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SAT-103 Extrauterine Growth Restriction (EUGR) in Preterm Infants: Incidence, Risk Factors, Nutrition, Auxological and Neurological Outcome.A Retrospective Study from 2010 to 2016.

Marta Del Pistoia, Maria Giulia Tozzi, Alessandra Carmignani, Massimiliano Ciantelli, Rosa Teresa Scaramuzzo, Francesca Moscuzza, Armando Maria Rosario Cuttano, Emilio Umberto Dino Sigali, Laura Lucaccioni,

AbstractEUGR is still a serious problem in very low birth weight preterm infants. The gradual improvement in neonatal intensive care has allowed the survival of newborns with increasing low weight and gestational age, with a higher incidence of major nutritional problems and diseases (Goldenberg 2008). EUGR was defined as growth ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(Suppl 1):]

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Health-Related Quality of Life and Metabolic Control in Immigrant and Italian Children and Adolescents with Type 1 Diabetes and in their Parents.

Barbara Predieri, Patrizia Bruzzi, Elena Bigi, Alessandra Boncompagni, Federica Bocchi, Valentina Cenciarelli, Simona F Madeo, Silvia Poluzzi, Marisa Pugliese, Carlotta Toffoli, Laura Lucaccioni, Lorenzo Iughetti,

OBJECTIVE:To determine if the diabetes-specific health-related quality of life (D-HRQOL) of young people with type 1 diabetes (T1D) and their parents is influenced by migrant status. SUBJECTS AND METHODS:One hundred and twenty-five patients (12.4±3.55 years, males 53.6%) with T1D and their parents (102 mothers, 37 fathers) were enrolled and categorized into: ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2020, :]

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Endocrine-Disrupting Chemicals and Their Effects during Female Puberty: A Review of Current Evidence.

Laura Lucaccioni, Viola Trevisani, Lucia Marrozzini, Natascia Bertoncelli, Barbara Predieri, Licia Lugli, Alberto Berardi, Lorenzo Iughetti,

Puberty is the process of physical changes between childhood and adulthood during which adolescents reach sexual maturity and become capable of reproduction. It is considered one of the main temporal windows of susceptibility for the influence of the endocrine-disrupting chemicals (EDCs). EDCs may act as single chemical agents or as ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(6):]

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Serial clinical observation for management of newborns at risk of early-onset sepsis.

Alberto Berardi, Luca Bedetti, Caterina Spada, Laura Lucaccioni, Adam Frymoyer,

PURPOSE OF REVIEW:Current management approaches for asymptomatic neonates at risk of early onset sepsis remain controversial. Strategies based entirely on clinical observation (SCO, serial clinical observation) have gained consensus. RECENT FINDINGS:We briefly compare different strategies for managing asymptomatic newborns suggested in four high-income countries. Then this review details the existing ... Read more >>

Curr. Opin. Pediatr. (Current opinion in pediatrics)
[2020, 32(2):245-251]

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Neuroprem: the Neuro-developmental outcome of very low birth weight infants in an Italian region.

Licia Lugli, Marisa Pugliese, Carlotta Plessi, Alberto Berardi, Isotta Guidotti, Gina Ancora, Sara Grandi, Giancarlo Gargano, Silvia Braibanti, Fabrizio Sandri, Silvia Soffritti, Elisa Ballardini, Vittoria Arena, Marcello Stella, Serafina Perrone, Sabrina Moretti, Vittoria Rizzo, Fabrizio Ferrari, , Odoardo Picciolini, Roberto Bellù, Daniela Turoli, Luigi Tommaso Corvaglia, Gianpaolo Garani, Vittoria Paoletti, Giacomo Biasucci, Augusto Biasini, Belinda Benenati, Paolo Stagi, Cristina Magnani, Sara Dallaglio, Elisa DellaCasa Muttini, Maria Federica Roversi, Luca Bedetti, Laura Lucaccioni, Natascia Bertoncelli, Alessandra Boncompagni,

INTRODUCTION:The survival of preterm babies has increased worldwide, but the risk of neuro-developmental disabilities remains high, which is of concern to both the public and professionals. The early identification of children at risk of neuro-developmental disabilities may increase access to intervention, potentially influencing the outcome. AIMS:Neuroprem is an area-based prospective ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):26]

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Intrapartum beta-lactam antibiotics for preventing group B streptococcal early-onset disease: can we abandon the concept of 'inadequate' intrapartum antibiotic prophylaxis?

