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Malignant tumor purity reveals the correlation between CD3E and low grade glioma microenvironment

WangRui Liu, Chuanyu Li, Wenhao Xu, Hao Lian, Yuanyuan Qu, Kui Chen, Huadong Huang, Haineng Huang, Chunlong Zhong,

Abstract Background: Tumor microenvironment (TME) contributes to the initiation and progression of low grade glioma (LGG); however, we are still unclear about the specifics of LGG's TME. Methods: In this article, we selected 161 LGG patients from the Cancer Genome Atlas (TCGA) as data, and calculated the percentage of tumor ... Read more >>

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Structural and Functional Overview of TEAD4 in Cancer Biology.

Mu Chen, Bingsong Huang, Lei Zhu, Kui Chen, Min Liu, Chunlong Zhong,

TEA domain transcription factor 4 (TEAD4) is an important member of the TEAD family. As a downstream effector of the Hippo pathway, TEAD4 has essential roles in cell proliferation, cell survival, tissue regeneration, and stem cell maintenance. TEAD4 contains a TEA DNA binding domain that binds the promoters of target ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2020, 13:9865-9874]

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Corrigendum to "LncRNA 1700020I14Rik/miR-297a/CGRP axis suppresses myocardial cell apoptosis in myocardial ischemia-reperfusion injury" [Mol. Immunol. 122 (2020) 54-61].

Fudong Hu, Jinhua Yang, Xi Chen, Yangyang Shen, Kui Chen, Xin Fu, Shengcun Guo, Zhengming Jiang,

Mol Immunol (Molecular immunology)
[2020, 127:146-149]

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[Characterization and Source Apportionment of PM2.5 Based on the Online Observation in Tianjin].

Zhi-Mei Xiao, Hong Xu, Li-Wei Li, Peng Li, Jie Yuan, Miao Tang, Ning Yang, Nai-Yuan Zheng, Kui Chen,

To study the characterization and source apportionment of PM2.5 in Tianjin, based on high-resolution online monitoring data from 2017 to 2019, the concentrations and its chemical compositions and sources of PM2.5 were analyzed. The results showed that the average concentration of PM2.5 was 61 μg ·m-3. The primary chemical compositions ... Read more >>

Huan Jing Ke Xue (Huan jing ke xue= Huanjing kexue)
[2020, 41(10):4355-4363]

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CueR activates transcription through a DNA distortion mechanism.

Chengli Fang, Steven J Philips, Xiaoxian Wu, Kui Chen, Jing Shi, Liqiang Shen, Juncao Xu, Yu Feng, Thomas V O'Halloran, Yu Zhang,

The MerR-family transcription factors (TFs) are a large group of bacterial proteins responding to cellular metal ions and multiple antibiotics by binding within central RNA polymerase-binding regions of a promoter. While most TFs alter transcription through protein-protein interactions, MerR TFs are capable of reshaping promoter DNA. To address the question ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Prognostic Value of the FOXK Family Expression in Patients with Locally Advanced Rectal Cancer Following Neoadjuvant Chemoradiotherapy.

Yiyi Zhang, Meifang Xu, Jianhua Chen, Kui Chen, Jinfu Zhuang, Yuanfeng Yang, Xing Liu, Guoxian Guan,

Purpose:To assess the role of the expression levels of FOXK family members, FOXK1 and FOXK2, in predicting response to neo-chemoradiotherapy (NCRT) and prognosis in locally advanced rectal cancer (LARC). Methods:A total of 256 LARC patients who underwent NCRT and radical resection between 2011 and 2017 were enrolled in the present ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2020, 13:9185-9201]

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[Characterization of Two Heavy Pollution Episodes in Tianjin in 2020].

Zhi-Mei Xiao, Hong Xu, Zi-Ying Cai, Peng Li, Bin Liu, Jie Yuan, Nai-Yuan Zheng, Miao Tang, Kui Chen, Xiao-Wen Deng,

High-resolution online monitoring data from January to February in 2020 was used to study the characterization of two heavy pollution episodes in Tianjin in 2020; the heavy pollution episode that lasted from January 16 to 18, 2020 (referred to as episode Ⅰ) and that from February 9 to 10, 2020 ... Read more >>

Huan Jing Ke Xue (Huan jing ke xue= Huanjing kexue)
[2020, 41(9):3879-3888]

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Effect of Exercise on Quality of Life in Parkinson's Disease: A Systematic Review and Meta-Analysis.

