Full Text Journal Articles by
Author Larry R Jackson

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The atrial fibrillation paradox -connecting hypertension to atrial disease and stroke.

Phil Mendys, Larry R Jackson, Elsayed Z Solimon, George Howard, Keith Ferdinand,

Am J Prev Cardiol (American journal of preventive cardiology)
[2021, 8:100284]

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Optimizing mechanically sensed atrial tracking in patients with atrioventricular-synchronous leadless pacemakers: A single-center experience.

Kelly Arps, Jonathan P Piccini, Rebecca Yapejian, Rhonda Leguire, Brenda Smith, Sana M Al-Khatib, Tristram D Bahnson, James P Daubert, Donald D Hegland, Kevin P Jackson, Larry R Jackson, Robert K Lewis, Sean D Pokorney, Albert Y Sun, Kevin L Thomas, Camille Frazier-Mills,

<h4>Background</h4>Atrioventricular (AV)-synchronous single-chamber leadless pacing using a mechanical atrial sensing algorithm produced high AV synchrony in clinical trials, but clinical practice experience with these devices has not yet been described.<h4>Objective</h4>To describe pacing outcomes and programming changes with AV-synchronous leadless pacemakers in clinical practice.<h4>Methods</h4>Consecutive patients without persistent atrial fibrillation who received ... Read more >>

Heart Rhythm O2 (Heart rhythm O2)
[2021, 2(5):455-462]

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Outcomes for patients with anterior myocardial infarction and prior cardiac arrest in the home automated external defibrillator trial (HAT).

Monique Anderson Starks, Larry R Jackson, Anne Hellkamp, Sana M Al-Khatib, Daniel B Mark, Kevin L Thomas, Graham Nichol, Kerry L Lee, Linda Davidson-Ray, Jeanne Poole, Jill Anderson, George Johnson, Gust H Bardy,

<h4>Background</h4>Patients with sudden cardiac arrest occurring in the acute phase of myocardial infarction (MI-SCA) are believed to be at similar risk of death after revascularization compared with MI patients without SCA (MI-no SCA). Among patients with anterior MI, we examined whether those with MI-SCA were at greater risk of all-cause ... Read more >>

Resuscitation (Resuscitation)
[2021, 168:75-83]

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Epidemiology and Outcomes Associated with PR Prolongation.

Larry R Jackson, Francis Ugowe,

PR prolongation is defined primarily as delayed conduction through the AV node, but can also signify delayed electrical impulse propagation through any part of the conduction system. The prevalence of PR prolongation ranges from 1% to 5% in patients younger than 50 years, with increasing prevalence, after the sixth decade ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):661-669]

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Percutaneous left atrial appendage occlusion: A review of current devices, clinical evidence, patient selection, and post procedural antithrombotic management.

Larry R Jackson, Kevin P Jackson, Kevin L Thomas,

Stroke is a major driver of increased morbidity and mortality in patients with non-valvular atrial fibrillation (NVAF). While systemic oral anticoagulation (OAC) continues to be the mainstay for stroke reduction therapy in patients with NVAF, several barriers prevent the sustained long-term use of OAC, including increased risk of bleeding, non-compliance, ... Read more >>

Prog Cardiovasc Dis (Progress in cardiovascular diseases)
[2021, 66:92-100]

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Communication Coaching in Cardiology (CCC): A study protocol and methodological challenges and solutions of a randomized controlled trial in outpatient cardiology clinics.

Danielle L Kennedy, Maren K Olsen, Hongqiu Yang, Xiaomei Gao, Aviel Alkon, Neil S Prose, Kayla Dunbar, Larry R Jackson, Kathryn I Pollak,

Given the role of effective communication in improving patient adherence and satisfaction, high quality patient-clinician communication is critical. Building on previous communication interventions in oncology and pediatrics, we developed a tailored communication coaching intervention to improve empathic communication quality and patient-centered care. In this randomized controlled trial, cardiologists record their ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2021, 105:106389]

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Dosing of Direct Oral Anticoagulants in Patients with Moderate Chronic Kidney Disease in US Clinical Practice: Results from the Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF II).

Larry R Jackson, Peter Schrader, Laine Thomas, Benjamin A Steinberg, Rosalia Blanco, Larry A Allen, Gregg C Fonarow, James V Freeman, Bernard J Gersh, Peter R Kowey, Kenneth W Mahaffey, Gerald Naccarelli, James Reiffel, Daniel E Singer, Eric D Peterson, Jonathan P Piccini, ,

<h4>Introduction</h4>Direct oral anticoagulants (DOACs) have partial renal clearance and generally require dosage adjustments based on renal function. While current US and European guidance recommends dose adjustments in patients with moderate chronic kidney disease (CKD), it is unclear how often this is done appropriately in routine clinical practice.<h4>Methods</h4>We examined rates of ... Read more >>

Am J Cardiovasc Drugs (American journal of cardiovascular drugs : drugs, devices, and other interventions)
[2021, 21(5):553-561]

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African American-Caucasian American differences in aortic valve replacement in patients with severe aortic stenosis.

