Full Text Journal Articles by
Author Laura MacPherson


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HBO1 is required for the maintenance of leukaemia stem cells.

Laura MacPherson, Juliana Anokye, Miriam M Yeung, Enid Y N Lam, Yih-Chih Chan, Chen-Fang Weng, Paul Yeh, Kathy Knezevic, Miriam S Butler, Annabelle Hoegl, Kah-Lok Chan, Marian L Burr, Linden J Gearing, Tracy Willson, Joy Liu, Jarny Choi, Yuqing Yang, Rebecca A Bilardi, Hendrik Falk, Nghi Nguyen, Paul A Stupple, Thomas S Peat, Ming Zhang, Melanie de Silva, Catalina Carrasco-Pozo, Vicky M Avery, Poh Sim Khoo, Olan Dolezal, Matthew L Dennis, Stewart Nuttall, Regina Surjadi, Janet Newman, Bin Ren, David J Leaver, Yuxin Sun, Jonathan B Baell, Oliver Dovey, George S Vassiliou, Florian Grebien, Sarah-Jane Dawson, Ian P Street, Brendon J Monahan, Christopher J Burns, Chunaram Choudhary, Marnie E Blewitt, Anne K Voss, Tim Thomas, Mark A Dawson,

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks of AML have progressed into clinical trials, but most show only modest efficacy owing to an inability to effectively ... Read more >>

Nature (Nature)
[2020, 577(7789):266-270]

Cited: 4 times

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A Behavioral Activation Mobile Health App for Smokers With Depression: Development and Pilot Evaluation in a Single-Arm Trial.

Jaimee L Heffner, Noreen L Watson, Edit Serfozo, Kristin E Mull, Laura MacPherson, Melissa Gasser, Jonathan B Bricker,

BACKGROUND:The integration of Behavioral Activation Treatment for Depression (BAT-D) into smoking cessation interventions is a promising approach to address depression as a barrier to quitting. However, this approach has only been tested as a face-to-face intervention, which has low reach. OBJECTIVE:The aims of the study were to develop a BAT-D ... Read more >>

JMIR Form Res (JMIR formative research)
[2019, 3(4):e13728]

Cited: 0 times

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Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia.

Charles C Bell, Katie A Fennell, Yih-Chih Chan, Florian Rambow, Miriam M Yeung, Dane Vassiliadis, Luis Lara, Paul Yeh, Luciano G Martelotto, Aljosja Rogiers, Brandon E Kremer, Olena Barbash, Helai P Mohammad, Timothy M Johanson, Marian L Burr, Arindam Dhar, Natalie Karpinich, Luyi Tian, Dean S Tyler, Laura MacPherson, Junwei Shi, Nathan Pinnawala, Chun Yew Fong, Anthony T Papenfuss, Sean M Grimmond, Sarah-Jane Dawson, Rhys S Allan, Ryan G Kruger, Christopher R Vakoc, David L Goode, Shalin H Naik, Omer Gilan, Enid Y N Lam, Jean-Christophe Marine, Rab K Prinjha, Mark A Dawson,

Non-genetic drug resistance is increasingly recognised in various cancers. Molecular insights into this process are lacking and it is unknown whether stable non-genetic resistance can be overcome. Using single cell RNA-sequencing of paired drug naïve and resistant AML patient samples and cellular barcoding in a unique mouse model of non-genetic ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):2723]

Cited: 8 times

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Mental health stigma in depressed Latinos over the course of therapy: Results from a randomized controlled trial.

Anahi Collado, Michael Zvolensky, Carl Lejuez, Laura MacPherson,

OBJECTIVE:The current study examined the course, correlates, and predictors of mental health stigma among depressed, Spanish-speaking Latinos that were receiving treatment. This population faces significant disparities in mental health treatment and carries high levels of mental health stigma. METHOD:The study utilized data generated from a randomized clinical trial (N = 46) that ... Read more >>

J Clin Psychol (Journal of clinical psychology)
[2019, 75(7):1179-1187]

Cited: 0 times

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Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity.

Alvin Gomez, Christian Bindesbøll, Somisetty V Satheesh, Giulia Grimaldi, David Hutin, Laura MacPherson, Shaimaa Ahmed, Laura Tamblyn, Tiffany Cho, Hilde Irene Nebb, Anders Moen, Jan Haug Anonsen, Denis M Grant, Jason Matthews,

Here, we report the biochemical characterization of the mono-ADP-ribosyltransferase 2,3,7,8-tetrachlorodibenzo-p-dioxin poly-ADP-ribose polymerase (TIPARP/ARTD14/PARP7), which is known to repress aryl hydrocarbon receptor (AHR)-dependent transcription. We found that the nuclear localization of TIPARP was dependent on a short N-terminal sequence and its zinc finger domain. Deletion and in vitro ADP-ribosylation studies identified ... Read more >>

Biochem J (The Biochemical journal)
[2018, 475(23):3827-3846]

Cited: 5 times

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An experimental paradigm examining the influence of frustration on risk-taking behavior.

