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Author L Cao

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Downregulation of miR-491-5p promotes neovascularization after traumatic brain injury.

Wei Tang, Zong-Duo Guo, Wei-Na Chai, Dong-Lin Du, Xiao-Min Yang, Lang Cao, Hong Chen, Chao Zhou, Chong-Jie Cheng, Xiao-Chuan Sun, Zhi-Jian Huang, Jian-Jun Zhong,

MicroRNA-491-5p (miR-491-5p) plays an important role in regulating cell proliferation and migration; however, the effect of miR-491-5p on neovascularization after traumatic brain injury remains poorly understood. In this study, a controlled cortical injury model in C57BL/6 mice and an oxygen-glucose deprivation model in microvascular endothelial cells derived from mouse brain ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):577-586]

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Development and validation of a survival model for esophageal adenocarcinoma based on autophagy-associated genes.

Lili Duan, Lu Cao, Rui Zhang, Liaoran Niu, Wanli Yang, Weibo Feng, Wei Zhou, Junfeng Chen, Xiaoqian Wang, Yiding Li, Yujie Zhang, Jinqiang Liu, Qingchuan Zhao, Daiming Fan, Liu Hong,

Autophagy is a highly conserved catabolic process which has been implicated in esophageal adenocarcinoma (EAC). We sought to investigate the biological functions and prognostic value of autophagy-related genes (ARGs) in EAC. A total of 21 differentially expressed ARGs were identified between EAC and normal samples. Gene Ontology (GO) and Kyoto ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3434-3454]

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MicroRNA-17-5p inhibits thyroid cancer progression by suppressing Early growth response 2 (EGR2).

Xiang Geng, YangYang Sun, JinJin Fu, Liang Cao, Yuan Li,

miR-17-5p has been proved that play important roles in many kinds of tumors progression. This study aimed at explore the function and mechanism of miR-17-5p in thyroid cancer (TC). RT-qPCR was used to detect miR-17-5p and Early growth response 2 (EGR2) expression in TC tissues and cells. CCK8 and colony ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2713-2722]

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Trelagliptin stimulates osteoblastic differentiation by increasing runt-related transcription factor 2 (RUNX2): a therapeutic implication in osteoporosis.

Haiyu Shao, Renzheng Wu, Li Cao, Haifeng Gu, Fang Chai,

Osteoporosis, an aging-associated bone metabolic disease, is affecting millions of people worldwide. The deregulated process of osteoblastic differentiation has been linked with the progression of osteoporosis. Trelagliptin is a long-acting inhibitor of DPP-4 used for the management of type 2 diabetes mellitus. However, it is unknown whether Trelagliptin possesses a ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):960-968]

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The miR-1906 mimic attenuates bone loss in osteoporosis by down-regulating the TLR4/MyD88/NF-κB pathway.

H Xie, L Cao, L Ye, G Shan, W Song,

In this study, the ability of microRNA-1906 (miR-1906) to attenuate bone loss in osteoporosis was evaluated by measuring the effects of a miR-1906 mimic and inhibitor on the cellular toxicity and cell viability of MC3T3-E1 cells. Bone marrow-derived macrophage (BMM) cells were isolated from female mice, and tartrate-resistant acid phosphatase ... Read more >>

Physiol Int (Physiology international)
[2021, 107(4):469-478]

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Natural ACTH Relieves Acute Inflammation of Gout by Changing the Function of Macrophages

Rui Xu, Li Zhao, Jiyu Liu, Lin Cao, Tianyi Zhao, Yiyun Yu, Dandan Xuan, Weiguo Wan, Hejian Zou, Yu Xue,

<h4>Objective: </h4> Gout is a common arthritis caused by deposition of monosodium urate crystals. Macrophage is crucial in the process of monosodium urate (MSU) -induced inflammation. Although it has been reported that adrenocorticotropic hormone (ACTH) in nature can be used to cure urarthritis, the mechanism concerning macrophage is still not ... Read more >>

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The Impact of COVID-19 on Time-to-treatment in Pancreatic Adenocarcinoma: A Single Institutional Experience

Kavin Sugumar, Lifen Cao, Jonathan J. Hue, Luke Rothermel, Lee M. Ocuin, John B. Ammori, Jeffrey M. Hardacre, Jordan M. Winter,

J Am Coll Surg (Journal of the American College of Surgeons)
[2021, 233(5):e114-e114]

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An ultrasound-driven immune-boosting molecular machine for systemic tumor suppression.