George S Yankey, Larry R Jackson, Colin Marts, Karen Chiswell, Angie Wu, Francis Ugowe, Jimica Wilson, Sreekanth Vemulapalli, Zainab Samad, Kevin L Thomas,

<h4>Background</h4>Among patients with severe aortic stenosis (AS), there are limited data on aortic valve replacement (AVR), reasons for nonreceipt and mortality by race.<h4>Methods</h4>Utilizing the Duke Echocardiography Laboratory Database, we analyzed data from 110,711 patients who underwent echocardiography at Duke University Medical Center between 1999 and 2013. We identified 1,111 patients ... Read more >>

Am Heart J (American heart journal)
[2021, 234:111-121]

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Evaluation of Women and Underrepresented Racial and Ethnic Group Representation in a General Cardiology Fellowship After a Systematic Recruitment Initiative.

Jennifer A Rymer, Camille G Frazier-Mills, Larry R Jackson, Kevin L Thomas, Pamela S Douglas, Andrew Wang, Manesh R Patel, Anna Lisa Crowley,

<h4>Importance</h4>The proportion of women and underrepresented racial and ethnic groups (UREGs) matriculating into general cardiology fellowships remains low.<h4>Objective</h4>To assess a systematic recruitment initiative aimed at ensuring adequate matriculation of women and UREGs in a general cardiology fellowship.<h4>Design, setting, and participants</h4>This quality improvement study took place at a large, tertiary academic ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(1):e2030832]

Cited: 1 time

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Catheter ablation of atrial fibrillation in patients with diabetes mellitus.

Allen Wang, Tracy Truong, Eric Black-Maier, Cynthia Green, Kristen B Campbell, Adam S Barnett, Janice Febre, Zak Loring, Sana M Al-Khatib, Brett D Atwater, James P Daubert, Camille Frazier-Mills, Donald D Hegland, Kevin P Jackson, Larry R Jackson, Jason I Koontz, Robert K Lewis, Sean D Pokorney, Albert Y Sun, Kevin L Thomas, Tristam D Bahnson, Jonathan P Piccini,

<h4>Background</h4>Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Few studies have compared clinical outcomes after catheter ablation between patients with and those without DM.<h4>Objective</h4>The purpose of this study was to compare AF ablation outcomes in patients with and those without DM.<h4>Methods</h4>We performed a retrospective analysis of ... Read more >>

Heart Rhythm O2 (Heart rhythm O2)
[2020, 1(3):180-188]

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Effectiveness of catheter ablation of atrial fibrillation according to heart failure etiology.

Eric Black-Maier, Benjamin A Steinberg, Kevin M Trulock, Frances Wang, Yuliya Lokhnygina, Wanda O'Neal, Sana Al-Khatib, Brett D Atwater, James P Daubert, Camille Frazier-Mills, Donald D Hegland, Kevin P Jackson, Larry R Jackson, Jason I Koontz, Robert K Lewis, Albert Y Sun, Kevin L Thomas, Tristram D Bahnson, Jonathan P Piccini,

Background:Catheter ablation is an important rhythm control therapy in patients with atrial fibrillation (AF) with concomitant heart failure (HF). The objective of this study was to assess the comparative efficacy of AF ablation patients with ischemic vs nonischemic heart failure. Methods:We conducted a retrospective, observational cohort study of patients with ... Read more >>

J Arrhythm (Journal of arrhythmia)
[2020, 36(1):84-92]

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Discontinuation rates of warfarin versus direct acting oral anticoagulants in US clinical practice: Results from Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II).

Larry R Jackson, Sunghee Kim, Rosalia Blanco, Laine Thomas, Jack Ansell, Gregg C Fonarow, Bernard J Gersh, Alan S Go, Peter R Kowey, Kenneth W Mahaffey, Elaine M Hylek, Eric D Peterson, Jonathan P Piccini, ,

While oral anticoagulation is a cornerstone of stroke prevention therapy in atrial fibrillation (AF), few studies have evaluated comparative discontinuation rates in clinical practice. The objective of this study is to evaluate discontinuation rates among patients on warfarin and direct oral anticoagulants (DOACs) in clinical practice.<h4>Methods</h4>The ORBIT-AF II Registry enrolled ... Read more >>

Am Heart J (American heart journal)
[2020, 226:85-93]

Cited: 1 time

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Racial and Ethnic Differences in Treatment and Outcomes of Severe Aortic Stenosis: A Review.

