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Efficacy of a Novel Penile Traction Device in Improving Penile Length and Erectile Function Post Prostatectomy: Results from a Single-Center Randomized, Controlled Trial.

Amir Toussi, Matthew Ziegelmann, David Yang, Madeleine Manka, Igor Frank, Stephen A Boorjian, Matthew Tollefson, Tobias Köhler, Landon Trost,

<h4>Purpose</h4>RestoreX is a novel penile traction therapy device, with randomized, controlled data demonstrating improvements in penile length and erectile function after 30 to 90 minutes of daily use in men with Peyronie's disease. We sought to determine if similar improvements could be achieved post prostatectomy.<h4>Materials and methods</h4>Men post prostatectomy were ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001792]

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Restorative Therapies for Erectile Dysfunction: Position Statement From the Sexual Medicine Society of North America (SMSNA).

James L Liu, Kevin Y Chu, Andrew T Gabrielson, Run Wang, Landon Trost, Gregory Broderick, Kelvin Davies, Gerald Brock, John Mulhall, Ranjith Ramasamy, Trinity J Bivalacqua,

<h4>Introduction</h4>Current non-invasive treatments for erectile dysfunction (ED) include oral medications, intracavernosal injections, and vacuum-assisted devices. Though these therapies work well for many, a subset of patients have contraindications or are unsatisfied with these options. Restorative therapies for ED are a new frontier of treatments focused on regenerating diseased tissue and ... Read more >>

Sex Med (Sexual medicine)
[2021, 9(3):100343]

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Amir Toussi, Matthew Ziegelmann, David Yang, Madeleine Manka, Igor Frank, Stephen A Boorjian, Matthew Tollefson, Tobias Köhler, Landon Trost,

J Urol (The Journal of urology)
[2021, :101097JU000000000000179203]

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Continuing Collagenase Clostridium Histolyticum Injections Among Initial Nonresponders Results in Significant Curvature Improvements in the Majority of Peyronie's Disease Men.

Manaf Alom, Holli Burgon, Matthew Ziegelmann, Tobias Köhler, Sevann Helo, Landon Trost,

<h4>Background</h4>It is currently unclear if men with Peyronie's Disease (PD) who achieve minimal benefits with the first 2 series of Collagenase Clostridium Histolyticum (CCH) injections should continue with additional injections.<h4>Aim</h4>To analyze curvature improvements from the final two series of CCH injections based on amount of improvement during the first 2 ... Read more >>

J Sex Med (The journal of sexual medicine)
[2021, :]

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Patient Attitudes Towards Surgical Management of Peyronie's Disease Prior to Men's Health Consultation.

Raevti Bole, Masaya Jimbo, Niki Parikh, Cameron Britton, Ajay Gopalakrishna, David Yang, Landon Trost, Sevann Helo, Tobias Kohler, Matthew Ziegelmann,

<h4>Objective</h4>To evaluate clinical characteristics associated with patient attitudes toward surgical treatment of Peyronie's disease (PD) prior to consultation in a high-volume male sexual health clinic.<h4>Methods</h4>From 2014-2018 a prospective database was created of patients presenting to the sexual health clinic at our institution. Multivariable regression analysis was conducted to determine factors ... Read more >>

Urology (Urology)
[2021, :]

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Treatment Patterns and Healthcare Outcomes with Collagenase Clostridium Histolyticum vs Surgery in Peyronie's Disease: A Retrospective Claims Database Analysis.

Landon Trost, Huan Huang, Xu Han, Chakkarin Burudpakdee, Yiqun Hu,

<h4>Introduction</h4>Treatments for Peyronie's disease (PD) include surgical management and collagenase clostridium histolyticum (CCH).<h4>Aims</h4>To evaluate PD treatment trends after CCH approval and compare clinical outcomes in CCH- and surgery-treated cohorts.<h4>Methods</h4>Patients newly diagnosed with PD between January 2011 and December 2017 were identified in a U.S. claims database. Cohorts initiating treatment with ... Read more >>

Sex Med (Sexual medicine)
[2021, 9(2):100321]

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Conservative management of suspected fractures in men undergoing collagenase clostridium histolyticum for Peyronie's Disease is not associated with worsening of erectile function.

