Full Text Journal Articles by
Author Laura E Simons

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Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case Designs.

Jane Nikles, Patrick Onghena, Johan W S Vlaeyen, Rikard K Wicksell, Laura E Simons, James M McGree, Suzanne McDonald,

In this article we briefly examine the unique features of Single-Case Designs (SCDs) (studies in a single participant), their history and current trends, and real-world clinical applications. The International Collaborative Network for N-of-1 Trials and Single-Case Designs (ICN) is a formal collaborative network for individuals with an interest in SCDs. ... Read more >>

Contemp Clin Trials Commun (Contemporary clinical trials communications)
[2021, 23:100826]

Cited: 0 times

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Leveraging Virtual Reality and Augmented Reality to Combat Chronic Pain in Youth: Position Paper From the Interdisciplinary Network on Virtual and Augmented Technologies for Pain Management.

Deirdre E Logan, Laura E Simons, Thomas J Caruso, Jeffrey I Gold, Walter Greenleaf, Anya Griffin, Christopher D King, Maria Menendez, Vanessa A Olbrecht, Samuel Rodriguez, Megan Silvia, Jennifer N Stinson, Ellen Wang, Sara E Williams, Luke Wilson,

<h4>Background</h4>Virtual reality (VR) and augmented reality (AR) interventions are emerging as promising tools in the treatment of pediatric chronic pain conditions. However, in this young field, there is little consensus to guide the process of engaging in the development and evaluation of targeted VR-based interventions.<h4>Objective</h4>The INOVATE-Pain (Interdisciplinary Network on Virtual ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2021, 23(4):e25916]

Cited: 2 times

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Gait Variability and Relationships With Fear, Avoidance, and Pain in Adolescents With Chronic Pain.

Justin A Beebe, Corey Kronman, Farah Mahmud, Molly Basch, Melinda Hogan, Eileen Li, Chris Ploski, Laura E Simons,

<h4>Objective</h4>Some children with chronic pain struggle with fear of pain, avoidance behaviors, and associated disability; however, movement adaptations in the context of chronic pain in childhood is virtually unknown. Variability in adaptive movement responses previously observed between individuals might be largely explained by the presence of problematic psychological drivers (eg, ... Read more >>

Phys Ther (Physical therapy)
[2021, 101(4):]

Cited: 1 time

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Longitudinal Narrative Analysis of Parent Experiences During Graded Exposure Treatment for Children With Chronic Pain.

Jenelle R Corey, Lauren C Heathcote, Farah Mahmud, Corey Kronman, Cora Mukerji, Ellen McGinnis, Melanie Noel, Christine Sieberg, Laura E Simons,

<h4>Objectives</h4>Parents have a vital influence over their child's chronic pain treatment and management. Graded exposure in vivo treatment (GET) is emerging as a promising intervention for youth with chronic pain. Yet, little is known about how parents perceive GET and its impact on their child's pain condition. This study aimed ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2021, 37(4):301-309]

Cited: 0 times

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Chronic Pain in Young Athletes: The Impact of Athletic Identity on Pain-related Distress and Functioning.

Connie Hsu, Nele Loecher, Anna L Park, Laura E Simons,

<h4>Background</h4>It is common for youth to engage in sport and unfortunately also common for chronic pain to emerge in childhood. The convergence of chronic pain and sports participation in youth has not been extensively studied.<h4>Objective</h4>The goal of this study was to examine the association between athletic identity (AI) and pain-related ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2021, 37(3):219-225]

Cited: 0 times

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Altered Brain Network Connectivity Underlies Persistent Post-Traumatic Headache following Mild Traumatic Brain Injury in Youth.

Jordan Lemme, Scott Holmes, Diana Sibai, Joud Mari, Laura E Simons, Rami Burstein, David Zurakowski, Alyssa Lebel, Michael O'Brien, Jaymin Upadhyay, David Borsook,

Post-traumatic headaches (PTHs) are associated with mild traumatic brain injuries (mTBI) and may predict the persistence of concussion symptoms. Altered brain networks implicated in brain injury and the affective components of headache-related pain may underlie the resolution of PTH. This is a hypothesis-generating investigation to evaluate the extent to which ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, 38(12):1632-1641]

Cited: 0 times

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ACTsmart: Guided Smartphone-Delivered Acceptance and Commitment Therapy for Chronic Pain-A Pilot Trial.