Jimica B Wilson, Larry R Jackson, Francis E Ugowe, Terrell Jones, George S A Yankey, Colin Marts, Kevin L Thomas,

Aortic stenosis (AS) is among the most common valvular heart diseases encountered in the United States. In this review the authors examine differences between racial and ethnic groups in the epidemiology and management of severe AS, explore potential explanations for these findings, and discuss the implications for improving the delivery ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2020, 13(2):149-156]

Cited: 5 times

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Videos to reduce racial disparities in ICD therapy Via Innovative Designs (VIVID) trial: Rational, design and methodology.

Kevin L Thomas, Lonnie T Sullivan, Sana M Al-Khatib, Nancy Allen LaPointe, Sam Sears, Andrzej S Kosinski, Larry R Jackson, Valentina Kutyifa, Eric D Peterson,

BACKGROUND:Despite a higher prevalence of sudden cardiac death (SCD), black individuals are less likely than whites to have an implantable cardioverter defibrillator (ICD) implanted. Racial differences in ICD utilization is in part explained by higher refusal rates in black individuals. Decision support can assist with treatment-related uncertainty and prepare patients ... Read more >>

Am Heart J (American heart journal)
[2020, 220:59-67]

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Predicting atrial fibrillation recurrence after ablation in patients with heart failure: Validity of the APPLE and CAAP-AF risk scoring systems.

Eric Black-Maier, Alice Parish, Benjamin A Steinberg, Cynthia L Green, Zak Loring, Adam S Barnett, Sana M Al-Khatib, Brett D Atwater, James P Daubert, Camille Frazier-Mills, Donald D Hegland, Kevin P Jackson, Larry R Jackson, Jason Koontz, Robert K Lewis, Sean D Pokorney, Albert Y Sun, Kevin L Thomas, Tristam D Bahnson, Jonathan P Piccini,

BACKGROUND:Compared with medical therapy, catheter ablation of atrial fibrillation (AF) in patients with heart failure (HF) improves cardiovascular outcomes. Risk scores (CAAP-AF and APPLE) have been developed to predict the likelihood of AF recurrence after ablation, have not been validated specifically in patients with AF and HF. METHODS:We analyzed baseline ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2019, 42(11):1440-1447]

Cited: 1 time

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Assessing heterogeneity of treatment effect analyses in health-related cluster randomized trials: A systematic review.

Monique Anderson Starks, Gillian D Sanders, Remy Rene Coeytaux, Isaretta L Riley, Larry R Jackson, Amanda McBroom Brooks, Kevin L Thomas, Kingshuk Roy Choudhury, Robert M Califf, Adrian F Hernandez,

<h4>Background</h4>Cluster-randomized trials (CRTs) are being increasingly used to test a range of interventions, including medical interventions commonly used in clinical practice. Policies created by the NIH and the Food and Drug Administration (FDA) require the reporting of demographics and the examination of demographic heterogeneity of treatment effect (HTE) for individually ... Read more >>

PLoS One (PloS one)
[2019, 14(8):e0219894]

Cited: 1 time

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Atrial Fibrillation and Diabetes Mellitus: Can We Modify Stroke Risk Through Glycemic Control?

Francis E Ugowe, Larry R Jackson, Kevin L Thomas,

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2019, 12(5):e007351]

Cited: 1 time

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Prevalence of atrial fibrillation and association with clinical, sociocultural, and ancestral correlates among Hispanic/Latinos: The Hispanic Community Health Study/Study of Latinos.

Jered D Linares, Larry R Jackson, Farah Z Dawood, Katrina Swett, Emelia J Benjamin, Neil Schneiderman, Elsayed Z Soliman, Jianwen Cai, Alvaro Alonso, Sylvia Wassertheil-Smoller, Gregory A Talavera, James P Daubert, Martha L Daviglus, Carlos J Rodriguez,

<h4>Background</h4>Hispanics/Latinos represent the largest ethnic minority group in the United States. Atrial fibrillation (AF) is the most common cardiac arrhythmia in the United States.<h4>Objective</h4>The purpose of this study was to provide data on the prevalence of AF and its correlates in a representative Hispanic/Latino population-based sample inclusive of all background ... Read more >>

Heart Rhythm (Heart rhythm)
[2019, 16(5):686-693]

Cited: 2 times

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Racial differences in long-term outcomes among black and white patients with drug-eluting stents.

