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MicroRNA miR-330-3p suppresses the progression of ovarian cancer by targeting RIPK4.

Li Cai, Lu Ye, Xiaoqing Hu, Wenfeng He, Debao Zhuang, Qi Guo, Kuanyong Shu, Youkun Jie,

Previous studies reported that miR-330-3p was involved in the progression of several cancers, but the potential roles of miR-330-3p in ovarian cancer (OC) were unclear. In the current study, we aimed to explore the expression pattern and functions of miR-330-3p in OC. The expression level of miR-330-3p in OC tissues ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):440-449]

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Epidemiological profile and molecular genetic characterization of HIV-1 among female sex workers and elderly male clients in Guangxi, China.

Xiu Chen, Chunwei Qin, Rongfeng Chen, Yunxuan Huang, Yuexiang Xu, Qiao Tang, Xianjun Liang, Bing Peng, Yi Shao, Yao Yang, Jie Chen, Xinwei Wang, Liufang Wen, Bingyu Liang, Li Ye, Xionglin Qin, Junjun Jiang, Hao Liang,

The HIV/AIDS prevalence in female sex workers (FSWs) and elderly male clients is increasing in Guangxi, China, but the transmission relationship between them remains unclear. This study aims to illuminate the transmission network between FSWs and elderly male clients using molecular epidemiological analyses. Phylogenetic analysis indicated that CRF01_AE was the ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):384-395]

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Esculin protects against methionine choline-deficient diet-induced non-alcoholic steatohepatitis by regulating the Sirt1/NF-κB p65 pathway.

Xi-Ding Yang, Zhuo Chen, Ling Ye, Jing Chen, Yong-Yu Yang,

<h4>Context</h4>Esculin, an active coumarin compound, has been demonstrated to exert anti-inflammatory effects. However, its potential role in non-alcoholic steatohepatitis (NASH) remains unclear.<h4>Objective</h4>This study explored the hepatoprotective effect and the molecular mechanism of esculin in methionine choline-deficient (MCD) diet-induced NASH.<h4>Materials and methods</h4>Fifty C57BL/6J mice were divided into five groups: control, model, ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):922-932]

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Resveratrol acts via melanoma-associated antigen A12 (MAGEA12)/protein kinase B (Akt) signaling to inhibit the proliferation of oral squamous cell carcinoma cells.

Yu Shang, Yu-Ling Jiang, Li-Jun Ye, Li-Na Chen, Yue Ke,

The present study examined how resveratrol affects cell growth and MAGEA12/Akt signaling pathway in OSCC cells. Cal-27 cells were transiently transfected with a plasmid encoding <i>MAGEA12</i>, and the effects of overexpression were assessed in terms of cell viability, colony formation and the epithelial-mesenchymal transition. Cal-27 cells and <i>MAGEA12</i>-overexpressing cells were ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2253-2262]

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Prognostic significance of microRNA miR-24 in cancers: a meta-analysis.

Rongqiang Liu, Weihao Kong, Shiyang Zheng, Chenyu Yu, Yajie Yu, Yuling Xu, Linsen Ye, Yi Shao,

The prognostic significance of miR-24 in tumors has not been determined. Therefore, we conducted a meta-analysis to systematically assess the correlation between miR-24 and its prognostic value in cancers PubMed, EMBASE, and Web of Science databases were used to search relevant articles (up to 1 October 2020). Studies that evaluated ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):450-460]

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Talaromyces marneffei promotes M2-like polarization of human macrophages by downregulating SOCS3 expression and activating the TLR9 pathway.

Wudi Wei, Chuanyi Ning, Jiegang Huang, Gang Wang, Jingzhen Lai, Jing Han, Jinhao He, Hong Zhang, Bingyu Liang, Yanyan Liao, Thuy Le, Qiang Luo, Zhen Li, Junjun Jiang, Li Ye, Hao Liang,

Little is known about how <i>Talaromyces marneffei</i>, a thermally dimorphic fungus that causes substantial morbidity and mortality in Southeast Asia, evades the human immune system. Polarization of macrophages into fungal-inhibiting M1-like and fungal-promoting M2-like types has been shown to play an important role in the innate immune response against fungal ... Read more >>

Virulence (Virulence)
[2021, 12(1):1997-2012]

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The miR-1906 mimic attenuates bone loss in osteoporosis by down-regulating the TLR4/MyD88/NF-κB pathway.

