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Author Kumaran Deiva

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Mild Encephalitis/Encephalopathy with reversible splenial lesion syndrome: An unusual presentation of anti-GFAP astrocytopathy.

Valentin Oger, Chloé Bost, Lucie Salah, Elise Yazbeck, Hélène Maurey, Céline Bellesme, Caroline Sevin, Catherine Adamsbaum, Pascale Chrétien, Marie Benaiteau, Jérôme Honnorat, Kumaran Deiva,

Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a rare recently defined antibody-mediated encephalitis. Meningo-encephalomyelitis presentation is frequent with lymphocytic pleiocytosis in the cerebro-spinal fluid and brain MRI classically demonstrates in 50% of cases, a linear perivascular enhancement extending radially from the ventricles. Here, we describe 2 cases of pediatric ... Read more >>

Eur. J. Paediatr. Neurol. (European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society)
[2020, :]

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Dramatic efficacy of ofatumumab in refractory pediatric-onset AQP4-IgG neuromyelitis optica spectrum disorder.

Elisabeth Maillart, Florence Renaldo, Caroline Papeix, Kumaran Deiva, Julie Bonheur, Teresa Kwon, Odile Boespflug-Tanguy, David Germanaud, Romain Marignier,

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(3):]

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Long-term outcome of vein of Galen malformation.

Hélène Taffin, Hélène Maurey, Augustin Ozanne, Philippe Durand, Béatrice Husson, Jean-François Knebel, Catherine Adamsbaum, Kumaran Deiva, Guillaume Saliou,

AIM:To describe the long-term outcomes of children by the time they reached school age with vein of Galen aneurysmal malformation (VGAM). METHOD:This was a retrospective observational study on a consecutive cohort of patients with VGAM. We included patients with at least one Francophone parent, aged between 6 and 11 years ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2020, 62(6):729-734]

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Intradermal vaccination prevents anti-MOG autoimmune encephalomyelitis in macaques.

Claire-Maëlle Fovet, Lev Stimmer, Vanessa Contreras, Philippe Horellou, Audrey Hubert, Nabila Seddiki, Catherine Chapon, Sabine Tricot, Carole Leroy, Julien Flament, Julie Massonneau, Nicolas Tchitchek, Bert A 't Hart, Sandra Zurawski, Peter Klucar, Philippe Hantraye, Kumaran Deiva, Gerard Zurawski, SangKon Oh, Roger Le Grand, Ché Serguera,

BACKGROUND:Autoimmune demyelinating diseases (ADD) are a major cause of neurological disability due to autoreactive cellular and humoral immune responses against brain antigens. A cure for chronic ADD could be obtained by appropriate immunomodulation. METHODS:We implemented a preclinical scheme to foster immune tolerance to myelin oligodendrocyte glycoprotein (MOG), in a cynomolgus-macaque ... Read more >>

EBioMedicine (EBioMedicine)
[2019, 47:492-505]

Cited: 2 times

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Consistent control of disease activity with fingolimod versus IFN β-1a in paediatric-onset multiple sclerosis: further insights from PARADIGMS.

Kumaran Deiva, Peter Huppke, Brenda Banwell, Tanuja Chitnis, Jutta Gärtner, Lauren Krupp, Emmanuelle Waubant, Tracy Stites, Gregory Lewis Pearce, Martin Merschhemke,

BACKGROUND:In PARADIGMS, a double-blind phase III trial in 215 paediatric patients with multiple sclerosis (MS) (10 to <18 years), fingolimod administered for up to 2 years significantly reduced the annualised relapse rate (ARR) and rate of new/newly enlarged T2 (n/neT2) lesions compared with interferon (IFN) β-1a. OBJECTIVES:To investigate (1) differences ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(1):58-66]

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Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG.

Emmanuelle Waubant, Brenda Banwell, Evangeline Wassmer, Maria-Pia Sormani, Maria-Pia Amato, Rogier Hintzen, Lauren Krupp, Kevin Rostásy, Silvia Tenembaum, Tanuja Chitnis, ,

OBJECTIVE:The impetus for this consensus discussion was to recommend clinical trial designs that can deliver high-quality data for effective therapies for pediatric patients, in a reasonable timeframe, with a key focus on short- and long-term safety. METHODS:The International Pediatric Multiple Sclerosis Study Group convened a meeting of experts to review ... Read more >>

Neurology (Neurology)
[2019, 92(22):e2538-e2549]

Cited: 1 time

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Fatigue, depression, and quality of life in children with multiple sclerosis: a comparative study with other demyelinating diseases.

