Full Text Journal Articles by
Author Kyoung Ho Song

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Increased risk of herpes zoster in gynecological cancer patients receiving radiotherapy combined with chemotherapy: a need for paying attention to vaccines.

Dong Hoon Shin, Kyoung Ho Song,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e35]

Cited: 0 times

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Psychological Consequences of Survivors of COVID-19 Pneumonia 1 Month after Discharge.

Hye Yoon Park, Jongtak Jung, Hye Youn Park, So Hee Lee, Eu Suk Kim, Hong Bin Kim, Kyoung Ho Song,

As the coronavirus disease 2019 (COVID-19) has rapidly spread worldwide, there are growing concerns about patients' mental health. We investigated psychological problems in COVID-19 patients assessed with self-reported questionnaires including the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7 scale, and Impact of Event Scale-Revised Korean version. Ten patients who recovered from ... Read more >>

J Korean Med Sci (Journal of Korean medical science)
[2020, 35(47):e409]

Cited: 1 time

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The Importance of Proper History Taking: Asking a Fever Pattern in Patients with Vivax Malaria.

Euijin Chang, Kyoung Ho Song, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Sang Won Park, Nam Joong Kim,

Characteristic fever patterns of malarial infection are clues for diagnosis. However, checking fever patterns in febrile patients has been usually missed, and unnecessary tests have been performed. We reviewed electrical medical record to check whether history-taking included questions on fever pattern in febrile patients. Main outcomes were time interval between ... Read more >>

J Korean Med Sci (Journal of Korean medical science)
[2020, 35(43):e386]

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Clinical Course and Outcomes of 3,060 Patients with Coronavirus Disease 2019 in Korea, January-May 2020.

Ho Kyung Sung, Jin Yong Kim, Jeonghun Heo, Haesook Seo, Young Soo Jang, Hyewon Kim, Bo Ram Koh, Neungsun Jo, Hong Sang Oh, Young Mi Baek, Kyung Hwa Park, Jeung A Shon, Min Chul Kim, Joon Ho Kim, Hyun Ha Chang, Yukyung Park, Yu Min Kang, Dong Hyun Lee, Dong Hyun Oh, Hyun Jung Park, Kyoung Ho Song, Eun Kyoung Lee, Hyeongseok Jeong, Ji Yeon Lee, Ja Young Ko, Jihee Choi, Eun Hwa Ryu, Ki Hyun Chung, Myoung Don Oh, ,

<h4>Background</h4>The fatality rate of patients with coronavirus disease 2019 (COVID-19) varies among countries owing to demographics, patient comorbidities, surge capacity of healthcare systems, and the quality of medical care. We assessed the clinical outcomes of patients with COVID-19 during the first wave of the epidemic in Korea.<h4>Methods</h4>Using a modified World ... Read more >>

J Korean Med Sci (Journal of Korean medical science)
[2020, 35(30):e280]

Cited: 13 times

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Pattern of inflammatory immune response determines the clinical course and outcome of COVID-19: unbiased clustering analysis.

Eunyoung Emily Lee, Kyoung-Ho Song, Woochang Hwang, Sin Young Ham, Hyeonju Jeong, Jeong-Han Kim, Hong Sang Oh, Yu Min Kang, Eun Bong Lee, Nam Joong Kim, Bum Sik Chin, Jin Kyun Park,

The objective of the study was to identify distinct patterns in inflammatory immune responses of COVID-19 patients and to investigate their association with clinical course and outcome. Data from hospitalized COVID-19 patients were retrieved from electronic medical record. Supervised k-means clustering of serial C-reactive protein levels (CRP), absolute neutrophil counts ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):8080]

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Development of key quality indicators for appropriate antibiotic use in the Republic of Korea: results of a modified Delphi survey.

Bongyoung Kim, Myung Jin Lee, Se Yoon Park, Song Mi Moon, Kyoung-Ho Song, Tae Hyong Kim, Eu Suk Kim, Hong Bin Kim, ,

<h4>Background</h4>An effective antibiotic stewardship program relies on the measurement of appropriate antibiotic use, on which there is a lack of consensus. We aimed to develop a set of key quality indicators (QIs) for nationwide point surveillance in the Republic of Korea.<h4>Methods</h4>A systematic literature search of PubMed, EMBASE, and Cochrane Library ... Read more >>

Antimicrob Resist Infect Control (Antimicrobial resistance and infection control)
[2021, 10(1):48]

Cited: 0 times

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Therapeutic Temperature Modulation for a Critically Ill Patient with COVID-19.

