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Author Kristopher B Deatrick

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A Comparison of Anticoagulation Strategies in Veno-venous Extracorporeal Membrane Oxygenation.

Aakash Shah, Chetan Pasrija, Anthony Kronfli, Eno-Obong Essien, Ya Zhou, Francis Brigante, Gregory Bittle, Jay Menaker, Daniel Herr, Michael A Mazzeffi, Kristopher B Deatrick, Zachary N Kon,

Bleeding remains a major source of morbidity associated with veno-venous extracorporeal membrane oxygenation (VV-ECMO). Moreover, there remains significant controversy, and a paucity of data regarding the ideal anticoagulation strategy for VV-ECMO patients. All patients undergoing isolated, peripheral VV-ECMO between January 2009 and December 2014 at our institution were retrospectively reviewed. ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, :]

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A descriptive evaluation of causes of death in venovenous extracorporeal membrane oxygenation.

Sagar B Dave, Kristopher B Deatrick, Samuel M Galvagno, Michael A Mazzeffi, David J Kaczorowski, Ronson J Madathil, Raymond Rector, Ali Tabatabai, Daniel J Haase, Daniel Herr, Thomas M Scalea, Jay Menaker,

Veno-venous extracorporeal membrane oxygenation (VV ECMO) has become an important support modality for patients with acute respiratory failure refractory to optimal medical therapy, such as low tidal volume mechanical ventilator support, early paralytic infusion, and early prone positioning. The objective of this cohort study was to investigate the causes and ... Read more >>

Perfusion (Perfusion)
[2021, :2676591211035938]

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Peripheral cannulation for extracorporeal membrane oxygenation yields superior neurologic outcomes in adult patients who experienced cardiac arrest following cardiac surgery.

Lauren E Levy, David J Kaczorowski, Chetan Pasrija, Gregory Boyajian, Michael Mazzeffi, Eric Krause, Aakash Shah, Ronson Madathil, Kristopher B Deatrick, Daniel Herr, Bartley P Griffith, James S Gammie, Bradley S Taylor, Mehrdad Ghoreishi,

<h4>Background</h4>Extracorporeal cardiopulmonary resuscitation (ECPR) for refractory cardiac arrest has improved mortality in post-cardiac surgery patients; however, loss of neurologic function remains one of the main and devastating complications. We reviewed our experience with ECPR and investigated the effect of cannulation strategy on neurologic outcome in adult patients who experienced cardiac ... Read more >>

Perfusion (Perfusion)
[2021, :2676591211018129]

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Precannulation International Normalized Ratio is Independently Associated With Mortality in Veno-Arterial Extracorporeal Membrane Oxygenation.

Michael E Plazak, Alison Grazioli, Elizabeth K Powell, Ashley R Menne, Allison L Bathula, Ronson J Madathil, Eric M Krause, Kristopher B Deatrick, Michael A Mazzeffi,

<h4>Objectives</h4>To explore whether precannulation international normalized ratio (INR) is associated with in-hospital mortality in venoarterial extracorporeal membrane oxygenation (VA-ECMO) patients.<h4>Design</h4>A retrospective, observational cohort study.<h4>Setting</h4>A quaternary care academic medical center.<h4>Participants</h4>Patients with cardiogenic shock on VA-ECMO for >24 hours.<h4>Interventions</h4>None, observational study.<h4>Measurements and main results</h4>A total of 188 patients who were on VA-ECMO ... Read more >>

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2021, :]

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Extracorporeal Life Support Organization (ELSO): Guidelines for Pediatric Cardiac Failure.

Georgia Brown, Katie M Moynihan, Kristopher B Deatrick, Aparna Hoskote, Hitesh S Sandhu, Devon Aganga, Shriprasad R Deshpande, Anuradha P Menon, Thomas Rozen, Lakshmi Raman, Peta M A Alexander,

These guidelines are applicable to neonates and children with cardiac failure as indication for extracorporeal life support. These guidelines address patient selection, management during extracorporeal membrane oxygenation, and pathways for weaning support or bridging to other therapies. Equally important issues, such as personnel, training, credentialing, resources, follow-up, reporting, and quality ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, 67(5):463-475]

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Breathing Life Back Into the Kidney-Continuous Renal Replacement Therapy and Veno-Venous Extracorporeal Membrane Oxygenation.