Alberto Berardi, Caterina Spada, Eleonora Vaccina, Alessandra Boncompagni, Luca Bedetti, Laura Lucaccioni,

Introduction: Neonatal sepsis remains a serious and potentially fatal illness. Intrapartum antibiotic prophylaxis (IAP) prevents group B streptococcal (GBS) early-onset sepsis. The optimal duration of IAP (adequate IAP) to reduce vertical transmission of GBS has been debated. Understanding the mechanism of action of IAP may help in minimizing neonatal evaluation ... Read more >>

Expert Rev Anti Infect Ther (Expert review of anti-infective therapy)
[2020, 18(1):37-46]

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Epidemiology and complications of late-onset sepsis: an Italian area-based study.

Alberto Berardi, Francesca Sforza, Lorenza Baroni, Caterina Spada, Simone Ambretti, Giacomo Biasucci, Serenella Bolognesi, Mariagrazia Capretti, Edoardo Carretto, Matilde Ciccia, Marcello Lanari, Maria Federica Pedna, Vittoria Rizzo, Claudia Venturelli, Crisoula Tzialla, Laura Lucaccioni, Maria Letizia Bacchi Reggiani,

BACKGROUND:Most studies regarding late-onset sepsis (LOS) address selected populations (i.e., neonates with low birth weight or extremely preterm neonates). Studying all age groups is more suitable to assess the burden of single pathogens and their clinical relevance. METHODS:This is a retrospective regional study involving paediatric departments and NICUs in Emilia-Romagna ... Read more >>

PLoS ONE (PloS one)
[2019, 14(11):e0225407]

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Heart failure caused by VGAM: a lesson for diagnosis and treatment from a case and literature review.

Caterina Spada, Elisa Pietrella, Elisa Caramaschi, Patrizia Bergonzini, Alberto Berardi, Laura Lucaccioni, Lorenzo Iughetti,

We describe the case of a neonate with signs of heart failure. Echocardiography showed a structural normal heart shape with left ventricular dysfunction. At 2 months of age, a vein of Galen arteriovenous malformation was diagnosed through a brain magnetic resonance imaging. Embolization therapy was accomplished and a clinical and ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, :1-7]

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Motor and Postural Patterns Concomitant with General Movements Are Associated with Cerebral Palsy at Term and Fidgety Age in Preterm Infants.

Fabrizio Ferrari, Carlotta Plessi, Laura Lucaccioni, Natascia Bertoncelli, Luca Bedetti, Luca Ori, Alberto Berardi, Elisa Della Casa, Lorenzo Iughetti, Roberto D'Amico,

General movements (GMs) in combination with neurological examination and magnetic resonance imaging at term age can accurately determine the risk of cerebral palsy. The present study aimed to assess whether 11 motor and postural patterns concomitant with GMs were associated with cerebral palsy. Video recordings performed after birth in 79 ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(8):]

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Cerebral Palsy: Early Markers of Clinical Phenotype and Functional Outcome.