Liu Wang, Guangzhe Li, Lei Cao, Yi Dong, Yang Wang, Shisheng Wang, Yueqing Li, Xiuhan Guo, Yi Zhang, Fangfang Sun, Xuemei Du, Jiangan Su, Qing Li, Xiaojun Peng, Kun Shao, Weijie Zhao,

[Figure: see text]. ... Read more >>

Sci Adv (Science advances)
[2021, 7(43):eabj4796]

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Longitudinal Large-Scale Semiquantitative Proteomic Data Stability Across Multiple Instrument Platforms.

Congcong Lu, Tina Glisovic-Aplenc, Kathrin M Bernt, Kevin Nestler, Joseph Cesare, Lusha Cao, Hyoungjoo Lee, Hossein Fazelinia, Asif Chinwalla, Yang Xu, Olga Shestova, Yi Xing, Saar Gill, Mingyao Li, Benjamin Garcia, Richard Aplenc,

With the rapid developments in mass spectrometry (MS)-based proteomics methods, label-free semiquantitative proteomics has become an increasingly popular tool for profiling global protein abundances in an unbiased manner. However, the reproducibility of these data across time and LC-MS platforms is not well characterized. Here, we evaluate the performance of three ... Read more >>

J Proteome Res (Journal of proteome research)
[2021, :]

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A digitalized isothermal nucleic acid testing platform based on a pump-free open droplet array microfluidic chip.

Ping Mao, Lei Cao, Zedong Li, Minli You, Bin Gao, Xianghong Xie, Zhenrui Xue, Ping Peng, Chunyan Yao, Feng Xu,

Digital PCR has shown great potential for quantitative nucleic acid testing (NAT), but most existing platforms are dependent on large auxiliary equipment (e.g., vacuum pump, amplification instrument, fluorescence microscope) to achieve target dispersion, amplification, signal capture and result analysis. Such complex, expensive and bulky NAT platforms have limited their applications ... Read more >>

Analyst (The Analyst)
[2021, :]

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Evaluating the Efficacy and Moderators of Algorithm-Guided Antidepressant Treatments of Major Depressive Disorder.

Huifeng Zhang, Zhiguo Wu, Lan Cao, Yousong Su, Fan Wang, Wu Hong, Yiyun Cai, Daihui Peng, Yiru Fang,

In spite of numerous options, the most efficacious treatment for major depressive disorder (MDD) remains elusive. Algorithm-guided treatments (AGTs) are proposed to address inadequate remission and optimize treatment delivery. This study aimed to evaluate the clinical benefit of AGTs for MDD, and to explore specific moderators of treatment outcomes for ... Read more >>

J Affect Disord (Journal of affective disorders)
[2021, :]

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The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum.

Weiwei Wang, Zhaoning Wang, Xiuna Yang, Yan Gao, Xiang Zhang, Long Cao, Aguang Dai, Jin Sun, Lei Sun, Lubin Jiang, Zhenguo Chen, Lanfeng Wang,

Cell Discov (Cell discovery)
[2021, 7(1):94]

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Correction to: Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal cancer.

Dan Wang, Weitang Yuan, Yaping Wang, Qian Wu, Li Yang, Feng Li, Xinfeng Chen, Zhen Zhang, Weina Yu, Nomathamsanqa Resegofetse Maimela, Ling Cao, Dong Wang, Junxia Wang, Zhenqiang Sun, Jinbo Liu, Yi Zhang,

J Transl Med (Journal of translational medicine)
[2021, 19(1):435]

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Mechanosensitive TRPV4 is required for crystal-induced inflammation.

