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Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients.

Zhouping Wang, Yufen Xu, Huazhong Zhou, Yanfei Wang, Wei Li, Zhaoliang Lu, Zhiyong Jiang, Xueping Gu, Hao Zheng, Lanlan Zeng, Ping Huang, Li Zhang, Xiaoqiong Gu,

Children with Kawasaki disease (KD) resistant to intravenous immunoglobulin (IVIG) have a higher incidence of coronary artery lesions (CAL). Despite the association between Purinergic receptor P2Y12 (P2RY12) polymorphism, KD genetic susceptibility, and CAL complications being proved, few studies have assessed the relationship between P2RY12 polymorphisms and IVIG resistance in patients ... Read more >>

Cardiovasc Ther (Cardiovascular Therapeutics)
[2020, 2020:3568608]

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Genetic testing for the diagnosis and classification of joint hypermobility: a case report of 15 patients

Lanlan Zeng, Li Zhang, Siyuan Linpeng, Zhuo Li, Desheng Liang, lingqian Wu,

Abstract The authors have withdrawn this preprint from Research Square. ... Read more >>

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The rare Alus element-mediated chimerism of multiple de novo complex rearrangement sequences in GAN result in giant axonal neuropathy.

Meizhen Shi, Xin Chen, Lanlan Zeng, Zhuo Li, Desheng Liang, Lingqian Wu,

Giant axonal neuropathy (GAN) is a rare and grievous autosomal recessive neurodegenerative disease due to loss-of-function mutation in GAN. However, the chimerism of complex rearrangement sequences of GAN has not been reported so far, and the mechanism for its complex rearrangements remains to be determined. We identified a family with ... Read more >>

Clin. Chim. Acta (Clinica chimica acta; international journal of clinical chemistry)
[2020, 502:91-98]

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Association between the miRNA-149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population.

Jiawen Li, Jinxin Wang, Xiaoping Su, Zhiyong Jiang, Xing Rong, Xueping Gu, Chang Jia, Lanlan Zeng, Hao Zheng, Xiaoqiong Gu, Maoping Chu,

BACKGROUND:Kawasaki disease (KD), which is characterized by vasculitis, is prone to occur in patients under 5 years of age, has an ambiguous etiology, and displays coronary artery lesions as the chief complication. Previous studies have linked miRNA-149 to cancers, and rs2292832 T>C is related to allergic diseases and inflammatory bowel disease, ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2020, 34(4):e23125]

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Incidence, Bacterial Profiles, And Antimicrobial Resistance Of Culture-Proven Neonatal Sepsis In South China.

Kankan Gao, Jie Fu, Xiaoshan Guan, Sufei Zhu, Lanlan Zeng, Xiaoming Xu, Chien-Yi Chang, Haiying Liu,

Background:Neonatal sepsis (NS) is one of the leading causes of infant morbidity and mortality, but little is known about pathogen incidence and distribution in China. Methods:In this retrospective study (January 2012 to December 2016), culture-proven cases aged less than 28 days with diagnosed NS in the Guangzhou Women and Children's ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2019, 12:3797-3805]

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28 novel mutations identified from 33 Chinese patients with cilia-related kidney disorders.

Nana Liang, Xuanyu Jiang, Lanlan Zeng, Zhuo Li, Desheng Liang, Lingqian Wu,

BACKGROUND:Cilia play an important role in cellular signaling pathways. Defective ciliary function causes a variety of disorders involve retina, skeleton, liver, kidney or others. Cilia-related kidney disorders are characterized by cystic renal disease, nephronophthisis and renal failure in general. METHODS:In this study, we collected 33 families clinically suspected of cilia-related ... Read more >>

Clin. Chim. Acta (Clinica chimica acta; international journal of clinical chemistry)
[2020, 501:207-215]

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Molecular genetic study of 59 Chinese Oculocutaneous albinism families.

Dan Luo, Siyuan Linpeng, Lanlan Zeng, Hu Tan, Zhuo Li, Lingqian Wu,

Oculocutaneous albinism is an autosomal recessive disorder characterized by either a complete lack of or reduction in melanin biosynthesis in the skin, hair, and eyes. The aim of the present study was to identify the molecular basis for 59 Chinese OCA families. In this study, compound heterozygous or homozygous pathogenic ... Read more >>

Eur J Med Genet (European journal of medical genetics)
[2019, 62(10):103709]

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Association between miRNA-196a2 rs11614913 T>C polymorphism and Kawasaki disease susceptibility in southern Chinese children.