Christa Einspieler, Arend F Bos, Magdalena Krieber-Tomantschger, Elsa Alvarado, Vanessa M Barbosa, Natascia Bertoncelli, Marlette Burger, Olena Chorna, Sabrina Del Secco, Raye-Ann DeRegnier, Britta Hüning, Jooyeon Ko, Laura Lucaccioni, Tomoki Maeda, Viviana Marchi, Erika Martín, Catherine Morgan, Akmer Mutlu, Alice Nogolová, Jasmin Pansy, Colleen Peyton, Florian B Pokorny, Lucia R Prinsloo, Eileen Ricci, Lokesh Saini, Anna Scheuchenegger, Cinthia R D Silva, Marina Soloveichick, Alicia J Spittle, Moreno Toldo, Fabiana Utsch, Jeanetta van Zyl, Carlos Viñals, Jun Wang, Hong Yang, Bilge N Yardımcı-Lokmanoğlu, Giovanni Cioni, Fabrizio Ferrari, Andrea Guzzetta, Peter B Marschik,

The Prechtl General Movement Assessment (GMA) has become a cornerstone assessment in early identification of cerebral palsy (CP), particularly during the fidgety movement period at 3-5 months of age. Additionally, assessment of motor repertoire, such as antigravity movements and postural patterns, which form the Motor Optimality Score (MOS), may provide ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(10):]

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Worse global intellectual and worse neuropsychological functioning in preterm-born children at preschool age: a meta-analysis.

Elena Arpi, Roberto D'Amico, Laura Lucaccioni, Luca Bedetti, Alberto Berardi, Fabrizio Ferrari,

AIM:Preterm births (<32 weeks of gestational age) are associated with cognitive problems that are difficult to diagnose in infancy but potentially detectable at preschool age. This review aimed to evaluate the extent to which total intelligence quotient (IQ) and neuropsychological functions at ages three to five years differ between children born ... Read more >>

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2019, 108(9):1567-1579]

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Risk factors for group B streptococcus early-onset disease: an Italian, area-based, case-control study.

Alberto Berardi, Caterina Spada, Roberta Creti, Simone Ambretti, Rossana Chiarabini, Agostino Barozzi, Rossella Pagano, Mario Sarti, Maria Federica Pedna, Sara Fornaciari, Milena Azzalli, Icilio Dodi, Maria Letizia Bacchi Reggiani, Angela Lanzoni, Eleonora Vaccina, Lorenzo Iughetti, Laura Lucaccioni,

Purpose: Intrapartum antibiotic prophylaxis (IAP) prevents group B streptococcus (GBS) early-onset disease (EOD). No European study evaluates the relative impact of risk factors (RFs) for EOD after a screening-based strategy and widespread IAP use We aimed to evaluate the risks of EOD in an Italian region where a screening-based strategy ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, 33(14):2480-2486]

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Further Delineation of Pyridoxine-Responsive Pyridoxine Phosphate Oxidase Deficiency Epilepsy: Report of a New Case and Review of the Literature With Genotype-Phenotype Correlation.

Licia Lugli, Maria Carolina Bariola, Luca Ori, Laura Lucaccioni, Alberto Berardi, Fabrizio Ferrari,

In recent years, the clinical spectrum of pyridoxine phosphate oxidase (PNPO) deficiency has broadened. There are a growing number of patients with a transient or lasting response to pyridoxine in addition to cases that respond more traditionally to pyridoxal-phosphate. However, among pyridoxine-responsive patients with PNPO gene mutation, there are only ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2019, 34(14):937-943]

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Isolated hypoaldosteronism as first sign of X-linked adrenal hypoplasia congenita caused by a novel mutation in NR0B1/DAX-1 gene: a case report.

Lorenzo Iughetti, Laura Lucaccioni, Patrizia Bruzzi, Silvia Ciancia, Elena Bigi, Simona Filomena Madeo, Barbara Predieri, Florence Roucher-Boulez,

BACKGROUND:X-linked Adrenal Hypoplasia Congenita (AHC) is a rare cause of primary adrenal insufficiency due to mutations in the NR0B1 gene, causing a loss of function of the nuclear receptor protein DAX-1. Adrenal insufficiency usually appears in the first 2 months of life, but can sometimes emerge during childhood. Hypogonadotropic Hypogonadism ... Read more >>

BMC Med. Genet. (BMC medical genetics)
[2019, 20(1):98]

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Clinical characterization of neonatal and pediatric enteroviral infections: an Italian single center study.

