Full Text Journal Articles by
Author Laura Ewing

Advertisement

Find full text journal articles






Evaluation of the U.S. Food and Drug Administration validated molecular method for detection of Cyclospora cayetanensis oocysts on fresh and frozen berries

Angela Assurian, Helen Murphy, Laura Ewing, Hediye Nese Cinar, Alexandre da Silva, Sonia Almeria,

Outbreaks and sporadic cases of Cyclospora cayetanensis have been linked to consumption of berries. The efficacy of the U.S. Food and Drug Administration (FDA) method for detection of C. cayetanensis was evaluated in fresh berries (blackberries, strawberries, blueberries and mixed berries) and in frozen mixed berries. The protocol included seeding ... Read more >>

Food Microbiol. (Food microbiology)
[2020, 87:Not Available]

Cited: 0 times

View full text PDF listing >>



Cannabidiol: From Drug Interaction Potential to Modulation of the Gut Microbiome.

Igor Kortubash, Charles Skinner, Laura Ewing, Mitchell McGill, Stefanie Kennon-McGill, Intawat Nookaew, Kristy Kutanzi, Charles Quick, Eric Yee, Larry Walker, Mahmoud ElSohly, Bill Gurley,

AbstractObjectivesCannabidiol (CBD) is the major non-psychotropic phytocannabinoid present in Cannabis sativa. In 2018, Congress designated select C. sativa cultivars as “hemp” removing them from the DEA's list of controlled substances. As a result, CBD-containing hemp extracts and other CBD products are now widely available and heavily marketed, yet their FDA ... Read more >>

Curr Dev Nutr (Current Developments in Nutrition)
[2020, 4(Suppl 2):418-418]

Cited: 0 times

View full text PDF listing >>



Advertisement

Green Tea Extract as a Safe and Effective Dietary Supplement: Lessons Learned from Mice.

Igor Kortubash, Laura Ewing, Charles Skinner, Intawat Nookaew, Bharathi Avula, Ikhlas Khan, Bill Gurley,

AbstractObjectivesGreen tea extracts (GTEs) are common ingredients among dietary supplements marketed for weight loss and weight management. However, GTEs and their various catechin polyphenols have also been linked to a number of hepatotoxicity cases.MethodsThe purpose of this study was to investigate, using various mouse models, the hepato- and cardiotoxic potential ... Read more >>

Curr Dev Nutr (Current Developments in Nutrition)
[2020, 4(Suppl 2):419-419]

Cited: 0 times

View full text PDF listing >>



Potential Probiotic or Trigger of Gut Inflammation - The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract.

Charles M Skinner, Intawat Nookaew, Laura E Ewing, Thidathip Wongsurawat, Piroon Jenjaroenpun, Charles M Quick, Eric U Yee, Brian D Piccolo, Mahmoud ElSohly, Larry A Walker, Bill Gurley, Igor Koturbash,

Cannabidiol (CBD) is the major non-psychotropic phytocannabinoid present in Cannabis sativa. In 2018, Congress designated certain C. sativa plant material as "hemp," thus removing it from the DEA's list of controlled substances. As a result, CBD-containing hemp extracts and other CBD products are now widely available and heavily marketed, yet ... Read more >>

J Diet Suppl (Journal of dietary supplements)
[2020, :1-18]

Cited: 0 times

View full text PDF listing >>



The Development and Characterization of an scFv-Fc Fusion-Based Gene Therapy to Reduce the Psychostimulant Effects of Methamphetamine Abuse.

Charles E Hay, Laura E Ewing, Michael D Hambuchen, Shannon M Zintner, Juliana C Small, Chris T Bolden, William E Fantegrossi, Paris Margaritis, S Michael Owens, Eric C Peterson,

Methamphetamine (METH) continues to be among the most addictive and abused drugs in the United States. Unfortunately, there are currently no Food and Drug Administration-approved pharmacological treatments for METH-use disorder. We have previously explored the use of adeno-associated viral (AAV)-mediated gene transfer of an anti-METH monoclonal antibody. Here, we advance ... Read more >>

J. Pharmacol. Exp. Ther. (The Journal of pharmacology and experimental therapeutics)
[2020, 374(1):16-23]

Cited: 0 times

View full text PDF listing >>



Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome.