Kiran L Sharma, Raevti Bole, David Yang, Manaf Alom, Joshua Savage, Matthew Ziegelmann, Landon Trost,

The optimal management of suspected penile fractures post collagenase clostridium histolyticum (CCH) remains indeterminate, with some advocating for observation and others surgical repair. To address this issue, the current study sent surveys to 158 men with Peyronie's Disease (PD) who completed four CCH injection series. The survey included the Erectile ... Read more >>

Int J Impot Res (International journal of impotence research)
[2020, :]

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Outcomes of RestoreX Penile Traction Therapy in Men With Peyronie's Disease: Results From Open Label and Follow-up Phases.

Jason Joseph, Matthew J Ziegelmann, Manaf Alom, Joshua Savage, Tobias S Köhler, Landon Trost,

<h4>Background</h4>A randomized, controlled clinical trial evaluating the efficacy of RestoreX traction therapy in men with Peyronie's disease (PD) has been completed, with the 3-month results previously reported. The present study presents outcomes from the open-label and follow-up phases of the original trial.<h4>Aim</h4>To report 6-month (open-label phase) and 9-month (follow-up phase) ... Read more >>

J Sex Med (The journal of sexual medicine)
[2020, 17(12):2462-2471]

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Vascular Necrosis of the Upper Extremity After Self-Treatment for Peyronie's Disease.

David Yang, Joshua Savage, Tobias Köhler, Sevann Helo, Landon Trost, Matthew Ziegelmann,

Peyronie's disease (PD) is associated with significant psychosocial distress, including anxiety, depression, and negative effects on interpersonal relationships. We report outcomes in a patient who researched an enzymatic supplement intended for oral administration for treatment of PD and subsequently self-injected it intravascularly. The enzyme, a combination of serrapeptase and nattokinase, ... Read more >>

Sex Med (Sexual medicine)
[2021, 9(1):100282]

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Predictors of Patient Willingness to Consider Surgery Prior to Consultation at Sexual Health Clinic.

Raevti Bole, Matthew Ziegelmann, Ajay Gopalakrishna, Charles Scott Collins, Manaf Alom, Landon Trost, Sevann Helo, Tobias S Köhler,

<h4>Objective</h4>To identify factors associated with patient willingness to consider surgical treatment for erectile dysfunction (ED) prior to urologic consultation.<h4>Methods</h4>A prospective database of patients presenting to the sexual health clinic at our institution was created from 2014 to 2018, consisting of previsit patient questionnaires and clinical information. Univariable and multivariable logistic ... Read more >>

Urology (Urology)
[2021, 147:172-177]

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Response to Commentary on Contemporary Considerations in a Man With Low Sex Drive.

Daniela Wittmann, Mohit Khera, Landon Trost, John Mulhall,

J Sex Med (The journal of sexual medicine)
[2020, 17(11):2311]

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Safety and Efficacy of Collagenase Clostridium histolyticum in the Treatment of Acute Phase Peyronie's Disease: A Multi-institutional Analysis.

Hoang Minh Tue Nguyen, Ayad Yousif, Amanda Chung, Ramón Virasoro, Ashley Tapscott, Matthew Ziegelmann, Landon Trost, Martin Gelbard, Wayne J G Hellstrom,

OBJECTIVE:To study, in a multi-institutional setting, the efficacy/safety outcomes in acute phase Peyronie's disease (PD) of multiple high-volume centers employing CCH to treat PD, which is defined as the abnormal formation of fibrous plaque(s) in the tunica albuginea of the penis. It is a chronic condition that afflicts 3%-13% of ... Read more >>

Urology (Urology)
[2020, 145:147-151]

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Discrepancy between Post-Vasectomy Semen Analysis Recommendation and Practice Patterns in the Post-2012 American Urological Association Guideline Era.

