Full Text Journal Articles by
Author Kunlin Cao


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End-to-end multimodal image registration via reinforcement learning.

Jing Hu, Ziwei Luo, Xin Wang, Shanhui Sun, Youbing Yin, Kunlin Cao, Qi Song, Siwei Lyu, Xi Wu,

Multimodal image registration is a vital initial step in several medical image applications for providing complementary information from different data modalities. Since images with different modalities do not exhibit the same characteristics, finding their accurate correspondences remains a challenge. For convolutional multimodal registration methods, two components are quite significant: descriptive ... Read more >>

Med Image Anal (Medical image analysis)
[2021, 68:101878]

Cited: 0 times

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Using Artificial Intelligence to Detect COVID-19 and Community-acquired Pneumonia Based on Pulmonary CT: Evaluation of the Diagnostic Accuracy.

Lin Li, Lixin Qin, Zeguo Xu, Youbing Yin, Xin Wang, Bin Kong, Junjie Bai, Yi Lu, Zhenghan Fang, Qi Song, Kunlin Cao, Daliang Liu, Guisheng Wang, Qizhong Xu, Xisheng Fang, Shiqin Zhang, Juan Xia, Jun Xia,

Background Coronavirus disease 2019 (COVID-19) has widely spread all over the world since the beginning of 2020. It is desirable to develop automatic and accurate detection of COVID-19 using chest CT. Purpose To develop a fully automatic framework to detect COVID-19 using chest CT and evaluate its performance. Materials and ... Read more >>

Radiology (Radiology)
[2020, 296(2):E65-E71]

Cited: 57 times

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An iterative multi-path fully convolutional neural network for automatic cardiac segmentation in cine MR images.

Zongqing Ma, Xi Wu, Xin Wang, Qi Song, Youbing Yin, Kunlin Cao, Yan Wang, Jiliu Zhou,

<h4>Purpose</h4>Segmentation of the left ventricle (LV), right ventricle (RV) cavities and the myocardium (MYO) from cine cardiac magnetic resonance (MR) images is an important step for diagnosis and monitoring cardiac diseases. Spatial context information may be highly beneficial for segmentation performance improvement. To this end, this paper proposes an iterative ... Read more >>

Med Phys (Medical physics)
[2019, 46(12):5652-5665]

Cited: 0 times

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Learning tree-structured representation for 3D coronary artery segmentation.

Bin Kong, Xin Wang, Junjie Bai, Yi Lu, Feng Gao, Kunlin Cao, Jun Xia, Qi Song, Youbing Yin,

Extensive research has been devoted to the segmentation of the coronary artery. However, owing to its complex anatomical structure, it is extremely challenging to automatically segment the coronary artery from 3D coronary computed tomography angiography (CCTA). Inspired by recent ideas to use tree-structured long short-term memory (LSTM) to model the ... Read more >>

Comput Med Imaging Graph (Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society)
[2020, 80:101688]

Cited: 1 time

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2D ultrasound imaging based intra-fraction respiratory motion tracking for abdominal radiation therapy using machine learning.

Pu Huang, Lin Su, Shuyang Chen, Kunlin Cao, Qi Song, Peter Kazanzides, Iulian Iordachita, Muyinatu A Lediju Bell, John W Wong, Dengwang Li, Kai Ding,

We have previously developed a robotic ultrasound imaging system for motion monitoring in abdominal radiation therapy. Owing to the slow speed of ultrasound image processing, our previous system could only track abdominal motions under breath-hold. To overcome this limitation, a novel 2D-based image processing method for tracking intra-fraction respiratory motion ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2019, 64(18):185006]

Cited: 0 times

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Precise diagnosis of intracranial hemorrhage and subtypes using a three-dimensional joint convolutional and recurrent neural network.