Charlotte Gentili, Vendela Zetterqvist, Jenny Rickardsson, Linda Holmström, Laura E Simons, Rikard K Wicksell,

<h4>Background</h4>Acceptance and commitment therapy (ACT) is a behavioral health intervention with strong empirical support for chronic pain but, to date, widespread dissemination is limited. Digital solutions improve access to care and can be integrated into patients' everyday lives.<h4>Objective</h4>ACTsmart, a guided smartphone-delivered ACT intervention, was developed to improve the accessibility of ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2021, 22(2):315-328]

Cited: 0 times

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Pain stickiness in pediatric complex regional pain syndrome: A role for the nucleus accumbens.

Andrew M Youssef, Ke Peng, Pearl Kijoo Kim, Alyssa Lebel, Navil F Sethna, Corey Kronman, David Zurakowski, David Borsook, Laura E Simons,

Some individuals with chronic pain experience improvement in their pain with treatment, whereas others do not. The neurobiological reason is unclear, but an understanding of brain structure and functional patterns may provide insights into pain's responsivity to treatment. In this investigation, we used magnetic resonance imaging (MRI) techniques to determine ... Read more >>

Neurobiol Pain (Neurobiology of pain (Cambridge, Mass.))
[2021, 9:100062]

Cited: 0 times

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The Concept of Pain Inventory (COPI): Assessing a Child's Concept of Pain.

Joshua W Pate, Laura E Simons, Mark J Hancock, Julia M Hush, Tim Noblet, Meg Pounder, Verity Pacey,

<h4>Objectives</h4>Clinical guidelines recommend that health care providers assist children to understand their experience of persistent pain, with pain science education a key component of clinical management in pediatric pain clinics. Currently, no tool exists to assess a child's concept of pain. The aim of this study was to develop such ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2020, 36(12):940-949]

Cited: 3 times

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Virtual Reality in Pain Rehabilitation for Youth With Chronic Pain: Pilot Feasibility Study.

Anya Griffin, Luke Wilson, Amanda B Feinstein, Adeline Bortz, Marissa S Heirich, Rachel Gilkerson, Jenny Fm Wagner, Maria Menendez, Thomas J Caruso, Samuel Rodriguez, Srinivas Naidu, Brenda Golianu, Laura E Simons,

<h4>Background</h4>In the field of pain, virtual reality (VR) technology has been increasingly common in the context of procedural pain management. As an interactive technology tool, VR has the potential to be extended beyond acute pain management to chronic pain rehabilitation with a focus on increasing engagement with painful or avoided ... Read more >>

JMIR Rehabil Assist Technol (JMIR rehabilitation and assistive technologies)
[2020, 7(2):e22620]

Cited: 4 times

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Something Else Going On? Diagnostic Uncertainty in Children with Chronic Pain and Their Parents.

Vivek Tanna, Lauren C Heathcote, Marissa S Heirich, Gillian Rush, Alexandra Neville, Melanie Noel, Joshua W Pate, Laura E Simons,

Diagnostic uncertainty, the perceived lack of an accurate explanation of the patient's health problem, remains relatively unstudied in children. This study examined the prevalence, familial concordance, and correlates of diagnostic uncertainty in children and their parents presenting to a multidisciplinary pain clinic in the United States. One hundred and twenty-six ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2020, 7(10):]

Cited: 2 times

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Symptom appraisal in uncertainty: a theory-driven thematic analysis with survivors of childhood cancer.

Lauren C Heathcote, Nele Loecher, Pamela Simon, Sheri L Spunt, Abbie Jordan, Perri R Tutelman, Sarah Cunningham, Lidia Schapira, Laura E Simons,

<h4>Objective</h4>Somatic symptoms capture attention, demand interpretation, and promote health behaviors. Symptom appraisal is particularly impactful within uncertain health contexts such as cancer survivorship. Yet, little is known about how individuals make sense of somatic symptoms within uncertain health contexts, nor how this process guides health behaviors.<h4>Design</h4>25 adolescent and young adult ... Read more >>

Psychol Health (Psychology & health)
[2021, 36(10):1182-1199]

Cited: 0 times

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Exploring the underlying mechanism of pain-related disability in hypermobile adolescents with chronic musculoskeletal pain.

