Full Text Journal Articles by
Author Kun Zhang

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Isomer of linker for NU-1000 yields a new she-type, catalytic, and hierarchically porous, Zr-based metal-organic framework.

Zhiyong Lu, Rui Wang, Yijun Liao, Omar K Farha, Wentuan Bi, Thomas R Sheridan, Kun Zhang, Jiaxin Duan, Jian Liu, Joseph T Hupp,

The well-known MOF (metal-organic framework) linker tetrakis(p-benzoate)pyrene (TBAPy<sup>4-</sup>) lacks steric hindrance between its benzoates. Changing the 1,3,6,8-siting of benzoates in TBAPy<sup>4-</sup> to 4,5,9,10-siting introduces substantial steric hindrance and, in turn, enables the synthesis of a new hierarchically porous, she-type MOF Zr<sub>6</sub>(μ<sub>3</sub>-O)<sub>4</sub>(μ<sub>3</sub>-OH)<sub>4</sub>(C<sub>6</sub>H<sub>5</sub>COO)<sub>3</sub>(COO)<sub>3</sub>(TBAPy-2)<sub>3/2</sub> (NU-601), where TBAPy-2<sup>4-</sup> is the 4,5,9,10 isomer of TBAPy<sup>4-</sup>. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(29):3571-3574]

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Tailoring the cationic lipid composition of lipo-DVDMS augments the phototherapy efficiency of burn infection.

Bingjie Mai, Yiru Gao, Min Li, Mengqi Jia, Shupei Liu, Xiaobing Wang, Kun Zhang, Quanhong Liu, Pan Wang,

Increase in infections with Gram-negative Pseudomonas aeruginosa (P. aeruginosa) is a serious global challenge in healthcare. Sinoporphyrin sodium (DVDMS) combined with photodynamic antimicrobial chemotherapy (PACT) can effectively eradicate Gram-positive organisms. However, the poor penetration of DVDMS into the Gram-negative bacterial cell membrane and bacterial biofilm greatly limits the photo-inspired antimicrobial ... Read more >>

Biomater Sci (Biomaterials science)
[2021, 9(6):2053-2066]

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Mechanosensory and mechanotransductive processes mediated by ion channels in articular chondrocytes: Potential therapeutic targets for osteoarthritis.

Kun Zhang, Lifu Wang, Zhongcheng Liu, Bin Geng, Yuanjun Teng, Xuening Liu, Qiong Yi, Dechen Yu, Xiangyi Chen, Dacheng Zhao, Yayi Xia,

Articular cartilage consists of an extracellular matrix including many proteins as well as embedded chondrocytes. Articular cartilage formation and function are influenced by mechanical forces. Hind limb unloading or simulated microgravity causes articular cartilage loss, suggesting the importance of the healthy mechanical environment in articular cartilage homeostasis and implying a ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):339-359]

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A bibliometric analysis and review of recent researches on Piezo (2010-2020).

Lifu Wang, Xuening Liu, Kun Zhang, Zhongcheng Liu, Qiong Yi, Jin Jiang, Yayi Xia,

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):310-321]

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Intramolecular charge transfer ampholytes with water-induced pendulum-type fluorescence variation.

Xiao-Bin Dong, Ling Chen, Mei Pan, Wen-Jie Huang, Hua Xiang, Hai-Ping Wang, Zong-Wen Mo, Jia-Wen Ye, Kun Zhang, Xiao-Ming Chen,

Triphenylimidazole-based ampholytes with intramolecular charge transfer were designed with the introduction of carboxyl groups. In solution, the synergistic solvent and ionization effects on the ampholytes led to a unique pendulum-type fluorescence variation during the water content increasing process. Among them, 4-(4,5-bis(4-hydroxyphenyl)-1H-imidazol-2-yl)benzoic acid showed the most prominent three-step fluorescence switching property. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(73):10702-10705]

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An N-linked disalicylaldehyde together with its caesium ion and dichloromethane sensing performances: 'dual key & lock' LMCT-enhanced fluorescence strategy.

Kun Zhang, Ting-Ting Chen, Yin-Jing Shen, Zhuo-Ran Yang, Yan Huang, Shishen Zhang, Jiadan Xue, Benxia Li,

The development of inexpensive, selective and rapid-response chemosensors for detecting Cs+ in waste water is highly desirable in the nuclear power industry. Here we demonstrate an efficient Cs+ optical sensor based on the N-linked disalicylaldehyde H2Qj with excited state intramolecular proton transfer (ESIPT), and it will transform into the ligand-to-metal ... Read more >>

Analyst (The Analyst)
[2020, 145(17):5826-5835]

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Environmentally responsive hydrogels for repair of cardiovascular tissue.