Hai Ye, Feng Gao, Youbing Yin, Danfeng Guo, Pengfei Zhao, Yi Lu, Xin Wang, Junjie Bai, Kunlin Cao, Qi Song, Heye Zhang, Wei Chen, Xuejun Guo, Jun Xia,

<h4>Objectives</h4>To evaluate the performance of a novel three-dimensional (3D) joint convolutional and recurrent neural network (CNN-RNN) for the detection of intracranial hemorrhage (ICH) and its five subtypes (cerebral parenchymal, intraventricular, subdural, epidural, and subarachnoid) in non-contrast head CT.<h4>Methods</h4>A total of 2836 subjects (ICH/normal, 1836/1000) from three institutions were included in ... Read more >>

Eur Radiol (European radiology)
[2019, 29(11):6191-6201]

Cited: 5 times

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Evaluation of fractional flow reserve in patients with stable angina: can CT compete with angiography?

Xin Liu, Yabin Wang, Heye Zhang, Youbing Yin, Kunlin Cao, Zhifan Gao, Huafeng Liu, William Kongto Hau, Lei Gao, Yundai Chen, Feng Cao, Wenhua Huang,

<h4>Background</h4>We aimed to compare the performance of FFR<sub>CT</sub> and FFR<sub>QCA</sub> in assessing the functional significance of coronary artery stenosis in patients suffering from coronary artery disease with stable angina.<h4>Method</h4>A total of 101 stable coronary heart disease (CAD) patients with 181 lesions were recruited. FFR<sub>CT</sub> and FFR<sub>QCA</sub> were compared using invasive ... Read more >>

Eur Radiol (European radiology)
[2019, 29(7):3669-3677]

Cited: 3 times

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Automated anatomical labeling of coronary arteries via bidirectional tree LSTMs.

Dan Wu, Xin Wang, Junjie Bai, Xiaoyang Xu, Bin Ouyang, Yuwei Li, Heye Zhang, Qi Song, Kunlin Cao, Youbing Yin,

<h4>Purpose</h4>Automated anatomical labeling facilitates the diagnostic process for physicians and radiologists. One of the challenges in automated anatomical labeling problems is the robustness to handle the large individual variability inherited in human anatomy. A novel deep neural network framework, referred to Tree Labeling Network (TreeLab-Net), is proposed to resolve this ... Read more >>

Int J Comput Assist Radiol Surg (International journal of computer assisted radiology and surgery)
[2019, 14(2):271-280]

Cited: 0 times

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A study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease.

Changzheng Shi, Dong Zhang, Kunlin Cao, Tao Zhang, Liangping Luo, Xin Liu, Heye Zhang,

<h4>Background</h4>The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method ... Read more >>

Biomed Eng Online (Biomedical engineering online)
[2017, 16(1):43]

Cited: 11 times

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The impact of heterologous catalase expression and superoxide dismutase overexpression on enhancing the oxidative resistance in Lactobacillus casei.

Jinzhong Lin, Yexia Zou, Kunlin Cao, Chengjie Ma, Zhengjun Chen,

Two heme-dependent catalase genes were amplified from genomic DNA of Lactobacillus plantarum WCFS1 (KatE1) and Lactobacillus brevis ATCC 367 (KatE2), respectively, and a manganese-containing superoxide dismutase from Lactobacillus casei MCJΔ1 (MnSOD) were cloned into plasmid pELX1, yielding pELX1-KatE1, pELX1-KatE2 and pELX1-MnSOD, then the recombinant plasmids were transferred into L. casei ... Read more >>

J Ind Microbiol Biotechnol (Journal of industrial microbiology & biotechnology)
[2016, 43(5):703-711]

Cited: 8 times

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Toward Quantitative Assessment of Rheumatoid Arthritis Using Volumetric Ultrasound.

Kunlin Cao, David M Mills, Ralf G Thiele, Kedar A Patwardhan,

<h4>Goal</h4>Rheumatoid arthritis (RA) is characterized by inflammation within the joint space as well as erosion or destruction of the bone surface. We believe that volumetric (3-D) ultrasound imaging of the joints in conjunction with automated image-analysis tools for segmenting and quantifying the regions of interest can lead to improved RA ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2016, 63(2):449-458]

Cited: 6 times

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A measure for characterizing sliding on lung boundaries.