Zhou Lan, Lvyi Chen, Jing Feng, Zili Xie, Zhiyong Liu, Fang Wang, Peng Liu, Xueping Yue, Lixia Du, Yonghui Zhao, Pu Yang, Jialie Luo, Zhe Zhu, Xueming Hu, Liang Cao, Ping Lu, Rajan Sah, Kory Lavine, Brian Kim, Hongzhen Hu,

Crystal structures activate innate immune cells, especially macrophages and initiate inflammatory responses. We aimed to understand the role of the mechanosensitive TRPV4 channel in crystal-induced inflammation. Real-time RT-PCR, RNAscope in situ hybridisation, and Trpv4eGFP mice were used to examine TRPV4 expression and whole-cell patch-clamp recording and live-cell Ca2+ imaging were ... Read more >>

Ann Rheum Dis (Annals of the rheumatic diseases)
[2021, :]

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Adjuvant trastuzumab with or without chemotherapy in stage 1 pT1N0 HER2+ breast cancer: a National Cancer Database analysis.

Lifen Cao, Robert Shenk, Nickolas Stabellini, Megan E Miller, Christopher W Towe, Alberto J Montero,

<h4>Purpose</h4>Approximately 20% of all breast cancers (BC) are HER2 amplified. In the APT trial, weekly paclitaxel/trastuzumab in node negative HER2+ BC with tumors < 3 cm was associated with a 7-year invasive disease-free survival of 93%. However, this was in the context of a non-randomized trial, and for pT1N0 HER2+ BC it remains ... Read more >>

Breast Cancer Res Treat (Breast cancer research and treatment)
[2021, :]

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Comparative Proteomics Reveals the Effect of the Transcriptional Regulator Sp13016 on Butenyl-Spinosyn Biosynthesis in Saccharopolyspora pogona.

Jianli Tang, Haocheng He, Yunlong Li, Zhudong Liu, Ziyuan Xia, Li Cao, Zirong Zhu, Ling Shuai, Yang Liu, Qianqian Wan, Yuewen Luo, Youming Zhang, Jie Rang, Liqiu Xia,

Butenyl-spinosyn is a highly effective and broad-spectrum biopesticide produced by Saccharopolyspora pogona. However, the yield of this compound is difficult to increase because the regulatory mechanism of secondary metabolism is still unknown. Here, the transcriptional regulator Sp13016 was discovered to be highly associated with butenyl-spinosyn synthesis and bacterial growth. Overexpression ... Read more >>

J Agric Food Chem (Journal of agricultural and food chemistry)
[2021, :]

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Effects of individualized PEEP obtained by two different titration methods on postoperative atelectasis in obese patients: study protocol for a randomized controlled trial.

Qing-Yuan Wang, Yu-Wei Ji, Li-Xin An, Lei Cao, Fu-Shan Xue,

<h4>Background</h4>The incidence of postoperative pulmonary complications (PPCs) is higher in obese patients undergoing general anesthesia and mechanical ventilation due to the reduction of oxygen reserve, functional residual capacity, and lung compliance. Individualized positive end-expiratory pressure (iPEEP) along with other lung-protective strategies is effective in alleviating postoperative atelectasis. Here, we compared ... Read more >>

Trials (Trials)
[2021, 22(1):704]

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T-Cell Large Granular Lymphocytic Leukemia with Atypical Immunophenotypes: A Single Center Retrospective Analysis of 17 Cases

Jing-jing Guo, Lei Cao, Hua-yuan Zhu, Yi Miao, Xin-yi Du, Yu-jie Wu, Li Wang, Wei Xu, Jian-yong Li, Lei Fan,

<h4>Purpose: </h4> T-cell large granular lymphocytic leukemia (T-LGLL) is characterized by expansion of cytotoxic T cells expressing αβ T cell receptor (TCR), CD2, surface CD3, CD8, CD57 as well as cytotoxic molecules. Atypical immunophenotypes of T-LGLL, including γδ TCR and CD4, reported in a small subset, remains to be well-defined. ... Read more >>

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A small molecule CFTR potentiator restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR.

