Full Text Journal Articles by
Author Kristin E Mullins

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Renin Kinetics Are Superior to Lactate Kinetics for Predicting In-Hospital Mortality in Hypotensive Critically Ill Patients.

Maniraj Jeyaraju, Michael T McCurdy, Andrea R Levine, Prasad Devarajan, Michael A Mazzeffi, Kristin E Mullins, Michaella Reif, David N Yim, Christopher Parrino, Allison S Lankford, Jonathan H Chow,

<h4>Objectives</h4>Whole blood lactate concentration is widely used in shock states to assess perfusion. We aimed to determine if the change in plasma renin concentration over time would be superior to the change in lactate concentration for predicting in-hospital mortality in hypotensive patients on vasopressors.<h4>Design</h4>Prospective, observational cohort study.<h4>Setting</h4>Tertiary academic ICU.<h4>Patients</h4>Adult patients ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

Cited: 0 times

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Performance of 4 Automated SARS-CoV-2 Serology Assay Platforms in a Large Cohort Including Susceptible COVID-19-Negative and COVID-19-Positive Patients.

Matthew D Ward, Kristin E Mullins, Elizabeth Pickett, VeRonika Merrill, Mark Ruiz, Heather Rebuck, Show-Hong Duh, Robert H Christenson,

<h4>Background</h4>Anti-SARS-CoV-2 serological responses may have a vital role in controlling the spread of the disease. However, the comparative performance of automated serological assays has not been determined in susceptible patients with significant comorbidities.<h4>Methods</h4>In this study, we used large numbers of samples from patients who were negative (n = 2030) or positive (n = 112) ... Read more >>

J Appl Lab Med (The journal of applied laboratory medicine)
[2021, 6(4):942-952]

Cited: 0 times

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Kinetics of SARS-CoV-2 antibody responses pre-COVID-19 and post-COVID-19 convalescent plasma transfusion in patients with severe respiratory failure: an observational case-control study.

Matthew N Klein, Elizabeth Wenqian Wang, Paul Zimand, Heather Beauchamp, Caitlin Donis, Matthew D Ward, Aidaelis Martinez-Hernandez, Ali Tabatabai, John W Baddley, Evan M Bloch, Kristin E Mullins, Magali J Fontaine,

<h4>Aims</h4>While the SARS-CoV-2 pandemic may be contained through vaccination, transfusion of convalescent plasma (CCP) from individuals who recovered from COVID-19 (CCP) is considered an alternative treatment. We investigate if CCP transfusion in patients with severe respiratory failure increases plasma titres of SARS-CoV-2 antibodies and improves clinical outcomes.<h4>Methods</h4>Patients with COVID-19 (n=34) ... Read more >>

J Clin Pathol (Journal of clinical pathology)
[2021, :]

Cited: 4 times

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Validation of COVID-19 serologic tests and large scale screening of asymptomatic healthcare workers.

Kristin E Mullins, VeRonika Merrill, Matthew Ward, Brent King, Peter Rock, Mary Caswell, Mark Ahlman, Anthony D Harris, Robert Christenson,

<h4>Objectives</h4>Serologic testing for SARS-CoV-2 is an important element in the fight to slow the COVID-19 pandemic. This study aimed to validate two serologic tests for total (IgM, IgG, IgA) SARS-CoV-2 antibodies, (i) the Ortho-Clinical Diagnostics Anti-SARS-CoV-2 Total Antibody assay for the Vitros 5600 analyzers and (ii) a manual laboratory developed ... Read more >>

Clin Biochem (Clinical biochemistry)
[2021, 90:23-27]

Cited: 1 time

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Navigating COVID-19 Testing: Special Considerations for the Cardiovascular Clinician.

Palak Shah, Christopher R deFilippi, Kristin E Mullins,

Circulation (Circulation)
[2020, 142(24):2293-2295]

Cited: 1 time

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Optimal Detection of Acute Myocardial Injury and Infarction with Cardiac Troponin: Beyond the 99th Percentile, into the High-Sensitivity Era.

Kristin E Mullins, Robert H Christenson,

<h4>Purpose of review</h4>Cardiac troponin (cTn) is the biomarker of choice for the diagnosis of acute myocardial infarction (MI); use of this biomarker has centered around the 99th percentile upper reference limit (URL) for healthy populations. Recent development and regulatory approval of high-sensitivity cardiac troponin (hs-cTn) assays have required a fresh ... Read more >>

Curr Cardiol Rep (Current cardiology reports)
[2020, 22(9):101]

Cited: 3 times

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Analytical and clinical characterization of a novel high-sensitivity cardiac troponin assay in a United States population.