Isabelle R Miousse, Laura E Ewing, Charles M Skinner, Rupak Pathak, Sarita Garg, Kristy R Kutanzi, Stepan Melnyk, Martin Hauer-Jensen, Igor Koturbash,

Methionine is an essential amino acid needed for a variety of processes in living organisms. Ionizing radiation depletes tissue methionine concentrations and leads to the loss of DNA methylation and decreased synthesis of glutathione. In this study, we aimed to investigate the effects of methionine dietary supplementation in CBA/CaJ mice ... Read more >>

Am. J. Physiol. Gastrointest. Liver Physiol. (American journal of physiology. Gastrointestinal and liver physiology)
[2020, 318(3):G439-G450]

Cited: 0 times

View full text PDF listing >>



Evaluation of the U.S. Food and Drug Administration validated molecular method for detection of Cyclospora cayetanensis oocysts on fresh and frozen berries.

Angela Assurian, Helen Murphy, Laura Ewing, Hediye Nese Cinar, Alexandre da Silva, Sonia Almeria,

Outbreaks and sporadic cases of Cyclospora cayetanensis have been linked to consumption of berries. The efficacy of the U.S. Food and Drug Administration (FDA) method for detection of C. cayetanensis was evaluated in fresh berries (blackberries, strawberries, blueberries and mixed berries) and in frozen mixed berries. The protocol included seeding ... Read more >>

Food Microbiol. (Food microbiology)
[2020, 87:103397]

Cited: 0 times

View full text PDF listing >>



Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.

Laura E Ewing, Charles M Skinner, Charles M Quick, Stefanie Kennon-McGill, Mitchell R McGill, Larry A Walker, Mahmoud A ElSohly, Bill J Gurley, Igor Koturbash,

The goal of this study was to investigate Cannabidiol (CBD) hepatotoxicity in 8-week-old male B6C3F1 mice. Animals were gavaged with either 0, 246, 738, or 2460 mg/kg of CBD (acute toxicity, 24 h) or with daily doses of 0, 61.5, 184.5, or 615 mg/kg for 10 days (sub-acute toxicity). These ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2019, 24(9):]

Cited: 1 time

View full text PDF listing >>



Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration.

Laura E Ewing, Mitchell R McGill, Eric U Yee, Charles M Quick, Charles M Skinner, Stefanie Kennon-McGill, Melissa Clemens, Joel H Vazquez, Sandra S McCullough, D Keith Williams, Kristy R Kutanzi, Larry A Walker, Mahmoud A ElSohly, Laura P James, Bill J Gurley, Igor Koturbash,

The goal of this study was to investigate the potential for a cannabidiol-rich cannabis extract (CRCE) to interact with the most common over-the-counter drug and the major known cause of drug-induced liver injury-acetaminophen (APAP)-in aged female CD-1 mice. Gavaging mice with 116 mg/kg of cannabidiol (CBD) [mouse equivalent dose (MED) ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2019, 24(12):]

Cited: 0 times

View full text PDF listing >>



The development and characterization of an scFv-Fc fusion based gene therapy to reduce the psychostimulant effects of methamphetamine abuse

Charles Hay, Laura Ewing, Michael Hambuchen, Shannon Zintner, Juliana Small, Chris Bolden, William Fantegrossi, Paris Margaritis, Michael Owens, Eric Peterson,

Abstract Methamphetamine (METH) continues to be amongst the most addictive and abused drugs in the US. Unfortunately, there are currently no FDA approved pharmacological treatments for METH substance abuse disorder. As an alternative approach, we have previously explored the use of Adeno-associated viral (AAV) mediated gene transfer of an anti-METH ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F₁ Mice.