Anca Florea, Helene Maurey, Melanie Le Sauter, Celine Bellesme, Caroline Sevin, Kumaran Deiva,

AIM:To evaluate fatigue, depression, and quality of life (QoL) of children with multiple sclerosis and compare to other acute demyelinating syndromes (ADS). METHOD:Children followed in the National Referral Centre of rare inflammatory brain and spinal diseases were included in this study. The Expanded Disability Status Scale, the fatigue severity scale, ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2020, 62(2):241-244]

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Targeting MOG to skin macrophages prevents EAE in macaques through TGFβ-induced peripheral tolerance

Claire-Maëlle Fovet, Lev Stimmer, Vanessa Contreras, Philippe Horellou, Audrey Hubert, Nabila Sediki, Catherine Chapon, Sabine Tricot, Carole Leroy, Julien Flament, Julie Massonneau, Nicolas Tchitchek, Bert ’t Hart, Sandra Zurawski, Peter Klucar, Kumaran Deiva, Gerard Zurawski, SangKon Oh, Roger Le Grand, Ché Serguera,

Abstract To study the effect of vaccination on tolerization to the myelin antigen MOG we used a macaque model of experimental autoimmune encephalitis (EAE) in which immunization with recombinant human myelin oligodendrocyte glycoprotein (rhMOG) elicits brain inflammation and demyelination mediated by MOG-specific autoreactive CD4+ T lymphocytes and anti-MOG IgG. For ... Read more >>

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Relapsing encephalopathy with cerebellar ataxia are caused by variants involving p.Arg756 in ATP1A3.

Pascal Sabouraud, Audrey Riquet, Marie-Aude Spitz, Kumaran Deiva, Sona Nevsimalova, Cyril Mignot, Gaëtan Lesca, Nathalie Bednarek, Diane Doummar, Christine Pietrement, Vincent Laugel,

Mutations in ATP1A3 lead to different phenotypes having in common acute neurological decompensation episodes triggered by a specific circumstance and followed by sequelae. Alongside Alternating Hemiplegia of Childhood (AHC), Rapid-onset Dystonia Parkinsonism (RDP) and Cerebellar ataxia, Areflexia, Pes cavus, Optic atrophy, Sensorineural hearing loss syndrome (CAPOS), a new Relapsing Encephalopathy ... Read more >>

Eur. J. Paediatr. Neurol. (European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society)
[2019, 23(3):448-455]

Cited: 1 time

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Cranial nerve involvement in patients with MOG antibody-associated disease.

Alvaro Cobo-Calvo, Xavier Ayrignac, Philippe Kerschen, Philippe Horellou, Francois Cotton, Pierre Labauge, Sandra Vukusic, Kumaran Deiva, Ché Serguera, Romain Marignier,

Objective:To describe clinical and radiologic features of cranial nerve (CN) involvement in patients with myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) and to assess the potential underlying mechanism of CN involvement using a nonhuman primate (NHP) model. Methods:Epidemiologic, clinical, and radiologic features from a national cohort of 273 MOG-IgG-positive patients were retrospectively ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2019, 6(2):e543]

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Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis.

Tanuja Chitnis, Douglas L Arnold, Brenda Banwell, Wolfgang Brück, Angelo Ghezzi, Gavin Giovannoni, Benjamin Greenberg, Lauren Krupp, Kevin Rostásy, Marc Tardieu, Emmanuelle Waubant, Jerry S Wolinsky, Amit Bar-Or, Tracy Stites, Yu Chen, Norman Putzki, Martin Merschhemke, Jutta Gärtner, ,

Treatment of patients younger than 18 years of age with multiple sclerosis has not been adequately examined in randomized trials. We compared fingolimod with interferon beta-1a in this population.In this phase 3 trial, we randomly assigned patients 10 to 17 years of age with relapsing multiple sclerosis in a 1:1 ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2018, 379(11):1017-1027]

Cited: 13 times

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Acute transverse myelitis following an opsoclonus-myoclonus syndrome: An unusual presentation.

Thomas Simon, Emmanuel Cheuret, Léa Fiedler, Catherine Mengelle, Eloïse Baudou, Kumaran Deiva,

Opso-myoclonus syndrome (OMS) is a very rare and severe condition. Ataxia, opsoclonus, myoclonus and/or behavioral and sleeping disturbances define that autoimmune disorder syndrome which is paraneoplastic or triggered by an infection. Here, we report a 3 year-old immunocompetent boy who developed an atypical OMS which was later complicated by an ... Read more >>

Eur. J. Paediatr. Neurol. (European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society)
[2018, 22(5):878-881]

Cited: 0 times

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Disease Course and Treatment Responses in Children With Relapsing Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.

