bolenz, Karim Bensalah, Arthur I Sagalowsky, Shahrokh F Shariat, Yair Lotan, Aditya Bagrodia, Payal Kapur, Vitaly Margulis,

PURPOSE:Enhancer of zeste homolog 2 is a methyltransferase encoded by the EZH2 gene, whose role in upper tract urothelial carcinoma (UTUC) is poorly understood. We sought to evaluate the prognostic value of EZH2 expression in UTUC. METHODS:We reviewed a multi-institutional cohort of patients who underwent radical nephroureterectomy for high-grade UTUC ... Read more >>

Urol Oncol (Urologic oncology)
[2018, 36(7):343.e1-343.e8]

Cited: 2 times

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Discordance between Ureteroscopic Biopsy and Final Pathology for Upper Tract Urothelial Carcinoma.

Ezra J Margolin, Justin T Matulay, Gen Li, Xiaosong Meng, Brian Chao, Varun Vijay, Hayley Silver, Timothy N Clinton, Laura-Maria Krabbe, Solomon L Woldu, Nirmish Singla, Aditya Bagrodia, Vitaly Margulis, William C Huang, Marc A Bjurlin, Ojas Shah, Christopher B Anderson,

PURPOSE:We evaluated the discordance between ureteroscopic biopsy and surgical pathology findings for grading and staging upper tract urothelial carcinoma. We also sought to establish preoperative predictors of aggressive tumors. MATERIALS AND METHODS:We retrospectively reviewed the records of 314 patients who underwent ureteroscopic biopsy followed by surgical management of upper tract ... Read more >>

J Urol (The Journal of urology)
[2018, 199(6):1440-1445]

Cited: 12 times

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