Lonnie T Sullivan, Hillary Mulder, Karen Chiswell, Linda K Shaw, Tracy Y Wang, Larry R Jackson, Kevin L Thomas,

<h4>Background</h4>Some studies suggest that black patients may have worse outcomes after drug-eluting stent (DES) placement. There are limited data characterizing long-term outcomes by race. The objective was to compare long-term outcomes between black and white patients after percutaneous coronary intervention (PCI) with DES implantation.<h4>Methods</h4>We analyzed 915 black and 3,559 white ... Read more >>

Am Heart J (American heart journal)
[2019, 214:46-53]

Cited: 1 time

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Race Effects in CVD Prediction Models.

Utibe R Essien, Larry R Jackson,

J Gen Intern Med (Journal of general internal medicine)
[2019, 34(4):484]

Cited: 1 time

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Association of Race/Ethnicity With Oral Anticoagulant Use in Patients With Atrial Fibrillation: Findings From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II.

Utibe R Essien, DaJuanicia N Holmes, Larry R Jackson, Gregg C Fonarow, Kenneth W Mahaffey, James A Reiffel, Benjamin A Steinberg, Larry A Allen, Paul S Chan, James V Freeman, Rosalia G Blanco, Karen S Pieper, Jonathan P Piccini, Eric D Peterson, Daniel E Singer,

<h4>Importance</h4>Black and Hispanic patients are less likely than white patients to use oral anticoagulants for atrial fibrillation. Little is known about racial/ethnic differences in use of direct-acting oral anticoagulants (DOACs) for atrial fibrillation.<h4>Objective</h4>To assess racial/ethnic differences in the use of oral anticoagulants, particularly DOACs, in patients with atrial fibrillation.<h4>Design, setting, ... Read more >>

JAMA Cardiol (JAMA cardiology)
[2018, 3(12):1174-1182]

Cited: 20 times

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Early therapeutic persistence on dabigatran versus warfarin therapy in patients with atrial fibrillation: results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.

Larry R Jackson, Sunghee Kim, Peter Shrader, Rosalia Blanco, Laine Thomas, Michael D Ezekowitz, Jack Ansell, Gregg C Fonarow, Bernard J Gersh, Alan S Go, Peter R Kowey, Kenneth W Mahaffey, Elaine M Hylek, Eric D Peterson, Jonathan P Piccini,

Anticoagulation is highly effective for the prevention of stroke in patients with atrial fibrillation (AF) but it is dependent on patients continuing therapy. While studies have demonstrated suboptimal therapeutic persistence on warfarin, few have studied persistence rates with non vitamin K antagonist oral anticoagulants (NOACs) such as dabigatran. We examined ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2018, 46(4):435-439]

Cited: 1 time

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Stroke Risk and Treatment in Patients with Atrial Fibrillation and Low CHA2DS2-VASc Scores: Findings From the ORBIT-AF I and II Registries.

Larry R Jackson, Sunghee Kim, Gregg C Fonarow, James V Freeman, Bernard J Gersh, Alan S Go, Elaine M Hylek, Peter R Kowey, Kenneth W Mahaffey, Daniel Singer, Laine Thomas, Rosalia Blanco, Eric D Peterson, Jonathan P Piccini, ,

Background Current American College of Cardiology/American Heart Association guidelines suggest that for patients with atrial fibrillation who are at low risk for stroke (CHA<sub>2</sub>DS<sub>2</sub>VASc=1) (or women with CHA<sub>2</sub>DS<sub>2</sub>VASc=2) a variety of treatment strategies may be considered. However, in clinical practice, patterns of treatment in these "low-risk" patients are not well ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2018, 7(16):e008764]

Cited: 3 times

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Atrial fibrillation and mortality risk: seeing the big picture.

Francis E Ugowe, Larry R Jackson,

Eur Heart J Qual Care Clin Outcomes (European heart journal. Quality of care & clinical outcomes)
[2019, 5(1):6-7]

Cited: 1 time

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Research Participation of a Professional Organization in Clinical Trials: The Association of Black cardiologists Clinical Trial Investigator Identification Project.

Chidiebube C Egwim, Alvin J Rucker, Deng C Madut, Goderfroy S Chery, Lonnie T Sullivan, Larry R Jackson, Wayne B Batchelor, Kevin L Thomas,

<h4>Introduction</h4>Black individuals continue to be underrepresented in clinical trials despite efforts by the National Institutes of Health and the Federal Drug Administration to increase their enrollment. Health care providers play a critical role in the recruitment of patients into clinical trials, as they have established relationships and are uniquely positioned ... Read more >>

J Natl Med Assoc (Journal of the National Medical Association)
[2019, 111(2):122-133]

Cited: 0 times

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