Kui Chen, Yan Tan, You Lu, Jiayan Wu, Xueyuan Liu, Yanxin Zhao,

Background:Exercise has an integral impact on the physical and mental wellbeing of patients with Parkinson's disease (PD), yet no comprehensive and quantitative analysis has been conducted on the effect of exercise on quality of life (QoL) in these patients. This study aimed to evaluate the effect of exercise on overall ... Read more >>

Parkinsons Dis (Parkinson's disease)
[2020, 2020:3257623]

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Novel biomarker for hepatocellular carcinoma: high tumoral PLK-4 expression is associated with better prognosis in patients without microvascular invasion.

Phillipe Abreu, Tommy Ivanics, Keruo Jiang, Kui Chen, Bettina E Hansen, Gonzalo Sapisochin, Anand Ghanekar,

BACKGROUND:Hepatocellular carcinoma (HCC) recurrence after liver resection (LR) adversely affects prognosis but is difficult to predict. Aberrant expression of Polo-Like Kinase 4 (PLK-4) is implicated in several adult malignancies. We sought to evaluate the prognostic value of PLK-4 expression in HCC after curative-intent LR. METHODS:Patients undergoing LR for HCC between ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2020, :]

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Maf1 regulates dendritic morphogenesis and influences learning and memory.

Kui Chen, Liang Zhu, Lin Guo, Yuan-Bo Pan, Dong-Fu Feng,

Maf1, a general transcriptional regulator and mTOR downstream effector, is highly expressed in the hippocampus and cortex, but the function of Maf1 in neurons is not well elucidated. Here, we first demonstrate that Maf1 plays a central role in the inhibition of dendritic morphogenesis and the growth of dendritic spines ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(7):606]

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New-onset non-convulsive status epilepticus in an adult with hemophagocytic lymphohistiocytosis: a case report.

Chunyu Han, Kui Chen, Dan Gao, Houzhen Tuo,

(Quantitative imaging in medicine and surgery)
[2020, 10(7):1559-1565]

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Ultrathin MoS2 nanosheets for high-performance photoelectrochemical applications via plasmonic coupling with Au nanocrystals.

Asad Ali, Farhana Akbar Mangrio, Xiaolin Chen, Yiwen Dai, Kui Chen, Xiaoliang Xu, Ruixiang Xia, Lixin Zhu,

In this work, we prepared ultrathin MoS2 nanosheets with exposed active edge sites and high electric conductivity that can sufficiently absorb light in the visible region to enable solar energy conversion. The gold nanocrystal-decorated MoS2 nanosheets facilitate sufficiently enhanced photoelectrochemical water splitting in the UV-visible region. Different Au nanostructures, such ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(16):7813-7824]

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MiR-219a-2 relieves myocardial ischemia-reperfusion injury by reducing calcium overload and cell apoptosis through HIF1α/ NMDAR pathway.

Fudong Hu, Shengye Zhang, Xi Chen, Xin Fu, Shengcun Guo, Zhengming Jiang, Kui Chen,

OBJECTIVE:During the process of myocardial ischemia-reperfusion injury (MIRI), the intracellular Ca2+ concentration ([Ca2+]i) continues to increase, leads to the cardiomyocyte apoptosis and eventually causes myocardial damage, while the upstream regulation mechanism of calcium overload is still unknown. This study focuses on the role of miR-219a-2 in MIRI and aims to ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, 395(1):112172]

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Network-based cancer gene relationship prediction method reveals perturbations in the cancer gene network

Jiajun Qiu, Kui Chen, Chunlong Zhong, Sihao Zhu, Xiao Ma,

Abstract The landscape of the gene relationship/network (such as activation, expression, phosphorylation, and binding) in cancer is found different from the general (non-disease) situation, and gene network perturbations are supposed to be the main cause of cancer. Thus, it makes no sense to use a regular gene relationship prediction method ... Read more >>

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Correction: Modulated podosome patterning in osteoclasts by fullerenol nanoparticles disturbs the bone resorption for osteoporosis treatment.

