Full Text Journal Articles by
Author Kunio Hamada

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Insufficient initial treatment but good recovery after diagnosis of pulmonary actinomycosis.

Toshiki Ito, Takayuki Yoshida, Motoki Sakuraba, Akihiko Tanaka, Kunio Hamada, Akihide Ito,

Actinomycosis is an infrequent invasive bacterial disease. Although multiple different clinical features of actinomycosis have been described, pulmonary actinomycosis (PA) is a rare but challenging diagnosis and complete cure to make. Here we report the case of a 41-year-old Asian woman who had a mass-like consolidation in the right middle ... Read more >>

Oxf Med Case Reports (Oxford medical case reports)
[2019, 2019(12):510-512]

Cited: 0 times

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Basal cell adenoma of the lung identified with obstructive pneumonia.

Hideki Shima, Takayuki Yoshida, Kunio Hamada, Akihide Ito, Toshiki Ito,

The seromucinous glands of the bronchi can give rise to tumors resembling those of the salivary glands. Basal cell adenoma (BCA) has not been reported in salivary gland-type tumors of the lung. Here, we report a case of an 86-year-old Asian man who suffered from pneumonia in the left upper ... Read more >>

Oxf Med Case Reports (Oxford medical case reports)
[2019, 2019(10):omz101]

Cited: 0 times

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Life-threatening pyogenic ventriculitis, complicating endocarditis, presenting as sudden hearing loss.

Toshiki Ito, Hiroaki Koiwa, Kazumasa Watanabe, Takayuki Yoshida, Kunio Hamada, Akihide Ito,

Approximately 70% of sudden sensorineural hearing loss (SSNHL) cases are idiopathic, but SSNHL may occasionally be related to fatality. Here, we report the case of a 54-year-old Asian female who complained of hearing loss as a primary symptom and was diagnosed with pyogenic ventriculitis (PV) derived from Streptococcus agalactiae endocarditis. ... Read more >>

Oxf Med Case Reports (Oxford medical case reports)
[2019, 2019(6):omz044]

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Poorly differentiated adenocarcinoma of an unknown primary with a thyroid tumour and an aggressive course: thyroid or lung carcinoma?

Toshiki Ito, Takayuki Yoshida, Tomoko Sakai, Kazumasa Watanabe, Hiroki Nishimura, Kunio Hamada, Akihide Ito,

Cancers of unknown primary (CUPs) are challenging for physicians to diagnose and treat. Metastases to the thyroid gland are rare, representing less than 1% of all thyroid malignancies. Here, we report a case of a 69-year-old Asian man who had both thyroid gland and lymph node enlargement in the neck ... Read more >>

Oxf Med Case Reports (Oxford medical case reports)
[2019, 2019(4):omy129]

Cited: 0 times

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Delayed diagnosis of odontogenic infection: a lesson from altered mental status and abnormal breathing.

Ai Sawaoka, Toshiki Ito, Takayuki Yoshida, Koichiro Muromachi, Tomoko Sakai, Kunio Hamada, Nobuyuki Tani-Ishii, Akihide Ito,

Altered mental status is a common, yet challenging, clinical presentation encountered by physicians. Here, we report a case of a 68-year-old Japanese female who was transferred to the emergency department due to faint. The laboratory results showed hyponatremia, ketonuria, hyperglycemia and acute kidney injury without fever or inflammatory findings. Although ... Read more >>

Oxf Med Case Reports (Oxford medical case reports)
[2018, 2018(11):omy079]

Cited: 0 times

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Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients.

Katsura Nagai, Hironi Makita, Masaru Suzuki, Kaoruko Shimizu, Satoshi Konno, Yoichi M Ito, Masaharu Nishimura, ,

The aim of the study was to examine the longitudinal change in quality of life components of patients with chronic obstructive pulmonary disease (COPD).In the Hokkaido COPD Cohort Study, 261 subjects were appropriately treated and followed over 5 years with a 74% follow-up rate at the end. The longitudinal changes ... Read more >>

Int J Chron Obstruct Pulmon Dis (International journal of chronic obstructive pulmonary disease)
[2015, 10:745-757]

Cited: 9 times

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Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease.

