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Author Kristine Krakauer

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Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis.

Thomas A Pollak, Matthew J Kempton, Conrad Iyegbe, Angela Vincent, Sarosh R Irani, Ester Coutinho, David A Menassa, Leslie Jacobson, Lieuwe de Haan, Stephan Ruhrmann, Gabriele Sachs, Anita Riecher-Rössler, Marie-Odile Krebs, Paul Amminger, Birte Glenthøj, Neus Barrantes-Vidal, Jim van Os, Bart P F Rutten, Rodrigo A Bressan, Mark van der Gaag, Robert Yolken, Matthew Hotopf, Lucia Valmaggia, James Stone, Anthony S David, , Philip McGuire,

Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with particular clinical features or outcomes. In a case-control study, sera ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2020, :]

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Effectiveness of cognitive remediation in the ultra-high risk state for psychosis.

Louise B Glenthøj, Lise S Mariegaard, Birgitte Fagerlund, Jens R M Jepsen, Tina D Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David L Roberts, Carsten Hjorthøj, Merete Nordentoft,

(World psychiatry : official journal of the World Psychiatric Association (WPA))
[2020, 19(3):401-402]

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Cognitive remediation plus standard treatment versus standard treatment alone for individuals at ultra-high risk of developing psychosis: Results of the FOCUS randomised clinical trial.

Louise B Glenthøj, Lise S Mariegaard, Birgitte Fagerlund, Jens R M Jepsen, Tina D Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David L Roberts, Carsten Hjorthøj, Merete Nordentoft,

BACKGROUND:Individuals at ultra-high risk (UHR) for psychosis have significant cognitive deficits that can impede functional recovery. Applying cognitive remediation (CR) before the onset of frank psychosis may improve the cognitive and functional prognosis of UHR individuals, however, little is known about the feasibility and efficacy of CR for this population. ... Read more >>

Schizophr Res (Schizophrenia research)
[2020, :]

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No Effects of Cognitive Remediation on Cerebral White Matter in Individuals at Ultra-High Risk for Psychosis-A Randomized Clinical Trial.

Tina D Kristensen, Bjørn H Ebdrup, Carsten Hjorthøj, René C W Mandl, Jayachandra M Raghava, Jens Richardt M Jepsen, Birgitte Fagerlund, Louise B Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Birte Y Glenthøj, Merete Nordentoft,

Background:Individuals at ultra-high risk for psychosis (UHR) present with subtle alterations in cerebral white matter (WM), which appear to be associated with clinical and functional outcome. The effect of cognitive remediation on WM organization in UHR individuals has not been investigated previously. Methods:In a randomized, clinical trial, UHR individuals aged ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:873]

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Dysregulated Lipid Metabolism Precedes Onset of Psychosis.

Alex M Dickens, Partho Sen, Matthew J Kempton, Neus Barrantes-Vidal, Conrad Iyegbe, Merete Nordentoft, Thomas Pollak, Anita Riecher-Rössler, Stephan Ruhrmann, Gabriele Sachs, Rodrigo Bressan, Marie-Odile Krebs, G Paul Amminger, Lieuwe de Haan, Mark van der Gaag, Lucia Valmaggia, Tuulia Hyötyläinen, , Matej Orešič, Philip McGuire,

BACKGROUND:A key clinical challenge in the management of individuals at clinical high risk for psychosis (CHR) is that it is difficult to predict their future clinical outcomes. Here, we investigated if the levels of circulating molecular lipids are related to adverse clinical outcomes in this group. METHODS:Serum lipidomic analysis was ... Read more >>

Biol. Psychiatry (Biological psychiatry)
[2020, :]

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T46. THE EFFECT OF COMPREHENSIVE COGNITIVE REMEDIATION IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS: A SINGLE-BLIND, RANDOMISED, CLINICAL TRIAL (FOCUS).

Louise Birkedal Glenthoej, Mariegaard Lise, Birgitte Fagerlund, Jens Richardt Jepsen, Tina Dam Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David Roberts, Carsten Hjorthøj, Merete Nordentoft,

AbstractBackgroundIndividuals at ultra-high risk (UHR) for psychosis display significant cognitive deficits that constitute a barrier to functional recovery. Applying cognitive remediation (CR) before the onset of manifest psychosis may improve cognition and the clinical and functional prognosis of UHR individuals.MethodsThis randomised, clinical trial randomly assigned 146 UHR individuals aged 18–40 ... Read more >>

(Schizophrenia bulletin)
[2020, 46(Suppl 1):S249-S249]

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T18. EFFECTS OF COGNITIVE REMEDIATION ON WHITE MATTER IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS – A RANDOMIZED, CONTROLLED CLINICAL TRIAL.

