Kathryn N Becker, Krista M Pettee, Amanda Sugrue, Kevin A Reinard, Jason L Schroeder, Kathryn M Eisenmann,
Glioblastoma (GBM) is a progressive and lethal brain cancer. Malignant control of actin and microtubule cytoskeletal mechanics facilitates two major GBM therapeutic resistance strategies-diffuse invasion and tumor microtube network formation. Actin and microtubule reorganization is controlled by Rho-GTPases, which exert their effects through downstream effector protein activation, including Rho-associated kinases ... Read more >>
Cells (Cells)
[2022, 11(9):1559]
Cited: 0 times
Krista M Pettee, Kathryn N Becker, Arthur S Alberts, Kevin A Reinard, Jason L Schroeder, Kathryn M Eisenmann,
High-grade glioma (HGG, WHO Grade IIIā»IV) accounts for the majority of adult primary malignant brain tumors. Failure of current therapies to target invasive glioma cells partly explains the minimal survival advantages: invasive tumors lack easily-defined surgical margins, and are inherently more chemo- and radioresistant. Much work centers upon Rho GTPase-mediated ... Read more >>
Cancers (Basel) (Cancers)
[2019, 11(3):E392]
Cited: 5 times