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Author Kumar Budur

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Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial.

Günter U Höglinger, Irene Litvan, Nuno Mendonca, Deli Wang, Hui Zheng, Beatrice Rendenbach-Mueller, Hoi-Kei Lon, Ziyi Jin, Nahome Fisseha, Kumar Budur, Michael Gold, Davis Ryman, Hana Florian, ,

<h4>Background</h4>Progressive supranuclear palsy is a neurodegenerative disorder associated with tau protein aggregation. Tilavonemab (ABBV-8E12) is a monoclonal antibody that binds to the N-terminus of human tau. We assessed the safety and efficacy of tilavonemab for the treatment of progressive supranuclear palsy.<h4>Methods</h4>We did a phase 2, multicentre, randomised, placebo-controlled, double-blind study ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):182-192]

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Advancing combination therapy for Alzheimer's disease.

Stephen P Salloway, Jeff Sevingy, Kumar Budur, Jan Torleif Pederson, Ronald B DeMattos, Philipp Von Rosenstiel, Antonio Paez, Rebecca Evans, Christopher J Weber, James A Hendrix, Susan Worley, Lisa J Bain, Maria C Carrillo,

The study of Alzheimer's disease (AD) has led to an increased understanding of the multiple pathologies and pathways of the disease. As such, it has been proposed that AD and its various stages might be most effectively treated with a combination approach rather than a single therapy; however, combination approaches ... Read more >>

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2020, 6(1):e12073]

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Innovative Approaches for Slowing Disease Progression in Parkinson's Disease: Takeaways from the 14th Annual International Society for Central Nervous System Clinical Trials and Methodology Scientific Meeting.

Monica Javidnia, Mark Frasier, Ira Shoulson, Ibrahim Turkoz, Kumar Budur,

The International Society for Central Nervous System Clinical Trials and Methodology (ISCTM) partnered with the Michael J. Fox Foundation for Parkinson's Research to hold a joint session on innovation in Parkinson's disease research at the ISCTM 14th Annual Scientific Meeting held February 20 to 22, 2018 in Washington, D.C. The ... Read more >>

Innov Clin Neurosci (Innovations in clinical neuroscience)
[2020, 17(1-3):14-19]

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TOMMORROW neuropsychological battery: German language validation and normative study.

Heather R Romero, Andreas U Monsch, Kathleen M Hayden, Brenda L Plassman, Alexandra S Atkins, Richard S E Keefe, Shyama Brewster, Carl Chiang, Janet O'Neil, Grant Runyan, Mark J Atkinson, Stephen Crawford, Kumar Budur, Daniel K Burns, Kathleen A Welsh-Bohmer,

<h4>Introduction</h4>Assessment of preclinical Alzheimer's disease (AD) requires reliable and validated methods to detect subtle cognitive changes. The battery of standardized cognitive assessments that is used for diagnostic criteria for mild cognitive impairment due to AD in the TOMMORROW study have only been fully validated in English-speaking countries. We conducted a ... Read more >>

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2018, 4:314-323]

Cited: 2 times

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Measuring cognition and function in the preclinical stage of Alzheimer's disease.

Sandra Weintraub, Maria C Carrillo, Sarah Tomaszewski Farias, Terry E Goldberg, James A Hendrix, Judith Jaeger, David S Knopman, Jessica B Langbaum, Denise C Park, Michael T Ropacki, Sietske A M Sikkes, Kathleen A Welsh-Bohmer, Lisa J Bain, Robert Brashear, Kumar Budur, Ana Graf, Ferenc Martenyi, Marta Segardahl Storck, Christopher Randolph,

The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. This review will cover the tools and instruments currently available to identify populations for prevention trials, and measure subtle disease progression in the ... Read more >>

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2018, 4:64-75]

Cited: 19 times

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Efficacy and safety of sublingual ramelteon as an adjunctive therapy in the maintenance treatment of bipolar I disorder in adults: A phase 3, randomized controlled trial.

Atul R Mahableshwarkar, Joseph R Calabrese, Thomas A Macek, Kumar Budur, Adedeji Adefuye, Xinxin Dong, Elizabeth Hanson, Gary S Sachs,

<h4>Background</h4>The optimal long-term management strategy for bipolar I disorder patients is not yet established. Evidence supports the rationale for circadian rhythm regulation to prevent mood episode relapse in bipolar patients. This study evaluated the efficacy and safety of a new sublingual formulation of the melatonin receptor agonist ramelteon (ramelteon SL) ... Read more >>

J Affect Disord (Journal of affective disorders)
[2017, 221:275-282]

Cited: 7 times

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Characterization of APOE and TOMM40 allele frequencies in the Japanese population.