Han Gil Jeong, Yunghee Lee, Kyoung Ho Song, In Chang Hwang, Eu Suk Kim, Young Jae Cho,

We report a rapidly deteriorating coronavirus disease 2019 (COVID-19) patient, a-58-year-old woman, with severe acute respiratory distress syndrome and shock with hyperpyrexia up to 41.8°C, probably due to the cytokine storm syndrome. Considering extracorporeal membrane oxygenation (ECMO) as the last resort, we applied therapeutic temperature modulation for management of hyperpyrexia. ... Read more >>

J Korean Med Sci (Journal of Korean medical science)
[2020, 35(22):e210]

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Impact of a computerised clinical decision support system on vancomycin loading and the risk of nephrotoxicity.

June Young Chun, Kyoung-Ho Song, Dong-Eun Lee, Joo-Hee Hwang, Hyun Gul Jung, Eunjeong Heo, Hyung-Sook Kim, Seonghae Yoon, Jeong Su Park, Pyoeng Gyun Choe, Jae-Yong Chung, Wan Beom Park, Ji Hwan Bang, Hee Hwang, Kyoung-Un Park, Sang Won Park, Nam Joong Kim, Myoung-Don Oh, Eu Suk Kim, Hong Bin Kim,

<h4>Background</h4>A vancomycin loading dose is recommended for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections. However, clinicians often do not adhere to these recommendations, mainly due to nephrotoxicity risk, unfamiliarity with the guideline, or complexity of calculating an individual dose. Therefore, we introduced a computerised clinical decision support system ... Read more >>

Int J Med Inform (International journal of medical informatics)
[2021, 149:104403]

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Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19.

Eu Suk Kim, Bum Sik Chin, Chang Kyung Kang, Nam Joong Kim, Yu Min Kang, Jae Phil Choi, Dong Hyun Oh, Jeong Han Kim, Boram Koh, Seong Eun Kim, Na Ra Yun, Jae Hoon Lee, Jin Yong Kim, Yeonjae Kim, Ji Hwan Bang, Kyoung Ho Song, Hong Bin Kim, Ki Hyun Chung, Myoung Don Oh, ,

<h4>Background</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China in December 2019. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea.<h4>Methods</h4>All of the cases confirmed by real time polymerase chain reaction ... Read more >>

J Korean Med Sci (Journal of Korean medical science)
[2020, 35(13):e142]

Cited: 74 times

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Clinical Score System to Differentiate Severe Fever with Thrombocytopenia Syndrome Patients from Patients with Scrub Typhus or Hemorrhagic Fever with Renal Syndrome in Korea.

Dae Hyuk Heo, Yu Min Kang, Kyoung Ho Song, Jun Won Seo, Jeong Han Kim, June Young Chun, Kang Il Jun, Chang Kyung Kang, Song Mi Moon, Pyoeng Gyun Choe, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang Won Park, Won Sup Oh, Nam Joong Kim, Myoung Don Oh,

BACKGROUND:Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high mortality in East Asia. This study aimed to develop, for primary care providers, a prediction score using initial symptoms and basic laboratory blood tests to differentiate between SFTS and other endemic zoonoses in Korea. METHODS:Patients aged ≥ ... Read more >>

J Korean Med Sci (Journal of Korean medical science)
[2020, 35(11):e77]

Cited: 1 time

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Stereotypic neutralizing VH antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals.

Sang Il Kim, Jinsung Noh, Sujeong Kim, Younggeun Choi, Duck Kyun Yoo, Yonghee Lee, Hyunho Lee, Jongtak Jung, Chang Kyung Kang, Kyoung-Ho Song, Pyoeng Gyun Choe, Hong Bin Kim, Eu Suk Kim, Nam-Joong Kim, Moon-Woo Seong, Wan Beom Park, Myoung-Don Oh, Sunghoon Kwon, Junho Chung,

Stereotypic antibody clonotypes exist in healthy individuals and may provide protective immunity against viral infections by neutralization. We observed that 13 of 17 patients with COVID-19 had stereotypic variable heavy chain (V<sub>H</sub>) antibody clonotypes directed against the receptor binding domain (RBD) of SARS-CoV-2 spike protein. These antibody clonotypes were composed ... Read more >>

