Full Text Journal Articles by
Author Landon Bellavia

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Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

Kara S Hughan, Stacy Gelhaus Wendell, Meghan Delmastro-Greenwood, Nicole Helbling, Catherine Corey, Landon Bellavia, Gopal Potti, George Grimes, Bret Goodpaster, Daniel B Kim-Shapiro, Sruti Shiva, Bruce A Freeman, Mark T Gladwin,

Dietary NO3- (nitrate) and NO2- (nitrite) support ˙NO (nitric oxide) generation and downstream vascular signaling responses. These nitrogen oxides also generate secondary nitrosating and nitrating species that react with low molecular weight thiols, heme centers, proteins, and unsaturated fatty acids. To explore the kinetics of NO3-and NO2-metabolism and the impact ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2017, 70(3):634-644]

Cited: 5 times

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In a canine pneumonia model of exchange transfusion, altering the age but not the volume of older red blood cells markedly alters outcome.

Irene Cortés-Puch, Kenneth E Remy, Steven B Solomon, Junfeng Sun, Dong Wang, Mariam Al-Hamad, Seth M Kelly, Derek Sinchar, Landon Bellavia, Tamir Kanias, Mark A Popovsky, Daniel B Kim-Shapiro, Harvey G Klein, Charles Natanson,

BACKGROUND:Massive exchange transfusion of 42-day-old red blood cells (RBCs) in a canine model of Staphylococcus aureus pneumonia resulted in in vivo hemolysis with increases in cell-free hemoglobin (CFH), transferrin-bound iron (TBI), non-transferrin-bound iron (NTBI), and mortality. We have previously shown that washing 42-day-old RBCs before transfusion significantly decreased NTBI levels ... Read more >>

Transfusion (Transfusion)
[2015, 55(11):2564-2575]

Cited: 14 times

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Detecting and monitoring NO, SNO and nitrite in vivo.

Landon Bellavia, Daniel B Kim-Shapiro, S Bruce King,

The detection and quantification of nitric oxide and related reactive nitrogen species in vivo is vital to the understanding of the pathology and/or treatment of numerous conditions. To that end, several detection and quantification methods have been developed to study NO, as well as its redox relatives, nitrite and S-nitrosothiols. ... Read more >>

Future Sci OA (Future science OA)
[2015, 1(1):]

Cited: 3 times

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Direct and nitroxyl (HNO)-mediated reactions of acyloxy nitroso compounds with the thiol-containing proteins glyceraldehyde 3-phosphate dehydrogenase and alkyl hydroperoxide reductase subunit C.

Susan Mitroka, Mai E Shoman, Jenna F DuMond, Landon Bellavia, Omar M Aly, Mohamed Abdel-Aziz, Daniel B Kim-Shapiro, S Bruce King,

Nitroxyl (HNO) reacts with thiols, and this reactivity requires the use of donors with 1-nitrosocyclohexyl acetate, pivalate, and trifluoroacetate, forming a new group. These acyloxy nitroso compounds inhibit glyceraldehyde 3-phosphate dehydrogenase (GAPDH) by forming a reduction reversible active site disulfide and a reduction irreversible sulfinic acid or sulfinamide modification at ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2013, 56(17):6583-6592]

Cited: 6 times

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Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia.

Irene Cortés-Puch, Dong Wang, Junfeng Sun, Steven B Solomon, Kenneth E Remy, Melinda Fernandez, Jing Feng, Tamir Kanias, Landon Bellavia, Derek Sinchar, Andreas Perlegas, Michael A Solomon, Walter E Kelley, Mark A Popovsky, Mark T Gladwin, Daniel B Kim-Shapiro, Harvey G Klein, Charles Natanson,

In a randomized controlled blinded trial, 2-year-old purpose-bred beagles (n = 24), with Staphylococcus aureus pneumonia, were exchanged-transfused with either 7- or 42-day-old washed or unwashed canine universal donor blood (80 mL/kg in 4 divided doses). Washing red cells (RBC) before transfusion had a significantly different effect on canine survival, ... Read more >>

Blood (Blood)
[2014, 123(9):1403-1411]

Cited: 37 times

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Nitroxyl accelerates the oxidation of oxyhemoglobin by nitrite.

Landon Bellavia, Jenna F DuMond, Andreas Perlegas, S Bruce King, Daniel B Kim-Shapiro,

Angeli's salt (Na₂N₂O₃) decomposes into nitroxyl (HNO) and nitrite (NO₂(-)), compounds of physiological and therapeutic interest for their impact on biological signaling both through nitric oxide and nitric oxide independent pathways. Both nitrite and HNO oxidize oxygenated hemoglobin to methemoglobin. Earlier work has shown that HNO catalyzes the reduction of ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2013, 31:38-47]

Cited: 1 time

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Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin.

Steven B Solomon, Landon Bellavia, Daniel Sweeney, Barbora Piknova, Andreas Perlegas, Christine C Helms, Gabriela A Ferreyra, S Bruce King, Nicolaas J H Raat, Steven J Kern, Junfeng Sun, Linda C McPhail, Alan N Schechter, Charles Natanson, Mark T Gladwin, Daniel B Kim-Shapiro,

Plasma hemoglobin (Hb) released during intravascular hemolysis has been associated with numerous deleterious effects that may stem from increased nitric oxide (NO) scavenging, but has also been associated with reactive oxygen species generation and platelet activation. Therapies that convert plasma oxyHb to metHb, or metHb to iron-nitrosyl Hb, could be ... Read more >>

Free Radic. Biol. Med. (Free radical biology & medicine)
[2012, 53(12):2229-2239]

Cited: 8 times

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