Bill J Gurley, Isabelle R Miousse, Intawat Nookaew, Laura E Ewing, Charles M Skinner, Piroon Jenjaroenpun, Thidathip Wongsurawat, Stefanie Kennon-McGill, Bharathi Avula, Ji-Yeong Bae, Mitchell R McGill, David Ussery, Ikhlas A Khan, Igor Koturbash,

The main purpose of this study was to investigate the hepatotoxic potential and effects on the gut microbiome of decaffeinated green tea extract (dGTE) in lean B6C3F₁ mice. Gavaging dGTE over a range of 1X-10X mouse equivalent doses (MED) for up to two weeks did not elicit significant histomorphological, physiological, ... Read more >>

Nutrients (Nutrients)
[2019, 11(4):]

Cited: 1 time

View full text PDF listing >>



NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity.

Laura E Ewing, Isabelle R Miousse, Rupak Pathak, Charles M Skinner, Stanley Kosanke, Marjan Boerma, Martin Hauer-Jensen, Igor Koturbash,

Purpose: Growing rates of metabolic syndrome and associated obesity warrant the development of appropriate animal models for better understanding of how those conditions may affect sensitivity to IR exposure.Materials and methods: We subjected male NZO/HlLtJ mice, a strain prone to spontaneous obesity and diabetes, to 0, 5.5, 6.37, 7.4 or ... Read more >>

Int. J. Radiat. Biol. (International journal of radiation biology)
[2020, 96(1):93-99]

Cited: 0 times

View full text PDF listing >>



Draft genomes of Cronobacter sakazakii strains isolated from dried spices bring unique insights into the diversity of plant-associated strains.

Hyein Jang, Jungha Woo, Youyoung Lee, Flavia Negrete, Samantha Finkelstein, Hannah R Chase, Nicole Addy, Laura Ewing, Junia Jean Gilles Beaubrun, Isha Patel, Jayanthi Gangiredla, Athmanya Eshwar, Ziad W Jaradat, Kunho Seo, Srikumar Shabarinath, Séamus Fanning, Roger Stephan, Angelika Lehner, Ben D Tall, Gopal R Gopinath,

Cronobacter sakazakii is a Gram-negative opportunistic pathogen that causes life- threatening infantile infections, such as meningitis, septicemia, and necrotizing enterocolitis, as well as pneumonia, septicemia, and urinary tract and wound infections in adults. Here, we report 26 draft genome sequences of C. sakazakii, which were obtained from dried spices from ... Read more >>

Stand Genomic Sci (Standards in genomic sciences)
[2018, 13:35]

Cited: 2 times

View full text PDF listing >>



Convulsant Effects of Abused Synthetic Cannabinoids JWH-018 and 5F-AB-PINACA Are Mediated by Agonist Actions at CB1 Receptors in Mice.

Catheryn D Wilson, Sherrica Tai, Laura Ewing, Jasmine Crane, Taylor Lockhart, Ryochi Fujiwara, Anna Radominska-Pandya, William E Fantegrossi,

Convulsant effects of abused synthetic cannabinoid (SCB) drugs have been reported in humans and laboratory animals, but the mechanism of these effects is not known. We compared convulsant effects of partial CB1R agonist ∆9-tetrahydrocannabinol (THC), full CB1R agonist SCBs JWH-018 and 5F-AB-PINACA, and classic chemical convulsant pentylenetetrazol (PTZ) using an ... Read more >>

J. Pharmacol. Exp. Ther. (The Journal of pharmacology and experimental therapeutics)
[2019, 368(2):146-156]

Cited: 3 times

View full text PDF listing >>



Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro™ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments.

Charles M Skinner, Isabelle R Miousse, Laura E Ewing, Vijayalakshmi Sridharan, Maohua Cao, Haixia Lin, D Keith Williams, Bharathi Avula, Saqlain Haider, Amar G Chittiboyina, Ikhlas A Khan, Mahmoud A ElSohly, Marjan Boerma, Bill J Gurley, Igor Koturbash,

Herbal dietary supplement (HDS)-induced hepato- and cardiotoxicity is an emerging clinical problem. In this study, we investigated the liver and heart toxicity of HDS OxyELITE-PRO™ New Formula (OEP-NF), a dietary supplement marketed for weight loss and performance enhancement that was recently withdrawn from the market. Using a novel NZO/HlLtJ obese ... Read more >>

Food Chem. Toxicol. (Food and Chemical Toxicology)
[2018, 122:21-32]

Cited: 3 times

View full text PDF listing >>



Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse.