Sci Transl Med (Science translational medicine)
[2021, 13(578):]

Cited: 3 times

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Comparison all-cause mortality between individuals with COVID-19 and propensity-score-matched individuals without COVID-19 in South Korea

Tak Kyu Oh, In-Ae Song, Kyoung-Ho Song, Young-Tae Jeon,

Abstract <h4>Background</h4> We compared all-cause mortality between individuals in South Korea with and without coronavirus disease (COVID-19), using propensity score (PS)-matching. <h4>Methods</h4> This population-based cohort study used data from the National Health Insurance Service COVID-19 cohort database. In the database, we included individuals (COVID-19 patients, control population, and test-negative individuals) ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, :]

Cited: 0 times

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Whole-Genome Sequencing for Investigating a Health Care-Associated Outbreak of Carbapenem-Resistant Acinetobacter baumannii.

Sang Mee Hwang, Hee Won Cho, Tae Yeul Kim, Jeong Su Park, Jongtak Jung, Kyoung-Ho Song, Hyunju Lee, Eu Suk Kim, Hong Bin Kim, Kyoung Un Park,

Carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) outbreaks in hospital settings challenge the treatment of patients and infection control. Understanding the relatedness of clinical isolates is important in distinguishing outbreak isolates from sporadic cases. This study investigated 11 CRAB isolates from a hospital outbreak by whole-genome sequencing (WGS), utilizing various bioinformatics tools for ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(2):]

Cited: 0 times

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Development of key quality indicators for appropriate antibiotic use in the Republic of Korea: results of a modified Delphi survey

Bongyoung Kim, Myung Jin Lee, Se Yoon Park, Song Mi Moon, Kyoung-Ho Song, Tae Hyong Kim, Eu Suk Kim, Hong Bin Kim,

<h4>Background: </h4> An effective antibiotic stewardship program relies on the measurement of appropriate antibiotic use, on which there is a lack of consensus. We aimed to develop a set of key quality indicators (QIs) for nationwide point surveillance in the Republic of Korea. <h4>Methods: </h4> A systematic literature search of ... Read more >>

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Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19.

Andre C Kalil, Thomas F Patterson, Aneesh K Mehta, Kay M Tomashek, Cameron R Wolfe, Varduhi Ghazaryan, Vincent C Marconi, Guillermo M Ruiz-Palacios, Lanny Hsieh, Susan Kline, Victor Tapson, Nicole M Iovine, Mamta K Jain, Daniel A Sweeney, Hana M El Sahly, Angela R Branche, Justino Regalado Pineda, David C Lye, Uriel Sandkovsky, Anne F Luetkemeyer, Stuart H Cohen, Robert W Finberg, Patrick E H Jackson, Babafemi Taiwo, Catharine I Paules, Henry Arguinchona, Nathaniel Erdmann, Neera Ahuja, Maria Frank, Myoung-Don Oh, Eu-Suk Kim, Seow Y Tan, Richard A Mularski, Henrik Nielsen, Philip O Ponce, Barbara S Taylor, LuAnn Larson, Nadine G Rouphael, Youssef Saklawi, Valeria D Cantos, Emily R Ko, John J Engemann, Alpesh N Amin, Miki Watanabe, Joanne Billings, Marie-Carmelle Elie, Richard T Davey, Timothy H Burgess, Jennifer Ferreira, Michelle Green, Mat Makowski, Anabela Cardoso, Stephanie de Bono, Tyler Bonnett, Michael Proschan, Gregory A Deye, Walla Dempsey, Seema U Nayak, Lori E Dodd, John H Beigel, ,

<h4>Background</h4>Severe coronavirus disease 2019 (Covid-19) is associated with dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus kinase inhibitor, plus remdesivir are not known.<h4>Methods</h4>We conducted a double-blind, randomized, placebo-controlled trial evaluating baricitinib plus remdesivir in hospitalized adults with Covid-19. All the patients received remdesivir (≤10 days) and either ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(9):795-807]

Cited: 60 times

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Impact of COVID-19 and Associated Preventive Measures on Cardiometabolic Risk Factors in South Korea: An Observational Study

Minji Sohn, Bo Kyung Koo, Soo Lim, Ho Il Yoon, Kyoung-Ho Song, Eu Suk Kim, Hong Bin Kim,

<h4>Background: </h4> During the COVID-19 pandemic, people have been required to follow preventive measures such as social distancing or staying at home, which can lead to an unhealthy lifestyle. We investigated the effect of these preventive measures on metabolic parameters in individuals with cardiometabolic risk factors. <h4>Methods: </h4> Using data ... Read more >>

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Toll-like receptor 2 downregulation and cytokine dysregulation predict mortality in patients with Staphylococcus aureus bacteremia.

