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Author Kristin Gurtner

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The SIOP-Renal Tumour Study Group consensus statement on flank target volume delineation for highly conformal radiotherapy.

Geert O Janssens, Patrick Melchior, Joeri Mul, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Line Claude, Kristin Gurtner, Kees P van de Ven, Martine van Grotel, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Xavier Muracciole, Tom Boterberg, Henry Mandeville, Jan Godzinski, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe,

For decades, radiotherapy with two opposing photon beams has been the standard technique used to cover the flank target volume in paediatric patients with renal tumours. Nowadays, many institutes are implementing advanced radiotherapy techniques that spare healthy tissue. To decrease the radiotherapy dose to healthy structures while preserving oncological efficacy, ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):846-852]

Cited: 0 times

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Radioresistance of KRAS/TP53-mutated lung cancer can be overcome by radiation dose escalation or EGFR tyrosine kinase inhibition in vivo.

Kristin Gurtner, Zofia Kryzmien, Lydia Koi, Meng Wang, Cyril H Benes, Sandra Hering, Henning Willers, Michael Baumann, Mechthild Krause,

Recent clinical data have linked KRAS/TP53 comutation (mut) to resistance to radiotherapy (RT), but supporting laboratory in vivo evidence is lacking. In addition, the ability of different radiation doses, with/without epidermal growth factor receptor (EGFR)-directed treatment, to achieve local tumor control as a function of KRAS status is unknown. Here, ... Read more >>

Int J Cancer (International journal of cancer)
[2020, 147(2):472-477]

Cited: 2 times

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EGFR-amplification plus gene expression profiling predicts response to combined radiotherapy with EGFR-inhibition: A preclinical trial in 10 HNSCC-tumour-xenograft models.

Lydia Koi, Steffen Löck, Annett Linge, Cedric Thurow, Sandra Hering, Michael Baumann, Mechthild Krause, Kristin Gurtner,

BACKGROUND AND PURPOSE:Improvement of the results of radiotherapy by EGFR inhibitors is modest, suggesting significant intertumoural heterogeneity of response. To identify potential biomarkers, a preclinical trial was performed on ten different human squamous cell carcinoma xenografts of the head and neck (HNSCC) studying in vivo and ex vivo the effect ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2017, 124(3):496-503]

Cited: 3 times

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Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway.

Meng Wang, Jing Han, Lynnette Marcar, Josh Black, Qi Liu, Xiangyong Li, Kshithija Nagulapalli, Lecia V Sequist, Raymond H Mak, Cyril H Benes, Theodore S Hong, Kristin Gurtner, Mechthild Krause, Michael Baumann, Jing X Kang, Johnathan R Whetstine, Henning Willers,

Lung cancers with activating KRAS mutations are characterized by treatment resistance and poor prognosis. In particular, the basis for their resistance to radiation therapy is poorly understood. Here, we describe a radiation resistance phenotype conferred by a stem-like subpopulation characterized by mitosis-like condensed chromatin (MLCC), high CD133 expression, invasive potential, ... Read more >>

Cancer Res (Cancer research)
[2017, 77(8):2018-2028]

Cited: 19 times

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[Proton therapy of pediatric rhabdomyosarcoma: Same tumor control as photon therapy, with less adverse effects].

Kristin Gurtner, Michael Baumann,

Strahlenther Onkol (Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al])
[2015, 191(10):814-816]

Cited: 1 time

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Radiosensitization of NSCLC cells by EGFR inhibition is the result of an enhanced p53-dependent G1 arrest.

Malte Kriegs, Kristin Gurtner, Yildiz Can, Ingo Brammer, Thorsten Rieckmann, Reinhard Oertel, Marek Wysocki, Franziska Dorniok, Andreas Gal, Tobias J Grob, Simon Laban, Ulla Kasten-Pisula, Cordula Petersen, Michael Baumann, Mechthild Krause, Ekkehard Dikomey,

PURPOSE: How EGF receptor (EGFR) inhibition induces cellular radiosensitization and with that increase in tumor control is still a matter of discussion. Since EGFR predominantly regulates cell cycle and proliferation, we studied whether a G1-arrest caused by EGFR inhibition may contribute to these effects. MATERIALS AND METHODS: We analyzed human ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2015, 115(1):120-127]

Cited: 27 times

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BAY 87-2243, a novel inhibitor of hypoxia-induced gene activation, improves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts.

Linda Helbig, Lydia Koi, Kerstin Brüchner, Kristin Gurtner, Holger Hess-Stumpp, Kerstin Unterschemmann, Michael Baumann, Daniel Zips, Ala Yaromina,

BACKGROUND:The transcription factor hypoxia-inducible factor-1 (HIF-1) pathway plays an important role in tumor response to cytotoxic treatments. We investigated the effects of a novel small molecule inhibitor of mitochondrial complex I and hypoxia-induced HIF-1 activity BAY-87-2243, on tumor microenvironment and response of human squamous cell carcinoma (hSCC) to clinically relevant ... Read more >>

Radiat Oncol (Radiation oncology (London, England))
[2014, 9:207]

Cited: 20 times

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Effect of combined irradiation and EGFR/Erb-B inhibition with BIBW 2992 on proliferation and tumour cure in cell lines and xenografts.

