Full Text Journal Articles by
Author Kyle Baumbauer

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MrgprdCre lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit.

Charles Warwick, Colleen Cassidy, Junichi Hachisuka, Margaret C Wright, Kyle M Baumbauer, Peter C Adelman, Kuan H Lee, Kelly M Smith, Tayler D Sheahan, Sarah E Ross, H Richard Koerber,

<h4>Abstract</h4>Most cutaneous C fibers, including both peptidergic and nonpeptidergic subtypes, are presumed to be nociceptors and respond to noxious input in a graded manner. However, mechanically sensitive, nonpeptidergic C fibers also respond to mechanical input in the innocuous range, so the degree to which they contribute to nociception remains unclear. ... Read more >>

Pain (Pain)
[2021, 162(7):2120-2131]

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Comprehensive Phenotyping of Cutaneous Afferents Reveals Rapid-Onset Alterations in Nociceptor Response Properties Following Spinal Cord Injury

Olivia Eller, Rena Stair, Christopher Neal, Peter Rowe, Jennifer Nelson-Brantley, Erin Young, Kyle Baumbauer,

Spinal cord injury (SCI) is a complex syndrome that has profound effects on patient well-being, including the development of medically-resistant chronic pain. The mechanisms underlying SCI pain have been the subject of thorough investigation but remain poorly understood. While the majority of the research has focused on changes occurring within ... Read more >>

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Optogenetic evaluation of the ability of different cutaneous C-fiber afferents to evoke aversive behaviors

Charles Warwick, Colleen Cassidy, Junichi Hachisuka, Margaret Wright, Kyle Baumbauer, Peter Adelman, Kuan Lee, Kelly Smith, Sarah Ross, Richard Koerber,

<h4>ABSTRACT</h4> Most cutaneous C-fibers, including both peptidergic and non-peptidergic subtypes are presumed to be nociceptors and respond to noxious input in a graded manner. However, mechanically sensitive, non-peptidergic C-fibers also respond to mechanical input in the innocuous range, and so the degree to which they contribute to nociception remains unclear. ... Read more >>

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The Potential Role of Preoperative Pain, Catastrophizing, and Differential Gene Expression on Pain Outcomes after Pediatric Spinal Fusion.

Mallory Perry, Christine B Sieberg, Erin E Young, Kyle Baumbauer, Vijender Singh, Cindy Wong, Angela Starkweather,

<h4>Background</h4>Adolescent idiopathic scoliosis is one of the most common spinal deformities in children and adolescents requiring extensive surgical intervention. Due to the nature of surgery, spinal fusion increases their risk of experiencing persistent postsurgical pain. Up to 20% of adolescents report pain for months or years after corrective spinal fusion ... Read more >>

Pain Manag Nurs (Pain management nursing : official journal of the American Society of Pain Management Nurses)
[2021, 22(1):44-49]

Cited: 1 time

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Contribution of COMT and BDNF Genotype and Expression to the Risk of Transition From Acute to Chronic Low Back Pain.

Kyle M Baumbauer, Divya Ramesh, Mallory Perry, Katherine B Carney, Thomas Julian, Nicole Glidden, Susan G Dorsey, Angela R Starkweather, Erin E Young,

OBJECTIVES:A number of factors, including heritability and the environment, contribute to risk of transition from acute low back pain to chronic low back pain (CLBP). The aim of this study was to (1) compare somatosensory function and pain ratings at low back pain (LBP) onset between the acute low back ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2020, 36(6):430-439]

Cited: 1 time

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TIMP-1 Attenuates the Development of Inflammatory Pain Through MMP-Dependent and Receptor-Mediated Cell Signaling Mechanisms.

Brittany E Knight, Nathan Kozlowski, Joshua Havelin, Tamara King, Stephen J Crocker, Erin E Young, Kyle M Baumbauer,

Unresolved inflammation is a significant predictor for developing chronic pain, and targeting the mechanisms underlying inflammation offers opportunities for therapeutic intervention. During inflammation, matrix metalloproteinase (MMP) activity contributes to tissue remodeling and inflammatory signaling, and is regulated by tissue inhibitors of metalloproteinases (TIMPs). TIMP-1 and -2 have known roles in ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2019, 12:220]

Cited: 3 times

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The Influence of Race, Ethnicity and Genetic Variants on Postoperative Pain Intensity: An Integrative Literature Review.