Thijs van Meulenbroek, Ivan P J Huijnen, Laura E Simons, Arnoud E A Conijn, Raoul H H Engelbert, Jeanine A Verbunt,

<h4>Objectives</h4>A significant proportion of adolescents with chronic musculoskeletal pain (CMP) experience difficulties in physical functioning, mood and social functioning, contributing to diminished quality of life. Generalized joint hypermobility (GJH) is a risk factor for developing CMP with a striking 35-48% of patients with CMP reporting GJH. In case GJH occurs ... Read more >>

Scand J Pain (Scandinavian journal of pain)
[2021, 21(1):22-31]

Cited: 3 times

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mHealth for pediatric chronic pain: state of the art and future directions.

Patricia A Richardson, Lauren E Harrison, Lauren C Heathcote, Gillian Rush, Deborah Shear, Chitra Lalloo, Korey Hood, Rikard K Wicksell, Jennifer Stinson, Laura E Simons,

<h4>Introduction</h4>Chronic pain conditions are common among children and engender cascading effects across social, emotional, and behavioral domains for the child and family. Mobile health (mHealth) describes the practice of delivering healthcare via mobile devices and may be an ideal solution to increase access and reach of evidence-based behavioral health interventions.<h4>Areas ... Read more >>

Expert Rev Neurother (Expert review of neurotherapeutics)
[2020, 20(11):1177-1187]

Cited: 1 time

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Stuck on pain? Assessing children's vigilance and awareness of pain sensations.

Lauren C Heathcote, Laura E Simons,

<h4>Background</h4>Attending towards pain is proposed as a key mechanism influencing the experience and chronification of pain. Persistent attention towards pain is proposed to drive poor outcomes in both adults and children with chronic pain. However, there are no validated self-report measures of pain-related attention for children.<h4>Methods</h4>The goals of this study ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2020, 24(7):1339-1347]

Cited: 0 times

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Parent physical and mental health contributions to interpersonal fear avoidance processes in pediatric chronic pain.

Kathryn A Birnie, Lauren C Heathcote, Rashmi P Bhandari, Amanda Feinstein, Isabel A Yoon, Laura E Simons,

Theoretical models and evidence increasingly identify chronic pain as a family issue. To date, much of this work has focused on risk conferred by parental chronic pain status despite evidence suggesting parent mental illness and non-pain-related chronic illness may also contribute to poorer chronic pain outcomes in children. This study ... Read more >>

Pain (Pain)
[2020, 161(6):1202-1211]

Cited: 3 times

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Parent Responses to Their Child's Pain: Systematic Review and Meta-Analysis of Measures.

Lauren E Harrison, Inge Timmers, Lauren C Heathcote, Emma Fisher, Vivek Tanna, Tom Duarte Silva Bans, Laura E Simons,

OBJECTIVE:Parent responses can have a major impact on their child's pain. The purpose of this systematic review is to (a) identify and describe measures assessing pain-related cognitive, affective, and behavioral responses in parents of children with chronic pain and (b) meta-analyze reported correlations between parent constructs and child outcomes (i.e., ... Read more >>

J Pediatr Psychol (Journal of pediatric psychology)
[2020, 45(3):281-298]

Cited: 1 time

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ACTsmart - development and feasibility of digital Acceptance and Commitment Therapy for adults with chronic pain.

Charlotte Gentili, Vendela Zetterqvist, Jenny Rickardsson, Linda Holmström, Laura E Simons, Rikard K Wicksell,

Accessibility of evidence-based behavioral health interventions is one of the main challenges in health care and effective treatment approaches are not always available for patients that would benefit from them. Digitization has dramatically changed the health care landscape. Although mHealth has shown promise in addressing issues of accessibility and reach, ... Read more >>

NPJ Digit Med (NPJ digital medicine)
[2020, 3:20]

Cited: 4 times

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Avoid or engage? Outcomes of graded exposure in youth with chronic pain using a sequential replicated single-case randomized design.

Laura E Simons, Johan W S Vlaeyen, Lies Declercq, Allison M Smith, Justin Beebe, Melinda Hogan, Eileen Li, Corey A Kronman, Farah Mahmud, Jenelle R Corey, Christine B Sieberg, Christine Ploski,

Pain-related fear is typically associated with avoidance behavior and pain-related disability in youth with chronic pain. Youth with elevated pain-related fear have attenuated treatment responses; thus, targeted treatment is highly warranted. Evidence supporting graded in vivo exposure treatment (GET) for adults with chronic pain is considerable, but just emerging for ... Read more >>

Pain (Pain)
[2020, 161(3):520-531]

Cited: 6 times

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Rapid identification and clinical indices of fear-avoidance in youth with chronic pain.