Kristin Gurtner, Nadja Ebert, Dorothee Pfitzmann, Wolfgang Eicheler, Daniel Zips, Michael Baumann, Mechthild Krause,

In previous experiments an enhanced anti-proliterative effect of the EGFR/ErbB tyrosine kinase inhibitor (TKI) BIBW 2992 with single dose irradiation was observed in FaDu tumour xenografts. Aim of the present experiment was to determine if this effect can also be seen in combination with a fractionated radiotherapy. Secondly we investigate ... Read more >>

Radiat Oncol (Radiation oncology (London, England))
[2014, 9:261]

Cited: 3 times

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Hypoxia-inducible factor pathway inhibition resolves tumor hypoxia and improves local tumor control after single-dose irradiation.

Linda Helbig, Lydia Koi, Kerstin Brüchner, Kristin Gurtner, Holger Hess-Stumpp, Kerstin Unterschemmann, Martin Pruschy, Michael Baumann, Ala Yaromina, Daniel Zips,

PURPOSE: To study the effects of BAY-84-7296, a novel orally bioavailable inhibitor of mitochondrial complex I and hypoxia-inducible factor 1 (HIF-1) activity, on hypoxia, microenvironment, and radiation response of tumors. METHODS AND MATERIALS: UT-SCC-5 and UT-SCC-14 human squamous cell carcinomas were transplanted subcutaneously in nude mice. When tumors reached 4 mm ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2014, 88(1):159-166]

Cited: 12 times

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β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy.

Iris Eke, Yvonne Deuse, Stephanie Hehlgans, Kristin Gurtner, Mechthild Krause, Michael Baumann, Anna Shevchenko, Veit Sandfort, Nils Cordes,

Integrin signaling critically contributes to the progression, growth, and therapy resistance of malignant tumors. Here, we show that targeting of β₁ integrins with inhibitory antibodies enhances the sensitivity to ionizing radiation and delays the growth of human head and neck squamous cell carcinoma cell lines in 3D cell culture and ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2012, 122(4):1529-1540]

Cited: 115 times

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Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression.

Kristin Gurtner, Yvonne Deuse, Rebecca Bütof, Katja Schaal, Wolfgang Eicheler, Reinhard Oertel, Reidar Grenman, Howard Thames, Ala Yaromina, Michael Baumann, Mechthild Krause,

PURPOSE: To compare functional effects of combined irradiation and EGFR inhibition in different HNSCC tumour models in vivo with the results of molecular evaluations, aiming to set a basis for the development of potential biomarkers for local tumour control. MATERIAL AND METHODS: In five HNSCC tumour models, all wild-type for ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2011, 99(3):323-330]

Cited: 44 times

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Combined treatment of the immunoconjugate bivatuzumab mertansine and fractionated irradiation improves local tumour control in vivo.

Kristin Gurtner, Franziska Hessel, Wolfgang Eicheler, Annegret Dörfler, Daniel Zips, Karl-Heinz Heider, Mechthild Krause, Michael Baumann,

BACKGROUND AND PURPOSE: To test whether BIWI 1 (bivatuzumab mertansine), an immunoconjugate of the humanized anti-CD44v6 monoclonal antibody BIWA 4 and the maytansinoid DM1, given simultaneously to fractionated irradiation improves local tumour control in vivo compared with irradiation alone. MATERIAL AND METHODS: For growth delay, FaDu tumours were treated with ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2012, 102(3):444-449]

Cited: 15 times

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Heterogeneity of tumour response to combined radiotherapy and EGFR inhibitors: differences between antibodies and TK inhibitors.

Mechthild Krause, Kristin Gurtner, Yvonne Deuse, Michael Baumann,

PURPOSE: Clinical and preclinical data show a wide variability of tumour response to combined inhibition of the Epidermal Growth Factor Receptor (EGFR) and radiotherapy or chemotherapy. Differences are obvious not only between different tumour entities, but also between different combination schedules and different classes of drugs. The underlying reasons are ... Read more >>

Int. J. Radiat. Biol. (International journal of radiation biology)
[2009, 85(11):943-954]

Cited: 25 times

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Epidermal growth factor receptor inhibitors for radiotherapy: biological rationale and preclinical results.

Daniel Zips, Mechthild Krause, Ala Yaromina, Annegret Dörfler, Wolfgang Eicheler, Christina Schütze, Kristin Gurtner, Michael Baumann,

Blocking the epidermal growth factor receptor (EGFR) represents a role model for a successful biological targeting approach to improving outcomes after radiotherapy. This review summarizes data from several local tumour control experiments in which EGFR inhibitors were combined with radiation in FaDu human squamous cell carcinomas xenografted into nude mice. ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2008, 60(8):1019-1028]

Cited: 16 times

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