Masaharu Nishimura, Hironi Makita, Katsura Nagai, Satoshi Konno, Yasuyuki Nasuhara, Masaru Hasegawa, Kaoruko Shimizu, Tomoko Betsuyaku, Yoichi M Ito, Satoshi Fuke, Takeshi Igarashi, Yasushi Akiyama, Shigeaki Ogura, ,

RATIONALE: Although the rate of annual decline in FEV1 is one of the most important outcome measures in chronic obstructive pulmonary disease (COPD), little is known about intersubject variability based on clinical phenotypes. OBJECTIVES: To examine the intersubject variability in a 5-year observational cohort study, particularly focusing on emphysema severity. ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2012, 185(1):44-52]

Cited: 128 times

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[A case of cytokeratin 19 positive extramammary Paget's disease with pulmonary metastases].

Kunio Hamada, Norihiro Onuma,

An 82-year-old woman was admitted because of progressing cough and dyspnea. Two years prior to admission, she had undergone an operation for extramammary Paget's disease which resected the primary lesion, the left labium majora, and ipsilateral inguinal and obturator lymph nodes. Thoracic images showed diffuse infiltrative shadows and bilateral effusions. ... Read more >>

Nihon Kokyuki Gakkai Zasshi (Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society)
[2010, 48(3):204-209]

Cited: 0 times

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Significance of pulmonary arterial pressure and diffusion capacity of the lung as prognosticator in patients with idiopathic pulmonary fibrosis.

Kunio Hamada, Sonoko Nagai, Shigeru Tanaka, Tomohiro Handa, Michio Shigematsu, Taishi Nagao, Michiaki Mishima, Masanori Kitaichi, Takateru Izumi,

To evaluate the long-term clinical course of patients with idiopathic pulmonary fibrosis (IPF) complicated with pulmonary arterial hypertension.Prospective analysis of consecutive IPF patients undergoing initial workup with right-heart catheterization (RHC) and pulmonary function testing (PFT). Pulmonary arterial pressure (PAP) and diffusion capacity of the lung for carbon monoxide (Dlco) were ... Read more >>

Chest (Chest)
[2007, 131(3):650-656]

Cited: 127 times

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[A case of idiopathic nonspecific interstitial pneumonia and autoimmune hemolytic anemia after complete cure of polymyalgia rheumatica].

Megumi Nakadate, Yasuyuki Nasuhara, Kunio Hamada, Masaharu Nishimura,

In 1997, at the age of 68, a man was admitted with polymyalgia rheumatica, which was successfully treated with oral prednisolone. In 1999, a chest X-ray revealed that he had interstitial changes in both lung fields. Because there were no symptoms, he was observed without treatment. However, from around 2003, ... Read more >>

Nihon Kokyuki Gakkai Zasshi (Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society)
[2006, 44(11):864-868]

Cited: 0 times

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Multiple bone fractures found in a young sarcoidosis patient with long stable disease.

Tomohiro Handa, Sonoko Nagai, Isao Ito, Michio Shigematsu, Kunio Hamada, Masanori Kitaichi, Kosuke Ohta, Takateru Izumi, Michiaki Mishima,

A 22-year-old Japanese man was found to have bilateral hilar lymphadenopathy (BHL), and was diagnosed with sarcoidosis in 1995. He was followed without treatment until 2002, when a bone fracture due to osseous sarcoidosis was found in his left thumb. Despite systemic treatment with corticosteroid and methotrexate, a new bone ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2005, 44(12):1269-1275]

Cited: 3 times

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Pulmonary infection of Mycobacterium avium-intracellulare complex with simultaneous organizing pneumonia.

Kunio Hamada, Sonoko Nagai, Yoshikazu Hara, Toyohiro Hirai, Michiaki Mishima,

A 67-year-old woman presented high-grade fever and dyspnea. Sputum culture confirmed Mycobacterium avium-intracellulare complex (MAC). Transbronchial lung biopsies revealed organizing pneumonia (OP) that was rapidly improved with corticosteroid. Five months after onset, a nodule emerged in the right lung. Although MAC was confirmed, the lesion was deemed too small to ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2006, 45(1):15-20]

Cited: 3 times

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Patient characteristics and clinical features of Japanese sarcoidosis patients with low bronchoalveolar lavage CD4/CD8 ratios.