Kristopher B Deatrick, Michael A Mazzeffi, Samuel M Galvagno, Kimberly Boswell, David J Kaczoroswki, Ronald P Rabinowitz, Ronson J Madathil, Christopher R Cornachione, Daniel L Herr, Thomas M Scalea, Jay Menaker,

The purpose of this study was to evaluate the incidence of continuous renal replacement therapy (CRRT) in patients supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Secondary outcomes included mortality and the need for hemodialysis on hospital discharge. We performed a retrospective cohort study of all patients admitted to a ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, 67(2):208-212]

Cited: 4 times

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Extracorporeal Life Support (ECLS): A Review and Focus on Considerations for COVID-19.

Ali Tabatabai, Samuel M Galvagno, James V O'Connor, Thomas M Scalea, Kristopher B Deatrick,

<h4>Abstract</h4>Extracorporeal life support (ECLS) is a support modality for patients with severe acute respiratory distress syndrome (ARDS) who have failed conventional treatments including low tidal volume ventilation, prone positioning, and neuromuscular blockade. In addition, ECLS can be used for hemodynamic support for patients with cardiogenic shock or following cardiac arrest. ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 55(6):742-751]

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A Dedicated Veno-Venous Extracorporeal Membrane Oxygenation Unit during a Respiratory Pandemic: Lessons Learned from COVID-19 Part II: Clinical Management.

Aakash Shah, Sagar Dave, Samuel Galvagno, Kristen George, Ashley R Menne, Daniel J Haase, Brian McCormick, Raymond Rector, Siamak Dahi, Ronson J Madathil, Kristopher B Deatrick, Mehrdad Ghoreishi, James S Gammie, David J Kaczorowski, Thomas M Scalea, Jay Menaker, Daniel Herr, Ali Tabatabai, Eric Krause,

(1) Background: COVID-19 acute respiratory distress syndrome (CARDS) has several distinctions from traditional acute respiratory distress syndrome (ARDS); however, patients with refractory respiratory failure may still benefit from veno-venous extracorporeal membrane oxygenation (VV-ECMO) support. We report our challenges caring for CARDS patients on VV-ECMO and alterations to traditional management strategies. ... Read more >>

Membranes (Basel) (Membranes)
[2021, 11(5):]

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Ultrasound-assisted catheter directed thrombolysis for pulmonary embolus during extracorporeal membrane oxygenation.

Douglas Tran, Nicole Hays, Aakash Shah, Chetan Pasrija, Rafael S Cires-Drouet, Shahab A Toursavadkohi, Michael A Mazzeffi, Daniel L Herr, Ronson J Madathil, James S Gammie, Bartley P Griffith, Kristopher B Deatrick, David J Kaczorowski,

<h4>Background</h4>Acute pulmonary embolism (PE) is the third most common cause of cardiovascular death. For patients who are hemodynamically unstable, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support has been shown to provide hemodynamic stability, and allow time for definitive treatment and recovery. Ultrasound-assisted catheter directed thrombolysis (USAT) has the potential to be ... Read more >>

J Card Surg (Journal of cardiac surgery)
[2021, 36(8):2685-2691]

Cited: 1 time

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A Dedicated Veno-Venous Extracorporeal Membrane Oxygenation Unit during a Respiratory Pandemic: Lessons Learned from COVID-19 Part I: System Planning and Care Teams.