Kui Chen, Huan Geng, Wei Liang, Haojun Liang, Yujiao Wang, Jianglong Kong, Jiaxin Zhang, Yuelan Liang, Ziteng Chen, Jiacheng Li, Ya-Nan Chang, Juan Li, Gengyan Xing, Gengmei Xing,

Correction for 'Modulated podosome patterning in osteoclasts by fullerenol nanoparticles disturbs the bone resorption for osteoporosis treatment' by Kui Chen et al., Nanoscale, 2020, 12, 9359-9365, DOI: 10.1039/D0NR01625J. ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(22):12174-12176]

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Fullerenol Nanoparticles Eradicate Helicobacter pylori via pH-Responsive Peroxidase Activity.

Jiaxin Zhang, Ziteng Chen, Jianglong Kong, Yuelan Liang, Kui Chen, Yanan Chang, Hui Yuan, Yujiao Wang, Haojun Liang, Jiacheng Li, Meiru Mao, Juan Li, Gengmei Xing,

Helicobacter pylori (H. pylori) eradication by antibiotics and proton pump inhibitor treatment is limited by the low pH microenvironment in the stomach and can lead to antibiotic resistance. We fabricated fullerenol nanoparticles (FNPs) with varied chemical structures responding to a pinacol rearrangement of vicinal hydroxyl to form carbonyls in low ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, :]

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Modulated podosome patterning in osteoclasts by fullerenol nanoparticles disturbs the bone resorption for osteoporosis treatment.

Kui Chen, Huan Geng, Wei Liang, Haojun Liang, Yujiao Wang, Jianglong Kong, Jiaxin Zhang, Yuelan Liang, Ziteng Chen, Jiacheng Li, Ya-Nan Chang, Juan Li, Gengyan Xing, Gengmei Xing,

Overactivation and excessive differentiation of osteoclasts (OCs) has been implicated in the course of bone metabolism-related diseases. Although fullerenol nanoparticles (fNPs) have been suggested to inhibit OC differentiation and OC function in our previous work, systemic studies on the effect of fNPs on bone diseases, e.g., osteoporosis (OP), in vivo ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(17):9359-9365]

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Prognostic value of pretreatment systemic inflammatory markers in patients with locally advanced rectal cancer following neoadjuvant chemoradiotherapy.

Yiyi Zhang, Xing Liu, Meifang Xu, Kui Chen, Shoufeng Li, Guoxian Guan,

The aim of this study was to explore the most powerful systemic inflammation marker of survival in locally advanced rectal cancer (LARC) patients and construct prognostic  nomograms. A total of 472 LARC patients undergoing neoadjuvant chemoradiotherapy (NCRT) and radical surgery from 2011 to 2015 were included. The optimal cutoff points ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):8017]

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A Heterojunction Structured WO2.9-WSe2 Nanoradiosensitizer Increases Local Tumor Ablation and Checkpoint Blockade Immunotherapy upon Low Radiation Dose.

Xinghua Dong, Ran Cheng, Shuang Zhu, Huimin Liu, Ruyi Zhou, Chenyang Zhang, Kui Chen, Linqiang Mei, Chengyan Wang, Chunjian Su, Xiangfeng Liu, Zhanjun Gu, Yuliang Zhao,

Radiotherapy (RT) in practical use often suffers from off-target side effects and ineffectiveness against hypoxic tumor microenvironment (TME) as well as remote metastases. With regard to these problems, herein, we provide semiconductor heterojunction structured WO2.9-WSe2-PEG nanoparticles to realize a synergistic RT/photothermal therapy (PTT)/checkpoint blockade immunotherapy (CBT) for enhanced antitumor and ... Read more >>

ACS Nano (ACS nano)
[2020, 14(5):5400-5416]

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LncRNA 1700020I14Rik/miR-297a/CGRP axis suppresses myocardial cell apoptosis in myocardial ischemia-reperfusion injury.