Mallory Perry, Kyle Baumbauer, Erin E Young, Susan G Dorsey, Jacquelyn Y Taylor, Angela R Starkweather,

<h4>Objectives</h4>Chronic postsurgical pain is pain that develops and persists for at least 3 months after a surgical procedure. The purpose of this review was to discover what evidence exists regarding the influence of race and ethnicity on postoperative pain intensity and what evidence exists regarding the influence of genetic polymorphisms on ... Read more >>

Pain Manag Nurs (Pain management nursing : official journal of the American Society of Pain Management Nurses)
[2019, 20(3):198-206]

Cited: 1 time

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Single cell q-PCR derived expression profiles of identified sensory neurons

Peter Adelman, Kyle Baumbauer, Robert Friedman, Mansi Shah, Margaret Wright, Erin Young, Michael Jankowski, Kathryn Albers, Richard Koerber,

Sensory neurons are chemically and functionally heterogeneous and this heterogeneity has been examined extensively over the last several decades. These studies have employed a variety of different methodologies, including anatomical, electrophysiological and molecular approaches. Recent studies using next generation sequencing techniques have examined the transcriptome of single sensory neurons. Although, ... Read more >>

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Single-cell q-PCR derived expression profiles of identified sensory neurons.

Peter C Adelman, Kyle M Baumbauer, Robert Friedman, Mansi Shah, Margaret Wright, Erin Young, Michael P Jankowski, Kathryn M Albers, H Richard Koerber,

Mol Pain (Molecular pain)
[2019, 15:1744806919884496]

Cited: 8 times

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Deletion of the murine ATP/UTP receptor P2Y2 alters mechanical and thermal response properties in polymodal cutaneous afferents.

Derek C Molliver, Kristofer K Rau, Michael P Jankowski, Deepak J Soneji, Kyle M Baumbauer, H Richard Koerber,

P2Y2 is a member of the P2Y family of G protein-coupled nucleotide receptors that is widely co-expressed with TRPV1 in peripheral sensory neurons of the dorsal root ganglia. To characterize P2Y2 function in cutaneous afferents, intracellular recordings from mouse sensory neurons were made using an ex vivo preparation in which ... Read more >>

Neuroscience (Neuroscience)
[2016, 332:223-230]

Cited: 3 times

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Factors Leading to Persistent Postsurgical Pain in Adolescents Undergoing Spinal Fusion: An Integrative Literature Review.

Mallory Perry, Angela Starkweather, Kyle Baumbauer, Erin Young,

Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity among children and adolescents and the most frequent reason for corrective spinal fusion (SF). Of the children and adolescents who undergo SF, a significant number will experience persistent postoperative pain (PPP). This integrative literature review was conducted to identify and ... Read more >>

J Pediatr Nurs (Journal of pediatric nursing)
[2018, 38:74-80]

Cited: 2 times

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Fixed spaced stimulation restores adaptive plasticity within the spinal cord: Identifying the eliciting conditions.

Kyle M Baumbauer, Joel D Turtle, James W Grau,

Prior work has shown that neurons within the spinal cord are sensitive to temporal relations and that stimulus regularity impacts nociceptive processing and adaptive plasticity. Application of brief (80ms) shocks (180-900) in a variable manner induces a form of maladaptive plasticity that inhibits spinally-mediated learning and enhances nociceptive reactivity. In ... Read more >>

Physiol Behav (Physiology & behavior)
[2017, 174:1-9]

Cited: 2 times

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Neurobiological Consequences of Early Painful Experience: Basic Science Findings and Implications for Evidence-Based Practice.