Jennifer M Loya, Katherine L McCauley, Andrea Chronis-Tuscano, Starr Z Chen, Abanoub Gad, Laura MacPherson, C W Lejuez,

The present study examined the impact of frustration on risk-taking in college students with low and high ADHD symptomatology (L-ADHD and H-ADHD). Participants completed the Balloon Analogue Risk Task (BART) following induced frustration from a mood manipulation task (experimental session) and following no mood manipulation (control session). A manipulation check ... Read more >>

Behav Processes (Behavioural processes)
[2019, 158:155-162]

Cited: 0 times

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The developmental trajectory of perceived stress mediates the relations between distress tolerance and internalizing symptoms among youth.

Julia W Felton, Anne N Banducci, Julia M Shadur, Ryan Stadnik, Laura MacPherson, Carl W Lejuez,

The current study examines the relation between distress tolerance, perceived stress, and internalizing symptoms across adolescence. Participants included 331 youth, ages 10 to 14 at the first wave of the study, assessed annually over 5 years. A latent growth curve approach was used to test three research questions, including whether ... Read more >>

Dev Psychopathol (Development and psychopathology)
[2017, 29(4):1391-1401]

Cited: 3 times

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Sex Differences in the Association between Heavy Drinking and Behavioral Distress Tolerance and Emotional Reactivity Among Non-Depressed College Students.

Paola Pedrelli, Laura MacPherson, Amanda J Khan, Benjamin G Shapero, Lauren B Fisher, Maren Nyer, Paolo Cassano, Lindsey Parnarouskis, Amy Farabaugh, Maurizio Fava, Marisa M Silveri,

Background:Heavy episodic drinking (HED) is a common behavior among college students that is associated with severe negative consequences. Negative reinforcement processes have been applied to elucidate mechanisms underlying relationships between consumption of alcohol and the desire to alleviate negative feelings. Distress tolerance (DT) and emotional reactivity are two mechanisms that ... Read more >>

Alcohol Alcohol (Alcohol and alcoholism (Oxford, Oxfordshire))
[2018, 53(6):674-681]

Cited: 0 times

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Early psychosocial deprivation and adolescent risk-taking: The role of motivation and executive control.

Catalina Kopetz, Jacqueline I Woerner, Laura MacPherson, Carl W Lejuez, Charles A Nelson, Charles H Zeanah, Nathan A Fox,

Risk-taking in adolescence has been often associated with early life adversities. However, the impact of such macrolevel factors on risk behavior has been rarely studied in humans. To address these gaps we recruited a sample of young adolescents who were part of a randomized control trial of foster care. Children ... Read more >>

J Exp Psychol Gen (Journal of experimental psychology. General)
[2019, 148(2):388-399]

Cited: 1 time

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Distress Tolerance Interacts With Negative Life Events to Predict Depressive Symptoms Across Adolescence.

Julia W Felton, Anahi Collado, Mazneen Havewala, Julia M Shadur, Laura MacPherson, Carl W Lejuez,

Adolescence is a vulnerable period for the development of depressive disorders. Recent research has demonstrated the importance of distress tolerance in the onset and maintenance of depression during adulthood; however, little is known about its role in predicting depressive symptoms among adolescents. The current study examines the effect of distress ... Read more >>

J Clin Child Adolesc Psychol (Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53)
[2019, 48(4):633-642]

Cited: 1 time

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Native freshwater species get out of the way: Prussian carp (Carassius gibelio) impacts both fish and benthic invertebrate communities in North America.

Jonathan L W Ruppert, Cassandra Docherty, Kenton Neufeld, Kyle Hamilton, Laura MacPherson, Mark S Poesch,

Prussian carp (Carassius gibelio) are one of the most noxious non-native species in Eurasia. Recently, Prussian carp, a non-native freshwater fish species, were genetically confirmed in Alberta, Canada and have been rapidly expanding their range in North America since establishment. Given their rapid range expansion, there is an increasing need ... Read more >>

R Soc Open Sci (Royal Society open science)
[2017, 4(10):170400]

Cited: 0 times

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Survival of the Fittest: Darwinian Selection Underpins Chemotherapy Resistance in AML.