Fudong Hu, Jinhua Yang, Xi Chen, Yangyang Shen, Kui Chen, Xin Fu, Shengcun Guo, Zhengming Jiang,

BACKGROUND:Long non-coding RNAs (lncRNAs) are closely related to various human diseases, but their role in myocardial injury has not been fully elucidated. In the current study, we found that the expression of lncRNA 1700020I14Rik was significantly down-regulated in myocardial injury tissues and the underlying mechanism by which lncRNA 1700020I14Rik regulated ... Read more >>

Mol Immunol (Molecular immunology)
[2020, 122:54-61]

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Intrinsic Biotaxi Solution Based on Blood Cell Membrane Cloaking Enables Fullerenol Thrombolysis In Vivo.

Kui Chen, Yujiao Wang, Haojun Liang, Shibo Xia, Wei Liang, Jianglong Kong, Yuelan Liang, Xia Chen, Meiru Mao, Ziteng Chen, Xue Bai, Jiaxin Zhang, Jiacheng Li, Ya-Nan Chang, Juan Li, Gengmei Xing,

We report the construction of blood cell membrane cloaked mesoporous silica nanoparticles for delivery of nanoparticles [fullerenols (Fols)] with fibrinolysis activity which endows the active Fol with successful thrombolysis effect in vivo. In vitro, Fols present excellent fibrinolysis activity, and the Fol with the best fibrinolysis activity is screened based ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(13):14958-14970]

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Health state prognostic of fuel cell based on wavelet neural network and cuckoo search algorithm.

Kui Chen, Salah Laghrouche, Abdesslem Djerdir,

This paper proposes a novel degradation prognosis of Proton Exchange Membrane Fuel Cell (PEMFC) based on Wavelet Neural Network (WNN) and Cuckoo Search Algorithm (CSA). The proposed method considering the main operating conditions of PEMFC can be applied to the health state prognostic of PEMFC under different conditions. First, the ... Read more >>

ISA Trans (ISA transactions)
[2020, :]

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Carboxylated gold nanoparticles inhibit bone erosion by disturbing the acidification of an osteoclast absorption microenvironment.

Xue Bai, Yuan Gao, Mingyi Zhang, Ya-Nan Chang, Kui Chen, Juan Li, Jiaxin Zhang, Yuelan Liang, Jianglong Kong, Yujiao Wang, Wei Liang, Gengyan Xing, Wei Li, Gengmei Xing,

Hyperactive osteoclasts (OCs) are a fundamental reason for excessive bone resorption and consequent osteoporosis that lead to one-third of the patients sustaining a fracture. OCs, with the help of acidifying vesicles containing vacuolar-type H+-ATPase (V-ATPase), transport cytoplasmic protons into a resorptive pit and create an acidic microenvironment where proteolytic enzymes ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(6):3871-3878]

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TGM6 variants in Parkinson's disease: clinical findings and functional evidence.

Kui Chen, You Lu, Fang Peng, Hui-Ling Yu, Jia-Yan Wu, Yan Tan, Yan-Xin Zhao,

TGM6 encodes transglutaminase 6, which catalyzes the covalent crosslinking of proteins through transamination reactions. Variants in TGM6 have been identified as the cause of spinocerebellar ataxia type 35. However, we found 12 TGM6 variants of low frequency among 308 patients with Parkinson's disease using next-generation sequencing technologies and multiple ligation-dependent ... Read more >>

J Integr Neurosci (Journal of integrative neuroscience)
[2020, 19(1):51-64]

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Structural and Functional Overview of TEAD4 in Cancer Biology

Mu Chen, Bingsong Huang, Lei Zhu, Kui Chen, Min Liu, Chunlong Zhong,

Abstract TEA domain transcription factor 4 (TEAD4) is an important member of the TEAD family. As a downstream effector of the Hippo pathway, TEAD4 has essential roles in cell proliferation, cell survival, tissue regeneration, and stem cell maintenance. TEAD4 contains a TEA DNA binding domain that binds the promoters of ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2020, 13:9865-9874]

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