Ryan E Amelon, Kunlin Cao, Joseph M Reinhardt, Gary E Christensen, Madhavan L Raghavan,

The lobes of the lung slide relative to each other during breathing. Quantifying lobar sliding can aid in better understanding lung function, better modeling of lung dynamics, and for studying phenomenon such as pleural adhesion. We propose a novel measure to characterize lobe sliding in the lung based on the ... Read more >>

Ann Biomed Eng (Annals of biomedical engineering)
[2014, 42(3):642-650]

Cited: 7 times

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Reproducibility of intensity-based estimates of lung ventilation.

Kaifang Du, John E Bayouth, Kai Ding, Gary E Christensen, Kunlin Cao, Joseph M Reinhardt,

<h4>Purpose</h4>Lung function depends on lung expansion and contraction during the respiratory cycle. Respiratory-gated CT imaging and image registration can be used to estimate the regional lung volume change by observing CT voxel density changes during inspiration or expiration. In this study, the authors examine the reproducibility of intensity-based estimates of ... Read more >>

Med Phys (Medical physics)
[2013, 40(6):063504]

Cited: 11 times

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Motion-compensated mega-voltage cone beam CT using the deformation derived directly from 2D projection images.

Mingqing Chen, Kunlin Cao, Yefeng Zheng, R Alfredo C Siochi,

This paper presents a novel method for respiratory motion compensated reconstruction for cone beam computed tomography (CBCT). The reconstruction is based on a time sequence of motion vector fields, which is generated by a dynamic geometrical object shape model. The dynamic model is extracted from the 2D projection images of ... Read more >>

IEEE Trans Med Imaging (IEEE transactions on medical imaging)
[2013, 32(8):1365-1375]

Cited: 3 times

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Tracking regional tissue volume and function change in lung using image registration.

Kunlin Cao, Gary E Christensen, Kai Ding, Kaifang Du, Maghavan L Raghavan, Ryan E Amelon, Kimberly M Baker, Eric A Hoffman, Joseph M Reinhardt,

We have previously demonstrated the 24-hour redistribution and reabsorption of bronchoalveolar lavage (BAL) fluid delivered to the lung during a bronchoscopic procedure in normal volunteers. In this work we utilize image-matching procedures to correlate fluid redistribution and reabsorption to changes in regional lung function. Lung CT datasets from six human ... Read more >>

Int J Biomed Imaging (International journal of biomedical imaging)
[2012, 2012:956248]

Cited: 0 times

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Improving Intensity-Based Lung CT Registration Accuracy Utilizing Vascular Information.

Kunlin Cao, Kai Ding, Joseph M Reinhardt, Gary E Christensen,

Accurate pulmonary image registration is a challenging problem when the lungs have a deformation with large distance. In this work, we present a nonrigid volumetric registration algorithm to track lung motion between a pair of intrasubject CT images acquired at different inflation levels and introduce a new vesselness similarity cost ... Read more >>

Int J Biomed Imaging (International journal of biomedical imaging)
[2012, 2012:285136]

Cited: 5 times

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Comparison of image registration based measures of regional lung ventilation from dynamic spiral CT with Xe-CT.

Kai Ding, Kunlin Cao, Matthew K Fuld, Kaifang Du, Gary E Christensen, Eric A Hoffman, Joseph M Reinhardt,

<h4>Purpose</h4>Regional lung volume change as a function of lung inflation serves as an index of parenchymal and airway status as well as an index of regional ventilation and can be used to detect pathologic changes over time. In this paper, the authors propose a new regional measure of lung mechanics-the ... Read more >>

Med Phys (Medical physics)
[2012, 39(8):5084-5098]

Cited: 24 times

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Volumetric ultrasound and computer-assisted analysis at the point-of-care: a musculoskeletal exemplar.

David M Mills, Kunlin Cao, Ralf Thiele, Kedar A Patwardhan,

In this paper we motivate the hypothesis that the use of volumetric ultrasound imaging and automated image analysis tools would improve clinical workflows as well as outcomes at the point-of-care. To make our case, this paper presents results from a rheumatoid arthritis (RA) study where several image analysis techniques have ... Read more >>

Annu Int Conf IEEE Eng Med Biol Soc (Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference)
[2012, 2012:2318-2322]

Cited: 0 times

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Evaluation of registration methods on thoracic CT: the EMPIRE10 challenge.