Laura MacPherson, Mark A Dawson,

Intratumor heterogeneity driving therapeutic resistance is a major challenge in cancer management. Recently in Nature, Shlush et al. (2017) provide a tour de force of genomics coupled to functional assays to demonstrate that resistance emerges from a pre-existing subpopulation of acute myeloid leukemia (AML) cells with a stem cell transcription program. ... Read more >>

Cell Stem Cell (Cell stem cell)
[2017, 21(3):291-292]

Cited: 1 time

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The prospective relationship between distress tolerance and cigarette smoking expectancies in adolescence.

Julia M Shadur, Andrew L Ninnemann, Aaron Lim, Carl W Lejuez, Laura MacPherson,

The current study examined the prospective relationship between distress tolerance (DT) and positive and negative cigarette smoking outcome expectancies, which are reliable predictors of the onset and maintenance of smoking behaviors. Data from a longitudinal study (N = 204) examining risk behaviors in adolescence were used to assess whether DT ... Read more >>

Psychol Addict Behav (Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors)
[2017, 31(5):625-635]

Cited: 3 times

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Click chemistry enables preclinical evaluation of targeted epigenetic therapies.

Dean S Tyler, Johanna Vappiani, Tatiana Cañeque, Enid Y N Lam, Aoife Ward, Omer Gilan, Yih-Chih Chan, Antje Hienzsch, Anna Rutkowska, Thilo Werner, Anne J Wagner, Dave Lugo, Richard Gregory, Cesar Ramirez Molina, Neil Garton, Christopher R Wellaway, Susan Jackson, Laura MacPherson, Margarida Figueiredo, Sabine Stolzenburg, Charles C Bell, Colin House, Sarah-Jane Dawson, Edwin D Hawkins, Gerard Drewes, Rab K Prinjha, Raphaël Rodriguez, Paola Grandi, Mark A Dawson,

The success of new therapies hinges on our ability to understand their molecular and cellular mechanisms of action. We modified BET bromodomain inhibitors, an epigenetic-based therapy, to create functionally conserved compounds that are amenable to click chemistry and can be used as molecular probes in vitro and in vivo. We ... Read more >>

Science (Science (New York, N.Y.))
[2017, 356(6345):1397-1401]

Cited: 23 times

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Negative affect mediates the relation between trait urgency and behavioral distress tolerance.

Allison M Borges, Jennifer Dahne, Aaron C Lim, Laura MacPherson,

Distress tolerance is associated with a range of psychopathology and risk-taking behavior. Current research suggests that the behavioral ability to persist at goal-directed behavior when distressed may be malleable. However, little is known about the contributing factors that underlie individual differences in distress tolerance. Trait urgency, or the tendency to ... Read more >>

Emotion (Emotion (Washington, D.C.))
[2017, 17(4):707-716]

Cited: 3 times

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A Prospective Examination of the Relations Between Emotional Abuse and Anxiety: Moderation by Distress Tolerance.

Anne N Banducci, C W Lejuez, Lea R Dougherty, Laura MacPherson,

Anxiety, the most common and impairing psychological problem experienced by youth, is associated with numerous individual and environmental factors. Two such factors include childhood emotional abuse (CEA) and low distress tolerance (DT). The current study aimed to understand how CEA and low DT impacted anxiety symptoms measured annually across 5 years ... Read more >>

Prev Sci (Prevention science : the official journal of the Society for Prevention Research)
[2017, 18(1):20-30]

Cited: 4 times

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A novel training approach to activate alternative behaviors for smoking in depressed smokers.

Catalina Kopetz, Laura MacPherson, Avery D Mitchell, Alexandra N Houston-Ludlam, Reinout W Wiers,

The current research developed and tested a novel training strategy to alter the implicit associations between alternative behaviors to smoking and negative affect, and explored its effects on depressive symptoms and on smoking behavior as part of a quit attempt. Using a joystick, participants identified as smokers with depressive symptoms ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2017, 25(1):50-60]

Cited: 3 times

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Risk-Taking Propensity in Older Adolescents: Internalizing Symptoms, Gender, and Negative Reinforcement.

Jennifer Dahne, Aaron C Lim, Allison M Borges, Laura MacPherson,

OBJECTIVE:Engagement in risk behaviors, including substance use, risky sex, and violence, tends to increase throughout adolescence into young adulthood. One motivational process that may underlie risk behaviors during adolescence is negative reinforcement. Moreover, gender and internalizing symptoms (e.g., depression and anxiety) may both convey risk for negative reinforcement-based risk taking. ... Read more >>

Psychiatry (Psychiatry)
[2017, 80(3):252-264]

Cited: 0 times

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Emotion regulation mediates the association between ADHD and depressive symptoms in a community sample of youth.