Madeleine G Manka, Adam Miller, Vidit Sharma, Mohit Butaney, Landon Trost, Matthew Ziegelmann,

PURPOSE:In 2012 the American Urological Association published vasectomy guidelines to promote best practices, including when to obtain post-vasectomy semen analyses. In this study we assessed practice patterns of post-vasectomy semen analysis since this guideline publication. MATERIALS AND METHODS:We retrospectively analyzed a database of men who underwent post-vasectomy semen analysis between ... Read more >>

J Urol (The Journal of urology)
[2020, 204(6):1312-1317]

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Intraoperative Use of Betadine Irrigation is Associated With a 9-Fold Increased Likelihood of Penile Prosthesis Infection: Results From a Retrospective Case-Control Study.

Madeleine G Manka, David Yang, Jack Andrews, Brian Chalmers, Kevin Hebert, Tobias S Köhler, Landon Trost,

<h4>Introduction</h4>Infection remains a persistent complication of penile prosthesis (PP) surgery. Despite popularity of Mulcahy's PP washout protocol, Betadine has known tissue toxicity.<h4>Aim</h4>We evaluated PP infection rate based on the type of intraoperative irrigation used, ½ strength Betadine vs vancomycin/gentamicin.<h4>Methods</h4>We reviewed a prospective database of men undergoing primary, revision, and salvage ... Read more >>

Sex Med (Sexual medicine)
[2020, 8(3):422-427]

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Characteristics of men who are bothered by rapid ejaculation: results from clinical intake surveys.

Ajay Gopalakrishna, Raevti Bole, Manaf Alom, Yifan Meng, Masaya Jimbo, Landon Trost, Sevann Helo, Tobias Kohler, Matthew Ziegelmann,

The objective of this study is to identify factors associated with bother with rapid ejaculation in a cohort of men presenting to a sexual dysfunction clinic, independent of a diagnosis of PE. A prospective institutional database has been maintained on patients completing an 89-item intake questionnaire querying various areas of ... Read more >>

Int J Impot Res (International journal of impotence research)
[2021, 33(3):369-375]

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Contemporary Considerations in the Pathophysiology of Low Sex Drive in Men.

Daniela Wittmann, Mohit Khera, Landon Trost, John Mulhall,

J Sex Med (The journal of sexual medicine)
[2020, 17(6):1049-1052]

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Prevalence and Predictors of Climacturia and Associated Patient/Partner Bother in Patients With History of Definitive Therapy for Prostate Cancer.

Masaya Jimbo, Manaf Alom, Zachary D Pfeifer, Eiftu S Haile, Dane A Stephens, Ajay Gopalakrishna, Matthew J Ziegelmann, Boyd R Viers, Landon W Trost, Tobias S Kohler,

<h4>Background</h4>Climacturia is an under-reported complication of definitive therapy for prostate cancer (PCa) - that is, radical prostatectomy (RP) and/or radiation therapy (RT).<h4>Aim</h4>We sought to identify the prevalence and predictors of climacturia and associated patient/partner bother in patients with and without prior PCa treatment.<h4>Methods</h4>We analyzed a database of patients who presented ... Read more >>

J Sex Med (The journal of sexual medicine)
[2020, 17(6):1126-1132]

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The Influence of Indentation Deformity on Outcomes With Intralesional Collagenase Clostridium Histolyticum Monotherapy for Peyronie's Disease.

Matthew J Ziegelmann, Daniel Heslop, Matthew Houlihan, Petar Bajic, Sevann Helo, Landon Trost, Tobias Kohler,

OBJECTIVE:To identify patient-specific factors associated with patient-reported improvements in functional outcomes after intralesional Collagenase Clostridium histolyticum (CCH) for Peyronie's Disease (PD). METHODS:We retrospectively explored our prospectively maintained CCH registry. We sought to identify patient-specific factors that prevented the need for surgical straightening and/or improved ability to engage in penetrative intercourse. ... Read more >>

Urology (Urology)
[2020, 139:122-128]

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Reinforcing vasal suture technique improves sperm concentration and pregnancy rates in men undergoing vasovasostomy for vasectomy reversal.