Tomohiro Handa, Sonoko Nagai, Michio Shigematsu, Rollin P Tabuena, Minoru Takeuchi, Takeshi Mikuniya, Kunio Hamada, Takateru Izumi, Michiaki Mishima,

Previous studies have shown that there is an association between low BALF (bronchoalveolar lavage fluid) CD4/CD8 ratio and lower remission rates in sarcoidosis patients.To investigate the patient characteristics and clinical features of Japanese sarcoidosis patients with low BALF CD4/CD8 ratios.322 Japanese sarcoidosis patients were retrospectively analyzed, and 3 groups were ... Read more >>

Sarcoidosis Vasc Diffuse Lung Dis (Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG)
[2005, 22(2):154-160]

Cited: 1 time

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Cell profiles of bronchoalveolar lavage fluid as prognosticators of idiopathic pulmonary fibrosis/usual interstitial pneumonia among Japanese Patients.

Rollin P Tabuena, Sonoko Nagai, Takeo Tsutsumi, Tomohiro Handa, Takeuchi Minoru, Takeshi Mikuniya, Michio Shigematsu, Kunio Hamada, Takateru Izumi, Michiaki Mishima,

BACKGROUND: The role of bronchoalveolar lavage fluid (BALF) cell profiles in predicting the clinical outcome of idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia (UIP) is still under discussion. OBJECTIVE: To determine whether BALF cell profiles affect the survival of patients with UIP diagnosed by surgical lung biopsy/autopsy at the early stage ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2005, 72(5):490-498]

Cited: 20 times

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Diabetes insipidus from neurosarcoidosis: long-term follow-up for more than eight years.

Rollin P Tabuena, Sonoko Nagai, Tomohiro Handa, Michio Shigematsu, Kunio Hamada, Isao Ito, Takateru Izumi, Michiaki Mishima, Om P Sharma,

Four patients with sarcoidosis presented as hypothalamic-hypophyseal syndrome including diabetes insipidus (DI) were followed up for more than 8 years from the onset of clinical manifestation. The mean age was 26 years, male : female ratio was 3 : 1 and the mean disease duration of 10 years. All patients ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2004, 43(10):960-966]

Cited: 17 times

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Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis.

Tomohiro Handa, Sonoko Nagai, Isao Ito, Rollin Tabuena, Michio Shigematsu, Kunio Hamada, Masanori Kitaichi, Takateru Izumi, Tomoki Aoyama, Junya Toguchida, Michiaki Mishima,

BACKGROUND: B7 proteins (CD80, CD86) are costimulatory molecules expressed on antigen-presenting cells and are essential factors for T cell activation. OBJECTIVES: The aim of this study is to investigate the relationship of B7 gene polymorphisms either to disease susceptibility or to cell profile of bronchoalveolar lavage (BAL) fluid in Japanese ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2005, 72(3):243-248]

Cited: 10 times

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Side effects and good effects from new chemotherapeutic agents. Case 2. Thalidomide-induced interstitial pneumonitis.

Masahiro Onozawa, Satoshi Hashino, Susumu Sogabe, Masahira Haneda, Hiromasa Horimoto, Koh Izumiyama, Takeshi Kondo, Luis Perez Aldana, Kunio Hamada, Masahiro Asaka,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2005, 23(10):2425-2426]

Cited: 19 times

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Cytotoxic T-lymphocyte antigen-4 (CTLA-4) exon 1 polymorphism affects lymphocyte profiles in bronchoalveolar lavage of patients with sarcoidosis.

Tomohiro Handa, Sonoko Nagai, Isao Ito, Michio Shigematsu, Kunio Hamada, Masanori Kitaichi, Takateru Izumi, Michiaki Mishima,

Sarcoidosis is a systemic disease characterized by T-cell activation and subsequent granuloma formation at the site of involvement. Genetic susceptibility is a key factor in the pathogenesis of this disease, and genes involved in T-cell regulation are potential candidates. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a negative regulator of T-cell activation ... Read more >>

Sarcoidosis Vasc Diffuse Lung Dis (Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG)
[2003, 20(3):190-196]

Cited: 6 times

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Open-label compassionate use one year-treatment with pirfenidone to patients with chronic pulmonary fibrosis.