Jinxin Wang, Jiawen Li, Huixian Qiu, Lanlan Zeng, Hao Zheng, Xing Rong, Zhiyong Jiang, Xueping Gu, Xiaoqiong Gu, Maoping Chu,

BACKGROUND:miRNAs play important roles in a variety of diseases. Thus, the association between miRNA-196a2 rs11614913 T>C polymorphism and Kawasaki disease susceptibility is still unknown. METHODS:We included 532 children with Kawasaki disease and 623 healthy children from South China, and their DNA was extracted for genotyping by TaqMan methodology. Odds ratios ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2019, 33(7):e22925]

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The rs6505162 C>A polymorphism in themiRNA-423gene exhibits a protective element of coronary artery in a southern Chinese population with Kawasaki disease

Jiawen Li, Jinxin Wang, Xiaoping Su, Zhiyong Jiang, Xing Rong, Xueping Gu, Huixian Qiu, Lanlan Zeng, Hao Zheng, Xiaoqiong Gu, Maoping Chu,

Abstract Background Manifesting as acute rash, fever and vasculitis, belonging to autoimmune syndrome, Kawasaki disease(KD) is prone to occur in infants and young children. Males and females is affected by KD at a ratio of 1.4 to 1.7: 1. KD is known to own many common clinical manifestations and complications, ... Read more >>

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An increasing trend of neonatal invasive multidrug-resistant group B streptococcus infections in southern China, 2011-2017.

Kankan Gao, Xiaoshan Guan, Lanlan Zeng, Jiabi Qian, Sufei Zhu, Qiulian Deng, Huamin Zhong, Shuying Pang, Fei Gao, Jielin Wang, Yan Long, Chien-Yi Chang, Haiying Liu,

Background:A multidrug-resistant (MDR) RR2 gene cluster was identified by whole-genome sequencing in several highly virulent (ST-17) Group B streptococcus (GBS) isolates, which caused neonatal invasive infections in southern China in 2016. Tracing the transmission and distribution of MDR isolates in this area is important for the effective management of future ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2018, 11:2561-2569]

Cited: 3 times

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An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease.

Yunfeng Liu, Lanyan Fu, Lei Pi, Di Che, Yufen Xu, Hao Zheng, Haifeng Long, Lanlan Zeng, Ping Huang, Li Zhang, Tao Yu, Xiaoqiong Gu,

Background:Kawasaki disease (KD) is an acute vasculitis disease that commonly causes acquired heart disease in children. Coronary artery aneurysm (CAA) is a major complication of KD. However, the pathogenesis of KD remains unclear. The results of a genome-wide association study (GWAS) showed that two functional single-nucleotide polymorphisms (SNPs; rs699A>G and ... Read more >>

Dis. Markers (Disease markers)
[2019, 2019:2849695]

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Novel GATAD2B loss-of-function mutations cause intellectual disability in two unrelated cases.

Xiaomei Luo, Yongyi Zou, Bo Tan, Yue Zhang, Jing Guo, Lanlan Zeng, Rui Zhang, Hu Tan, Xianda Wei, Yiqiao Hu, Yu Zheng, Desheng Liang, Lingqian Wu,

GATA zinc finger domain-containing 2B (GATAD2B) is a subunit of the methyl-CpG-binding protein-1 complex (MECP1), which deacetylates methylated nucleosomes and regresses transcriptional activity. Recently, GATAD2B has been elucidated as a candidate gene in patients with intellectual disability (ID). In this study, we identified two novel heterozygous frameshift mutations of GATAD2B ... Read more >>

J. Hum. Genet. (Journal of human genetics)
[2017, 62(4):513-516]

Cited: 2 times

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A novel de novo POGZ mutation in a patient with intellectual disability.

Bo Tan, Yongyi Zou, Yue Zhang, Rui Zhang, Jianjun Ou, Yidong Shen, Jingping Zhao, Xiaomei Luo, Jing Guo, Lanlan Zeng, Yiqiao Hu, Yu Zheng, Qian Pan, Desheng Liang, Lingqian Wu,

POGZ, the gene encoding pogo transposable element-derived protein with zinc-finger domain, has been implicated in autism spectrum disorder and it is widely expressed in the human tissues, including the brain. Intellectual disability (ID) is highly heterogeneous neurodevelopment disorder and affects ~2-3% of the general population. Here we report the identification ... Read more >>

J. Hum. Genet. (Journal of human genetics)
[2016, 61(4):357-359]

Cited: 4 times

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Rapid quantitative detection method and detection kit for clostridium perfringens

YULING SHI, LINHAI LI, LUXIA WANG, YANG LIAO, LIDAN CHEN, JIANYUN CHEN, YASONG ZHANG, LANLAN ZENG,

The invention provides a method for quantitative detection of clostridium perfringens, including the following steps: (a) obtaining secretion of a patient and extracting genomic DNA of bacteria therein (b) carrying out fluorescence quantitative PCR amplification on the DNA obtained in the step (a) by taking the sequences SEQ ID NO:1 ... Read more >>

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