Joshua Savage, Madeleine Manka, Tiffany Rindels, Manaf Alom, Kiran L Sharma, Landon Trost,

Background:Vasovasostomy (VV) is a well-described surgical technique with few notable modifications since microsurgical adaptation in the 1970s. Although contemporary reversal success rates are 70-90%, these most often are based on a lenient definition of >0 sperm (patency) and include only VV procedures. With stricter definitions, success rates drop >30%. To ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(1):73-81]

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Peyronie's Disease Intervention Studies: An Exploration of Modern-Era Challenges in Study Design and Evaluating Treatment Outcomes.

Matthew J Ziegelmann, Landon W Trost, Giorgio I Russo, Laurence A Levine,

INTRODUCTION:Peyronie's disease (PD) is characterized by pain, deformity, sexual dysfunction, and psychological bother. Several treatments are available with varying levels of efficacy, and significant limitations exist with the currently available literature. AIM:To explore modern-era methodological challenges inherent to PD research as they pertain to intervention studies. METHODS:We performed a critical ... Read more >>

J Sex Med (The journal of sexual medicine)
[2020, 17(3):364-377]

Cited: 1 time

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Future considerations in prosthetic urology.

Landon Trost,

Since their popularization, genitourinary prosthetics have remained a gold-standard therapy for the treatment of erectile dysfunction and stress urinary incontinence and in cases of testicular loss or dysfunction. They have also represented an area of significant innovation, which has contributed to excellent long-term outcomes. Given this history, the objective of ... Read more >>

Asian J Androl (Asian journal of andrology)
[2020, 22(1):70-75]

Cited: 2 times

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Sperm retrieval rates in non-mosaic Klinefelter patients undergoing testicular sperm extraction: What expectations do we have in the real-life setting?

Luca Boeri, Franco Palmisano, Mirko Preto, Mattia Sibona, Paolo Capogrosso, Alessandro Franceschelli, Eduard Ruiz-Castañé, Joaquim Sarquella-Geli, Lluís Bassas-Arnau, Fabrizio Ildefonso Scroppo, Antonino Saccà, Giorgio Gentile, Marco Falcone, Massimiliano Timpano, Carlo Ceruti, Franco Gadda, Landon Trost, Fulvio Colombo, Luigi Rolle, Paolo Gontero, Francesco Montorsi, Josvany Sánchez-Curbelo, Andrea Salonia, Emanuele Montanari,

<h4>Background</h4>A recent meta-analysis (Human Reproduction Update 23, 2017 and 265) reported positive sperm retrieval rates (SRR) in 50% of patients with Klinefelter syndrome (KS) undergoing testicular sperm extraction (TESE). However, these results do not reflect the rates of SR that we observe in clinical practice. We assessed the rate and ... Read more >>

Andrology (Andrology)
[2020, 8(3):680-687]

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Corrigendum to 'Plaque calcification: An important predictor of collagenase clostridium histolyticum treatment outcomes for men with Peyronie's Disease'.

Kevin Wymer, Matthew Ziegelmann, Joshua Savage, Tobias Kohler, Landon Trost,

Urology (Urology)
[2020, 135:174-175]

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Two dimensional penile ultrasound vibro-elastography for measuring penile tissue viscoelasticity: A pilot patient study and its correlation with penile ultrasonography.

Xiaoming Zhang, Boran Zhou, Stephen L Kopecky, Landon W Trost,

The purpose of this research is to demonstrate the feasibility of a 2 dimensional (2D) penile ultrasound vibro-elastography (PUVE) technique for measuring the shear wave speed map over an area of regional of interest (ROI) in the penis. In PUVE, a 0.1 s harmonic vibration at a low frequency is generated ... Read more >>

J Mech Behav Biomed Mater (Journal of the mechanical behavior of biomedical materials)
[2020, 103:103570]

Cited: 1 time

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Intercourse frequency among men presenting to a sexual health clinic: does age matter?

Mary E Westerman, Francisco Maldonado, Jack R Andrews, Vidit Sharma, Landon Trost, Matthew J Ziegelmann,

We assessed the association between intercourse frequency and sexual function among 583 consecutive males with sexual partners presenting to a men's health clinic over a 2-year period. Median age was 62 and men reported a median of 2 (IQR 0, 5) episodes of intercourse per month. Younger age, shorter relationship ... Read more >>

Int J Impot Res (International journal of impotence research)
[2021, 33(1):49-54]

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