Jia Liu, Allison P Berg, Yiting Wang, Walailak Jantarajit, Katy J Sutcliffe, Edward B Stevens, Lishuang Cao, Marko J Pregel, David N Sheppard,

<h4>Background and purpose</h4>Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators are small molecules developed to treat the genetic disease cystic fibrosis (CF). They interact directly with CFTR Cl<sup>-</sup> channels at the plasma membrane to enhance channel gating. Here, we investigate the action of a new CFTR potentiator, CP-628006 with a distinct ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2021, :]

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Nucleocytoplasmic Shuttling of Porcine Parvovirus NS1 Protein Mediated by the CRM1 Nuclear Export Pathway and the Importin α/β Nuclear Import Pathway.

Liyan Cao, Fang Fu, Jianfei Chen, Hongyan Shi, Xin Zhang, Jianbo Liu, Da Shi, Yong Huang, Dewen Tong, Li Feng,

Porcine parvovirus (PPV) NS1, the major nonstructural protein of this virus, plays an important role in PPV replication. We show, for the first time, that NS1 dynamically shuttles between the nucleus and cytoplasm, although its subcellular localization is predominantly nuclear. NS1 contains two nuclear export signals (NESs) at amino acids ... Read more >>

J Virol (Journal of virology)
[2021, :JVI0148121]

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Moderate conformational transition promotes the formation of a self-reinforced highly oriented silk fibroin network structure.

Ting Shu, Jing Cui, Zhuochen Lv, Leitao Cao, Jing Ren, Shengjie Ling,

A highly oriented molecular network structure (HOMNS) is a common and favorable design in natural and regenerated silks to achieve self-reinforcement of the material. However, the fundamental issues related to the formation of the HOMNS in silk fibroin materials and its influence on mechanical performance have not yet been addressed. ... Read more >>

Soft Matter (Soft matter)
[2021, :]

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Femtosecond laser trapping nanoprinting of silver micro/nanostructures.

Zhong-Yun Chen, Hong-Zhong Cao, Liang-Cheng Cao, Gan Fang, Xuan-Ming Duan,

In this paper, silver micro/nanostructures composed of sintered nanoparticles were printed by capturing silver nanoparticles in water with 800 nm femtosecond laser trapping. Relationships of laser power, scanning speed, nanoparticle concentration, and the width and morphology of fabricated silver wire were systematically investigated. It is found that low scanning speed ... Read more >>

Nanotechnology (Nanotechnology)
[2021, 32(50):]

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Correction: Autophagy receptor CCDC50 modulates STING-mediated interferon response in viral infection and autoimmune disease.

Panpan Hou, Yuxin Lin, Zibo Li, Ruiqing Lu, Yicheng Wang, Tian Tian, Penghui Jia, Xi Zhang, Liu Cao, Zhongwei Zhou, Chunmei Li, Jieruo Gu, Deyin Guo,

Cell Mol Immunol (Cellular & molecular immunology)
[2021, :]

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Novel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA.

Quanbin Zhang, Lina Wang, Lili Cao, Tao Wei,

In recent researches, circular RNAs (circRNAs) have been shown to exert critical functions in osteosarcoma biology. Nevertheless, the contribution of circRNAs to osteosarcoma remains largely unclear. Results indicated that expression of circATRNL1 was higher in osteosarcoma tissues and cells. The high-expression of circATRNL1 was significantly correlated with aggressive features and ... Read more >>

Bioengineered (Bioengineered)
[2021, :]

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Increased NOX1 and DOUX2 Expression in the Colonic Mucosa of Patients with Chronic Functional Constipation

Xiuqin Wei, Chunbo Kang, Lei Gao, Mengqiao Zhang, Mei Xue, Chao Ma, Yufeng Zheng, Lei Cao, Pan Chen, Shujing Jiang, Fong-Fong Chu, Qiang Gao,

<h4>Aim: </h4> To determine whether oxidative stress and inflammation are associated with constipation by examining the expression of the main producers of reactive oxygen species, NADPH oxidases, and pro-inflammatory cytokines in the colon of patients with chronic functional constipation. Methods The colonic biopsies were collected from 32 patients with ... Read more >>

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