Tina Kristensen, Bjørn H Ebdrup, Carsten Hjorthøj, Rene C W Mandl, Jayachandra Mitta Raghava, Jens Richardt Møllegaard Jepsen, Birgitte Fagerlund, Louise B Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Birte Y Glenthøj, Merete Nordentoft,

AbstractBackgroundIndividuals at ultra-high risk for psychosis (UHR) present with subtle white matter alterations, which have been associated with clinical and functional outcome. The effect of cognitive remediation on white matter (WM) in UHR-individuals has not been investigated.MethodsIn a randomized, clinical intervention-trial (FOCUS), UHR-individuals aged 18–40 years were assigned to treatment ... Read more >>

(Schizophrenia bulletin)
[2020, 46(Suppl 1):S237-S238]

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Associations between facial affect recognition and neurocognition in subjects at ultra-high risk for psychosis: A case-control study.

Lasse Randers, Jens Richardt M Jepsen, Birgitte Fagerlund, Dorte Nordholm, Kristine Krakauer, Carsten Hjorthøj, Birte Glenthøj, Merete Nordentoft,

The nature of facial affect recognition (FAR) deficits in subjects at ultra-high risk (UHR) for psychosis remains unclear. In schizophrenia, associations between FAR impairment and poor neurocognition have been demonstrated meta-analytically, but this potential link is understudied in the UHR population. Our study investigated a cross-sectional sample of UHR subjects ... Read more >>

Psychiatry Res (Psychiatry research)
[2020, 290:112969]

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No Effects of Cognitive Remediation on Cerebral White Matter in Individuals at Ultra-High Risk for Psychosis—A Randomized Clinical Trial

Tina D. Kristensen, Bjørn H. Ebdrup, Carsten Hjorthøj, René C. W. Mandl, Jayachandra M. Raghava, Jens Richardt M. Jepsen, Birgitte Fagerlund, Louise B. Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Birte Y. Glenthøj, Merete Nordentoft,

Background Individuals at ultra-high risk for psychosis (UHR) present with subtle alterations in cerebral white matter (WM), which appear to be associated with clinical and functional outcome. The effect of cognitive remediation on WM organization in UHR individuals has not been investigated previously. Methods In a randomized, clinical trial, UHR ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:]

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Cerebral Glutamate and Gamma-Aminobutyric Acid Levels in Individuals at Ultra-high Risk for Psychosis and the Association With Clinical Symptoms and Cognition.

Christina Wenneberg, Merete Nordentoft, Egill Rostrup, Louise Birkedal Glenthøj, Kirsten Borup Bojesen, Birgitte Fagerlund, Carsten Hjorthøj, Kristine Krakauer, Tina Dam Kristensen, Camilla Schwartz, Richard A E Edden, Brian Villumsen Broberg, Birte Yding Glenthøj,

BACKGROUND:Studies examining glutamate or gamma-aminobutyric acid (GABA) in ultra-high risk for psychosis (UHR) and the association with pathophysiology and cognition have shown conflicting results. We aimed to determine whether perturbed glutamate and GABA levels in the anterior cingulate cortex and glutamate levels in the left thalamus were present in UHR ... Read more >>

Biol Psychiatry Cogn Neurosci Neuroimaging (Biological psychiatry. Cognitive neuroscience and neuroimaging)
[2020, 5(6):569-579]

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Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis.

Tina D Kristensen, René C W Mandl, Jayachandra M Raghava, Kasper Jessen, Jens Richardt M Jepsen, Birgitte Fagerlund, Louise B Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Merete Nordentoft, Birte Y Glenthøj, Bjørn H Ebdrup,

In schizophrenia patients, cognitive functions appear linked to widespread alterations in cerebral white matter microstructure. Here we examine patterns of associations between regional white matter and cognitive functions in individuals at ultra-high risk for psychosis. One hundred and sixteen individuals at ultra-high risk for psychosis and 49 matched healthy controls ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2019, 40(18):5185-5201]

Cited: 2 times

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Gender differences of patients at-risk for psychosis regarding symptomatology, drug use, comorbidity and functioning - Results from the EU-GEI study.

