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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance.

M Raymond V Finlay, Peter Barton, Sue Bickerton, Michal Bista, Nicola Colclough, Darren A E Cross, Laura Evans, Nicolas Floc'h, Clare Gregson, Carine M Guérot, David Hargreaves, Xiaoming Kang, Eva M Lenz, Xu Li, Yi Liu, Olivier Lorthioir, Matthew J Martin, Darren McKerrecher, Claire McWhirter, Daniel O'Neill, Jonathan P Orme, Arash Mosallanejad, Amar Rahi, Paul D Smith, Verity Talbot, Richard A Ward, Gail Wrigley, Marta Wylot, Lin Xue, Tieguang Yao, Yang Ye, Xiliang Zhao,

The epidermal growth factor receptor (EGFR) harboring activating mutations is a clinically validated target in non-small-cell lung cancer, and a number of inhibitors of the EGFR tyrosine kinase domain, including osimertinib, have been approved for clinical use. Resistance to these therapies has emerged due to a variety of molecular events ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2021, 64(18):13704-13718]

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Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome.

Imran Sulaiman, Matthew Chung, Luis Angel, Jun-Chieh J Tsay, Benjamin G Wu, Stephen T Yeung, Kelsey Krolikowski, Yonghua Li, Ralf Duerr, Rosemary Schluger, Sara A Thannickal, Akiko Koide, Samaan Rafeq, Clea Barnett, Radu Postelnicu, Chang Wang, Stephanie Banakis, Lizzette Pérez-Pérez, Guomiao Shen, George Jour, Peter Meyn, Joseph Carpenito, Xiuxiu Liu, Kun Ji, Destiny Collazo, Anthony Labarbiera, Nancy Amoroso, Shari Brosnahan, Vikramjit Mukherjee, David Kaufman, Jan Bakker, Anthony Lubinsky, Deepak Pradhan, Daniel H Sterman, Michael Weiden, Adriana Heguy, Laura Evans, Timothy M Uyeki, Jose C Clemente, Emmie de Wit, Ann Marie Schmidt, Bo Shopsin, Ludovic Desvignes, Chan Wang, Huilin Li, Bin Zhang, Christian V Forst, Shohei Koide, Kenneth A Stapleford, Kamal M Khanna, Elodie Ghedin, Leopoldo N Segal,

Respiratory failure is associated with increased mortality in COVID-19 patients. There are no validated lower airway biomarkers to predict clinical outcome. We investigated whether bacterial respiratory infections were associated with poor clinical outcome of COVID-19 in a prospective, observational cohort of 589 critically ill adults, all of whom required mechanical ... Read more >>

Nat Microbiol (Nature microbiology)
[2021, 6(10):1245-1258]

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Toward Norepinephrine as a First-Line Treatment for All Hospitalized Patients With Hepatorenal Syndrome.

Cary H Paine, Raimund H Pichler, Laura Evans, Scott W Biggins,

Liver Transpl (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2021, 27(8):1087-1088]

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Variation in Initial U.S. Hospital Responses to the Coronavirus Disease 2019 Pandemic.

Kusum S Mathews, Kevin P Seitz, Kelly C Vranas, Abhijit Duggal, Thomas S Valley, Bo Zhao, Stephanie Gundel, Michael O Harhay, Steven Y Chang, Catherine L Hough, ,

<h4>Objectives</h4>The coronavirus disease 2019 pandemic has strained many healthcare systems. In response, U.S. hospitals altered their care delivery systems, but there are few data regarding specific structural changes. Understanding these changes is important to guide interpretation of outcomes and inform pandemic preparedness. We sought to characterize emergency responses across hospitals ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(7):1038-1048]

Cited: 1 time

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Twitches emerge postnatally during quiet sleep in human infants and are synchronized with sleep spindles.

Greta Sokoloff, James C Dooley, Ryan M Glanz, Rebecca Y Wen, Meredith M Hickerson, Laura G Evans, Haley M Laughlin, Keith S Apfelbaum, Mark S Blumberg,

In humans and other mammals, the stillness of sleep is punctuated by bursts of rapid eye movements (REMs) and myoclonic twitches of the limbs.<sup>1</sup> Like the spontaneous activity that arises from the sensory periphery in other modalities (e.g., retinal waves),<sup>2</sup> sensory feedback arising from twitches is well suited to drive ... Read more >>

Curr Biol (Current biology : CB)
[2021, 31(15):3426-3432.e4]

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Detection and genetic characterisation of Toxoplasma gondii circulating in free-range chickens, pigs and seropositive pregnant women in Benue state, Nigeria.