Yael Hacohen, Yu Yi Wong, Christian Lechner, Maciej Jurynczyk, Sukhvir Wright, Bahadir Konuskan, Judith Kalser, Anne Lise Poulat, Helene Maurey, Esther Ganelin-Cohen, Evangeline Wassmer, Chery Hemingway, Rob Forsyth, Eva Maria Hennes, M Isabel Leite, Olga Ciccarelli, Banu Anlar, Rogier Hintzen, Romain Marignier, Jacqueline Palace, Matthias Baumann, Kevin Rostásy, Rinze Neuteboom, Kumaran Deiva, Ming Lim,

Importance:Myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) are consistently identified in a range of demyelinating disorders in adults and children. Current therapeutic strategies are largely center specific, and no treatments have been formally evaluated. Objective:To examine the clinical phenotypes, treatment responses, and outcomes of children with relapsing MOG-Ab-associated disease. Design, Setting, and ... Read more >>

JAMA Neurol (JAMA neurology)
[2018, 75(4):478-487]

Cited: 35 times

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Paediatric optic neuritis: factors leading to unfavourable outcome and relapses.

Delphine Averseng-Peaureaux, Marie Mizzi, Helene Colineaux, Laurence Mahieu, Maria Carmela Pera, David Brassat, Yves Chaix, Emilie Berard, Kumaran Deiva, Emmanuel Cheuret, ,

OBJECTIVES:To identify prognostic factors associated with poor visual recovery and chronic relapsing diseases, for example, multiple sclerosis (MS), in children with optic neuritis (ON) at onset. METHODS:This multicentre retrospective study included 102 children with a first ON episode between 1990 and 2012. The primary criterion was poor visual recovery determined ... Read more >>

Br J Ophthalmol (The British journal of ophthalmology)
[2018, 102(6):808-813]

Cited: 1 time

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Neuromyelitis optica spectrum disorders with antibodies to myelin oligodendrocyte glycoprotein or aquaporin-4: Clinical and paraclinical characteristics in Algerian patients.

Melissa Bouzar, Smail Daoudi, Samira Hattab, Amel A Bouzar, Kumaran Deiva, Brigitte Wildemann, Markus Reindl, Sven Jarius,

Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disorder of the central nervous system. NMO and its abortive forms are referred to as NMO spectrum disorders (NMOSD). NMOSD are mostly associated with antibodies to aquaporin-4 (AQP4-IgG). However, recent studies have demonstrated antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) in a subset ... Read more >>

J. Neurol. Sci. (Journal of the neurological sciences)
[2017, 381:240-244]

Cited: 8 times

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Intracerebral gene therapy in children with mucopolysaccharidosis type IIIB syndrome: an uncontrolled phase 1/2 clinical trial.

Marc Tardieu, Michel Zérah, Marie-Lise Gougeon, Jérome Ausseil, Stéphanie de Bournonville, Béatrice Husson, Dimitrios Zafeiriou, Giancarlo Parenti, Philippe Bourget, Béatrice Poirier, Valérie Furlan, Cécile Artaud, Thomas Baugnon, Thomas Roujeau, Ronald G Crystal, Christian Meyer, Kumaran Deiva, Jean-Michel Heard,

BACKGROUND:Mucopolysaccharidosis type IIIB syndrome (also known as Sanfilippo type B syndrome) is a lysosomal storage disease resulting in progressive deterioration of cognitive acquisition after age 2-4 years. No treatment is available for the neurological manifestations of the disease. We sought to assess the safety and efficacy of a novel intracerebral ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2017, 16(9):712-720]

Cited: 25 times

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MOG antibody-related disorders: common features and uncommon presentations.

Álvaro Cobo-Calvo, Anne Ruiz, Hyacintha D'Indy, Anne-Lise Poulat, Maryline Carneiro, Nicolas Philippe, Françoise Durand-Dubief, Kumaran Deiva, Sandra Vukusic, Vincent Desportes, Romain Marignier,

Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) have been reported in acute demyelinating encephalomyelitis (ADEM), optic neuritis (ON), and neuromyelitis optica spectrum disorders (NMOSD) in adults and pediatrics. We aimed to delineate the common features of MOG-Ab-related disorders in children and adults, and report uncommon presentations. Twenty-seven consecutive pediatric and adult patients ... Read more >>

J. Neurol. (Journal of neurology)
[2017, 264(9):1945-1955]

Cited: 15 times

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Neurological outcome of patients with cryopyrin-associated periodic syndrome (CAPS).

Nafissa Mamoudjy, Hélène Maurey, Isabelle Marie, Isabelle Koné-Paut, Kumaran Deiva,

To assess the neurological involvement and outcome, including school and professional performances, of adults and children with cryopyrin-associated periodic syndrome (CAPS).In this observational study, patients with genetically proven CAPS and followed in the national referral centre for autoinflammatory diseases at Bicêtre hospital were assessed. Neurological manifestations, CSF data and MRI ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2017, 12(1):33]

Cited: 3 times

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Vessel Wall Contrast Enhancement on Magnetic Resonance Imaging May Be Suggestive for Future Development of Further Arterial Changes.