Karen E Seymour, Andrea Chronis-Tuscano, Derek K Iwamoto, Gretchen Kurdziel, Laura Macpherson,

The purpose of this study was to examine the longitudinal relationship between attention-deficit/hyperactivity disorder (ADHD) symptoms, emotion regulation (ER) ability, and depressive symptoms within a diverse community sample of 277 youth, ages 9-12 (56 % male). Participants were drawn from a larger study examining adolescent risk behaviors, and completed annual assessments ... Read more >>

J Abnorm Child Psychol (Journal of abnormal child psychology)
[2014, 42(4):611-621]

Cited: 28 times

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Training responsibly to improve global surgical and anaesthesia capacity through institutional health partnerships: a case study.

Laura Macpherson, Maggie Collins,

Urgent investment in human resources for surgical and anaesthesia care is needed globally. Responsible training and education is required to ensure healthcare providers are confident and skilled in the delivery of this care in both the rural and the urban setting. The Tropical Health and Education Trust (THET), a UK-based ... Read more >>

Trop Doct (Tropical doctor)
[2017, 47(1):73-77]

Cited: 2 times

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Functional interdependence of BRD4 and DOT1L in MLL leukemia.

Omer Gilan, Enid Y N Lam, Isabelle Becher, Dave Lugo, Ester Cannizzaro, Gerard Joberty, Aoife Ward, Meike Wiese, Chun Yew Fong, Sarah Ftouni, Dean Tyler, Kym Stanley, Laura MacPherson, Chen-Fang Weng, Yih-Chih Chan, Margherita Ghisi, David Smil, Christopher Carpenter, Peter Brown, Neil Garton, Marnie E Blewitt, Andrew J Bannister, Tony Kouzarides, Brian J P Huntly, Ricky W Johnstone, Gerard Drewes, Sarah-Jane Dawson, Cheryl H Arrowsmith, Paola Grandi, Rab K Prinjha, Mark A Dawson,

Targeted therapies against disruptor of telomeric silencing 1-like (DOT1L) and bromodomain-containing protein 4 (BRD4) are currently being evaluated in clinical trials. However, the mechanisms by which BRD4 and DOT1L regulate leukemogenic transcription programs remain unclear. Using quantitative proteomics, chemoproteomics and biochemical fractionation, we found that native BRD4 and DOT1L exist ... Read more >>

Nat Struct Mol Biol (Nature structural & molecular biology)
[2016, 23(7):673-681]

Cited: 40 times

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Evaluation of the Environmental Supports Scale with a Community Sample of Adolescents.

Cristina M Risco, Anahi D Collado, Elizabeth K Reynolds, Carl W Lejuez, Laura MacPherson,

Environmental sources of psychosocial support have been found to modulate or protect against the development of psychopathology and risk behavior among adolescents. Capturing sources of environmental support across multiple developmental contexts requires the availability of well-validated, concise assessments-of which there are few in the existing literature. In order to address ... Read more >>

Prev Sci (Prevention science : the official journal of the Society for Prevention Research)
[2016, 17(4):493-502]

Cited: 1 time

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Depressive Symptoms and Cigarette Demand as a Function of Induced Stress.

Jennifer Dahne, James G Murphy, Laura MacPherson,

Depressed smokers may disproportionately value cigarettes as compared to other reinforcers in the context of increases in negative affect (NA). Thus, cigarette demand may be an important construct for understanding the relationship between depression, NA change, and tobacco use. The aim of the current study was to examine the interaction ... Read more >>

Nicotine Tob Res (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco)
[2017, 19(1):49-58]

Cited: 6 times

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Different pathways explain alcohol-related problems in female and male college students.

Paola Pedrelli, Anahi Collado, Benjamin G Shapero, Charlotte Brill, Laura MacPherson,

OBJECTIVES:Comprehensive models elucidating the intricate associations of depressive symptoms, coping motives, alcohol use, alcohol-related problems (ARPs), and gender among young adults have been scarcely examined. This study investigated relationships among these variables and the effect of gender on these pathways. METHODS:College students (N = 163; 49.7% female) completed self-report measures ... Read more >>

J Am Coll Health (Journal of American college health : J of ACH)
[2016, 64(7):535-544]

Cited: 3 times

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Pilot of the brief behavioral activation treatment for depression in latinos with limited english proficiency: preliminary evaluation of efficacy and acceptability.

Anahi Collado, Soraida D Castillo, Fabian Maero, C W Lejuez, Laura Macpherson,

Latinos with limited English proficiency (LEP) experience multiple barriers to accessing efficacious mental health treatments. Using a stage model of behavior therapy research, this Stage I investigation evaluated the Brief Behavioral Activation Treatment for Depression (BATD), an intervention that may be well equipped to address existing treatment barriers. A sample ... Read more >>

Behav Ther (Behavior therapy)
[2014, 45(1):102-115]

Cited: 16 times

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