Sagar Dave, Aakash Shah, Samuel Galvagno, Kristen George, Ashley R Menne, Daniel J Haase, Brian McCormick, Raymond Rector, Siamak Dahi, Ronson J Madathil, Kristopher B Deatrick, Mehrdad Ghoreishi, James S Gammie, David J Kaczorowski, Thomas M Scalea, Jay Menaker, Daniel Herr, Eric Krause, Ali Tabatabai,

<h4>Background</h4>The most critically ill patients with coronavirus disease 2019 (COVID-19) may require advanced support modalities, such as veno-venous extracorporeal membrane oxygenation (VV-ECMO). A systematic, methodical approach to a respiratory pandemic on a state and institutional level is critical.<h4>Methods</h4>We conducted retrospective review of our institutional response to the COVID-19 pandemic, focusing ... Read more >>

Membranes (Basel) (Membranes)
[2021, 11(4):]

Cited: 1 time

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Mortality Risk Assessment in COVID-19 Venovenous Extracorporeal Membrane Oxygenation.

Ali Tabatabai, Mira H Ghneim, David J Kaczorowski, Aakash Shah, Sagar Dave, Daniel J Haase, Roumen Vesselinov, Kristopher B Deatrick, Joseph Rabin, Ronald P Rabinowitz, Samuel Galvagno, James V O'Connor, Jay Menaker, Daniel L Herr, James S Gammie, Thomas M Scalea, Ronson J Madathil,

<h4>Background</h4>A life-threatening complication of coronavirus disease 2019 (COVID-19) is acute respiratory distress syndrome (ARDS) refractory to conventional management. Venovenous (VV) extracorporeal membrane oxygenation (ECMO) (VV-ECMO) is used to support patients with ARDS in whom conventional management fails. Scoring systems to predict mortality in VV-ECMO remain unvalidated in COVID-19 ARDS. This ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, 112(6):1983-1989]

Cited: 1 time

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Extracorporeal Membrane Oxygenation for COVID-19.

Zachary Sanford, Ronson J Madathil, Kristopher B Deatrick, Ali Tabatabai, Jay Menaker, Samuel M Galvagno, Michael A Mazzeffi, Joseph Rabin, Mehrdad Ghoreishi, Raymond Rector, Daniel L Herr, David J Kaczorowski,

Innovations (Phila) (Innovations (Philadelphia, Pa.))
[2020, 15(4):306-313]

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Complete percutaneous decannulation from femoral venoarterial extracorporeal membrane oxygenation.

Aakash Shah, Mehrdad Ghoreishi, Bradley S Taylor, Shahab Toursavadkohi, David J Kaczorowski, ,

<h4>Objectives</h4>To evaluate the clinical outcomes and perioperative complications associated with complete percutaneous decannulation of femoral venoarterial extracorporeal membrane oxygenation (VA-ECMO) with the MANTA closure device.<h4>Methods</h4>This is a retrospective analysis of a single surgeon consecutive series of 14 patients at a single center who underwent decannulation from VA-ECMO, 10 of whom ... Read more >>

JTCVS Tech (JTCVS techniques)
[2021, 6:75-81]

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Does Weight Matter? Outcomes in Adult Patients on Venovenous Extracorporeal Membrane Oxygenation When Stratified by Obesity Class.

Samuel M Galvagno, Stacy Pelekhaty, Christopher R Cornachione, Kristopher B Deatrick, Michael A Mazzeffi, Thomas M Scalea, Jay Menaker,

<h4>Background</h4>Many believe obesity is associated with higher rates of mortality in the critically ill. The purpose of this retrospective observational study is to evaluate the association between body mass index (BMI) and survival in patients receiving venovenous (VV) extracorporeal membrane oxygenation (ECMO) for acute hypoxic or hypercarbic respiratory failure.<h4>Methods</h4>All of ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, 131(3):754-761]

Cited: 8 times

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Exosomes isolated from human cardiosphere-derived cells attenuate pressure overload-induced right ventricular dysfunction.