Shuaimeng Guan, Jiankang Li, Kun Zhang, Jingan Li,

Cardiovascular diseases (CVDs) pose a serious threat to human health, which are characterized by high disability and mortality rate globally such as myocardial infarction (MI), atherosclerosis, and heart failure. Although stem cells transplantation and growth factors therapy are promising, their low survival rate and loss at the site of injury ... Read more >>

Heart Fail Rev (Heart failure reviews)
[2021, 26(5):1273-1285]

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Inducing rapid polysulfide transformation through enhanced interfacial electronic interaction for lithium-sulfur batteries.

Chao Shen, Kun Zhang, You You, Hui Wang, Ruiqi Ning, Yaqin Qi, Nan Li, Cuimin Ding, Keyu Xie, Bingqing Wei,

Sluggish dynamics of polysulfide (LiPS) conversion leads to reduced utilization of active sulfur and rapid capacity decay. Introducing catalysts into lithium-sulfur battery systems is a feasible and imperative strategy to tackle this problem. Previous research studies have mainly been focused on selecting new catalysts and design functional structures to improve ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(26):13980-13986]

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Neuronal activity-induced SUMOylation of Akt1 by PIAS3 is required for long-term potentiation of synaptic transmission.

Li Meng, Cai-Ping Du, Chun-Yuan Lu, Kun Zhang, Lin Li, Jing-Zhi Yan, Xiao-Yu Hou,

Neuronal activity regulates spatial distribution of the SUMOylation system in cytosolic and dendritic sites, which has been implicated in learning, memory, and underlying synaptic structural and functional remodeling in the hippocampus. However, the functional target proteins for activated small ubiquitin-like modifiers (SUMOs) and downstream molecular consequences behind long-term potentiation (LTP) ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(8):e21769]

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Host-Guest Assembly of H-Bonding Networks in Covalent Organic Frameworks for Ultrafast and Anhydrous Proton Transfer.

Xiaowei Wu, Ziya Liu, Hu Guo, You-Lee Hong, Bingqing Xu, Kun Zhang, Yusuke Nishiyama, Wei Jiang, Satoshi Horike, Susumu Kitagawa, Gen Zhang,

An anhydrous proton conductor represents a key material for the manufacture of high-energy electrical devices. Incorporation of proton carriers into the vacancies of the porous solid provides an effective method for their preparation, but the weak or even no interactions between the ion carriers and the porous solids causing a ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, :]

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Direct synthesis of 2-substituted benzonitriles via alkylcyanation of arynes with N,N-disubstituted aminomalononitriles.

Wen Bao, Zhu-Peng Gao, Da-Ping Jin, Cao-Gen Xue, Huan Liang, Ling-Sheng Lei, Xue-Tao Xu, Kun Zhang, Shao-Hua Wang,

An efficient alkylcyanation of in situ generated arynes by N,N-disubstituted aminomalononitriles is described, enabling the direct synthesis of 2-substituted benzonitriles. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(55):7641-7644]

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Field-free spin-orbit torque-induced switching of perpendicular magnetization in a ferrimagnetic layer with a vertical composition gradient.

Zhenyi Zheng, Yue Zhang, Victor Lopez-Dominguez, Luis Sánchez-Tejerina, Jiacheng Shi, Xueqiang Feng, Lei Chen, Zilu Wang, Zhizhong Zhang, Kun Zhang, Bin Hong, Yong Xu, Youguang Zhang, Mario Carpentieri, Albert Fert, Giovanni Finocchio, Weisheng Zhao, Pedram Khalili Amiri,

Current-induced spin-orbit torques (SOTs) are of interest for fast and energy-efficient manipulation of magnetic order in spintronic devices. To be deterministic, however, switching of perpendicularly magnetized materials by SOT requires a mechanism for in-plane symmetry breaking. Existing methods to do so involve the application of an in-plane bias magnetic field, ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4555]

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A green strategy for the preparation of a honeycomb-like silicon composite with enhanced lithium storage properties.