Charles E Hay, Guillermo A Gonzalez, Laura E Ewing, E Elizabeth Reichard, Michael D Hambuchen, Nisha Nanaware-Kharade, Sinthia Alam, Chris T Bolden, S Michael Owens, Paris Margaritis, Eric C Peterson,

Methamphetamine (METH) substance abuse disorders have major impact on society, yet no medications have proven successful at preventing METH relapse or cravings. Anti-METH monoclonal antibodies can reduce METH brain concentrations; however, this therapy has limitations, including the need for repeated dosing throughout the course of addiction recovery. An adeno-associated viral ... Read more >>

PLoS ONE (PloS one)
[2018, 13(6):e0200060]

Cited: 0 times

View full text PDF listing >>



Whole-Genome Sequences of Cronobacter sakazakii Isolates Obtained from Foods of Plant Origin and Dried-Food Manufacturing Environments.

Hyein Jang, Nicole Addy, Laura Ewing, Junia Jean-Gilles Beaubrun, YouYoung Lee, JungHa Woo, Flavia Negrete, Samantha Finkelstein, Ben D Tall, Angelika Lehner, Athmanya Eshwar, Gopal R Gopinath,

Here, we present draft genome sequences of 29 Cronobacter sakazakii isolates obtained from foods of plant origin and dried-food manufacturing facilities. Assemblies and annotations resulted in genome sizes ranging from 4.3 to 4.5 Mb and 3,977 to 4,256 gene-coding sequences with G+C contents of ∼57.0%. ... Read more >>

Genome Announc (Genome announcements)
[2018, 6(15):]

Cited: 2 times

View full text PDF listing >>



Evaluation of the Impact of Varied Carvacrol Concentrations on Salmonella Recovery in Oregano and How Corn Oil Can Minimize the Effect of Carvacrol during Preenrichment.

Junia Jean-Gilles Beaubrun, Nicole Addy, Zachary Keltner, Samantha Farris, Laura Ewing, Gopal Gopinath, Darcy E Hanes,

Phenolic compounds, like carvacrol, in oregano interfere with the detection of foodborne pathogens such as Salmonella enterica. Carvacrol concentration varies based on plant cultivars and growth region. Six oregano cultivars were used to compare the impact of carvacrol concentration on Salmonella and to evaluate the effectiveness of corn oil to ... Read more >>

J. Food Prot. (Journal of food protection)
[2018, 81(6):977-985]

Cited: 1 time

View full text PDF listing >>



DNA Methylation in Radiation-Induced Carcinogenesis: Experimental Evidence and Clinical Perspectives.

Isabelle R Miousse, Laura E Ewing, Kristy R Kutanzi, Robert J Griffin, Igor Koturbash,

Ionizing radiation is a valuable tool in many spheres of human life. At the same time, it is a genotoxic agent with a well-established carcinogenic potential. Progress achieved in the last two decades has demonstrated convincingly that ionizing radiation can also target the cellular epigenome. Epigenetics is defined as heritable ... Read more >>

Crit Rev Oncog (Critical reviews in oncogenesis)
[2018, 23(1-2):1-11]

Cited: 0 times

View full text PDF listing >>



MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects.

Haixia Lin, Laura E Ewing, Igor Koturbash, Bill J Gurley, Isabelle R Miousse,

MicroRNAs (miRNAs) are short regulatory RNAs that are involved in various biological processes that regulate gene expression posttranscriptionally. Changes in miRNA expression can be detected in many physiological and pathological events, such as liver injury. Drug induced liver injury is a life threatening condition that frequently requires organ transplantation. Hepatotoxicity ... Read more >>

Food Chem. Toxicol. (Food and Chemical Toxicology)
[2017, 110:229-239]

Cited: 8 times

View full text PDF listing >>



Evaluation of a multiplex PCR method to serotype Salmonella in animal feeds pre-enrichment broth cultures.