Stephanie Menghini-Müller, Erich Studerus, Sarah Ittig, Ulrike Heitz, Laura Egloff, Christina Andreou, Lucia R Valmaggia, Matthew J Kempton, Mark van der Gaag, Lieuwe de Haan, Barnaby Nelson, Neus Barrantes-Vidal, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P Rutten, Jim van Os, Anita Riecher-Rössler, , Philip McGuire, Lucia R Valmaggia, Matthew J Kempton, Maria Calem, Stefania Tognin, Gemma Modinos, Lieuwe de Haan, Mark van der Gaag, Eva Velthorst, Tamar C Kraan, Daniella S van Dam, Nadine Burger, Barnaby Nelson, Patrick McGorry, G Paul Amminger, Christos Pantelis, Athena Politis, Joanne Goodall, Anita Riecher-Rössler, Stefan Borgwardt, Charlotte Rapp, Sarah Ittig, Erich Studerus, Renata Smieskova, Rodrigo Bressan, Ary Gadelha, Elisa Brietzke, Graccielle Asevedo, Elson Asevedo, Andre Zugman, Neus Barrantes-Vidal, Tecelli Domínguez-Martínez, Anna Racioppi, Paula Cristóbal-Narváez, Thomas R Kwapil, Manel Monsonet, Mathilde Kazes, Claire Daban, Julie Bourgin, Olivier Gay, Célia Mam-Lam-Fook, Marie-Odile Krebs, Dorte Nordholm, Lasse Randers, Kristine Krakauer, Louise Glenthøj, Birte Glenthøj, Merete Nordentoft, Stephan Ruhrmann, Dominika Gebhard, Julia Arnhold, Joachim Klosterkötter, Gabriele Sachs, Iris Lasser, Bernadette Winklbaur, Philippe A Delespaul, Bart P Rutten, Jim van Os,

BACKGROUND:Gender differences in symptomatology in chronic schizophrenia and first episode psychosis patients have often been reported. However, little is known about gender differences in those at risk of psychotic disorders. This study investigated gender differences in symptomatology, drug use, comorbidity (i.e. substance use, affective and anxiety disorders) and global functioning ... Read more >>

Eur. Psychiatry (European psychiatry : the journal of the Association of European Psychiatrists)
[2019, 59:52-59]

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T97. PATTERNS OF COGNITIVE FUNCTION ARE UNIQUELY ASSOCIATED WITH WHITE MATTER-MICROSTRUCTURE IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS.

Tina Kristensen, Rene C W Mand, Jaychandra Raghava, Kasper Jessen, Jens Richardt M Jepsen, Birgitte Fagerlund, Louise B Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Merete Nordentoft, Birte Y Glenthøj, Bjørn H Ebdrup,

AbstractBackgroundIndividuals at ultra-high-risk for psychosis (UHR) are characterized by decline in cognitive functions. As cognition are suggested to be structural dependent on cerebral white matter organization, we here examine, if patterns of cognitive functions are associated with alterations in white matter for UHR compared to healthy controls (HC).Methods116 UHR and ... Read more >>

(Schizophrenia bulletin)
[2019, 45(Suppl 2):S241-S242]

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Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients.

Dorte Nordholm, Egill Rostrup, Valeria Mondelli, Lasse Randers, Mette Ø Nielsen, Sanne Wulff, Henrik Nørbak-Emig, Brian V Broberg, Kristine Krakauer, Paola Dazzan, Patricia A Zunszain, Merete Nordentoft, Birte Glenthøj,

INTRODUCTION:Abnormalities within hypothalamus-pituitary-adrenal (HPA) axis might interact with other neurobiological systems to enhance the risk of psychosis. Most of the neurodevelopmental and HPA axis changes occur in adolescence; this is also the period when prodromal and psychotic symptoms occur for the first time. More knowledge about how various stress components ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2018, 92:72-80]

Cited: 5 times

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Examining speed of processing of facial emotion recognition in individuals at ultra-high risk for psychosis: Associations with symptoms and cognition.

Louise Birkedal Glenthøj, Birgitte Fagerlund, Nikolaj Bak, Carsten Hjorthøj, Maja Gregersen, Tina Dam Kristensen, Christina Wenneberg, Kristine Krakauer, Joseph Ventura, Jens Richardt Møllegaard Jepsen, Merete Nordentoft,

Schizophr. Res. (Schizophrenia research)
[2018, 195:562-563]

Cited: 1 time

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Psychopathology and social functioning of 42 subjects from a Danish ultra high-risk cohort.

Helle Karkov Madsen, Dorte Nordholm, Kristine Krakauer, Lasse Randers, Merete Nordentoft,

AIM:To make a thorough characterization of the co-morbidity, psychopathology and demographics in the first Danish ultra high-risk (UHR) sample. METHOD:Forty-two UHR subjects went through comprehensive interviews assessing their psychopathology, psychiatric disorders, substance use and family history of psychiatric disorders. RESULTS:All UHR subjects met the criteria of at least 1 axis ... Read more >>

Early Interv Psychiatry (Early intervention in psychiatry)
[2018, 12(6):1181-1187]

Cited: 2 times

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SA81. Glutamatergic and GABAergic Disturbances in Individuals at Ultra-High Risk of Psychosis: Implications for Clinical and Functional Outcome.