Erin E Young, Amy DʼAgata, Dorothy Vittner, Kyle M Baumbauer,

As healthcare teams have worked to improve infant survival rates, the management of painful events experienced by these hospitalized neonates has increased and yet pain management remains highly variable between healthcare institutions. At the same time, emerging evidence suggests that these early painful experiences may alter the trajectory of development ... Read more >>

J Perinat Neonatal Nurs (The Journal of perinatal & neonatal nursing)
[2017, 31(2):178-185]

Cited: 1 time

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Variations in COMT and NTRK2 Influence Symptom Burden in Women Undergoing Breast Cancer Treatment.

Erin E Young, Debra Lynch Kelly, Insop Shim, Kyle M Baumbauer, Angela Starkweather, Debra E Lyon,

Women with breast cancer frequently report distressing symptoms during and after treatment that can significantly erode quality of life (QOL). Symptom burden among women with breast cancer is of complex etiology and is likely influenced by disease, treatment, and environmental factors as well as individual genetic differences. The purpose of ... Read more >>

Biol Res Nurs (Biological research for nursing)
[2017, 19(3):318-328]

Cited: 7 times

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Cutaneous neurturin overexpression alters mechanical, thermal, and cold responsiveness in physiologically identified primary afferents.

Michael P Jankowski, Kyle M Baumbauer, Ting Wang, Kathryn M Albers, Brian M Davis, H Richard Koerber,

Neurotrophic factors play an important role in the regulation of functional properties of sensory neurons under normal and pathological conditions. The GDNF family member neurturin is one such factor that has been linked to modulating responsiveness to peripheral stimuli. Neurturin binds to the GFRα2 receptor, a receptor found primarily in ... Read more >>

J Neurophysiol (Journal of neurophysiology)
[2017, 117(3):1258-1265]

Cited: 3 times

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Semi-intact ex vivo approach to investigate spinal somatosensory circuits.

Junichi Hachisuka, Kyle M Baumbauer, Yu Omori, Lindsey M Snyder, H Richard Koerber, Sarah E Ross,

The somatosensory input that gives rise to the perceptions of pain, itch, cold and heat are initially integrated in the superficial dorsal horn of the spinal cord. Here, we describe a new approach to investigate these neural circuits in mouse. This semi-intact somatosensory preparation enables recording from spinal output neurons, ... Read more >>

Elife (eLife)
[2016, 5:]

Cited: 16 times

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Managing Chronic Pain in Special Populations with Emphasis on Pediatric, Geriatric, and Drug Abuser Populations.

Kyle M Baumbauer, Erin E Young, Angela R Starkweather, Jessica W Guite, Beth S Russell, Renee C B Manworren,

In the adult population chronic pain can lead to loss of productivity and earning potential, and decreased quality of life. There are distinct groups with increased vulnerability for the emergence of chronic pain. These groups may be defined by developmental status and/or life circumstances. Within the pediatric, geriatric, and drug ... Read more >>

Med Clin North Am (The Medical clinics of North America)
[2016, 100(1):183-197]

Cited: 3 times

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Keratinocytes can modulate and directly initiate nociceptive responses.

Kyle M Baumbauer, Jennifer J DeBerry, Peter C Adelman, Richard H Miller, Junichi Hachisuka, Kuan Hsien Lee, Sarah E Ross, H Richard Koerber, Brian M Davis, Kathryn M Albers,

How thermal, mechanical and chemical stimuli applied to the skin are transduced into signals transmitted by peripheral neurons to the CNS is an area of intense study. Several studies indicate that transduction mechanisms are intrinsic to cutaneous neurons and that epidermal keratinocytes only modulate this transduction. Using mice expressing channelrhodopsin ... Read more >>

Elife (eLife)
[2015, 4:]

Cited: 44 times

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Learning about time within the spinal cord: evidence that spinal neurons can abstract and store an index of regularity.

Kuan H Lee, Joel D Turtle, Yung-Jen Huang, Misty M Strain, Kyle M Baumbauer, James W Grau,

Prior studies have shown that intermittent noxious stimulation has divergent effects on spinal cord plasticity depending upon whether it occurs in a regular (fixed time, FT) or irregular (variable time, VT) manner: In spinally transected animals, VT stimulation to the tail or hind leg impaired spinal learning whereas an extended ... Read more >>

Front Behav Neurosci (Frontiers in behavioral neuroscience)
[2015, 9:274]

Cited: 9 times

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Metaplasticity and behavior: how training and inflammation affect plastic potential within the spinal cord and recovery after injury.