Junia Jean-Gilles Beaubrun, Laura Ewing, Kim Dudley, Faiza Benhamed, Hua Wang, Darcy E Hanes,

The identification of Salmonella enterica serotypes remains a highly important public health concern for microbiological analysis of foods, feeds, and clinical samples. Outbreaks of human salmonellosis are sometimes linked to contact with infected animals and animal feeds. To possibly reduce the number of outbreaks, it is important to rapidly, efficiently ... Read more >>

MethodsX (MethodsX)
[2017, 4:335-345]

Cited: 0 times

View full text PDF listing >>



Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains.

Isabelle R Miousse, Charles M Skinner, Haixia Lin, Laura E Ewing, Stanley D Kosanke, D Keith Williams, Bharathi Avula, Ikhlas A Khan, Mahmoud A ElSohly, Bill J Gurley, Igor Koturbash,

Herbal dietary supplements have gained wide acceptance as alternatives to conventional therapeutic agents despite concerns regarding their efficacy and safety. In 2013, a spate of severe liver injuries across the United States was linked to the dietary supplement OxyELITE Pro-New Formula (OEP-NF), a multi-ingredient product marketed for weight loss and ... Read more >>

Food Chem. Toxicol. (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association)
[2017, 109(Pt 1):194-209]

Cited: 9 times

View full text PDF listing >>



The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats.

Michael D Hambuchen, Howard P Hendrickson, Melinda G Gunnell, Samantha J McClenahan, Laura E Ewing, Dillon M Gibson, Michael D Berquist, S Michael Owens,

BACKGROUND:These studies investigated the serum pharmacokinetic (PK) profile of racemic (3,4)-methylenedioxypyrovalerone [(R,S)-MDPV)] and its (R)- and (S)-enantiomers in female and male Sprague Dawley rats. METHODS:Intravenous (R,S)-MDPV (3 and 5.6mg/kg) and single enantiomer of (R)- and (S)-MDPV (1.5mg/kg) were administered to both sexes for PK studies. Intraperitoneal (ip) bioavailability was determined ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2017, 179:347-354]

Cited: 1 time

View full text PDF listing >>



Evaluation of corn oil as an additive in the pre-enrichment step to increase recovery of Salmonella enterica from oregano

Junia Jean-Gilles Beaubrun, Chris Grim, Darcy E. Hanes, Gopal Gopinath, Karen Jarvis, Laura Ewing, Marie-Laure Flamer, Nicole Addy,

Phenolic compounds associated with essential oils of spices and herbs possess a variety of antioxidant and antimicrobial properties that interfere with Salmonella detection from fresh and dried products. Finding a compound to neutralize the effect of these antimicrobial compounds, while allowing Salmonella growth during pre-enrichment, is a crucial step in ... Read more >>

Food Microbiol. (Food microbiology)
[2016, 57:195-203]

Cited: 1 time

View full text PDF listing >>



Whole Genome DNA Sequence Analysis of Salmonella subspecies enterica serotype Tennessee obtained from related peanut butter foodborne outbreaks.

Mark R Wilson, Eric Brown, Chris Keys, Errol Strain, Yan Luo, Tim Muruvanda, Christopher Grim, Junia Jean-Gilles Beaubrun, Karen Jarvis, Laura Ewing, Gopal Gopinath, Darcy Hanes, Marc W Allard, Steven Musser,

Establishing an association between possible food sources and clinical isolates requires discriminating the suspected pathogen from an environmental background, and distinguishing it from other closely-related foodborne pathogens. We used whole genome sequencing (WGS) to Salmonella subspecies enterica serotype Tennessee (S. Tennessee) to describe genomic diversity across the serovar as well ... Read more >>

PLoS ONE (PloS one)
[2016, 11(6):e0146929]

Cited: 13 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0904 s