Akira Nishimura, Hidenori Nonomura, Shingo Tanaka, Michihiro Yoshida, Yuka Maruyama, Yutaka Aritomi, Ann M Saunders, Daniel K Burns, Michael W Lutz, Grant Runyan, Eric Lai, Kumar Budur, Allen D Roses,

<h4>Introduction</h4>Dementia is one of the major health threats to our aging society, and Alzheimer's disease (AD) is the leading cause. In Japan, ∼15% of the elderly population has dementia. The apolipoprotein E (<i>APOE</i>) genotype and a polymorphism (rs10524523) in the translocase of outer mitochondrial membrane 40 (<i>TOMM40</i>) gene have been ... Read more >>

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2017, 3(4):524-530]

Cited: 3 times

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Rapid Eye Movement Sleep Behavior Disorder: A Review of the Literature and Update on Current Concepts.

Carlos L Rodriguez, Nattapong Jaimchariyatam, Kumar Budur,

Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by abnormal behaviors emerging during REM sleep that may cause injury or sleep disruption. The diagnosis requires polysomnography (PSG) demonstrating a loss of normal skeletal muscle atonia during REM sleep. RBD results from dysfunction of the brain stem circuits responsible ... Read more >>

Chest (Chest)
[2017, 152(3):650-662]

Cited: 2 times

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Sleep-related cortical arousals in adult subjects with negative polysomnography.

Nattapong Jaimchariyatam, Carlos L Rodriguez, Kumar Budur,

<h4>Purpose</h4>The arousal index (AI) quantifies cortical arousal relative to total sleep time and is widely used to determine the severity of sleep fragmentation. It usually includes arousals secondary to respiratory events, limb movements, and spontaneous arousals. No systematic studies have been undertaken to determine AI cutoff in subjects with negative ... Read more >>

Sleep Breath (Sleep & breathing = Schlaf & Atmung)
[2015, 19(3):989-996]

Cited: 0 times

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New applications of disease genetics and pharmacogenetics to drug development.

Allen D Roses, Ann M Saunders, Michael W Lutz, Nanyin Zhang, Ahmad R Hariri, Karen E Asin, Donna G Crenshaw, Kumar Budur, Daniel K Burns, Stephen K Brannan,

TOMMORROW is a Phase III delay of onset clinical trial to determine whether low doses of pioglitazone, a molecule that induces mitochondrial doubling, delays the onset of MCI-AD in normal subjects treated with low dose compared to placebo. BOLD imaging studies in rodents and man were used to find the ... Read more >>

Curr Opin Pharmacol (Current opinion in pharmacology)
[2014, 14:81-89]

Cited: 28 times

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Prevalence and correlates of alpha-delta sleep in major depressive disorders.

Nattapong Jaimchariyatam, Carlos L Rodriguez, Kumar Budur,

Objective. Major depressive disorder is associated with sleep disturbances. An electroencephalographic pattern of alpha wave intrusion in delta wave sleep (alpha-delta sleep) is observed in some subjects with major depressive disorder. The treatment-resistant symptoms in major depressive disorder, nonrestorative sleep and fatigue, are associated with alpha-delta sleep. The objective of ... Read more >>

Innov Clin Neurosci (Innovations in clinical neuroscience)
[2011, 8(7):35-49]

Cited: 7 times

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Does CPAP treatment in mild obstructive sleep apnea affect blood pressure?

Nattapong Jaimchariyatam, Carlos L Rodriguez, Kumar Budur,

<h4>Objectives</h4>Obstructive sleep apnea (OSA) is associated with significant cardiovascular (CV) morbidity. Continuous positive airway pressure (CPAP) is the standard treatment for moderate to severe OSA, resulting in a reduction in CV morbidity. No studies have compared CV outcomes between CPAP and no CPAP in mild OSA (5>or=AHI<15).<h4>Methods</h4>Retrospective cohort study of ... Read more >>

Sleep Med (Sleep medicine)
[2010, 11(9):837-842]

Cited: 11 times

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Sleep disorders in substance abusers: how common are they?

Youssef Mahfoud, Farid Talih, David Streem, Kumar Budur,

<h4>Unlabelled</h4>Substance abuse is a major public health problem with high morbidity and mortality. Comorbid disorders are suspected to cause a high relapse rate. Subjects with sleep disorders tend to self medicate with alcohol and tranquilizers to promote sleep or abuse stimulants to stay awake during the day. Substance abuse can, ... Read more >>

Psychiatry (Edgmont) (Psychiatry (Edgmont (Pa. : Township)))
[2009, 6(9):38-42]

Cited: 45 times

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Posttraumatic stress disorder in primary care patients.