Runsheng Gao, Jie Tang, Xiaoliang Yu, Kun Zhang, Kiyoshi Ozawa, Lu-Chang Qin,

The high-performance silicon (Si) composite electrodes are being widely developed due to their considerable theoretical capacity. Coating with carbon-based materials is an efficient way to solve the common issues of Si-based materials. Currently, most of the reported strategies are complicated, pollutive, or uneconomic, which hamper their practical applications. Herein, a ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(24):12849-12855]

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Facile Production of Phosphorene Nanoribbons towards Application in Lithium Metal Battery.

Wei Yu, Jinlin Yang, Jing Li, Kun Zhang, Haomin Xu, Xin Zhou, Wei Chen, Kian Ping Loh,

Like phosphorene, phosphorene nanoribbon (PNR) promises exotic properties but unzipping phosphorene into edge-defined PNR is non-trivial because of uncontrolled cutting of phosphorene along random directions. Here a facile electrochemical strategy to fabricate zigzag-edged PNRs in high yield (>80%) is reported. The presence of chemically active zigzag edges in PNR allows ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2021, :e2102083]

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Molecular mechanism of the anti-lung cancer effect of Jin Ning Fang based on network pharmacology and experimental verification

Chunxiao Wu, Qiquan Yu, Weizhen Shou, Kun Zhang, Yang Li, Wentao Guo, Qi Bao,

<h4>Background</h4> Jin Ning Fang (JNF) is widely used as an adjuvant therapy for lung cancer. However, its molecular mechanism against lung cancer is still unclear. <h4>Methods</h4> The chemical compounds JNF were screened from the TCMSP database and its target proteins were then predicted. The genes related to lung cancer were ... Read more >>

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An atlas of healthy and injured cell states and niches in the human kidney

Blue Lake, Rajasree Menon, Seth Winfree, Qiwen Hu, Ricardo Melo Ferreira, Kian Kalhor, Daria Barwinska, Edgar Otto, Michael Ferkowicz, Dinh Diep, Nongluk Plongthongkum, Amanda Knoten, Sarah Urata, Abhijit Naik, Sean Eddy, Bo Zhang, Yan Wu, Diane Salamon, James Williams, Xin Wang, Karol Balderrama, Paul Hoover, Evan Murray, Anitha Vijayan, Fei Chen, Sushrut Waikar, Sylvia Rosas, Francis Wilson, Paul Palevsky, Krzysztof Kiryluk, John Sedor, Robert Toto, Chirag Parikh, Eric Kim, Evan Macosko, Peter Kharchenko, Joseph Gaut, Jeffrey Hodgin, Michael Eadon, Pierre Dagher, Tarek El-Achkar, Kun Zhang, Matthias Kretzler, Sanjay Jain, ,

Understanding kidney disease relies upon defining the complexity of cell types and states, their associated molecular profiles, and interactions within tissue neighborhoods. We have applied multiple single-cell or -nucleus assays (>400,000 nuclei/cells) and spatial imaging technologies to a broad spectrum of healthy reference (n = 42) and disease (n = ... Read more >>

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Effects of Carbon Nanomaterials Hybridization of Poly(3,4-ethylenedioxythiophene): Poly (styrene sulfonate) on Thermoelectric Performance.

Yihan Wang, Siqi Wu, Rui Zhang, Kai Du, Qiang Yin, Bo Jiang, Qinjian Yin, Kun Zhang,

The influence of multiple dimensional carbon nanomaterials, such as graphene quantum dots (GQD), multi-walled carbon nanotubes (MWCNT), and graphene sheets (GNS) of the thermoelectric properties in poly(3,4-ethylenedioxythiophene): poly (styrene sulfonate) (PEDOT: PSS)-based hybrids have been investigated. PEDOT: PSS matrix was successfully used to prepare PEDOT: PSS/GQDs (PGQD), PEDOT: PSS/MWCNT (PCNT) ... Read more >>

Nanotechnology (Nanotechnology)
[2021, :]

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Intramedullary Nailing Combined With Adjunct Plate or Blocking Screw for Proximal Tibial Fractures

Jie li, Qian Wang, Zhong Li, Kun Zhang,

<h4>Objective: </h4> To compare the traditional approach of intramedullary nail with an extra plate versus the nail combined with blocking screws for proximal tibia fractures without the knee involved. <h4>Methods: </h4>: From January 2013 to January 2017, a total of 36 patients who suffered from proximal tibial fractures unaffecting the ... Read more >>

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Temporal Analyses of Postnatal Liver Development and Maturation by Single Cell Transcriptomics

Yan Liang, Kota Kaneko, Bing Xin, Jin Lee, Xin Sun, Kun Zhang, Gen-Sheng Feng,

<h4>SUMMARY</h4> Liver is the major metabolic organ, although its postnatal development and maturation are inadequately understood. We analyzed 52,834 single cell transcriptomes and identified 31 cell types or states in mouse livers at postnatal day 1, 3, 7, 21 and 56. We observed unexpectedly high levels of hepatocyte heterogeneity in ... Read more >>

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"Plug and Play" Functionalized Erythrocyte Nanoplatform for Target Atherosclerosis Management.