Lauren C Heathcote, Rashmi P Bhandari, Inge Timmers, Lauren E Harrison, Laura E Simons,

Pain-related fear and avoidance are increasingly demonstrated to play an important role in adult and childhood chronic pain. The Fear of Pain Questionnaire for Children (FOPQC) is a 24-item measure of pain-related fear-avoidance in youth that has demonstrated good indices of reliability and validity, treatment responsiveness, and associations with brain ... Read more >>

Pain (Pain)
[2020, 161(3):565-573]

Cited: 2 times

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Brain signatures of threat-safety discrimination in adolescent chronic pain.

Lauren C Heathcote, Inge Timmers, Corey A Kronman, Farah Mahmud, J Maya Hernandez, Jason Bentley, Andrew M Youssef, Daniel S Pine, David Borsook, Laura E Simons,

Approximately 1.7 million youth suffer from debilitating chronic pain in the US alone, conferring risk of continued pain in adulthood. Aberrations in threat-safety (T-S) discrimination are proposed to contribute to pain chronicity in adults and youth by interacting with pain-related distress. Yet, few studies have examined the neural circuitry underlying ... Read more >>

Pain (Pain)
[2020, 161(3):630-640]

Cited: 5 times

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A Network Analysis of Potential Antecedents and Consequences of Pain-Related Activity Avoidance and Activity Engagement in Adolescents.

Melanie Beeckman, Laura E Simons, Sean Hughes, Tom Loeys, Liesbet Goubert,

<h4>Objective</h4>This study sets out to identify potential daily antecedents and consequences of pain-related activity avoidance and engagement behavior in adolescents with chronic pain.<h4>Methods</h4>Adolescents (N = 65, Mage = 14.41) completed baseline self-reports and a diary for 14 days. Afternoon and evening reports were used to infer a network structure of within-day associations between ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2020, 21(2):e89-e101]

Cited: 2 times

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The interaction between stress and chronic pain through the lens of threat learning.

Inge Timmers, Conny W E M Quaedflieg, Connie Hsu, Lauren C Heathcote, Cynthia R Rovnaghi, Laura E Simons,

Stress and pain are interleaved at multiple levels - interacting and influencing each other. Both are modulated by psychosocial factors including fears, beliefs, and goals, and are served by overlapping neural substrates. One major contributing factor in the development and maintenance of chronic pain is threat learning, with pain as ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2019, 107:641-655]

Cited: 9 times

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Graded exposure treatment for adolescents with chronic pain (GET Living): Protocol for a randomized controlled trial enhanced with single case experimental design.

Laura E Simons, Lauren E Harrison, Shannon F O'Brien, Marissa S Heirich, Nele Loecher, Derek B Boothroyd, Johan W S Vlaeyen, Rikard K Wicksell, Deborah Schofield, Korey K Hood, Michael Orendurff, Salinda Chan, Sam Lyons,

Chronic musculoskeletal pain in adolescence is a significant public health concern with 3-5% of adolescents suffering from significant pain-related disability. Pain-related fear and avoidance of activities has been found to have a significant influence on pain outcomes in children and adolescents and is a risk factor for less favorable response ... Read more >>

Contemp Clin Trials Commun (Contemporary clinical trials communications)
[2019, 16:100448]

Cited: 1 time

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Investigating How Parental Instructions and Protective Responses Mediate the Relationship Between Parental Psychological Flexibility and Pain-Related Behavior in Adolescents With Chronic Pain: A Daily Diary Study.

Melanie Beeckman, Laura E Simons, Sean Hughes, Tom Loeys, Liesbet Goubert,

Background:Parental behavior can influence how well adolescents cope with chronic pain. Previous research has largely focused on how parents negatively impact adolescent functioning. Yet more recent work suggests that parents - and particularly parental psychological flexibility - can foster better adolescent pain-related functioning. In this study we examined if parental ... Read more >>

Front Psychol (Frontiers in psychology)
[2019, 10:2350]

Cited: 2 times

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