James W Grau, J Russell Huie, Kuan H Lee, Kevin C Hoy, Yung-Jen Huang, Joel D Turtle, Misty M Strain, Kyle M Baumbauer, Rajesh M Miranda, Michelle A Hook, Adam R Ferguson, Sandra M Garraway,

Research has shown that spinal circuits have the capacity to adapt in response to training, nociceptive stimulation and peripheral inflammation. These changes in neural function are mediated by physiological and neurochemical systems analogous to those that support plasticity within the hippocampus (e.g., long-term potentiation and the NMDA receptor). As observed ... Read more >>

Front Neural Circuits (Frontiers in neural circuits)
[2014, 8:100]

Cited: 34 times

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Maladaptive spinal plasticity opposes spinal learning and recovery in spinal cord injury.

Adam R Ferguson, J Russell Huie, Eric D Crown, Kyle M Baumbauer, Michelle A Hook, Sandra M Garraway, Kuan H Lee, Kevin C Hoy, James W Grau,

Synaptic plasticity within the spinal cord has great potential to facilitate recovery of function after spinal cord injury (SCI). Spinal plasticity can be induced in an activity-dependent manner even without input from the brain after complete SCI. A mechanistic basis for these effects is provided by research demonstrating that spinal ... Read more >>

Front Physiol (Frontiers in physiology)
[2012, 3:399]

Cited: 41 times

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Temporal regularity determines the impact of electrical stimulation on tactile reactivity and response to capsaicin in spinally transected rats.

K M Baumbauer, K H Lee, D A Puga, S A Woller, A J Hughes, J W Grau,

Nociceptive plasticity and central sensitization within the spinal cord depend on neurobiological mechanisms implicated in learning and memory in higher neural systems, suggesting that the factors that impact brain-mediated learning and memory could modulate how stimulation affects spinal systems. One such factor is temporal regularity (predictability). The present paper shows ... Read more >>

Neuroscience (Neuroscience)
[2012, 227:119-133]

Cited: 9 times

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Impact of behavioral control on the processing of nociceptive stimulation.

James W Grau, J Russell Huie, Sandra M Garraway, Michelle A Hook, Eric D Crown, Kyle M Baumbauer, Kuan H Lee, Kevin C Hoy, Adam R Ferguson,

How nociceptive signals are processed within the spinal cord, and whether these signals lead to behavioral signs of neuropathic pain, depends upon their relation to other events and behavior. Our work shows that these relations can have a lasting effect on spinal plasticity, inducing a form of learning that alters ... Read more >>

Front Physiol (Frontiers in physiology)
[2012, 3:262]

Cited: 26 times

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Glial tumor necrosis factor alpha (TNFα) generates metaplastic inhibition of spinal learning.

J Russell Huie, Kyle M Baumbauer, Kuan H Lee, Jacqueline C Bresnahan, Michael S Beattie, Adam R Ferguson, James W Grau,

Injury-induced overexpression of tumor necrosis factor alpha (TNFα) in the spinal cord can induce chronic neuroinflammation and excitotoxicity that ultimately undermines functional recovery. Here we investigate how TNFα might also act to upset spinal function by modulating spinal plasticity. Using a model of instrumental learning in the injured spinal cord, ... Read more >>

PLoS One (PloS one)
[2012, 7(6):e39751]

Cited: 31 times

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Brain-derived neurotrophic factor promotes adaptive plasticity within the spinal cord and mediates the beneficial effects of controllable stimulation.

J R Huie, S M Garraway, K M Baumbauer, K C Hoy, B S Beas, K S Montgomery, J L Bizon, J W Grau,

Brain-derived neurotrophic factor (BDNF) has been characterized as a potent modulator of neural plasticity in both the brain and spinal cord. The present experiments use an in vivo model system to demonstrate that training with controllable stimulation increases spinal BDNF expression and engages a BDNF-dependent process that promotes adaptive plasticity. ... Read more >>

Neuroscience (Neuroscience)
[2012, 200:74-90]

Cited: 34 times

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