Alberto Berardi, Marcello Sandoni, Carlotta Toffoli, Alessandra Boncompagni, William Gennari, Maria Barbara Bergamini, Laura Lucaccioni, Lorenzo Iughetti,

BACKGROUND:Enteroviruses (EVs) are an important cause of illness, especially in neonates and young infants. Clinical and laboratory findings at different ages, brain imaging, and outcomes have been inadequately investigated. METHODS:We retrospectively investigated EV infections occurring at an Italian tertiary care center during 2006-2017. Cases were confirmed with a positive polymerase ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2019, 45(1):94]

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Unusual meningitis caused by non-typhoid Salmonella in an Italian infant: a case report.

Monica Ficara, Valentina Cenciarelli, Lisa Montanari, Beatrice Righi, Simone Fontjin, Greta Cingolani, Barbara Predieri, Alberto Berardi, Laura Lucaccioni, Lorenzo Iughetti,

BACKGROUND:Non-typhoid Salmonella (NTS) is an important cause of bacterial meningitis in newborn and infants in developing countries, but rarely in industrialized ones. We describe an unusual presentation of bacterial meningitis in an infant, focusing on his diagnostic and therapeutic management. CASE REPORT:An Italian two-month old male presented high fever and ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(2):333-338]

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Severe metabolic alkalosis due to diuretic treatment in a patient with distal renal tubular acidosis: a rare association.

Laura Lucaccioni, Elena Coccolini, Alessandra Dozza, Sante Lucio Cantatore, Alberto Berardi, Barbara Predieri, Lorenzo Iughetti,

INTRODUCTION:Distal renal tubular acidosis is a rare genetic disease, characterised by deficit in renal tubular transport. Clinical features are metabolic acidosis with hypercloraemia and hypokalemia, and inability in urine acidification. Hypercalciuria may also be present, often treated with the use of a diuretic therapy with thiazides. CASE PRESENTATION:We present a ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(2):348-352]

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Group B Streptococcus early-onset disease and observation of well-appearing newborns.

Alberto Berardi, Caterina Spada, Maria Letizia Bacchi Reggiani, Roberta Creti, Lorenza Baroni, Maria Grazia Capretti, Matilde Ciccia, Valentina Fiorini, Lucia Gambini, Giancarlo Gargano, Irene Papa, Giancarlo Piccinini, Vittoria Rizzo, Fabrizio Sandri, Laura Lucaccioni, ,

BACKGROUND:International guidelines lack a substantial consensus regarding management of asymptomatic full-term and late preterm neonates at risk for early-onset disease (EOS). Large cohorts of newborns are suitable to increase the understanding of the safety and efficacy of a given strategy. METHODS:This is a prospective, area-based, cohort study involving regional birth ... Read more >>

PLoS ONE (PloS one)
[2019, 14(3):e0212784]

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Changes of intestinal microbiota in early life.

Monica Ficara, Elisa Pietrella, Caterina Spada, Elisa Della Casa Muttini, Laura Lucaccioni, Lorenzo Iughetti, Alberto Berardi,

There is an increasing evidence that the intestinal microbiota plays a pivotal role in the maturation of the immune system and in the prevention of diseases occurring during the neonatal period, childhood, and adulthood. A number of nonphysiological conditions during the perinatal period (i.e. caesarean section, prolonged hospitalization, formula feeding, ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, 33(6):1036-1043]

Cited: 2 times

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Brain-derived neurotrophic factor and epilepsy: a systematic review.