David Bronson, Kathleen Franco, Kumar Budur,

Posttraumatic stress disorder (PTSD) is a common psychiatric condition. PTSD patients can present with a wide variety of symptoms, and these patients are also at a higher risk of other physical, psychiatric, and substance abuse problems. Recent advances in the treatment of this condition can help the majority of patients ... Read more >>

Compr Ther (Comprehensive therapy)
[2007, 33(4):208-215]

Cited: 1 time

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Advances in treating insomnia.

Kumar Budur, Carlos Rodriguez, Nancy Foldvary-Schaefer,

Too often, insomnia is treated as a symptom without investigation of the cause. Insomnia may be a condition unto itself (primary insomnia), or it may be associated with a medical or psychiatric condition (comorbid insomnia), and it may be acute or chronic. Inadequate treatment often leads to significant frustration and ... Read more >>

Cleve Clin J Med (Cleveland Clinic journal of medicine)
[2007, 74(4):251-2, 255-8, 261-2 passim]

Cited: 6 times

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Non-stimulant treatment for attention deficit hyperactivity disorder.

Kumar Budur, Maju Mathews, Babatunde Adetunji, Manu Mathews, Jamal Mahmud,

Psychiatry (Edgmont) (Psychiatry (Edgmont (Pa. : Township)))
[2005, 2(7):44-48]

Cited: 3 times

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The CATIE study.

Biju Basil, Maju Mathews, Babatunde Adetunji, Kumar Budur,

Am J Psychiatry (The American journal of psychiatry)
[2006, 163(3):555; author reply 555-6]

Cited: 3 times

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Major depression with psychosis after resection of a giant middle fossa hemangiopericytoma.

Burak Sade, Kumar Budur, Dae Kyu Lee, Kathleen Franco, Joung H Lee,

<h4>Background</h4>Postoperative onset of acute major depression in a patient with no previous history of psychiatric disorder is highly unexpected after skull base surgery.<h4>Case description</h4>A 38-year-old woman with no previous physical or mental illness presented with a 3-month history of left ear pain, short-term memory disturbance, and motor dysphasia. Magnetic resonance ... Read more >>

Surg Neurol (Surgical neurology)
[2006, 65(3):290-2; discussion 292]

Cited: 0 times

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Review of the literature on major mental disorders in adult patients with mitochondrial diseases.

Omar Fattal, Kumar Budur, Aaron J Vaughan, Kathleen Franco,

Mitochondria are intracellular organelles crucial to the production cellular energy. Mitochondrial disease results from a malfunction in this biochemical cascade. These disorders can affect any organ system, producing diverse signs and symptoms, including psychiatric ones. Several authors argue that mitochondrial dysfunction is related to the pathophysiology of bipolar disorder and ... Read more >>

Psychosomatics (Psychosomatics)
[2006, 47(1):1-7]

Cited: 97 times

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Diagnosing and managing posttraumatic stress disorder.

Kumar Budur, Tatiana Falcone, Kathleen Franco,

In addition to being associated with combat, posttraumatic stress disorder (PTSD) also occurs in civilians exposed to severe trauma or serious illness. Manifestations of PTSD are varied and commonly include nonspecific physical symptoms, sleep disturbances, and psychological problems. Treatment with selective serotonin reuptake inhibitors (SSRIs) is usually effective. ... Read more >>

Cleve Clin J Med (Cleveland Clinic journal of medicine)
[2006, 73(2):121-2, 125-6, 128-9]

Cited: 0 times

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India plans to audit clinical trials.

Biju Basil, Maju Mathews, Jamal Mahmud, Babatunde Adetunji, Kumar Budur,

BMJ (BMJ (Clinical research ed.))
[2005, 331(7526):1204-1205]

Cited: 0 times

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Methylphenidate-induced neuroleptic malignant syndrome: a case report.

Biju Basil, Maju Mathews, Kumar Budur,

Prim Care Companion J Clin Psychiatry (Primary care companion to the Journal of clinical psychiatry)
[2006, 8(1):47]

Cited: 2 times

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Dangerous people with severe personality disorders.

Maju Mathews, Manu Mathews, Kumar Budur,

Psychiatr Serv (Psychiatric services (Washington, D.C.))
[2005, 56(7):873-4; author reply 874]

Cited: 0 times

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Pathological lying.

Babatunde Adetunji, Biju Basil, Kumar Budur, Olakunle Oladinni,

J Am Acad Psychiatry Law (The journal of the American Academy of Psychiatry and the Law)
[2006, 34(1):131-2; author reply 132-3]

Cited: 0 times

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Couvade syndrome equivalent?

Kumar Budur, Maju Mathews, Manu Mathews,

Psychosomatics (Psychosomatics)
[2005, 46(1):71-72]

Cited: 3 times

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