Nak-Hyun Kim, Ji Yeon Sung, Yoon Jung Choi, Su-Jin Choi, Soyeon Ahn, Eunjeong Ji, Moonsuk Kim, Chung Jong Kim, Kyoung-Ho Song, Pyoeng Gyun Choe, Wan Beom Park, Eu Suk Kim, Kyoung Un Park, Nam-Joong Kim, Myoung-Don Oh, Hong Bin Kim,

<h4>Background</h4>Staphylococcus aureus bacteremia (SAB) presents heterogeneously, owing to the differences in underlying host conditions and immune responses. Although Toll-like receptor 2 (TLR2) is important in recognizing S. aureus, its function during S. aureus infection remains controversial. We aimed to examine the association of TLR2 expression and associated cytokine responses with ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2020, 20(1):901]

Cited: 0 times

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Clonal hematopoiesis is associated with risk of severe Covid-19

Kelly Bolton, Youngil Koh, Michael Foote, Hogune Im, Justin Jee, Choong Hyun Sun, Anton Safonov, Ryan Ptashkin, Joon Ho Moon, Ji Yeon Lee, Jongtak Jung, Chang Kyung Kang, Kyoung-Ho Song, Pyeong Gyun Choe, Wan Beom Park, Hong Bin Kim, Myoung-don Oh, Han Song, Sugyeong Kim, Minal Patel, Andriy Derkach, Erika Gedvilaite, Kaitlyn Tkachuk, Lior Braunstein, Teng Gao, Elli Papaemmanuil, Esther Babady, Melissa Pessin, Mini Kamboj, Luis Diaz, Marc Ladanyi, Michael Rauh, Pradeep Natarajan, Mitchell Machiela, Philip Awadalla, Vijai Joseph, Kenneth Offit, Larry Norton, Michael Berger, Ross Levine, Eu Suk Kim, Nam Joong Kim, Ahmet Zehir,

<h4>ABSTRACT</h4> Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular and malignant diseases, and decreased overall survival. 1–4 These adverse sequelae may be mediated by altered inflammatory profiles observed in patients with CH. 2,5,6 A pro-inflammatory immunologic ... Read more >>

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PD-1-Expressing SARS-CoV-2-Specific CD8+ T Cells Are Not Exhausted, but Functional in Patients with COVID-19.

Min-Seok Rha, Hye Won Jeong, Jae-Hoon Ko, Seong Jin Choi, In-Ho Seo, Jeong Seok Lee, Moa Sa, A Reum Kim, Eun-Jeong Joo, Jin Young Ahn, Jung Ho Kim, Kyoung-Ho Song, Eu Suk Kim, Dong Hyun Oh, Mi Young Ahn, Hee Kyoung Choi, Ji Hoon Jeon, Jae-Phil Choi, Hong Bin Kim, Young Keun Kim, Su-Hyung Park, Won Suk Choi, Jun Yong Choi, Kyong Ran Peck, Eui-Cheol Shin,

Memory T cell responses have been demonstrated in COVID-19 convalescents, but ex vivo phenotypes of SARS-CoV-2-specific T cells have been unclear. We detected SARS-CoV-2-specific CD8<sup>+</sup> T cells by MHC class I multimer staining and examined their phenotypes and functions in acute and convalescent COVID-19. Multimer<sup>+</sup> cells exhibited early differentiated effector-memory phenotypes in the early ... Read more >>

Immunity (Immunity)
[2021, 54(1):44-52.e3]

Cited: 7 times

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Pneumocystis jirovecii pneumonia in diffuse large B-cell Lymphoma treated with R-CHOP.

Ji Yun Lee, Minsu Kang, Koung Jin Suh, Ji-Won Kim, Se Hyun Kim, Jin Won Kim, Yu Jung Kim, Kyoung-Ho Song, Eu Suk Kim, Hong Bin Kim, Keun-Wook Lee, Jee Hyun Kim, Soo-Mee Bang, Jong-Seok Lee, Jeong-Ok Lee,

<h4>Background</h4>The aim of this study was to estimate the incidence of and risk factors for Pneumocystis pneumonia (PCP) infection in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP).<h4>Methods</h4>The medical records of 739 DLBCL patients who received R-CHOP between May 2004 and January ... Read more >>

Mycoses (Mycoses)
[2021, 64(1):60-65]

Cited: 0 times

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Cell-Mediated Immunogenicity of Influenza Vaccination in Patients With Cancer Receiving Immune Checkpoint Inhibitors.