Lorenzo Iughetti, Laura Lucaccioni, Francesco Fugetto, Barbara Predieri, Alberto Berardi, Fabrizio Ferrari,

Several in vitro, ex vivo and in vivo studies imply brain-derived neurotrophic factor (BDNF) in the pathophysiology of epilepsy. Aim of our work is to report the most important findings regarding BDNF and its potential role in epilepsy. We targeted those publications addressing both in vitro and in vivo evidences ... Read more >>

Neuropeptides (Neuropeptides)
[2018, 72:23-29]

Cited: 6 times

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Shifting of the body center of gravity in low-risk preterm infants: A video-pedoscope study.

Natascia Bertoncelli, Laura Lucaccioni, Luca Ori, Christa Einspieler, Heinz F R Prechtl, Fabrizio Ferrari,

AIM:To evaluate whether there is any developmental course of the shifting of the center of gravity (COG) in healthy preterm infants. METHODS:Eleven healthy preterm infants were assessed on a computerized pedoscope from early preterm to term age. Data from the pedoscope and the videorecorder were analyzed with a special software ... Read more >>

Early Hum. Dev. (Early human development)
[2018, 124:33-37]

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Secondary prevention of early-onset sepsis: a less invasive Italian approach for managing neonates at risk.

Alberto Berardi, Chryssoula Tzialla, Laura Travan, Jenny Bua, Daniele Santori, Milena Azzalli, Caterina Spada, Laura Lucaccioni, ,

Strategies to prevent early-onset sepsis (EOS) have led to a substantial decline in many countries. However, one of the most controversial topics in neonatology is the management of asymptomatic full-term and late preterm neonates at risk for EOS, and guidelines lack substantial consensus regarding this issue. A strategy for managing ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2018, 44(1):73]

Cited: 1 time

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Pitfalls in the diagnosis of meningitis in neonates and young infants: the role of lumbar puncture.

Luca Bedetti, Lucia Marrozzini, Alessandro Baraldi, Elisabetta Spezia, Lorenzo Iughetti, Laura Lucaccioni, Alberto Berardi,

Meningitis occurs frequently in neonates and can lead to a number of acute, severe complications and long-term disabilities. An early diagnosis of neonatal meningitis is essential to reduce mortality and to improve outcomes. Initial clinical signs of meningitis are often subtle and frequently overlap with those of sepsis, and current ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, 32(23):4029-4035]

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Brain cooling reduces the risk of post-neonatal epilepsy in newborns affected by moderate to severe hypoxic-ischemic encephalopathy.

Licia Lugli, Eleonora Balestri, Alberto Berardi, Isotta Guidotti, Francesca Cavalleri, Alessandra Todeschini, Marisa Pugliese, Elisa Muttini Della Casa, Laura Lucaccioni, Fabrizio Ferrari,

Neonatal hypoxic-ischemic encephalopathy is still a significant cause of neonatal death and neurodevelopmental disabilities, such as cerebral palsy, mental delay, and epilepsy. After the introduction of therapeutic hypothermia, the prognosis of hypoxic-ischemic encephalopathy has improved, with reduction of death and disabilities. However, few studies evaluated whether hypothermia affects rate and ... Read more >>

Minerva Pediatr. (Minerva pediatrica)
[2018, :]

Cited: 1 time

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Strategies for preventing early-onset sepsis and for managing neonates at-risk: wide variability across six Western countries.

Alberto Berardi, Cecilia Rossi, Caterina Spada, Giulia Vellani, Isotta Guidotti, Angela Lanzoni, Milena Azzalli, Irene Papa, Chiara Giugno, Laura Lucaccioni, ,

Objective: Group B streptococcus (GBS) early-onset sepsis (EOS) has declined after widespread intrapartum antibiotic prophylaxis. However, strategies for preventing EOS may differ across countries. The analysis of their strategies allows to compare the effectiveness of prevention in different countries and suggests opportunities for improvement. Methods: We compared six western countries. ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, 32(18):3102-3108]

Cited: 2 times

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