Robert H Christenson, Show-Hong Duh, Kristin E Mullins, Margot M LeClair, Ilya L Grigorov, W Frank Peacock,

<h4>Background</h4>Cardiac troponin (cTn) is the keystone for diagnosis of acute myocardial infarction (AMI). We examined the analytical and clinical diagnostic characteristics of the ACCESS hsTnI assay in a United States (US) population.<h4>Methods</h4>All measurements and studies were conducted using a lithium heparin matrix. Sex-specific 99th percentile upper reference limits (URLs) were ... Read more >>

Clin Biochem (Clinical biochemistry)
[2020, 83:28-36]

Cited: 2 times

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Rickettsial Infections among Cats and Cat Fleas in Riverside County, California.

Kristin E Mullins, Alice N Maina, Laura Krueger, Ju Jiang, Robert Cummings, Allan Drusys, Greg Williams, Major Dhillon, Allen L Richards,

Presently, few studies have investigated the role of domestic cats (Felis catus) in the recrudescence of flea-borne rickettsioses in California and the southern United States. In this study, we aimed to investigate the presence of Rickettsia typhi or Rickettisa felis in domestic cats (F. catus) and the fleas (primarily Ctenocephalides ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2018, 99(2):291-296]

Cited: 4 times

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Whole-Genome Analysis of Bartonella ancashensis, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru.

Kristin E Mullins, Jun Hang, Robert J Clifford, Fatma Onmus-Leone, Yu Yang, Ju Jiang, Mariana Leguia, Matthew R Kasper, Ciro Maguina, Emil P Lesho, Richard G Jarman, Allen Richards, David Blazes,

The genus Bartonella contains >40 species, and an increasing number of these Bartonella species are being implicated in human disease. One such pathogen is Bartonella ancashensis, which was isolated in blood samples from 2 patients living in Caraz, Peru, during a clinical trial of treatment for bartonellosis. Three B. ancashensis ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2017, 23(3):430-438]

Cited: 10 times

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Description of Bartonella ancashensis sp. nov., isolated from the blood of two patients with verruga peruana.

Kristin E Mullins, Jun Hang, Ju Jiang, Mariana Leguia, Matthew R Kasper, Palmira Ventosilla, Ciro Maguiña, Richard G Jarman, David Blazes, Allen L Richards,

Three novel isolates of the genus Bartonella were recovered from the blood of two patients enrolled in a clinical trial for the treatment of chronic stage Bartonella bacilliformis infection (verruga peruana) in Caraz, Ancash, Peru. The isolates were initially characterized by sequencing a fragment of the gltA gene, and found ... Read more >>

Int J Syst Evol Microbiol (International journal of systematic and evolutionary microbiology)
[2015, 65(10):3339-3343]

Cited: 13 times

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Complete Genome Sequence of Bartonella ancashensis Strain 20.00, Isolated from the Blood of a Patient with Verruga Peruana.

Jun Hang, Kristin E Mullins, Robert J Clifford, Fatma Onmus-Leone, Yu Yang, Ju Jiang, Mariana Leguia, Matthew R Kasper, Ciro Maguiña, Emil P Lesho, Richard G Jarman, Allen L Richards, David Blazes,

Here we present the complete genome sequence of Bartonella ancashensis strain 20.00, isolated from the blood of a Peruvian patient with verruga peruana, known as Carrion's disease. Bartonella ancashensis is a Gram-negative bacillus, phylogenetically most similar to Bartonella bacilliformis, the causative agent of Oroya fever and verruga peruana. ... Read more >>

Genome Announc (Genome announcements)
[2015, 3(6):]

Cited: 4 times

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Molecular typing of "Candidatus Bartonella ancashi," a new human pathogen causing verruga peruana.

Kristin E Mullins, Jun Hang, Ju Jiang, Mariana Leguia, Matthew R Kasper, Ciro Maguiña, Richard G Jarman, David L Blazes, Allen L Richards,

A recently described clinical isolate, "Candidatus Bartonella ancashi," was obtained from a blood sample of a patient presenting with verruga peruana in the Ancash region of Peru. This sample and a second isolate obtained 60 days later from the same patient were molecularly typed using multilocus sequence typing (MLST) and ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2013, 51(11):3865-3868]

Cited: 14 times

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