H Xie, L Cao, L Ye, G Shan, W Song,

In this study, the ability of microRNA-1906 (miR-1906) to attenuate bone loss in osteoporosis was evaluated by measuring the effects of a miR-1906 mimic and inhibitor on the cellular toxicity and cell viability of MC3T3-E1 cells. Bone marrow-derived macrophage (BMM) cells were isolated from female mice, and tartrate-resistant acid phosphatase ... Read more >>

Physiol Int (Physiology international)
[2021, 107(4):469-478]

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Prognostic Value of the Nutritional Risk Screening 2002 Scale in Patients With Acute Myocardial Infarction: Insights From the Retrospective Multicenter Study for Early Evaluation of Acute Chest Pain.

Fanghui Li, Dongze Li, Jing Yu, Yu Jia, Ying Jiang, Xiaoli Chen, Yongli Gao, Lei Ye, Zhi Wan, Yu Cao, Zhi Zeng, Rui Zeng,

<h4>Background</h4>The Nutritional Risk Screening 2002 (NRS-2002) scale is a rapid and effective screening instrument that assesses nutritional risk among hospitalized patients.<h4>Objective</h4>The present study aimed to explore the prognostic value of the NRS-2002 scale in acute myocardial infarction (AMI) considering its uncertain role in this particular condition.<h4>Methods</h4>Patients with AMI included in ... Read more >>

J Cardiovasc Nurs (The Journal of cardiovascular nursing)
[2021, 36(6):546-555]

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An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination.

Dengning Xia, Rui Jin, Gaurav Byagathvalli, Huan Yu, Ling Ye, Chao-Yi Lu, M Saad Bhamla, Chinglai Yang, Mark R Prausnitz,

Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other pathogens with pandemic potential requires safe, protective, inexpensive, and easily accessible vaccines that can be developed and manufactured rapidly at a large scale. DNA vaccines can achieve these criteria, but induction of strong immune responses has often required bulky, ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(45):]

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NELL1 Augments Osteogenesis and Inhibits Inflammation of Human Periodontal Ligament Stem Cells Induced by BMP9.

Liu Wang, Xiangfen Li, Yao Song, Lan Zhang, Ling Ye, Xuedong Zhou, Dongzhe Song, Dingming Huang,

<h4>Background</h4>Periodontitis could lead to periodontal destruction such as the loss of alveolar bone. The issue that how to achieve the regeneration of alveolar bone and periodontal tissues under the inflammatory environment needs to be solved urgently. BMP9 is one of the most potent osteo-inductive BMPs and induces osteogenic differentiation of ... Read more >>

J Periodontol (Journal of periodontology)
[2021, :]

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Studies on transmittance modulation and ions transfer kinetic based on capacitive-controlled 2D V2O5 inverse opal film for electrochromic energy storage application.

Lili Zhao, Junwei Kuang, Weifeng Zhuang, Jie Chao, Wenbo Liao, Xiaobo Fu, Chao Li, Lingyun Ye, Hailu Liu,

Two-dimensional vanadium pentoxide inverse opal (2D V2O5 IO) architecture was fabricated by polystyrene (PS) sphere template assisted electrodeposition process. In comparison to the un-templated V2O5 film, the 2D V2O5 IO film exhibited a highly ordered hexagonal close-packed bowel-like array, as well as noticeable electrochromism, such as transmittance modulation up to ... Read more >>

Nanotechnology (Nanotechnology)
[2021, :]

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Ru doping induces the construction of a unique core-shell microflower self-supporting electrocatalyst for highly efficient overall water splitting.