Sonoko Nagai, Kunio Hamada, Michio Shigematsu, Masayosi Taniyama, Shitotomo Yamauchi, Takateru Izumi,

OBJECTIVE:We attempted to evaluate the feasibility (therapeutic efficacy, tolerance, and clinical courses after treatment) of pirfenidone, an anti-fibrotic drug for patients with chronic pulmonary fibroses such as idiopathic pulmonary fibrosis (IPF). METHODS:Open-label one-year treatment for compassionate-use. PATIENTS OR MATERIALS:Oral pirfenidone (40 mg/kg body weight) was administered to 8 patients with ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2002, 41(12):1118-1123]

Cited: 57 times

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Sarcoidosis complicated with IgA nephropathy.

Kunio Hamada, Sonoko Nagai, Takahiko Ono, Eri Muso, Taishi Nagao, Michio Shigematsu, Takateru Izumi, Michiaki Mishima,

Though IgA nephropathy (IgAN) and sarcoidosis have been reported simultaneously in patients occasionally, it remains controversial whether there is any association between the two. In this report we describe our experience with one definite and two subclinical cases of IgAN diagnosed during the clinical course of sarcoidosis. Our findings suggest ... Read more >>

Sarcoidosis Vasc Diffuse Lung Dis (Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG)
[2003, 20(1):69-73]

Cited: 3 times

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Sarcoidosis with bilateral epididymal and testicular lesions.

Tomohiro Handa, Sonoko Nagai, Kunio Hamada, Isao Ito, Yuma Hoshino, Michio Shigematsu, Takateru Izumi, Michiaki Mishima,

We report a case of genital sarcoidosis that presented characteristic features on MRI. A 25-year-old man sarcoidosis patient with ocular and lung lesions presented a painful mass in the left scrotum together with systemic symptoms of fever, appetite loss, headache, and stomach-ache during the tapering of steroids. The patient was ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2003, 42(1):92-97]

Cited: 6 times

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Cyclophosphamide-induced late-onset lung disease.

Kunio Hamada, Sonoko Nagai, Masanori Kitaichi, Guang Jin, Michio Shigematsu, Taishi Nagao, Atsuyasu Sato, Michiaki Mishima,

We report the case of a 58-year-old woman who was considered to have died of cyclophosphamide (CPA)-induced late-onset lung disease. She underwent a right-sided mastectomy due to breast cancer at the age of 50 followed by daily administration of 50 mg CPA and 20 mg tamoxifen for 2 years. A ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2003, 42(1):82-87]

Cited: 15 times

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Serial evaluation of high-resolution computed tomography findings in patients with idiopathic pulmonary fibrosis in usual interstitial pneumonia.

Taishi Nagao, Sonoko Nagai, Yoshihide Hiramoto, Kunio Hamada, Michio Shigematsu, Michio Hayashi, Takateru Izumi, Michiaki Mishima,

The development of well-matured fibrosis in usual interstitial pneumonia (UIP) is strongly associated with an unfavorable outcome of patients with idiopathic pulmonary fibrosis (IPF). However, differences in the rates of development are likely to result in variable clinical courses in IPF patients.We tried to evaluate the progression of honeycombing and ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2002, 69(5):413-419]

Cited: 24 times

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Serum concentrations of ionized calcium reflect renal function in patients with sarcoidosis.

Kunio Hamada, Sonoko Nagai, Michio Shigematsu, Taishi Nagao, Michio Hayaschi, Takeo Tsutsumi, Takateru Izumi,

Decrease in renal function was investigated in relation to altered metabolism of calcium in patients with sarcoidosis.Fifty consecutive patients with pulmonary sarcoidosis (23 men and 27 women, 47 +/- 15 years as mean +/- SD) were studied on a daily diet consisting of 500 mg of calcium and 1000 mg ... Read more >>

Sarcoidosis Vasc Diffuse Lung Dis (Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG)
[2002, 19(1):71-77]

Cited: 1 time

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