Full Text Journal Articles by
Author Laura Belloni

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From Development to Aging: The Path to Cellular Senescence.

Alessandra Sacco, Laura Belloni, Lucia Latella,

Significance: Senescence is a cellular state induced by internal or external stimuli, which result in cell cycle arrest, morphological changes, and dysfunctions in mitochondrial and lysosomal functionality as well as the senescence-associated secretory phenotype. Senescent cells accumulate in tissues in physiological and pathological conditions such as development, tissue repair, aging, ... Read more >>

Antioxid. Redox Signal. (Antioxidants & redox signaling)
[2020, :]

Cited: 0 times

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Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription.

Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Oceane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddari, Laura Belloni, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri,

OBJECTIVE:The HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host cellular chromatin. DESIGN:We explored, in relevant cellular models of HBV replication, the functional consequences of HBx interaction with DLEU2, a long non-coding RNA ... Read more >>

Gut (Gut)
[2020, :]

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Inducing and Characterizing Vesicular Steatosis in Differentiated HepaRG Cells.

Silvia Di Cocco, Laura Belloni, Abigail D G Nunn, Debora Salerno, Silvia Piconese, Massimo Levrero, Natalia Pediconi,

Hepatic steatosis represents a metabolic dysfunction that results from an accumulation of triglyceride-containing lipid droplets in hepatocytes. Excessive fat accumulation leads to non-alcoholic fatty liver disease (NAFLD),  which is potentially reversible and may evolve into non-alcoholic steatohepatitis (NASH) and eventually cirrhosis and hepatocellular carcinoma (HCC). The molecular mechanisms linking lipid ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2019, (149):]

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EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells.

Natalia Pediconi, Debora Salerno, Leonardo Lupacchini, Annapaola Angrisani, Giovanna Peruzzi, Enrico De Smaele, Massimo Levrero, Laura Belloni,

Modification of histones by lysine methylation plays a role in many biological processes, and it is dynamically regulated by several histone methyltransferases and demethylases. The polycomb repressive complex contains the H3K27 methyltransferase EZH2 and controls dimethylation and trimethylation of H3K27 (H3K27me2/3), which trigger gene suppression. JMJD3 and UTX have been ... Read more >>

Cell Death Dis (Cell death & disease)
[2019, 10(7):518]

Cited: 2 times

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Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model.

Laura Belloni, Silvia Di Cocco, Francesca Guerrieri, Abigail D G Nunn, Silvia Piconese, Debora Salerno, Barbara Testoni, Claudio Pulito, Federica Mori, Matteo Pallocca, Andrea Sacconi, Elisa Vivoli, Fabio Marra, Sabrina Strano, Giovanni Blandino, Massimo Levrero, Natalia Pediconi,

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease. Although genetic predisposition and epigenetic factors contribute to the development of NAFLD, our understanding of the molecular mechanism involved in the pathogenesis of the disease is still emerging. Here we investigated a possible role of a microRNAs-STAT3 ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):13638]

Cited: 2 times

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Correction: IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome.

Gianna Aurora Palumbo, Cecilia Scisciani, Natalia Pediconi, Leonardo Lupacchini, Dulce Alfaiate, Francesca Guerrieri, Ludovica Calvo, Debora Salerno, Silvia Di Cocco, Massimo Levrero, Laura Belloni,

PLoS ONE (PloS one)
[2015, 10(12):e0145555]

Cited: 0 times

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TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.

Antonio Costanzo, Natalia Pediconi, Alessandra Narcisi, Francesca Guerrieri, Francesca Guerrieri, Laura Belloni, Francesca Fausti, Elisabetta Botti, Massimo Levrero,

TP53 belongs to a small gene family that includes, in mammals, two additional paralogs, TP63 and TP73. The p63 and p73 proteins are structurally and functionally similar to p53 and their activity as transcription factors is regulated by a wide repertoire of shared and unique post-translational modifications and interactions with ... Read more >>

FEBS Lett. (FEBS letters)
[2014, 588(16):2590-2599]

Cited: 15 times

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Correction: Early intra-intensive care unit psychological intervention promotes recovery from post traumatic stress disorders, anxiety and depression symptoms in critically ill patients.

Adriano Peris, Manuela Bonizzoli, Dario Iozzelli, Maria Luisa Migliaccio, Giovanni Zagli, Alberto Bacchereti, Marta Debolini, Elisetta Vannini, Massimo Solaro, Ilaria Balzi, Elisa Bendoni, Ilaria Bacchi, Monica Trevisan, Valtere Giovannini, Laura Belloni,

Crit Care (Critical Care)
[2011, 15(2):418-418]

Cited: 3 times

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Early intra-intensive care unit psychological intervention promotes recovery from post traumatic stress disorders, anxiety and depression symptoms in critically ill patients.

Adriano Peris, Manuela Bonizzoli, Dario Iozzelli, Maria Luisa Migliaccio, Giovanni Zagli, Alberto Bacchereti, Marta Debolini, Elisetta Vannini, Massimo Solaro, Ilaria Balzi, Elisa Bendoni, Ilaria Bacchi, Monica Trevisan, Valtere Giovannini, Laura Belloni,

INTRODUCTION: Critically ill patients who require intensive care unit (ICU) treatment may experience psychological distress with increasing development of psychological disorders and related morbidity. Our aim was to determine whether intra-ICU clinical psychologist interventions decrease the prevalence of anxiety, depression and posttraumatic stress disorder (PTSD) after 12 months from ICU ... Read more >>

Crit Care (Critical care (London, England))
[2011, 15(1):R41]

Cited: 63 times

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hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage.

Natalia Pediconi, Francesca Guerrieri, Francesca Guerrieri, Stefania Vossio, Tiziana Bruno, Laura Belloni, Valeria Schinzari, Cecilia Scisciani, Maurizio Fanciulli, Massimo Levrero,

The NAD(+)-dependent histone deacetylase hSirT1 regulates cell survival and stress responses by inhibiting p53-, NF-kappaB-, and E2F1-dependent transcription. Here we show that the hSirT1/PCAF interaction controls the E2F1/p73 apoptotic pathway. hSirT1 represses E2F1-dependent P1p73 promoter activity in untreated cells and inhibits its activation in response to DNA damage. hSirT1, PCAF, ... Read more >>

Mol. Cell. Biol. (Molecular and cellular biology)
[2009, 29(8):1989-1998]

Cited: 37 times

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Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

Natalia Pediconi, Alessandra Ianari, Antonio Costanzo, Laura Belloni, Rita Gallo, Letizia Cimino, Antonio Porcellini, Isabella Screpanti, Clara Balsano, Edoardo Alesse, Alberto Gulino, Massimo Levrero,

E2F1, a member of the E2F family of transcription factors, in addition to its established proliferative effect, has also been implicated in the induction of apoptosis through p53-dependent and p53-independent pathways. Several genes involved in the activation or execution of the apoptotic programme have recently been shown to be upregulated ... Read more >>

Nat. Cell Biol. (Nature cell biology)
[2003, 5(6):552-558]

Cited: 157 times

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