Lei Ye, Yeqing Zhang, Buwen Guo, Duanlin Cao, Yaqiong Gong,

Since the large reaction energy barrier caused by multi-step electron transfer processes of the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) gravely restricts the practical application of electrocatalytic water splitting, it is urgent to develop a dual-functional electrocatalyst which can effectively reduce the reaction energy barrier and actually ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2021, 50(39):13951-13960]

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Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)

Xing Zhang, Chaoyue Zhao, Chaoyuan Cheng, Hongyue Li, Tao Yu, Kevin Lawrence, Jimin Sun, Zeyu Yang, Ling Ye, Hongliang Chu, Ying Wang, Xiaohu Han, Yongchao Jia, Shuozhang Fan, Hirotaka Kanuka, Tetsuya Tanaka, Cheryl Jenkins, Kristene Gedye, Shona Chandra, Dana Price, Qiyong Liu, Young Ki Choi, Xiangjiang Zhan, Guogang Zhang, Zhibin Zhang, Aihua Zheng,

Severe fever with thrombocytopenia syndrome virus (SFTSV) is spreading rapidly in Asia. It is transmitted by Haemaphysalis longicornis (Asian longhorned tick, ALT), which has both parthenogenetically and sexually reproducing populations. Parthenogenetic populations were found in at least 15 provinces in China and strongly correlated with the distribution of SFTS. The ... Read more >>

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Thermoplastic Elastomer Tunes Phase Structure and Promotes Stretchability of High-Efficiency Organic Solar Cells.

Zhongxiang Peng, Kaihu Xian, Yong Cui, Qingchun Qi, Junwei Liu, Ye Xu, Yubo Chai, Chunming Yang, Jianhui Hou, Yanhou Geng, Long Ye,

Top-performance organic solar cells (OSCs) consisting of conjugated polymer donors and nonfullerene small molecule acceptors (NF-SMAs) deliver rapid increases in efficiencies. Nevertheless, many of the polymer donors exhibit high stiffness and small molecule acceptors are very brittle, which limit their applications in wearable devices. Here, a simple and effective strategy ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2021, :e2106732]

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Asymmetric dearomatization catalysed by chiral Brønsted acids via activation of ynamides.

Ying-Qi Zhang, Yang-Bo Chen, Ji-Ren Liu, Shao-Qi Wu, Xin-Yang Fan, Zhi-Xin Zhang, Xin Hong, Long-Wu Ye,

Chiral Brønsted acid-catalysed asymmetric synthesis has received tremendous interest over the past decades, and numerous efficient synthetic methods have been developed based on this approach. However, the use of chiral Brønsted acids in these reactions is mostly limited to the activation of imine and carbonyl moieties, and the direct activation ... Read more >>

Nat Chem (Nature chemistry)
[2021, :]

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The detoxification effect of cytochrome P450 3A4 on gelsemine-induced toxicity.

Guoquan You, Ruopeng Yang, Yingjie Wei, Wanyu Hu, Lili Gan, Cong Xie, Zhijie Zheng, Zhongqiu Liu, Rongxin Liao, Ling Ye,

Gelsemine (GA), the principal alkaloid in Gelsemium elegans Benth, exhibits potent and specific antinociception in chronic pain without the induction of apparent tolerance. However, GA also exerts neurotoxicity and hepatotoxicity when overdosed, and potential detoxification pathways are urgently needed. Cytochrome P450 enzymes (CYPs) are important phase I enzymes involved in ... Read more >>

Toxicol Lett (Toxicology letters)
[2021, :]

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Study on Flow Model and Flow Equation of Shale Gas Based on Micro Flow Mechanism

Huaxun Liu, Chunyan Jiao, Shusheng Gao, Liyou Ye, Weiguo An,

Shale flow has microscale effects, and the flow is more complex. In this paper, the flow model and flow equation which can be used in the analysis of shale gas flow is established,which is based on the single nanotube model and combined with pore throat test results of the shale ... Read more >>

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PM2.5 promoted lipid accumulation in macrophage via inhibiting JAK2/STAT3 signaling pathways and aggravating the inflammatory reaction.