Gregory J Bittle, David Morales, Nicholas Pietris, Nathaniel Parchment, Dawn Parsell, Kiel Peck, Kristopher B Deatrick, Luis Rodriguez-Borlado, Rachel R Smith, Linda Marbán, Sunjay Kaushal,

<h4>Objectives</h4>Cardiosphere-derived cell (CDC) transplantation has been shown to attenuate right ventricular (RV) dysfunction in patients with hypoplastic left heart syndrome. However, live cell transplantation requires complex handling protocols that may limit its use. Exosomes are protein and nucleic acid-containing nanovesicles secreted by many cell types, including stem cells, which have ... Read more >>

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2021, 162(3):975-986.e6]

Cited: 2 times

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Outcomes of Venovenous Extracorporeal Membrane Oxygenation When Stratified by Age: How Old Is Too Old?

Kristopher B Deatrick, Michael A Mazzeffi, Samuel M Galvagno, Ronald B Tesoriero, David J Kaczoroswki, Daniel L Herr, Katelyn Dolly, Ronald P Rabinowitz, Thomas M Scalea, Jay Menaker,

The purpose of this study was to evaluate survival to hospital discharge for patients on venovenous extracorporeal membrane oxygenation (VV ECMO) when stratified by age. We performed a retrospective study at single, academic, tertiary care center intensive care unit for VV ECMO. All patients, older than 17 years of age, ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2020, 66(8):946-951]

Cited: 4 times

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Normoxic re-oxygenation ameliorates end-organ injury after cardiopulmonary bypass.

Yun-Wen Peng, Terry Major, Azmath Mohammed, Kristopher B Deatrick, John R Charpie,

<h4>Background</h4>In a rabbit model of cardiopulmonary bypass (CPB) and cardioplegic arrest, we previously showed that hyperoxic myocardial reperfusion was associated with increased left ventricular (LV) systolic dysfunction and myocardial injury compared with normoxic reperfusion. The aim of this study was to evaluate in our experimental model the impact of post-CPB ... Read more >>

J Cardiothorac Surg (Journal of cardiothoracic surgery)
[2020, 15(1):134]

Cited: 1 time

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Cardiac Arrest Prior to Initiation of Veno-Venous Extracorporeal Membrane Oxygenation Is Not Associated with Increased In-Hospital Mortality.

Kevin M Jones, Laura DiChiacchio, Kristopher B Deatrick, Katelyn Dolly, Jeffrey Rea, Samuel Galvagno, Daniel Herr, James O'Connor, Thomas Scalea, Jay Menaker,

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2020, 66(6):e79-e81]

Cited: 1 time

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Early Decompressive Laparotomy for Intra-Abdominal Hypertension Following Initiation of Venovenous Extracorporeal Membrane Oxygenation.

Francesca M Boulos, Chetan Pasrija, Laura DiChiacchio, Michael Rouse, Maxwell Raithel, Kristen Mackowick, Raymond Rector, Michael A Mazzeffi, Bartley P Griffith, Jose J Diaz, Zachary N Kon, Kristopher B Deatrick,

Patients supported with venovenous extracorporeal membrane oxygenation are at risk for intra-abdominal hypertension and abdominal compartment syndrome. Flow through the return cannula may be compromised in these patients, resulting in inadequate support and end-organ malperfusion. Early decompressive laparotomy can mitigate these complications and potentially improve outcomes. Here we review a ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2020, 66(5):520-523]

Cited: 2 times

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Sutureless Closure of Arterial Cannulation Sites.

Chetan Pasrija, Daniel A Bernstein, Maryjoe Rice, Douglas Tran, David Morales, David Morales, Todd Grintz, Kristopher B Deatrick, James S Gammie, Ronson Madathil, David J Kaczorowski,

<h4>Objective</h4>Percutaneous femoral cannulation for venoarterial extracorporeal membrane oxygenation (ECMO) is commonly performed but percutaneous removal of arterial cannulas has not been broadly accepted. We hypothesized that a system that allows endovascular access to ECMO circuits along with the MANTA<sup>®</sup> large-bore vascular closure device could be used to successfully close arterial ... Read more >>

Innovations (Phila) (Innovations (Philadelphia, Pa.))
[2020, 15(2):138-141]

Cited: 1 time

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Oxandrolone in Patients on Venovenous Extracorporeal Membrane Oxygenation: A Case Series.