Guillaume Saliou, Marc Tardieu, Marie Theaudin, Sarah Power, Kumaran Deiva,

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2016, 43(5):728-730]

Cited: 0 times

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Catatonia and Autoimmune Conditions in Children and Adolescents: Should We Consider a Therapeutic Challenge?

Vladimir Ferrafiat, Marie Raffin, Kumaran Deiva, Xavier Salle-Collemiche, Anne Lepine, Michel Spodenkiewicz, Isabelle Michelet, Julien Haroche, Zahir Amoura, Priscille Gerardin, David Cohen, Angèle Consoli,

OBJECTIVE:Catatonia as a result of autoimmune conditions offers new therapeutic opportunities for patients that child and adolescent psychiatrists should consider. However, the diagnosis is sometimes challenging when an autoimmune signature is not identified. METHODS:In this study, we aim to summarize seven cases from a 20-year series of 84 youths with ... Read more >>

J Child Adolesc Psychopharmacol (Journal of child and adolescent psychopharmacology)
[2017, 27(2):167-176]

Cited: 0 times

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Pediatric transverse myelitis.

Michael Absoud, Benjamin M Greenberg, Ming Lim, Tim Lotze, Terrence Thomas, Kumaran Deiva,

Pediatric acute transverse myelitis (ATM) is an immune-mediated CNS disorder and contributes to 20% of children experiencing a first acquired demyelinating syndrome (ADS). ATM must be differentiated from other presentations of myelopathy and may be the first presentation of relapsing ADS such as neuromyelitis optica (NMO) or multiple sclerosis (MS). ... Read more >>

Neurology (Neurology)
[2016, 87(9 Suppl 2):S46-52]

Cited: 13 times

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Comparative efficacy of fingolimod vs natalizumab: A French multicenter observational study.

Laetitia Barbin, Chloe Rousseau, Natacha Jousset, Romain Casey, Marc Debouverie, Sandra Vukusic, Jerome De Sèze, David Brassat, Sandrine Wiertlewski, Bruno Brochet, Jean Pelletier, Patrick Vermersch, Gilles Edan, Christine Lebrun-Frenay, Pierre Clavelou, Eric Thouvenot, Jean-Philippe Camdessanché, Ayman Tourbah, Bruno Stankoff, Abdullatif Al Khedr, Philippe Cabre, Caroline Papeix, Eric Berger, Olivier Heinzlef, Thomas Debroucker, Thibault Moreau, Olivier Gout, Bertrand Bourre, Alain Créange, Pierre Labauge, Laurent Magy, Gilles Defer, Yohann Foucher, David A Laplaud, ,

OBJECTIVE:To compare natalizumab and fingolimod on both clinical and MRI outcomes in patients with relapsing-remitting multiple sclerosis (RRMS) from 27 multiple sclerosis centers participating in the French follow-up cohort Observatoire of Multiple Sclerosis. METHODS:Patients with RRMS included in the study were aged from 18 to 65 years with an Expanded ... Read more >>

Neurology (Neurology)
[2016, 86(8):771-778]

Cited: 29 times

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Rituximab monitoring and redosing in pediatric neuromyelitis optica spectrum disorder.

Margherita Nosadini, Gulay Alper, Catherine J Riney, Leslie A Benson, Shekeeb S Mohammad, Sudarshini Ramanathan, Melinda Nolan, Richard Appleton, Richard J Leventer, Kumaran Deiva, Fabienne Brilot, Mark P Gorman, Amy T Waldman, Brenda Banwell, Russell C Dale,

To study rituximab in pediatric neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD) and the relationship between rituximab, B cell repopulation, and relapses in order to improve rituximab monitoring and redosing.Multicenter retrospective study of 16 children with NMO/NMOSD receiving ≥2 rituximab courses. According to CD19 counts, events during rituximab were categorized as ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2016, 3(1):e188]

Cited: 15 times

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Promoting physical activity to control multiple sclerosis from childhood.

Maria A Rocca, Massimo Filippi, Kumaran Deiva,

Neurology (Neurology)
[2015, 85(19):1644-1645]

Cited: 2 times

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Subcutaneous interferon β-1a in pediatric patients with multiple sclerosis: Regional differences in clinical features, disease management, and treatment outcomes in an international retrospective study.

Lauren B Krupp, Daniela Pohl, Angelo Ghezzi, Alexey Boyko, Silvia Tenembaum, Liang Chen, Ernesto Aycardi, Brenda Banwell, ,

To further understand management of pediatric patients with multiple sclerosis (MS), we examined disease features, clinical practice patterns, and response to treatment in the United States (US) and seven other countries ('rest of World'; ROW).Anonymized data, recorded as part of routine clinical practice, were obtained from medical records (1997-2009) of ... Read more >>

J. Neurol. Sci. (Journal of the neurological sciences)
[2016, 363:33-38]

Cited: 4 times

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