Chang Kyung Kang, Hang-Rae Kim, Kyoung-Ho Song, Bhumsuk Keam, Seong Jin Choi, Pyoeng Gyun Choe, Eu Suk Kim, Nam Joong Kim, Yu Jung Kim, Wan Beom Park, Hong Bin Kim, Myoung-Don Oh,

<h4>Background</h4>We assessed cell-mediated immune (CMI) responses of influenza vaccination in patients with cancer receiving immune checkpoint inhibitors (ICIs), which remain elusive.<h4>Methods</h4>Vaccine-elicited CMI responses in patients receiving ICIs or cytotoxic agents were investigated by flow cytometry. Polyfunctional cells were defined as T cells that express 2 or more of interleukin 2 ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, 222(11):1902-1909]

Cited: 2 times

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Dysfunctional accessory gene regulator (agr) as a prognostic factor in invasive Staphylococcus aureus infection: a systematic review and meta-analysis.

Soon Ok Lee, Shinwon Lee, Jeong Eun Lee, Kyoung-Ho Song, Chang Kyung Kang, Yu Mi Wi, Rafael San-Juan, Luis E López-Cortés, Alicia Lacoma, Cristina Prat, Hee-Chang Jang, Eu Suk Kim, Hong Bin Kim, Sun Hee Lee,

The accessory gene regulator (agr) locus of Staphylococcus aureus is a quorum-sensing virulence regulator. Although there are many studies concerning the effect of dysfunctional agr on the outcomes of S. aureus infection, there is no systematic review to date. We systematically searched for clinical studies reporting outcomes of invasive S. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):20697]

Cited: 1 time

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Delays in Isolating Patients Admitted to Hospital with Pulmonary Tuberculosis in Korea.

Dae Hyuk Heo, Jun Won Seo, Jeong Han Kim, June Young Chun, Kang Il Jun, Chang Kyung Kang, Song Mi Moon, Kyoung Ho Song, Pyoeng Gyun Choe, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Sang Won Park, Nam Joong Kim, Myoung Don Oh, Hong Bin Kim,

BACKGROUND:Delays in isolating patients admitted to hospital with active pulmonary tuberculosis (PTB) can contribute to nosocomial transmission; however, in Korea, patients with clinically diagnosed PTB are not routinely isolated while awaiting microbiological confirmation of the diagnosis. We aimed to assess the extent of delays in isolating patients admitted with PTB ... Read more >>

J Korean Med Sci (Journal of Korean medical science)
[2019, 34(43):e270]

Cited: 3 times

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81. Physicians’ Knowledge, Attitude, and Practice regarding Prolonged Antimicrobial Use

Da Young Kim, Dahye kim, Eunjeong Heo, Hyung-sook kim, Ji Young Park, Hyunju lee, Jun-won Seo, Jongtak Jung, Song Mi Moon, Kyoung-Ho Song, Eu Suk Kim, Hong Bin Kim,

Abstract <h4>Background</h4> To reduce unnecessary long-term antibiotic therapies, pharmacist-led intervention followed by the involvement of infectious diseases (ID) specialist was implemented. In addition, a survey for the prescribers was conducted to find the gaps for improvement. <h4>Methods</h4> The “less is better” intervention was implemented between August 1, 2018 and February ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S58-S58]

Cited: 0 times

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Waning Antibody Responses in Asymptomatic and Symptomatic SARS-CoV-2 Infection.

Pyoeng Gyun Choe, Chang Kyung Kang, Hyeon Jeong Suh, Jongtak Jung, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang Won Park, Nam Joong Kim, Wan Beom Park, Myoung-Don Oh,

We investigated the kinetics of severe acute respiratory syndrome coronavirus 2 neutralizing antibodies in 7 asymptomatic persons and 11 patients with pneumonia. The geometric mean titer of neutralizing antibodies declined from 219.4 at 2 months to 143.7 at 5 months after infection, indicating a waning antibody response. ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(1):]

Cited: 5 times

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