Ifeoma N Nzelu, Jacob K P Kwaga, Junaidu Kabir, Idris A Lawal, Christy Beazley, Laura Evans, Damer P Blake,

Toxoplasma gondii parasites present strong but geographically varied signatures of population structure. Populations sampled from Europe and North America have commonly been defined by over-representation of a small number of clonal types, in contrast to greater diversity in South America. The occurrence and extent of genetic diversity in African T. ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2021, 15(6):e0009458]

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Assessing real-world medication data completeness.

Laura Evans, Jack W London, Matvey B Palchuk,

<h4>Objective</h4>Analysis of healthcare Real-World Data (RWD) provides an opportunity to observe actual patient diagnostic, treatment and outcomes events. However, researchers should understand the possible limitations of RWD. In particular, these data may be incomplete, which would affect the validity of study conclusions.<h4>Materials and methods</h4>The completeness of medication RWD was investigated ... Read more >>

J Biomed Inform (Journal of biomedical informatics)
[2021, 119:103847]

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Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19.

Safia Kuriakose, Kanal Singh, Alice K Pau, Eric Daar, Rajesh Gandhi, Pablo Tebas, Laura Evans, Roy M Gulick, H Clifford Lane, Henry Masur, , Judith A Aberg, Adaora A Adimora, Jason Baker, Lisa Baumann Kreuziger, Roger Bedimo, Pamela S Belperio, Stephen V Cantrill, Craig M Coopersmith, Susan L Davis, Amy L Dzierba, John J Gallagher, David V Glidden, Birgit Grund, Erica J Hardy, Carl Hinkson, Brenna L Hughes, Steven Johnson, Marla J Keller, Arthur Y Kim, Jeffrey L Lennox, Mitchell M Levy, Jonathan Z Li, Greg S Martin, Susanna Naggie, Andrew T Pavia, Nitin Seam, Steven Q Simpson, Susan Swindells, Phyllis Tien, Alpana A Waghmare, Kevin C Wilson, Jinoos Yazdany, Philip Zachariah, Danielle M Campbell, Carly Harrison, Timothy Burgess, Joseph Francis, Virginia Sheikh, Timothy M Uyeki, Robert Walker, John T Brooks, Laura Bosque Ortiz, Richard T Davey, Laurie K Doepel, Robert W Eisinger, Alison Han, Elizabeth S Higgs, Martha C Nason, Page Crew, Andrea M Lerner, Claire Lund, Christopher Worthington,

The development of the National Institutes of Health (NIH) COVID-19 Treatment Guidelines began in March 2020 in response to a request from the White House Coronavirus Task Force. Within 4 days of the request, the NIH COVID-19 Treatment Guidelines Panel was established and the first meeting took place (virtually-as did ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2021, 174(8):1151-1158]

Cited: 1 time

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Trauma Laparotomy in the UK: A Prospective National Service Evaluation.

Max E R Marsden, Paul E D Vulliamy, Rich Carden, David N Naumann, Ross A Davenport, ,

<h4>Background</h4>Trauma patients requiring abdominal operation have considerable morbidity and mortality, yet no specific quality indicators are measured in the trauma systems of the UK. The aims of this study were to describe the characteristics and outcomes of patients undergoing emergency abdominal operation and key processes of care.<h4>Study design</h4>A prospective multicenter ... Read more >>

J Am Coll Surg (Journal of the American College of Surgeons)
[2021, 233(3):383-394.e1]

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Development and Validation of a Machine Learning Model to Estimate Bacterial Sepsis Among Immunocompromised Recipients of Stem Cell Transplant.

Margaret L Lind, Stephen J Mooney, Marco Carone, Benjamin M Althouse, Catherine Liu, Laura E Evans, Kevin Patel, Phuong T Vo, Steven A Pergam, Amanda I Phipps,

<h4>Importance</h4>Sepsis disproportionately affects recipients of allogeneic hematopoietic cell transplant (allo-HCT), and timely detection is crucial. However, the atypical presentation of sepsis within this population makes detection challenging, and existing clinical sepsis tools have limited prognostic value among this high-risk population.<h4>Objective</h4>To develop a full risk factor (demographic, transplant, clinical, and laboratory ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(4):e214514]

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Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study.