Stacy L Pelekhaty, Mehrnaz Pajoumand, Kristen S Omanwa, Samuel M Galvagno, James H Lantry, Kristopher B Deatrick, Christopher R Cornachione, Jay Menaker,

Venovenous extracorporeal membrane oxygenation (VV ECMO) induces a systemic inflammatory response, which may progress to persistent inflammation, immunosuppression, and catabolism syndrome (PICS). The anabolic steroid oxandrolone may improve the metabolic aberrations of PICS. We report our experience with 3 patients on VV ECMO who received oxandrolone after demonstrating refractory catabolism ... Read more >>

Nutr Clin Pract (Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition)
[2020, 35(3):514-521]

Cited: 0 times

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Early tracheostomy after initiation of venovenous extracorporeal membrane oxygenation is associated with decreased duration of extracorporeal membrane oxygenation support.

Laura DiChiacchio, Francesca M Boulos, Francis Brigante, Maxwell Raithel, Aakash Shah, Chetan Pasrija, Kristen Mackowick, Jay Menaker, Michael Mazzeffi, Daniel Herr, Zachary N Kon, Kristopher B Deatrick,

Timing of tracheostomy placement for patients with respiratory failure requiring venovenous extracorporeal membrane oxygenation support is variable and continues to depend on surgeon preference. We retrospectively reviewed all consecutive adult patients supported with peripheral venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome at a single institution with the hypothesis ... Read more >>

Perfusion (Perfusion)
[2020, 35(6):509-514]

Cited: 1 time

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High-efficiency, high-flux in-line hemofiltration using a high blood flow extracorporeal circuit.

Alison Grazioli, Sanjeev R Shah, Joseph Rabin, Rashmikant Shah, Ronson J Madathil, Joshua D King, Laura DiChiacchio, Raymond P Rector, Kristopher B Deatrick, Zhongjun J Wu, Daniel L Herr,

The ability of current renal replacement therapy modalities to achieve rapid solute removal is limited by membrane surface area and blood flow rate. Extracorporeal membrane oxygenation offers high blood flow and hemodynamic support that may be harnessed to overcome limitations in traditional renal replacement therapy. Using an extracorporeal membrane oxygenation ... Read more >>

Perfusion (Perfusion)
[2020, 35(4):351-355]

Cited: 1 time

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Predictors of Recovery in Patients Supported With Venoarterial Extracorporeal Membrane Oxygenation for Acute Massive Pulmonary Embolism.

Mehrdad Ghoreishi, Laura DiChiacchio, Chetan Pasrija, Anahita Ghazi, Kristopher B Deatrick, Jean Jeudy, Bartley P Griffith, Zachary N Kon,

<h4>Background</h4>Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has emerged as a promising initial support strategy for acute massive pulmonary embolism. However, it remains unclear which patients will ultimately require surgical pulmonary embolectomy (SPE) vs anticoagulation alone.<h4>Methods</h4>All consecutive patients (2015-2018) with confirmed massive PE, placed on VA-ECMO utilizing a protocolized approach, were reviewed. ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2020, 110(1):70-75]

Cited: 3 times

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Early Experience With Preclinical Perioperative Cardiac Xenograft Dysfunction in a Single Program.

Laura DiChiacchio, Avneesh K Singh, Billeta Lewis, Tianshu Zhang, Naomi Hardy, Chetan Pasrija, David Morales, Patrick Odonkor, Erik Strauss, Brittney Williams, Kristopher B Deatrick, David J Kaczorowski, David Ayares, Bartley P Griffith, Stephen T Bartlett, Muhammad M Mohiuddin,

<h4>Background</h4>Perioperative cardiac xenograft dysfunction (PCXD) was described by McGregor and colleagues as a major barrier to the translation of heterotopic cardiac xenotransplantation into the orthotopic position. It is characterized by graft dysfunction in the absence of rejection within 24 to 48 hours of transplantation. We describe our experience with PCXD ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2020, 109(5):1357-1361]

Cited: 1 time

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