Keelin Murphy, Bram van Ginneken, Joseph M Reinhardt, Sven Kabus, Kai Ding, Xiang Deng, Kunlin Cao, Kaifang Du, Gary E Christensen, Vincent Garcia, Tom Vercauteren, Nicholas Ayache, Olivier Commowick, Grégoire Malandain, Ben Glocker, Nikos Paragios, Nassir Navab, Vladlena Gorbunova, Jon Sporring, Marleen de Bruijne, Xiao Han, Mattias P Heinrich, Julia A Schnabel, Mark Jenkinson, Cristian Lorenz, Marc Modat, Jamie R McClelland, Sébastien Ourselin, Sascha E A Muenzing, Max A Viergever, Dante De Nigris, D Louis Collins, Tal Arbel, Marta Peroni, Rui Li, Gregory C Sharp, Alexander Schmidt-Richberg, Jan Ehrhardt, René Werner, Dirk Smeets, Dirk Loeckx, Gang Song, Nicholas Tustison, Brian Avants, James C Gee, Marius Staring, Stefan Klein, Berend C Stoel, Martin Urschler, Manuel Werlberger, Jef Vandemeulebroucke, Simon Rit, David Sarrut, Josien P W Pluim,

EMPIRE10 (Evaluation of Methods for Pulmonary Image REgistration 2010) is a public platform for fair and meaningful comparison of registration algorithms which are applied to a database of intrapatient thoracic CT image pairs. Evaluation of nonrigid registration techniques is a nontrivial task. This is compounded by the fact that researchers ... Read more >>

IEEE Trans Med Imaging (IEEE transactions on medical imaging)
[2011, 30(11):1901-1920]

Cited: 155 times

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Three-dimensional characterization of regional lung deformation.

Ryan Amelon, Kunlin Cao, Kai Ding, Gary E Christensen, Joseph M Reinhardt, Madhavan L Raghavan,

The deformation of the lung during inspiration and expiration involves regional variations in volume change and orientational preferences. Studies have reported techniques for measuring the displacement field in the lung based on imaging or image registration. However, means of interpreting all the information in the displacement field in a physiologically ... Read more >>

J Biomech (Journal of biomechanics)
[2011, 44(13):2489-2495]

Cited: 22 times

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Analysis of regional mechanics in canine lung injury using forced oscillations and 3D image registration.

David W Kaczka, Kunlin Cao, Gary E Christensen, Jason H T Bates, Brett A Simon,

Acute lung injury is characterized by heterogeneity of regional mechanical properties, which is thought to be correlated with disease severity. The feasibility of using respiratory input impedance (Z(rs)) and computed tomographic (CT) image registration for assessing parenchymal mechanical heterogeneity was evaluated. In six dogs, measurements of Z(rs) before and after ... Read more >>

Ann Biomed Eng (Annals of biomedical engineering)
[2011, 39(3):1112-1124]

Cited: 39 times

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Evaluation of lobar biomechanics during respiration using image registration.

Kai Ding, Youbing Yin, Kunlin Cao, Gary E Christensen, Ching-Long Lin, Eric A Hoffman, Joseph M Reinhardt,

The human lungs are divided into five independent compartments called lobes. The lobar fissures separate the lung lobes. It is hypothesized that the lobar surfaces slide against each other during respiration. We propose a method to evaluate the sliding motion of the lobar surfaces during respiration using lobe-by-lobe mass-preserving non-rigid ... Read more >>

Med Image Comput Comput Assist Interv (Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention)
[2009, 12(Pt 1):739-746]

Cited: 12 times

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Registration-derived estimates of local lung expansion as surrogates for regional ventilation.

Joseph M Reinhardt, Gary E Christensen, Eric A Hoffman, Kai Ding, Kunlin Cao,

The main function of the respiratory system is gas exchange. Since many disease or injury conditions can cause biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung ventilation. We describe a registration-based technique for estimating local lung expansion from multiple ... Read more >>

Inf Process Med Imaging (Information processing in medical imaging : proceedings of the ... conference)
[2007, 20:763-774]

Cited: 9 times

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