Pavan K Bhatraju, Eric D Morrell, Leila Zelnick, Neha A Sathe, Xin-Ya Chai, Sana S Sakr, Sharon K Sahi, Anthony Sader, Dawn M Lum, Ted Liu, Neall Koetje, Ashley Garay, Elizabeth Barnes, Jonathan Lawson, Gail Cromer, Mary K Bray, Sudhakar Pipavath, Bryan R Kestenbaum, W Conrad Liles, Susan L Fink, T Eoin West, Laura Evans, Carmen Mikacenic, Mark M Wurfel,

<h4>Background</h4>Analyses of blood biomarkers involved in the host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection can reveal distinct biological pathways and inform development and testing of therapeutics for COVID-19. Our objective was to evaluate host endothelial, epithelial and inflammatory biomarkers in COVID-19.<h4>Methods</h4>We prospectively enrolled 171 ICU ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):148]

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The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients.

Ishaq Lat, Craig M Coopersmith, Daniel De Backer, , , , , , , , , , , , , , , , , ,

<h4>Objective</h4>Expand upon the priorities of fluid resuscitation and vasopressor therapy research priorities identified by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.<h4>Data sources</h4>Original article, literature search.<h4>Study selection</h4>Several members of the original task force with expertise specific to the ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(4):623-635]

Cited: 3 times

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Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model.

Claudia De Fusco, Marianne Schimpl, Ulf Börjesson, Tony Cheung, Iain Collie, Laura Evans, Priyanka Narasimhan, Christopher Stubbs, Mercedes Vazquez-Chantada, David J Wagner, Michael Grondine, Matthew G Sanders, Sharon Tentarelli, Elizabeth Underwood, Argyrides Argyrou, James M Smith, James T Lynch, Elisabetta Chiarparin, Graeme Robb, Sharan K Bagal, James S Scott,

MAT2a is a methionine adenosyltransferase that synthesizes the essential metabolite <i>S</i>-adenosylmethionine (SAM) from methionine and ATP. Tumors bearing the co-deletion of p16 and MTAP genes have been shown to be sensitive to MAT2a inhibition, making it an attractive target for treatment of MTAP-deleted cancers. A fragment-based lead generation campaign identified ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2021, 64(10):6814-6826]

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The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness.

Craig M Coopersmith, Massimo Antonelli, Seth R Bauer, Clifford S Deutschman, Laura E Evans, Ricard Ferrer, Judith Hellman, Sameer Jog, Jozef Kesecioglu, Niranjan Kissoon, Ignacio Martin-Loeches, Mark E Nunnally, Hallie C Prescott, Andrew Rhodes, Daniel Talmor, Pierre Tissieres, Daniel De Backer,

<h4>Objectives</h4>To identify research priorities in the management, pathophysiology, and host response of coronavirus disease 2019 in critically ill patients.<h4>Design</h4>The Surviving Sepsis Research Committee, a multiprofessional group of 17 international experts representing the European Society of Intensive Care Medicine and Society of Critical Care Medicine, was virtually convened during the coronavirus ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(4):598-622]

Cited: 6 times

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Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.

Waleed Alhazzani, Laura Evans, Fayez Alshamsi, Morten Hylander Møller, Marlies Ostermann, Hallie C Prescott, Yaseen M Arabi, Mark Loeb, Michelle Ng Gong, Eddy Fan, Simon Oczkowski, Mitchell M Levy, Lennie Derde, Amy Dzierba, Bin Du, Flavia Machado, Hannah Wunsch, Mark Crowther, Maurizio Cecconi, Younsuck Koh, Lisa Burry, Daniel S Chertow, Wojciech Szczeklik, Emilie Belley-Cote, Massimiliano Greco, Malgorzata Bala, Ryan Zarychanski, Jozef Kesecioglu, Allison McGeer, Leonard Mermel, Manoj J Mammen, Sheila Nainan Myatra, Amy Arrington, Ruth Kleinpell, Giuseppe Citerio, Kimberley Lewis, Elizabeth Bridges, Ziad A Memish, Naomi Hammond, Frederick G Hayden, Muhammed Alshahrani, Zainab Al Duhailib, Greg S Martin, Lewis J Kaplan, Craig M Coopersmith, Massimo Antonelli, Andrew Rhodes,

<h4>Background</h4>The coronavirus disease 2019 pandemic continues to affect millions worldwide. Given the rapidly growing evidence base, we implemented a living guideline model to provide guidance on the management of patients with severe or critical coronavirus disease 2019 in the ICU.<h4>Methods</h4>The Surviving Sepsis Campaign Coronavirus Disease 2019 panel has expanded to ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):e219-e234]

Cited: 37 times

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The surviving sepsis campaign: fluid resuscitation and vasopressor therapy research priorities in adult patients.