Yuan Zhong, Xian Qin, Yi Wang, Kai Qu, Li Luo, Kun Zhang, Boyan Liu, Essam Abdo Mohammed Saad Obaid, Wei Wu, Guixue Wang,

For atherosclerosis (AS) management, a therapeutic drug intervention is the most widely used strategy. However, there are some problems such as low location specificity, high intake, and side effects. Nanomedicine can prolong the half-life of drug solubilization, reduce toxic and side effects, and improve the distribution of drug objects. Herein, ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, 13(29):33862-33873]

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KIF15 upregulation promotes leiomyosarcoma cell growth via promoting USP15-mediated DEK deubiquitylation.

Weiming Ge, Yuxuan Chen, Yusheng Guo, Dawei Zhao, Ling Mu, Kun Zhang, Wenkun Zhuo,

Kinesin Family Member 15 (KIF15) is a plus end-directed microtubule motor, which exerts complex regulations in cancer biology. This study aimed to explore the functional role of KIF15 in leiomyosarcoma (LMS). Bioinformatic analysis was carried out using data from The Cancer Genome Atlas (TCGA)-Sarcoma (SARC). LMS cell lines SK-UT-1 and ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 570:117-124]

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Radical Trifluoroacetylation of Alkenes Triggered by a Visible-Light-Promoted C-O Bond Fragmentation of Trifluoroacetic Anhydride.

Kun Zhang, David Rombach, Nicolas Yannick Nötel, Gunnar Jeschke, Dmitry Katayev,

Here we report a mild and operationally simple trifluoroacylation strategy of olefines, that utilizes trifluoroacetic anhydride as a low-cost and readily available reagent. This light-mediated process is fundamentally different from conventional methodologies and occurs through a trifluoroacyl radical mechanism promoted by a photocatalyst, which triggers an C-O bond fragmentation. Detailed ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2021, :]

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Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.

Linh T Bui, Nichelle I Winters, Mei-I Chung, Chitra Joseph, Austin J Gutierrez, Arun C Habermann, Taylor S Adams, Jonas C Schupp, Sergio Poli, Lance M Peter, Chase J Taylor, Jessica B Blackburn, Bradley W Richmond, Andrew G Nicholson, Doris Rassl, William A Wallace, Ivan O Rosas, R Gisli Jenkins, Naftali Kaminski, Jonathan A Kropski, Nicholas E Banovich, ,

Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19) and poor outcomes. Here, we analyze the transcriptomes of 611,398 single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in patients with ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4314]

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A deep imputation and inference framework for estimating personalized and race-specific causal effects of genomic alterations on PSA.

Zhong Chen, Bo Cao, Andrea Edwards, Hongwen Deng, Kun Zhang,

Prostate Specific Antigen (PSA) level in the serum is one of the most widely used markers in monitoring prostate cancer (PCa) progression, treatment response, and disease relapse. Although significant efforts have been taken to analyze various socioeconomic and cultural factors that contribute to the racial disparities in PCa, limited research ... Read more >>

J Bioinform Comput Biol (Journal of bioinformatics and computational biology)
[2021, :2150016]

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Study on clinical nursing pathway to promote the effective implementation of sepsis bundle in septic shock.

Chun-Xia Liu, Xian-Lei Wang, Kun Zhang, Gui-Zhen Hao, Wei-Yan Han, Yi-Qing Tian, Lan Ge, Li-Min Shen,

<h4>Background</h4>There is still a certain gap between the effective implementation and requirements of sepsis bundle. Our aim is to establish the clinical nursing pathway of the cluster treatment of septic shock in the Intensive Care Unit and promote effective implementation of the cluster treatment of septic shock.<h4>Methods</h4>By means of evidence-based ... Read more >>

Eur J Med Res (European journal of medical research)
[2021, 26(1):69]

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