Liwei Yang, Zikai Song, Yang Pan, Tianyang Zhao, Yanbin Shi, Jiqiang Xing, Aipeng Ju, Liting Zhou, Lin Ye,

<h4>Background</h4>Abnormal lipid accumulation in macrophages may lead to macrophages foaming, which is the most important pathological process of atherosclerosis. Atmospheric PM<sub>2.5</sub> could enter the blood circulation and further affect the lipid metabolism of macrophages. But the underlying mechanism is not unclear. This study was undertaken to clarify the effect of ... Read more >>

Ecotoxicol Environ Saf (Ecotoxicology and environmental safety)
[2021, 226:112872]

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Impacts of eosinophil percentage on prognosis acute type A aortic dissection patients

Yue Shao, Liu Ye, Hao-ming Shi, Xin-mei Wang, Jun Luo, Lu Liu, Qing-chen Wu,

<h4>Background: </h4> Eosinophils are pro-inflammatory cells involved in thrombosis and have been proposed as a prognosis marker in acute ischemic stroke and ST-elevation myocardial Infarction. Here, we sought to clarify the prognostic value of eosinophil percentage (EOS%) in patients with acute type A aortic dissection (AAAD). Methods We examined ... Read more >>

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Nonlinear causal analysis reveals an effective water level regulation approach for phytoplankton blooms controlling in reservoirs.

Lin Ye, Lu Tan, Xinghua Wu, Qinghua Cai, B Larry Li,

Reservoirs are a rapidly increasing water body providing water supply, irrigation, and many other benefits for human societies globally. However, due to changes in hydrological conditions, building reservoirs tends to bring adverse effects such as eutrophication and phytoplankton blooms, reducing the ecosystem service values. This study focuses on using the ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, :150948]

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Advances in Pharmacotherapy of Hepatocellular Carcinoma: A State of the Art Review.

Florian P Reiter, Najib Ben Khaled, Liangtao Ye, Changhua Zhang, Max Seidensticker, Mark Op den Winkel, Gerald Denk, Andreas Geier, Enrico N De Toni,

Dig Dis (Digestive diseases (Basel, Switzerland))
[2021, :]

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Extremely stretchable and tough hybrid hydrogels based on gelatin, κ-carrageenan and polyacrylamide.

Xingyue Sun, Lina Ye, Haiyi Liang,

Nowadays, several approaches are being suggested to endow hydrogels with improved mechanical properties for practical applications as cartilage and skin replacements, soft electronics, and actuators. However, it remains a challenge to develop DN gels with both high fracture toughness and fracture stretch. Here, we introduce (bio)polyelectrolyte complexes (PECs) consisting of ... Read more >>

Soft Matter (Soft matter)
[2021, :]

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Research on the drying Mechanism of Astragali Radix during Processing

Jie Peng, Meng-Mei Wu, Li-Fang Ye, Meng-Hua Wu, Zhi-Guo Ma, Hui Cao, Ying Zhang,

<h4>Backgrounds: </h4>tragali Radix (Huangqi) is an important Chinese herbal medicine that is always processed into pieces for clinical use. There are many operations required after harvesting, among which drying of AR pieces is a key step. Unfortunately, research on the drying mechanism is still limited.MethodsLow-field nuclear magnetic resonance (LF-NMR) and ... Read more >>

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A transcription factor DAF-5 functions in Haemonchus contortus development.

Wenda Di, Fangfang Li, Li He, Chunqun Wang, Caixian Zhou, Lu Liu, Lisa Ye, Jian Chen, Min Hu,

<h4>Background</h4>Abnormal dauer formation gene (daf-5), located downstream of the DAF-7 signalling pathway, mainly functions in dauer formation and reproductive processes in the free-living nematode Caenorhabditis elegans. Although the structure and function of daf-5 have been clarified in C. elegans, they still remain totally unknown in Haemonchus contortus, a socio-economically important ... Read more >>

Parasit Vectors (Parasites & vectors)
[2021, 14(1):529]

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A novel linear and broadly neutralizing peptide in the SARS-CoV-2 S2 protein for universal vaccine development.

Tuofan Li, Qiuqi Kan, Jinying Ge, Zhimin Wan, Mengqi Yuan, Yao Huang, Quan Xie, Yi Yang, Hongxia Shao, Xiangdong Li, Lilin Ye, Aijian Qin, Zhigao Bu, Pinghuang Liu, Jianqiang Ye,

Cell Mol Immunol (Cellular & molecular immunology)
[2021, :]

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