Christina Wenneberg, Birte Y. Glenthøj, Brian V. Broberg, Louise B. Glenthøj, Tina D. Kristensen, Kristine Krakauer, Egill Rostrup, Merete Nordentoft,

Abstract CAARMS criteria identifies individuals at ultra-high risk (UHR) of psychosis of which approximately 30% develop psychosis within 2 years. These criteria require loss of function and a genetic predisposition or attenuated psychotic symptoms. Recent studies indicate that fewer UHR individuals have transition to psychosis, hence stratification of UHR individuals ... Read more >>

(Schizophrenia bulletin)
[2017, 43(Suppl 1):S142-S142]

Cited: 0 times

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Premorbid adjustment in individuals at ultra-high risk for developing psychosis: a case-control study.

Anders L Dannevang, Lasse Randers, Matthias Gondan, Kristine Krakauer, Dorte Nordholm, Merete Nordentoft,

AIM:Deterioration in premorbid adjustment is related to ultra-high risk (UHR) individuals developing psychosis, but it has not been examined how UHR individuals' development differs compared to healthy controls. This study investigates differences in premorbid adjustment between UHR individuals and a healthy control group. METHOD:A total of 48 UHR individuals and ... Read more >>

Early Interv Psychiatry (Early intervention in psychiatry)
[2018, 12(5):839-847]

Cited: 4 times

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Social cognition in patients at ultra-high risk for psychosis: What is the relation to social skills and functioning?

Louise B Glenthøj, Birgitte Fagerlund, Carsten Hjorthøj, Jens R M Jepsen, Nikolaj Bak, Tina D Kristensen, Christina Wenneberg, Kristine Krakauer, David L Roberts, Merete Nordentoft,

OBJECTIVE:Patients at ultra-high risk (UHR) for psychosis show significant impairments in functioning. It is essential to determine which factors influence functioning, as it may have implications for intervention strategies. This study examined whether social cognitive abilities and clinical symptoms are associated with functioning and social skills. METHODS:The study included 65 ... Read more >>

(Schizophrenia research. Cognition)
[2016, 5:21-27]

Cited: 7 times

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Systemic oxidative DNA and RNA damage are not increased during early phases of psychosis: A case control study.

Dorte Nordholm, Henrik Enghusen Poulsen, Carsten Hjorthøj, Lasse Randers, Mette Ø Nielsen, Sanne Wulff, Kristine Krakauer, Henrik Nørbak-Emig, Trine Henriksen, Birte Glenthøj, Merete Nordentoft,

It has been suggested that patients with schizophrenia develop higher levels of oxidative stress, which may contribute to deteriorating mental illness. In order to examine oxidative stress in the early stages of severe mental illness, we examined the levels of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2'-deoxyguanosine ... Read more >>

Psychiatry Res (Psychiatry research)
[2016, 241:201-206]

Cited: 8 times

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EFFECTIVENESS OF DIALECTICAL BEHAVIOR THERAPY VERSUS COLLABORATIVE ASSESSMENT AND MANAGEMENT OF SUICIDALITY TREATMENT FOR REDUCTION OF SELF-HARM IN ADULTS WITH BORDERLINE PERSONALITY TRAITS AND DISORDER-A RANDOMIZED OBSERVER-BLINDED CLINICAL TRIAL.

Kate Andreasson, Jesper Krogh, Christina Wenneberg, Helle K L Jessen, Kristine Krakauer, Christian Gluud, Rasmus R Thomsen, Lasse Randers, Merete Nordentoft,

Many psychological treatments have shown effect on reducing self-harm in adults with borderline personality disorder. There is a need of brief psychotherapeutical treatment alternative for suicide prevention in specialized outpatient clinics.The DiaS trial was designed as a pragmatic single-center, two-armed, parallel-group observer-blinded, randomized clinical superiority trial. The participants had at ... Read more >>

Depress Anxiety (Depression and anxiety)
[2016, 33(6):520-530]

Cited: 15 times

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The FOCUS trial: cognitive remediation plus standard treatment versus standard treatment for patients at ultra-high risk for psychosis: study protocol for a randomised controlled trial.

Louise B Glenthøj, Birgitte Fagerlund, Lasse Randers, Carsten R Hjorthøj, Christina Wenneberg, Kristine Krakauer, Astrid Vosgerau, Christian Gluud, Alice Medalia, David L Roberts, Merete Nordentoft,

Cognitive deficits are a distinct feature among people at ultra-high risk (UHR) for psychosis and pose a barrier to functional recovery. Insufficient evidence exists on how to ameliorate these cognitive deficits in patients at UHR for psychosis and hence improve daily living and quality of life. The aim of the ... Read more >>

Trials (Trials)
[2015, 16:25]

Cited: 11 times

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