Ishaq Lat, Craig M Coopersmith, Daniel De Backer, Craig M Coopersmith, ,

<h4>Objective</h4>To expand upon the priorities of fluid resuscitation and vasopressor therapy research priorities identified by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.<h4>Data sources</h4>Original paper and literature search.<h4>Study selection</h4>Several members of the original task force with expertise specific ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2021, 9(1):10]

Cited: 1 time

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Should we ration extracorporeal membrane oxygenation during the COVID-19 pandemic?

Alexander Supady, Jenelle Badulak, Laura Evans, J Randall Curtis, Daniel Brodie,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(4):326-328]

Cited: 3 times

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Twitches emerge postnatally during quiet sleep in human infants and are synchronized with sleep spindles

Greta Sokoloff, James Dooley, Ryan Glanz, Rebecca Wen, Meredith Hickerson, Laura Evans, Haley Laughlin, Keith Apfelbaum, Mark Blumberg,

<h4>S ummary </h4> In humans and other mammals, the stillness of sleep is punctuated by bursts of rapid eye movements (REMs) and myoclonic twitches of the limbs [1]. Contrary to the notion that twitches are mere by-products of dreams, sensory feedback arising from twitching limbs provides a rich and unique ... Read more >>

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The Impact of Socioeconomic Risk Factors on the Survival Outcomes of Patients With Newly Diagnosed Multiple Myeloma: A Cross-analysis of a Population-based Registry and a Tertiary Care Center.

Laura A Evans, Ronald Go, Rahma Warsame, Bharat Nandakumar, Francis K Buadi, Angela Dispenzieri, David Dingli, Martha Q Lacy, Suzanne R Hayman, Prashant Kapoor, Nelson Leung, Amie Fonder, Miriam Hobbs, Yi Lisa Hwa, Eli Muchtar, Taxiarchis V Kourelis, Stephen Russell, John A Lust, Yi Lin, Mustaqeem Siddiqui, Robert A Kyle, Morie A Gertz, S Vincent Rajkumar, Shaji Kumar, Wilson I Gonsalves,

<h4>Background</h4>Multiple myeloma (MM) is a heterogeneous clonal plasma cell disorder leading to differences in clinical outcomes such as overall survival (OS) among patients. We hypothesized that with expensive, novel therapeutic agents and paradigm shifts to maintain continuous therapy and improvement in OS, patients with MM are subject to the pressures ... Read more >>

Clin Lymphoma Myeloma Leuk (Clinical lymphoma, myeloma & leukemia)
[2021, 21(7):451-460.e2]

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Institutional policies and readiness in management of critical illness among patients with viral hemorrhagic fever.

Madeline A DiLorenzo, Christoph A Baker, Jocelyn J Herstein, Laura Evans, John J Lowe, Shawn G Gibbs, Nahid Bhadelia,

<h4>Objective</h4>In response to the 2013-2016 Ebola virus disease outbreak, the US government designated certain healthcare institutions as Ebola treatment centers (ETCs) to better prepare for future emerging infectious disease outbreaks. This study investigated ETC experiences and critical care policies for patients with viral hemorrhagic fever (VHF).<h4>Design</h4>A 58-item questionnaire elicited information ... Read more >>

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2021, :1-6]

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In Vivo Assessment of Glutamine Anaplerosis into the TCA Cycle in Human Pre-malignant and Malignant Clonal Plasma Cells

Wilson Gonsalves, Jin Sung Jang, Erik Jessen, Taro Hitosugi, Laura Evans, Dragan Jevremovic, Xuan-Mai Petterson, Alexander Graham Bush, Jaimee Gransee, Emilie Anderson, Shaji Kumar, Sreekumaran,

<h4>Background: </h4> Overexpression of c-Myc is required for the progression of pre-malignant plasma cells in monoclonal gammopathy of undetermined significance (MGUS) to malignant plasma cells in multiple myeloma (MM). c-Myc also increases glutamine anaplerosis into the tricarboxylic acid (TCA) cycle within cancer cells. Whether increased glutamine anaplerosis is associated with ... Read more >>

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Convalescent Plasma for the Treatment of COVID-19: Perspectives of the National Institutes of Health COVID-19 Treatment Guidelines Panel.

Alice K Pau, Judith Aberg, Jason Baker, Pamela S Belperio, Craig Coopersmith, Page Crew, Birgit Grund, Roy M Gulick, Carly Harrison, Arthur Kim, H Clifford Lane, Henry Masur, Virginia Sheikh, Kanal Singh, Jinoos Yazdany, Pablo Tebas, ,

Ann Intern Med (Annals of internal medicine)
[2021, 174(1):93-95]

Cited: 14 times

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